Cysltr1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cysltr1
Entrez Gene ID	114099
Full Name	cysteinyl leukotriene receptor 1
Synonyms	Cyslt1
General protein information	Preferred Names cysteinyl leukotriene receptor 1 Names cysteinyl leukotriene receptor 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: X Map Location: Xq22
Summary	plays a role in the development of eosinophilic airway inflammation [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006257158.2	XP_006257220.1	cysteinyl leukotriene receptor 1 isoform X1
NM_053641.1	NP_446093.1	cysteinyl leukotriene receptor 1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	CYSLTR1	XP_003435638.1
Danio rerio (zebrafish)	cysltr1	NP_001018484.1
	CYSLTR1	XP_001100982.1
Rattus norvegicus (Norway rat)	Cysltr1	NP_446093.1
Gallus gallus (chicken)	CYSLTR1	XP_426249.3
Pan troglodytes (chimpanzee)	CYSLTR1	XP_003317577.1
Bos taurus (cattle)	CYSLTR1	NP_001093196.1
Mus musculus (house mouse)	Cysltr1	NP_001268788.1
Homo sapiens (human)	CYSLTR1	NP_001269115.1
Xenopus tropicalis (tropical clawed frog)	cysltr1	XP_004916956.1

Gene Ontology
Bibliography

Related articles in PubMed

The anti-inflammatory effect of montelukast, a cysteinyl leukotriene receptor-1 antagonist, against estradiol-induced nonbacterial inflammation in the rat prostate.
Said MM, Bosland MC
Naunyn-Schmiedeberg's archives of pharmacology390(2)197-205(2017 Feb)

[Cysteinyl leukotriene receptor 1 is involved in rotenone-induced injury of PC12 cells].
Yu SY, Zhao B, Zhang XY, Zhang XY, Wang YF, Zhang LH, Lu YB, Wei EQ
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences41(2)139-45(2012 Mar)

Cysteinyl leukotriene type I receptor desensitization sustains Ca2+-dependent gene expression.
Ng SW, Bakowski D, Nelson C, Mehta R, Almeyda R, Bates G, Parekh AB
Nature482(7383)111-5(2012 Jan)

Involvement of cysteinyl leukotriene receptors in angiogenesis in rat thoracic aortic rings.
Xu L, Zhang L, Liu L, Fang S, Lu Y, Wei E, Zhang W
Die Pharmazie65(10)750-4(2010 Oct)

[Lung fibrosis induced by mechanical ventilation with different tidal volume in neonatal rats].
Huang JJ, Wu BQ, Ding L, Chen L
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics12(10)799-803(2010 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Cysteinyl leukotriene receptor-1 antagonist montelukast prevents estradiol-induced nonbacterial inflammation in the rat prostate.
Title: The anti-inflammatory effect of montelukast, a cysteinyl leukotriene receptor-1 antagonist, against estradiol-induced nonbacterial inflammation in the rat prostate.

The expression of CysLT(1) receptor increased after rotenone treatment of PC12 cells.
Title: [Cysteinyl leukotriene receptor 1 is involved in rotenone-induced injury of PC12 cells].

abolishing leukotriene receptor desensitization suppresses agonist-driven gene expression in a rat cell line
Title: Cysteinyl leukotriene type I receptor desensitization sustains Ca2+-dependent gene expression.

At 0 to 3 hours after renal ischemia-reperfusion, CysLT1R expression on endothelial cells gradually became stronger, being most intense at 3 hours after reperfusion
Title: Study of cysteinyl leukotriene-1 receptor in rat renal ischemia-reperfusion injury.

Thus, we conclude that cysteinyl leukotriene receptor 1 mediates acute neuronal damage and subacute/chronic astrogliosis after focal cerebral ischemia.
Title: Increased expression of cysteinyl leukotriene receptor-1 in the brain mediates neuronal damage and astrogliosis after focal cerebral ischemia in rats.

The following Cysltr1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cysltr1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa40057	NM_053641.1 Latest version!	Rattus norvegicus cysteinyl leukotriene receptor 1 (Cysltr1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
ORa40057	XM_006257158.2 Latest version!	Rattus norvegicus cysteinyl leukotriene receptor 1 (Cysltr1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cysltr1 ( NM_053641.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_446093.1 Rattus norvegicus cysteinyl leukotriene receptor 1 (Cysltr1), mRNA.

