Nfatc1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nfatc1
Entrez Gene ID	100361818
Full Name	nuclear factor of activated T-cells 1
General protein information	Preferred Names nuclear factor of activated T-cells 1 Names nuclear factor of activated T-cells, cytoplasmic 1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 18 Map Location: 18q12.3

mRNA and Protein(s)

mRNA	Protein	Name
NM_001244933.1	NP_001231862.1	nuclear factor of activated T-cells, cytoplasmic 1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	NFATC1	NP_001160087.1
Xenopus tropicalis (tropical clawed frog)	nfatc1	NP_001072740.1
Pan troglodytes (chimpanzee)	NFATC1	XP_512184.4
Gallus gallus (chicken)	NFATC1	XP_418906.4
	NFATC1	XP_001088054.1
Canis lupus familiaris (dog)	NFATC1	XP_005615343.1
Mus musculus (house mouse)	Nfatc1	NP_001157584.1
Danio rerio (zebrafish)	nfatc1	NP_001038624.1
Homo sapiens (human)	NFATC1	NP_001265598.1
Rattus norvegicus (Norway rat)	Nfatc1	NP_001231862.1

Gene Ontology
Bibliography

Related articles in PubMed

Peptide 11R-VIVIT stimulates osteoblastogenesis through regulating the expression of nuclear factor of activated T cells cytoplasmic 1.
Li M, Wang X, Bian Z, Yao W, He Q, Tian F, Zhang J, Zhu L
Cellular and molecular biology (Noisy-le-Grand, France)63(4)46-52(2017 Apr)

Role of RANKL in the regulation of NFATc1 and c?Src mRNA expression in osteoclast?like cells.
Fu J, Tao YD, Chen J, Zhang Y, He J
Molecular medicine reports13(6)5163-8(2016 Jun)

Tmem178 acts in a novel negative feedback loop targeting NFATc1 to regulate bone mass.
Decker CE, Yang Z, Rimer R, Park-Min KH, Macaubas C, Mellins ED, Novack DV, Faccio R
Proceedings of the National Academy of Sciences of the United States of America112(51)15654-9(2015 Dec)

Calcineurin-NFATc regulates type 2 inositol 1,4,5-trisphosphate receptor (InsP3R2) expression during cardiac remodeling.
Sankar N, deTombe PP, Mignery GA
The Journal of biological chemistry289(9)6188-98(2014 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These data suggest that RANKL could regulate the expression of NFATc1 and cSrc mRNA in the marrow culture system.
Title: Role of RANKL in the regulation of NFATc1 and c?Src mRNA expression in osteoclast?like cells.

ITPR2 and hypertrophy specific gene expression is regulated, in part, by a positive feedback regulation between InsP3R2 and calcineurin-NFATc signaling pathways.
Title: Calcineurin-NFATc regulates type 2 inositol 1,4,5-trisphosphate receptor (InsP3R2) expression during cardiac remodeling.

this study identified two crucial immune-related molecules-CD28 and NFATc1, as putative targets of miR-145 in human and experimental myasthenia gravis
Title: Identification of novel MicroRNA signatures linked to experimental autoimmune myasthenia gravis pathogenesis: down-regulated miR-145 promotes pathogenetic Th17 cell response.

findings show that ASIC1a-mediated calcium entry plays a critical role in osteoclastogenesis by regulating activation of the NFATc1
Title: Acid-sensing ion channel 1a is involved in acid-induced osteoclastogenesis by regulating activation of the transcription factor NFATc1.

reduced myonuclear NFATc1 accumulation is a signs of slow-type myofibre atrophy, myofibre type remodelling
Title: Increased myofiber remodelling and NFATc1-myonuclear translocation in rat postural skeletal muscle after experimental vestibular deafferentation.

The following Nfatc1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nfatc1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13192	NM_001244933.1 Latest version!	Rattus norvegicus nuclear factor of activated T-cells 1 (Nfatc1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nfatc1 ( NM_001244933.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001231862.1 Rattus norvegicus nuclear factor of activated T-cells 1 (Nfatc1), mRNA.

