Gene Symbol | HTRA1 |
Entrez Gene ID | 705855 |
Full Name | HtrA serine peptidase 1 |
Gene Type | protein-coding |
Organism | Macaca mulatta(Rhesus monkey) |
ORF » Species Summary » Macaca mulatta » HTRA1 cDNA ORF clone
Gene Symbol | HTRA1 |
Entrez Gene ID | 705855 |
Full Name | HtrA serine peptidase 1 |
Gene Type | protein-coding |
Organism | Macaca mulatta(Rhesus monkey) |
mRNA | Protein | Name |
---|---|---|
NM_001258176.1 | NP_001245105.1 | serine protease HTRA1 precursor |
Homo sapiens (human) | HTRA1 | NP_002766.1 |
Rattus norvegicus (Norway rat) | Htra1 | NP_113909.1 |
Xenopus tropicalis (tropical clawed frog) | htra1 | NP_001072730.2 |
HTRA1 | XP_001103628.1 | |
Bos taurus (cattle) | HTRA1 | NP_001231162.1 |
Danio rerio (zebrafish) | htra1a | NP_001002219.1 |
Danio rerio (zebrafish) | htra1b | NP_001104652.1 |
Mus musculus (house mouse) | Htra1 | NP_062510.2 |
A new rhesus macaque assembly and annotation for next-generation sequencing analyses.
Zimin AV, Cornish AS, Maudhoo MD, Gibbs RM, Zhang X, Pandey S, Meehan DT, Wipfler K, Bosinger SE, Johnson ZP, Tharp GK, Mar?ais G, Roberts M, Ferguson B, Fox HS, Treangen T, Salzberg SL, Yorke JA, Norgren RB Jr
Biology direct9(1)20(2014 Oct)
1,25-Dihydroxyvitamin D decreases HTRA1 promoter activity in the rhesus monkey--a plausible explanation for the influence of vitamin D on age-related macular degeneration?
Pahl L, Schubert S, Skawran B, Sandbothe M, Schmidtke J, Stuhrmann M
Experimental eye research116234-9(2013 Nov)
Characterization of the 10q26-orthologue in rhesus monkeys corroborates a functional connection between ARMS2 and HTRA1.
Pahl L, Spangenberg A, Schubert S, Sch?nmann U, Schmidtke J, Stuhrmann M
Experimental eye research9875-8(2012 May)
Rhesus monkeys and humans share common susceptibility genes for age-related macular disease.
Francis PJ, Appukuttan B, Simmons E, Landauer N, Stoddard J, Hamon S, Ott J, Ferguson B, Klein M, Stout JT, Neuringer M
Human molecular genetics17(17)2673-80(2008 Sep)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Our data point to a yet unexpected effect of decreased HTRA1 expression on drusen pathogenesis. Thus not only a higher HTRA1 expression, but an imbalance of HTRA1 might be disease-relevant.
Title: 1,25-Dihydroxyvitamin D decreases HTRA1 promoter activity in the rhesus monkey--a plausible explanation for the influence of vitamin D on age-related macular degeneration?
Tests for association revealed a variant in the promoter region of HTRA1 and two variants in the 5'-UTR of ARMS2 to be associated with drusen.
Title: Characterization of the 10q26-orthologue in rhesus monkeys corroborates a functional connection between ARMS2 and HTRA1.
As in humans, one variant within LOC387715/ARMS2 and one in HTRA1 were significantly associated with age-related macular degeneration.
Title: Rhesus monkeys and humans share common susceptibility genes for age-related macular disease.
The following HTRA1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HTRA1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMb01829 | |
Clone ID Related Accession (Same CDS sequence) | NM_001258176.1 | |
Accession Version | NM_001258176.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1446bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-27 | |
Organism | Macaca mulatta(Rhesus monkey) | |
Product | serine protease HTRA1 precursor | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JU335497.1. On Apr 19, 2012 this sequence version replaced XM_001103628.2. ##Evidence-Data-START## Transcript exon combination :: JU335497.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4688315, SAMEA4688316 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGCAGATCC CGCGCGCCGC GCTGCTCCCA CTGCTGCTAC TGCTGCTGCT GGCGGCGCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001245105.1 |
CDS | 64..1509 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001258176.1 |
1 | ATGCAGATCC CGCGCGCCGC GCTGCTCCCA CTGCTGCTAC TGCTGCTGCT GGCGGCGCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
A new rhesus macaque assembly and annotation for next-generation sequencing analyses. |
1,25-Dihydroxyvitamin D decreases HTRA1 promoter activity in the rhesus monkey--a plausible explanation for the influence of vitamin D on age-related macular degeneration? |
Characterization of the 10q26-orthologue in rhesus monkeys corroborates a functional connection between ARMS2 and HTRA1. |
Rhesus monkeys and humans share common susceptibility genes for age-related macular disease. |