RT1-A cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	RT1-A
Entrez Gene ID	100188935
Full Name	RT1 class I, locus A
Synonyms	RTA,Rt1.aa
General protein information	Preferred Names RT1 class I, locus A Names RT1 class I, locus A MHC class I RT1.Aa alpha-chain RT1 class I gene(A) RT1-region, class I (A)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Summary	gene complex that may play a role in antigen presentation [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001134701.1	NP_001128173.1	RT1 class I, locus A precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

[Expression of the RT1A molecule of the class I major histocompatibility complex in a Walker 256 tumor after transplantation into Brattleboro rats with a genetic defect of arginine-vasopressin synthesis].
Mel'nikova VI, Khega? II, Afanas'eva MA, Ivanova LN, Zakharova LA
Izvestiia Akademii nauk. Seriia biologicheskaia(1)99-102(2013 Jan-Feb)

Intragraft gene expression profile associated with the induction of tolerance by allochimeric MHC I in the rat heart transplantation model.
Lisik W, Gong Y, Tejpal N, Skelton TS, Bremer EG, Kloc M, Ghobrial RM
Genesis (New York, N.Y. : 2000)48(1)8-19(2010 Jan)

Crystal structures of two rat MHC class Ia (RT1-A) molecules that are associated differentially with peptide transporter alleles TAP-A and TAP-B.
Rudolph MG, Stevens J, Speir JA, Trowsdale J, Butcher GW, Joly E, Wilson IA
Journal of molecular biology324(5)975-90(2002 Dec)

Co-evolution of rat TAP transporters and MHC class I RT1-A molecules.
Joly E, Le Rolle AF, Gonz?lez AL, Mehling B, Stevens J, Coadwell WJ, H?nig T, Howard JC, Butcher GW
Current biology : CB8(3)169-72(1998 Jan)

Concerted evolution of class I genes in the major histocompatibility complex of murine rodents.
Rada C, Lorenzi R, Powis SJ, van den Bogaerde J, Parham P, Howard JC
Proceedings of the National Academy of Sciences of the United States of America87(6)2167-71(1990 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

a simultaneous increase in the portion of cells that express the RT1A antigen and in the level of its expression per cell was observed
Title: [Expression of the RT1A molecule of the class I major histocompatibility complex in a Walker 256 tumor after transplantation into Brattleboro rats with a genetic defect of arginine-vasopressin synthesis].

Data show that allochimeric Rt1 treatment caused upregulation of genes involved in structural integrity of heart muscle, downregulation of IL-1b and gamma PAR6.
Title: Intragraft gene expression profile associated with the induction of tolerance by allochimeric MHC I in the rat heart transplantation model.

Crystal structures of two rat MHC class Ia (RT1-A) molecules that are associated differentially with peptide transporter alleles TAP-A and TAP-B
Title: Crystal structures of two rat MHC class Ia (RT1-A) molecules that are associated differentially with peptide transporter alleles TAP-A and TAP-B.

The following RT1-A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RT1-A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa03423	NM_001134701.1 Latest version!	Rattus norvegicus RT1 class I, locus A (RT1-A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RT1-A ( NM_001134701.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001128173.1 Rattus norvegicus RT1 class I, locus A (RT1-A), mRNA.

Price & Availability↑

CloneID	ORa03423
Clone ID Related Accession (Same CDS sequence)	NM_001134701.1
Accession Version	NM_001134701.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1113bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-06-24
Organism	Rattus norvegicus(Norway rat)
Product	RT1 class I, locus A precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC166751.1. On Jun 26, 2012 this sequence version replaced XM_003754675.1. ##Evidence-Data-START## Transcript exon combination :: BC166751.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN01906347, SAMN01906354 [ECO:0000350] ##Evidence-Data-END##