Price & Availability↑

CloneID	ORa13192
Clone ID Related Accession (Same CDS sequence)	NM_001244933.1
Accession Version	NM_001244933.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2484bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-01-12
Organism	Rattus norvegicus(Norway rat)
Product	nuclear factor of activated T-cells, cytoplasmic 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from FQ222003.1. On Oct 7, 2011 this sequence version replaced XM_002728567.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: FQ222003.1, FQ223020.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGCCAAGTA CCAGCTTTCC AGTCCCTTCC AAGTTTCCAC TCGGCCCTCC GGCCGCAGTC 
TGCGGGAGCG GAGAAACTTT GCGGCCCGCG CCGCTCGCCG GCGGCACCAT GAAGGCGGCC 
GAGGAAGAAC ACTACAGTTA TGCGTCCCCT AGCGTCACCT CAACTCTGCC CCTTCCCACA 
GCACACTCCG CCTTGCCAGC GGCATGCCAT GACCTCCAGA CGTCCACCCC GGGCATCTCA 
GCTGTTCCTT CGGCCAATCA CCCCTCTGGT TATGGGGGCG CTGTGGACAG TGGGCCTTCA 
GGATACTTCC TGTCCTCCGG CAACACGAGA CCCAATGGGG CCCCGACTCT CGAGAGTCCT 
CGAATCGAGA TCACCTCCTA TCTGGGCCTT CACCACGGCA GCAACCAATT TTTCCACGAT 
GTGGAGGTGG AAGACGTACT TCCTAGCTGC AAGCGGTCAC CATCTACAGC AACCCTGCAC 
CTGCCCAGTC TGGAAGCCTA CAGAGACCCC TCCTGCCTGA GCCCAGCCAG CAGCCTGTCC 
TCCAGGAGCT GTAACTCTGA GGCGTCCTCC TATGAGTCCA ACTATTCATA CCCGTACGCA 
TCCCCCCAGA CCTCTCCATG GCAGTCACCC TGTGTGTCTC CCAAGACCAC GGACCCAGAG 
GAGGGCTTTC CCCGAAGCCT GGGTGCCTGC CACTTGCTGG GATCGCCAAG GCACTCCCCA 
TCCACCTCTC CTCGTGCAAG CGTCACCGAG GAGAGCTGGC TCGGTGCCCG TGGCTCCCGG 
CCCACATCCC CCTGCAACAA GCGCAAATAC AGTCTCAACG GCAGGCAGCC CTCCTGCTCA 
CCCCACCACT CGCCCACACC ATCCCCCCAT GGCTCCCCTC GGGTCAGCGT GACGGAAGAC 
ACCTGGCTTG GTAACACCAC CCAGTACACC AGCTCTGCTA TTGTGGCAGC CATCAACGCC 
CTGACCACTG ATAGCACTCT GGACCTGGGT GACGGTGTCT CTATCAAGTC TCGAAAGACA 
GCCCTGGAGC ACGTGCCCTC TGTGGCCCTC AAGGTAGAGC CGGCTGGGGA AGACCTGGGC 
ACCACACCAC CCACTTCTGA CTTCCCACCC GAGGAGTTCG CCTTCCAGCA CCTTCGGAAG 
GGTGCCTTTT GTGAGCAGTA TCTGTCGGTG CCACAGGCCT CGTATCAGTG GGCAAAGCCC 
AAGTCTCTAT CCCCAACGTC ATACATGAGC CCATCCCTGC CTGCCCTTGA CTGGCAGCTG 
CCGTCGCACT CTGGTCCGTA TGAACTCCGG ATCGAGGTGC AACCCAAGTC TCACCACAGG 
GCTCACTATG AGACGGAAGG CAGCCGGGGA GCTGTGAAGG CTTCTGCTGG AGGACACCCT 