Price & Availability↑

CloneID	ORa40057
Clone ID Related Accession (Same CDS sequence)	XM_006257158.2 , NM_053641.1
Accession Version	NM_053641.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1020bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-23
Organism	Rattus norvegicus(Norway rat)
Product	cysteinyl leukotriene receptor 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB052685.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB052685.1 [ECO:0000332] ##Evidence-Data-END##

ATGGTTGGAG CTGAAAATAT GACAGCATCT TTCAGTAATA ACAGATGTCA TGACACAATT 
GATGAATTCC GAAATCAGGT GTACTCCACA ATGTACTCTA TGATCTCCGT TGTGGGTTTC 
TTTGGCAATA GCTTTGTCCT CTATGTCCTC ATAAAAACAT ACCATGAGAA ATCAGCCTTC 
CAAGTATACA TGATTAATCT AGCCATAGCA GATCTACTCT GTGTATGTAC ATTGCCTCTC 
CGTGTGGTCT ACTATGTTCA CAAAGGCAAG TGGTTCTTTG GTGACTTTTT GTGCCGCCTC 
ACCACCTATG CCTTATATGT TAACCTCTAT TGTAGCATCT TCTTTATGAC AGCCATGAGC 
TTTTTCCGGT GTGTTGCAAT TGTCTTTCCA GTCCAGAACA TTAATTTGGT TACACAGAAA 
AAAGCCAGGT TTGTGTGTGT TGGAATTTGG ATTTTTGTGA TTTTGACAAG TTCTCCATTT 
TTACTGAGCA AATCTTACCA AGATGAGAAA AACAATACTA AATGTTTTGA GCCTCCACAG 
GACAAACAAA CTAAAAAATA TGTTTTGGTC TTGCATTATG TGTCATTAAT CTTTGGTTTC 
ATCATCCCTT TTGTCACCAT AATTGTCTGT TACACAATGA TCATTCTGAC CTTACTAAAA 
AATACAATGA AGAAAAACCT GCCAAGTCGA AGGAAGGCTA TAGGAATGAT CATAGTTGTG 
ACAGCTGCCT TTTTAGTCAG CTTCATGCCA TATCATATTC AACGAGCTAT CCACCTTCAC 
TTTTTACACA GTGAAACTAG ATCCTGTGAC TCTGTCCTTA GGATGCAGAA GTCAGTGGTC 
ATAACCTTAT CTCTAGCTGC ATCAAATTGT TGCTTTGATC CTCTGCTATA TTTCTTTTCA 
GGTGGAAACT TTAGGAGAAG GCTGTCTACA TTTAGAAAGC ATTCTTTGTC CAGTATGACT 
TACATACCCA AAAAGAAAGC TTCCTTGCCA GAAAAAGGAG AAGAAATGTG TAAAGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_446093.1
CDS	1..1020
Translation	MVGAENMTASFSNNRCHDTIDEFRNQVYSTMYSMISVVGFFGNSFVLYVLIKTYHEKSAFQVYMINLAIADLLCVCTLPLRVVYYVHKGKWFFGDFLCRLTTYALYVNLYCSIFFMTAMSFFRCVAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLLSKSYQDEKNNTKCFEPPQDKQTKKYVLVLHYVSLIFGFIIPFVTIIVCYTMIILTLLKNTMKKNLPSRRKAIGMIIVVTAAFLVSFMPYHIQRAIHLHFLHSETRSCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRRRLSTFRKHSLSSMTYIPKKKASLPEKGEEMCKE

Target ORF information:

RefSeq Version	NM_053641.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cysteinyl leukotriene receptor 1 (Cysltr1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053641.1

ORF Insert Sequence:

ATGGTTGGAG CTGAAAATAT GACAGCATCT TTCAGTAATA ACAGATGTCA TGACACAATT 
GATGAATTCC GAAATCAGGT GTACTCCACA ATGTACTCTA TGATCTCCGT TGTGGGTTTC 
TTTGGCAATA GCTTTGTCCT CTATGTCCTC ATAAAAACAT ACCATGAGAA ATCAGCCTTC 
CAAGTATACA TGATTAATCT AGCCATAGCA GATCTACTCT GTGTATGTAC ATTGCCTCTC 
CGTGTGGTCT ACTATGTTCA CAAAGGCAAG TGGTTCTTTG GTGACTTTTT GTGCCGCCTC 
ACCACCTATG CCTTATATGT TAACCTCTAT TGTAGCATCT TCTTTATGAC AGCCATGAGC 
TTTTTCCGGT GTGTTGCAAT TGTCTTTCCA GTCCAGAACA TTAATTTGGT TACACAGAAA 
AAAGCCAGGT TTGTGTGTGT TGGAATTTGG ATTTTTGTGA TTTTGACAAG TTCTCCATTT 
TTACTGAGCA AATCTTACCA AGATGAGAAA AACAATACTA AATGTTTTGA GCCTCCACAG 
GACAAACAAA CTAAAAAATA TGTTTTGGTC TTGCATTATG TGTCATTAAT CTTTGGTTTC 
ATCATCCCTT TTGTCACCAT AATTGTCTGT TACACAATGA TCATTCTGAC CTTACTAAAA 
AATACAATGA AGAAAAACCT GCCAAGTCGA AGGAAGGCTA TAGGAATGAT CATAGTTGTG 
ACAGCTGCCT TTTTAGTCAG CTTCATGCCA TATCATATTC AACGAGCTAT CCACCTTCAC 
TTTTTACACA GTGAAACTAG ATCCTGTGAC TCTGTCCTTA GGATGCAGAA GTCAGTGGTC 
ATAACCTTAT CTCTAGCTGC ATCAAATTGT TGCTTTGATC CTCTGCTATA TTTCTTTTCA 
GGTGGAAACT TTAGGAGAAG GCTGTCTACA TTTAGAAAGC ATTCTTTGTC CAGTATGACT 
TACATACCCA AAAAGAAAGC TTCCTTGCCA GAAAAAGGAG AAGAAATGTG TAAAGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cysltr1 ( XM_006257158.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006257220.1 Rattus norvegicus cysteinyl leukotriene receptor 1 (Cysltr1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa40057
Clone ID Related Accession (Same CDS sequence)	XM_006257158.2 , NM_053641.1
Accession Version	XM_006257158.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1020bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	cysteinyl leukotriene receptor 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005120.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 7, 2014 this sequence version replaced XM_006257158.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTTGGAG CTGAAAATAT GACAGCATCT TTCAGTAATA ACAGATGTCA TGACACAATT 
GATGAATTCC GAAATCAGGT GTACTCCACA ATGTACTCTA TGATCTCCGT TGTGGGTTTC 
TTTGGCAATA GCTTTGTCCT CTATGTCCTC ATAAAAACAT ACCATGAGAA ATCAGCCTTC 
CAAGTATACA TGATTAATCT AGCCATAGCA GATCTACTCT GTGTATGTAC ATTGCCTCTC 
CGTGTGGTCT ACTATGTTCA CAAAGGCAAG TGGTTCTTTG GTGACTTTTT GTGCCGCCTC 
ACCACCTATG CCTTATATGT TAACCTCTAT TGTAGCATCT TCTTTATGAC AGCCATGAGC 
TTTTTCCGGT GTGTTGCAAT TGTCTTTCCA GTCCAGAACA TTAATTTGGT TACACAGAAA 
AAAGCCAGGT TTGTGTGTGT TGGAATTTGG ATTTTTGTGA TTTTGACAAG TTCTCCATTT 
TTACTGAGCA AATCTTACCA AGATGAGAAA AACAATACTA AATGTTTTGA GCCTCCACAG 
GACAAACAAA CTAAAAAATA TGTTTTGGTC TTGCATTATG TGTCATTAAT CTTTGGTTTC 
ATCATCCCTT TTGTCACCAT AATTGTCTGT TACACAATGA TCATTCTGAC CTTACTAAAA 
AATACAATGA AGAAAAACCT GCCAAGTCGA AGGAAGGCTA TAGGAATGAT CATAGTTGTG 
ACAGCTGCCT TTTTAGTCAG CTTCATGCCA TATCATATTC AACGAGCTAT CCACCTTCAC 
TTTTTACACA GTGAAACTAG ATCCTGTGAC TCTGTCCTTA GGATGCAGAA GTCAGTGGTC 
ATAACCTTAT CTCTAGCTGC ATCAAATTGT TGCTTTGATC CTCTGCTATA TTTCTTTTCA 
GGTGGAAACT TTAGGAGAAG GCTGTCTACA TTTAGAAAGC ATTCTTTGTC CAGTATGACT 
TACATACCCA AAAAGAAAGC TTCCTTGCCA GAAAAAGGAG AAGAAATGTG TAAAGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006257220.1
CDS	715..1734
Translation	MVGAENMTASFSNNRCHDTIDEFRNQVYSTMYSMISVVGFFGNSFVLYVLIKTYHEKSAFQVYMINLAIADLLCVCTLPLRVVYYVHKGKWFFGDFLCRLTTYALYVNLYCSIFFMTAMSFFRCVAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLLSKSYQDEKNNTKCFEPPQDKQTKKYVLVLHYVSLIFGFIIPFVTIIVCYTMIILTLLKNTMKKNLPSRRKAIGMIIVVTAAFLVSFMPYHIQRAIHLHFLHSETRSCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRRRLSTFRKHSLSSMTYIPKKKASLPEKGEEMCKE

