Gene Symbol | PGD |
Entrez Gene ID | 443541 |
Full Name | phosphogluconate dehydrogenase |
Synonyms | 6-PGDH |
Gene Type | protein-coding |
Organism | Ovis aries(sheep) |
ORF » Species Summary » Ovis aries » PGD cDNA ORF clone
Gene Symbol | PGD |
Entrez Gene ID | 443541 |
Full Name | phosphogluconate dehydrogenase |
Synonyms | 6-PGDH |
Gene Type | protein-coding |
Organism | Ovis aries(sheep) |
mRNA | Protein | Name |
---|---|---|
NM_001009467.2 | NP_001009467.1 | 6-phosphogluconate dehydrogenase, decarboxylating |
Role of methionine-13 in the catalytic mechanism of 6-phosphogluconate dehydrogenase from sheep liver.
Cervellati C, Dallocchio F, Bergamini CM, Cook PF
Biochemistry44(7)2432-40(2005 Feb)
Structure of 6-phosphogluconate dehydrogenase refined at 2 A resolution.
Phillips C, Gover S, Adams MJ
Acta crystallographica. Section D, Biological crystallography51(Pt 3)290-304(1995 May)
Crystallographic study of coenzyme, coenzyme analogue and substrate binding in 6-phosphogluconate dehydrogenase: implications for NADP specificity and the enzyme mechanism.
Adams MJ, Ellis GH, Gover S, Naylor CE, Phillips C
Structure (London, England : 1993)2(7)651-68(1994 Jul)
Amino acid sequence of ovine 6-phosphogluconate dehydrogenase.
Carne A, Walker JE
The Journal of biological chemistry258(21)12895-906(1983 Nov)
The three dimensional structure of sheep liver 6-phosphogluconate dehydrogenase at 2.6 A resolution.
Adams MJ, Archibald IG, Bugg CE, Carne A, Gover S, Helliwell JR, Pickersgill RW, White SW
The EMBO journal2(6)1009-14(1983)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Methionine at position 13 plays a significant role in orienting the cofactor nicotinamide ring with respect to geometry and distance, thereby optimizing the geometry for hydride transfer, and perhaps the decarboxylation step in the 6PGDH reaction.
Title: Role of methionine-13 in the catalytic mechanism of 6-phosphogluconate dehydrogenase from sheep liver.
The following PGD gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PGD cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSm00035 | |
Clone ID Related Accession (Same CDS sequence) | NM_001009467.2 | |
Accession Version | NM_001009467.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1452bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-24 | |
Organism | Ovis aries(sheep) | |
Product | 6-phosphogluconate dehydrogenase, decarboxylating | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X60195.1. On Sep 13, 2008 this sequence version replaced NM_001009467.1. ##Evidence-Data-START## Transcript exon combination :: X60195.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA104494974, SAMEA104494976 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGGCCCAAG CTGACATTGC CCTGATTGGA CTGGCTGTCA TGGGCCAGAA CTTAATTTTA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001009467.1 |
CDS | 71..1522 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001009467.2 |
1 | ATGGCCCAAG CTGACATTGC CCTGATTGGA CTGGCTGTCA TGGGCCAGAA CTTAATTTTA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Role of methionine-13 in the catalytic mechanism of 6-phosphogluconate dehydrogenase from sheep liver. |
Structure of 6-phosphogluconate dehydrogenase refined at 2 A resolution. |
Crystallographic study of coenzyme, coenzyme analogue and substrate binding in 6-phosphogluconate dehydrogenase: implications for NADP specificity and the enzyme mechanism. |
Amino acid sequence of ovine 6-phosphogluconate dehydrogenase. |
The three dimensional structure of sheep liver 6-phosphogluconate dehydrogenase at 2.6 A resolution. |