GTCGTGCAGC TACATGGTTA CTTGGAAAAC GAGCCTCTCA CGCTCCAGCT GTTCATTGGG 
ACGGCTGACG ACCGCCTGCT ACGGCCCCAT GCCTTCTACC AGGTCCACCG GATCACGGGG 
AAGACTGTCT CCACCACCAG CCACGAGGCT ATCCTGTCCA ACACCAAAGT CCTGGAGATC 
CCACTGCTTC CAGAAAATAA CATGCGAGCC ATCATCGACT GTGCTGGGAT CCTGAAGCTC 
AGAAACTCTG ATATCGAGCT GAGGAAAGGG GAGACAGACA TCGGGAGAAA GAACACCAGG 
GTGCGGCTGG TCTTCCGAGT CCACATCCCC CAGCCCAGCG GCCGGACGCT GTCTCTCCAG 
GTGGCCTCAA ACCCGATCGA GTGCTCCCAG CGGTCGGCCC AGGAACTGCC CCTCGTGGAG 
AAGCAGAGCA CAGACAGCTA CCCGGTCATT GGAGGGAAGA AGATGGTGTT GTCTGGCCAT 
AACTTTCTGC AAGACTCCAA GGTCATCTTC GTGGAGAAGG CCCCAGATGG CCACCATGTC 
TGGGAGATGG AAGCGAAAAC TGACCGAGAC CTGTGCAAGC CAAATTCCCT GGTGCTGGAG 
ATACCACCTT TCCGCAACCA GAGAATAACC AGCCCCGTCC AAGTCAGCTT CTATGTCTGC 
AACGGGAAGC GGAAGAGAAG CCAGTACCAG CATTTCACGT ACCTTCCTGC CAATGTTCCA 
ATTATAAAGA CAGAACCCAC GGACGACTTT GAGCCAGCTC TGACCTGTGG ACCAATGAGC 
CAGGGACTTA GCCCTCTGCC GAGGCCTTAC TATAGCCAAC AACTCACCGC GCCTCCTGAC 
CCTGGCTCCT GCCTTGTGGC CGGCTTTGCC CCCTGCTCAC AGAGGAACAC GCCGATGCCC 
ACGTCTCCCA ATGCAAGCCC AAAGCTCCAC GACCTTTCCT CTCCCGCCTA CGCCAAGGGC 
CTCGCCAACC CAGGCCACAG TGGTCACCTT GGACTTCAGC CACCAGCTTC AGAGGCCCCC 
ACCATGCAGG AATTGCCGAG ACCCATGGCC GTCCAGCCCA ACTCGCCTGA GCAGCCCACA 
TCCGTCAGGC TACAGCCGCA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001231862.1
CDS	304..2787
Translation	MPSTSFPVPSKFPLGPPAAVCGSGETLRPAPLAGGTMKAAEEEHYSYASPSVTSTLPLPTAHSALPAACHDLQTSTPGISAVPSANHPSGYGGAVDSGPSGYFLSSGNTRPNGAPTLESPRIEITSYLGLHHGSNQFFHDVEVEDVLPSCKRSPSTATLHLPSLEAYRDPSCLSPASSLSSRSCNSEASSYESNYSYPYASPQTSPWQSPCVSPKTTDPEEGFPRSLGACHLLGSPRHSPSTSPRASVTEESWLGARGSRPTSPCNKRKYSLNGRQPSCSPHHSPTPSPHGSPRVSVTEDTWLGNTTQYTSSAIVAAINALTTDSTLDLGDGVSIKSRKTALEHVPSVALKVEPAGEDLGTTPPTSDFPPEEFAFQHLRKGAFCEQYLSVPQASYQWAKPKSLSPTSYMSPSLPALDWQLPSHSGPYELRIEVQPKSHHRAHYETEGSRGAVKASAGGHPVVQLHGYLENEPLTLQLFIGTADDRLLRPHAFYQVHRITGKTVSTTSHEAILSNTKVLEIPLLPENNMRAIIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGRTLSLQVASNPIECSQRSAQELPLVEKQSTDSYPVIGGKKMVLSGHNFLQDSKVIFVEKAPDGHHVWEMEAKTDRDLCKPNSLVLEIPPFRNQRITSPVQVSFYVCNGKRKRSQYQHFTYLPANVPIIKTEPTDDFEPALTCGPMSQGLSPLPRPYYSQQLTAPPDPGSCLVAGFAPCSQRNTPMPTSPNASPKLHDLSSPAYAKGLANPGHSGHLGLQPPASEAPTMQELPRPMAVQPNSPEQPTSVRLQPQ