Target ORF information:

RefSeq Version	XM_006257158.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cysteinyl leukotriene receptor 1 (Cysltr1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006257158.2

ORF Insert Sequence:

ATGGTTGGAG CTGAAAATAT GACAGCATCT TTCAGTAATA ACAGATGTCA TGACACAATT 
GATGAATTCC GAAATCAGGT GTACTCCACA ATGTACTCTA TGATCTCCGT TGTGGGTTTC 
TTTGGCAATA GCTTTGTCCT CTATGTCCTC ATAAAAACAT ACCATGAGAA ATCAGCCTTC 
CAAGTATACA TGATTAATCT AGCCATAGCA GATCTACTCT GTGTATGTAC ATTGCCTCTC 
CGTGTGGTCT ACTATGTTCA CAAAGGCAAG TGGTTCTTTG GTGACTTTTT GTGCCGCCTC 
ACCACCTATG CCTTATATGT TAACCTCTAT TGTAGCATCT TCTTTATGAC AGCCATGAGC 
TTTTTCCGGT GTGTTGCAAT TGTCTTTCCA GTCCAGAACA TTAATTTGGT TACACAGAAA 
AAAGCCAGGT TTGTGTGTGT TGGAATTTGG ATTTTTGTGA TTTTGACAAG TTCTCCATTT 
TTACTGAGCA AATCTTACCA AGATGAGAAA AACAATACTA AATGTTTTGA GCCTCCACAG 
GACAAACAAA CTAAAAAATA TGTTTTGGTC TTGCATTATG TGTCATTAAT CTTTGGTTTC 
ATCATCCCTT TTGTCACCAT AATTGTCTGT TACACAATGA TCATTCTGAC CTTACTAAAA 
AATACAATGA AGAAAAACCT GCCAAGTCGA AGGAAGGCTA TAGGAATGAT CATAGTTGTG 
ACAGCTGCCT TTTTAGTCAG CTTCATGCCA TATCATATTC AACGAGCTAT CCACCTTCAC 
TTTTTACACA GTGAAACTAG ATCCTGTGAC TCTGTCCTTA GGATGCAGAA GTCAGTGGTC 
ATAACCTTAT CTCTAGCTGC ATCAAATTGT TGCTTTGATC CTCTGCTATA TTTCTTTTCA 
GGTGGAAACT TTAGGAGAAG GCTGTCTACA TTTAGAAAGC ATTCTTTGTC CAGTATGACT 
TACATACCCA AAAAGAAAGC TTCCTTGCCA GAAAAAGGAG AAGAAATGTG TAAAGAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The anti-inflammatory effect of montelukast, a cysteinyl leukotriene receptor-1 antagonist, against estradiol-induced nonbacterial inflammation in the rat prostate.
Naunyn-Schmiedeberg's archives of pharmacology390(2)197-205(2017 Feb)
Said MM,Bosland MC

[Cysteinyl leukotriene receptor 1 is involved in rotenone-induced injury of PC12 cells].
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences41(2)139-45(2012 Mar)
Yu SY,Zhao B,Zhang XY,Zhang XY,Wang YF,Zhang LH,Lu YB,Wei EQ

Cysteinyl leukotriene type I receptor desensitization sustains Ca2+-dependent gene expression.
Nature482(7383)111-5(2012 Jan)
Ng SW,Bakowski D,Nelson C,Mehta R,Almeyda R,Bates G,Parekh AB

Involvement of cysteinyl leukotriene receptors in angiogenesis in rat thoracic aortic rings.
Die Pharmazie65(10)750-4(2010 Oct)
Xu L,Zhang L,Liu L,Fang S,Lu Y,Wei E,Zhang W

[Lung fibrosis induced by mechanical ventilation with different tidal volume in neonatal rats].
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics12(10)799-803(2010 Oct)
Huang JJ,Wu BQ,Ding L,Chen L