ATGGAGGCGA TGGCACCGCG CACGCTGCTC CTGCTGCTGG CGGCGGTCCT GGCCCCGACC 
CAGACCCGCG CGGGCTCACA CTCGCTGCGG TATTTCTACA CCGCCGTGTC CCGGCCCGGC 
CTCGGGGAGC CCCGGTTCAT CGCTGTCGGC TACGTGGACG ACACCGAGTT CGTGCGCTTC 
GACAGCGACG CGGAGAATCC GAGGATGGAG CCGCGGGCGC GGTGGATGGA GCGGGAGGGG 
CCGGAGTATT GGGAGGAGGA GACACAGATC GCCAAGGGAC ACGAGCAGAT TTACCGAGTG 
GACCTGAGGA CCCTGCGCGG CTACTACAAC CAGAGCGAGG GCGGCTCTCA CACCATCCAG 
GAGATGTATG GCTGTGACGT GGGGTCGGAC GGGAGCCTCC TCCGCGGATA TAGGCAGGAC 
GCCTACGATG GCCGCGATTA CATCGCCCTG AACGAAGACC TGAAGACGTG GACGGCGGCG 
GACTTTGCGG CACAGATCAC CCGGAACAAG TGGGAGCGGG CTCGTTATGC AGAGAGACTC 
AGGGCCTACC TGGAGGGCAC GTGCGTGGAG TCGCTCCGCA GATACCTGGA GCTCGGGAAG 
GAGACACTGC TGCGCTCAGA TCCCCCAGAG GCACATGTGA CCCTTCACCC CAGACCTGAA 
GGTGATGTCA CCCTGAGGTG CTGGGCCCTG GGCTTCTACC CTGCTGACAT CACCCTGACC 
TGGCAGTTGA ATGGGGAGGA CCTGACCCAG GACATGGAGC TTGTGGAGAC CAGGCCTGCA 
GGGGATGGAA CCTTCCAGAA GTGGGCATCT GTGGTGGTGC CTCTTGGGAA GGAGCAGAAT 
TACACATGCC GTGTGGAGCA TGAGGGGCTG CCTAAGCCAC TTTCCCAGAG ATGGGAACCT 
TCTCCATCGA CTGACTCCAA CATGGAAACC ACTGTCATTT ATGTCATCCT TGGAGCTGTG 
GCCATGATTG GAGCTGTGGC CATCATAGGA GCTATGGTGG CTGTTGTGAG GAGGAGGAAG 
AGAAACACAG GTGGAAAAGG AGACTACGCC CCTGCTCCAG GCAGGGACAG CTCCCAGAGC 
TCCGATGTGT CTCTCCCAGA TTGTAAAGCA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001128173.1
CDS	6..1118
Translation	MEAMAPRTLLLLLAAVLAPTQTRAGSHSLRYFYTAVSRPGLGEPRFIAVGYVDDTEFVRFDSDAENPRMEPRARWMEREGPEYWEEETQIAKGHEQIYRVDLRTLRGYYNQSEGGSHTIQEMYGCDVGSDGSLLRGYRQDAYDGRDYIALNEDLKTWTAADFAAQITRNKWERARYAERLRAYLEGTCVESLRRYLELGKETLLRSDPPEAHVTLHPRPEGDVTLRCWALGFYPADITLTWQLNGEDLTQDMELVETRPAGDGTFQKWASVVVPLGKEQNYTCRVEHEGLPKPLSQRWEPSPSTDSNMETTVIYVILGAVAMIGAVAIIGAMVAVVRRRKRNTGGKGDYAPAPGRDSSQSSDVSLPDCKA

Target ORF information:

RefSeq Version	NM_001134701.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus RT1 class I, locus A (RT1-A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001134701.1

ORF Insert Sequence:

ATGGAGGCGA TGGCACCGCG CACGCTGCTC CTGCTGCTGG CGGCGGTCCT GGCCCCGACC 
CAGACCCGCG CGGGCTCACA CTCGCTGCGG TATTTCTACA CCGCCGTGTC CCGGCCCGGC 
CTCGGGGAGC CCCGGTTCAT CGCTGTCGGC TACGTGGACG ACACCGAGTT CGTGCGCTTC 
GACAGCGACG CGGAGAATCC GAGGATGGAG CCGCGGGCGC GGTGGATGGA GCGGGAGGGG 
CCGGAGTATT GGGAGGAGGA GACACAGATC GCCAAGGGAC ACGAGCAGAT TTACCGAGTG 
GACCTGAGGA CCCTGCGCGG CTACTACAAC CAGAGCGAGG GCGGCTCTCA CACCATCCAG 
GAGATGTATG GCTGTGACGT GGGGTCGGAC GGGAGCCTCC TCCGCGGATA TAGGCAGGAC 
GCCTACGATG GCCGCGATTA CATCGCCCTG AACGAAGACC TGAAGACGTG GACGGCGGCG 
GACTTTGCGG CACAGATCAC CCGGAACAAG TGGGAGCGGG CTCGTTATGC AGAGAGACTC 
AGGGCCTACC TGGAGGGCAC GTGCGTGGAG TCGCTCCGCA GATACCTGGA GCTCGGGAAG 
GAGACACTGC TGCGCTCAGA TCCCCCAGAG GCACATGTGA CCCTTCACCC CAGACCTGAA 
GGTGATGTCA CCCTGAGGTG CTGGGCCCTG GGCTTCTACC CTGCTGACAT CACCCTGACC 
TGGCAGTTGA ATGGGGAGGA CCTGACCCAG GACATGGAGC TTGTGGAGAC CAGGCCTGCA 
GGGGATGGAA CCTTCCAGAA GTGGGCATCT GTGGTGGTGC CTCTTGGGAA GGAGCAGAAT 
TACACATGCC GTGTGGAGCA TGAGGGGCTG CCTAAGCCAC TTTCCCAGAG ATGGGAACCT 
TCTCCATCGA CTGACTCCAA CATGGAAACC ACTGTCATTT ATGTCATCCT TGGAGCTGTG 
GCCATGATTG GAGCTGTGGC CATCATAGGA GCTATGGTGG CTGTTGTGAG GAGGAGGAAG 
AGAAACACAG GTGGAAAAGG AGACTACGCC CCTGCTCCAG GCAGGGACAG CTCCCAGAGC 
TCCGATGTGT CTCTCCCAGA TTGTAAAGCA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

[Expression of the RT1A molecule of the class I major histocompatibility complex in a Walker 256 tumor after transplantation into Brattleboro rats with a genetic defect of arginine-vasopressin synthesis].
Izvestiia Akademii nauk. Seriia biologicheskaia(1)99-102(2013 Jan-Feb)
Mel'nikova VI,Khega? II,Afanas'eva MA,Ivanova LN,Zakharova LA

Intragraft gene expression profile associated with the induction of tolerance by allochimeric MHC I in the rat heart transplantation model.
Genesis (New York, N.Y. : 2000)48(1)8-19(2010 Jan)
Lisik W,Gong Y,Tejpal N,Skelton TS,Bremer EG,Kloc M,Ghobrial RM

Crystal structures of two rat MHC class Ia (RT1-A) molecules that are associated differentially with peptide transporter alleles TAP-A and TAP-B.
Journal of molecular biology324(5)975-90(2002 Dec)
Rudolph MG,Stevens J,Speir JA,Trowsdale J,Butcher GW,Joly E,Wilson IA

Co-evolution of rat TAP transporters and MHC class I RT1-A molecules.
Current biology : CB8(3)169-72(1998 Jan)
Joly E,Le Rolle AF,Gonz?lez AL,Mehling B,Stevens J,Coadwell WJ,H?nig T,Howard JC,Butcher GW

Concerted evolution of class I genes in the major histocompatibility complex of murine rodents.
Proceedings of the National Academy of Sciences of the United States of America87(6)2167-71(1990 Mar)
Rada C,Lorenzi R,Powis SJ,van den Bogaerde J,Parham P,Howard JC

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RT1-A cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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