Target ORF information:

RefSeq Version	NM_001244933.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus nuclear factor of activated T-cells 1 (Nfatc1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001244933.1

ORF Insert Sequence:

ATGCCAAGTA CCAGCTTTCC AGTCCCTTCC AAGTTTCCAC TCGGCCCTCC GGCCGCAGTC 
TGCGGGAGCG GAGAAACTTT GCGGCCCGCG CCGCTCGCCG GCGGCACCAT GAAGGCGGCC 
GAGGAAGAAC ACTACAGTTA TGCGTCCCCT AGCGTCACCT CAACTCTGCC CCTTCCCACA 
GCACACTCCG CCTTGCCAGC GGCATGCCAT GACCTCCAGA CGTCCACCCC GGGCATCTCA 
GCTGTTCCTT CGGCCAATCA CCCCTCTGGT TATGGGGGCG CTGTGGACAG TGGGCCTTCA 
GGATACTTCC TGTCCTCCGG CAACACGAGA CCCAATGGGG CCCCGACTCT CGAGAGTCCT 
CGAATCGAGA TCACCTCCTA TCTGGGCCTT CACCACGGCA GCAACCAATT TTTCCACGAT 
GTGGAGGTGG AAGACGTACT TCCTAGCTGC AAGCGGTCAC CATCTACAGC AACCCTGCAC 
CTGCCCAGTC TGGAAGCCTA CAGAGACCCC TCCTGCCTGA GCCCAGCCAG CAGCCTGTCC 
TCCAGGAGCT GTAACTCTGA GGCGTCCTCC TATGAGTCCA ACTATTCATA CCCGTACGCA 
TCCCCCCAGA CCTCTCCATG GCAGTCACCC TGTGTGTCTC CCAAGACCAC GGACCCAGAG 
GAGGGCTTTC CCCGAAGCCT GGGTGCCTGC CACTTGCTGG GATCGCCAAG GCACTCCCCA 
TCCACCTCTC CTCGTGCAAG CGTCACCGAG GAGAGCTGGC TCGGTGCCCG TGGCTCCCGG 
CCCACATCCC CCTGCAACAA GCGCAAATAC AGTCTCAACG GCAGGCAGCC CTCCTGCTCA 
CCCCACCACT CGCCCACACC ATCCCCCCAT GGCTCCCCTC GGGTCAGCGT GACGGAAGAC 
ACCTGGCTTG GTAACACCAC CCAGTACACC AGCTCTGCTA TTGTGGCAGC CATCAACGCC 
CTGACCACTG ATAGCACTCT GGACCTGGGT GACGGTGTCT CTATCAAGTC TCGAAAGACA 
GCCCTGGAGC ACGTGCCCTC TGTGGCCCTC AAGGTAGAGC CGGCTGGGGA AGACCTGGGC 
ACCACACCAC CCACTTCTGA CTTCCCACCC GAGGAGTTCG CCTTCCAGCA CCTTCGGAAG 
GGTGCCTTTT GTGAGCAGTA TCTGTCGGTG CCACAGGCCT CGTATCAGTG GGCAAAGCCC 
AAGTCTCTAT CCCCAACGTC ATACATGAGC CCATCCCTGC CTGCCCTTGA CTGGCAGCTG 
CCGTCGCACT CTGGTCCGTA TGAACTCCGG ATCGAGGTGC AACCCAAGTC TCACCACAGG 
GCTCACTATG AGACGGAAGG CAGCCGGGGA GCTGTGAAGG CTTCTGCTGG AGGACACCCT 
GTCGTGCAGC TACATGGTTA CTTGGAAAAC GAGCCTCTCA CGCTCCAGCT GTTCATTGGG 
ACGGCTGACG ACCGCCTGCT ACGGCCCCAT GCCTTCTACC AGGTCCACCG GATCACGGGG 
AAGACTGTCT CCACCACCAG CCACGAGGCT ATCCTGTCCA ACACCAAAGT CCTGGAGATC 
CCACTGCTTC CAGAAAATAA CATGCGAGCC ATCATCGACT GTGCTGGGAT CCTGAAGCTC 
AGAAACTCTG ATATCGAGCT GAGGAAAGGG GAGACAGACA TCGGGAGAAA GAACACCAGG 
GTGCGGCTGG TCTTCCGAGT CCACATCCCC CAGCCCAGCG GCCGGACGCT GTCTCTCCAG 
GTGGCCTCAA ACCCGATCGA GTGCTCCCAG CGGTCGGCCC AGGAACTGCC CCTCGTGGAG 
AAGCAGAGCA CAGACAGCTA CCCGGTCATT GGAGGGAAGA AGATGGTGTT GTCTGGCCAT 
AACTTTCTGC AAGACTCCAA GGTCATCTTC GTGGAGAAGG CCCCAGATGG CCACCATGTC 
TGGGAGATGG AAGCGAAAAC TGACCGAGAC CTGTGCAAGC CAAATTCCCT GGTGCTGGAG 
ATACCACCTT TCCGCAACCA GAGAATAACC AGCCCCGTCC AAGTCAGCTT CTATGTCTGC 
AACGGGAAGC GGAAGAGAAG CCAGTACCAG CATTTCACGT ACCTTCCTGC CAATGTTCCA 
ATTATAAAGA CAGAACCCAC GGACGACTTT GAGCCAGCTC TGACCTGTGG ACCAATGAGC 
CAGGGACTTA GCCCTCTGCC GAGGCCTTAC TATAGCCAAC AACTCACCGC GCCTCCTGAC 
CCTGGCTCCT GCCTTGTGGC CGGCTTTGCC CCCTGCTCAC AGAGGAACAC GCCGATGCCC 
ACGTCTCCCA ATGCAAGCCC AAAGCTCCAC GACCTTTCCT CTCCCGCCTA CGCCAAGGGC 
CTCGCCAACC CAGGCCACAG TGGTCACCTT GGACTTCAGC CACCAGCTTC AGAGGCCCCC 
ACCATGCAGG AATTGCCGAG ACCCATGGCC GTCCAGCCCA ACTCGCCTGA GCAGCCCACA 
TCCGTCAGGC TACAGCCGCA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Peptide 11R-VIVIT stimulates osteoblastogenesis through regulating the expression of nuclear factor of activated T cells cytoplasmic 1.
Cellular and molecular biology (Noisy-le-Grand, France)63(4)46-52(2017 Apr)
Li M,Wang X,Bian Z,Yao W,He Q,Tian F,Zhang J,Zhu L

Role of RANKL in the regulation of NFATc1 and c?Src mRNA expression in osteoclast?like cells.
Molecular medicine reports13(6)5163-8(2016 Jun)
Fu J,Tao YD,Chen J,Zhang Y,He J

Tmem178 acts in a novel negative feedback loop targeting NFATc1 to regulate bone mass.
Proceedings of the National Academy of Sciences of the United States of America112(51)15654-9(2015 Dec)
Decker CE,Yang Z,Rimer R,Park-Min KH,Macaubas C,Mellins ED,Novack DV,Faccio R

Calcineurin-NFATc regulates type 2 inositol 1,4,5-trisphosphate receptor (InsP3R2) expression during cardiac remodeling.
The Journal of biological chemistry289(9)6188-98(2014 Feb)
Sankar N,deTombe PP,Mignery GA

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Nfatc1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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