vvd cDNA ORF clone, Neurospora crassa OR74A

The genome sequence of the filamentous fungus Neurospora crassa.
Galagan JE, Calvo SE, Borkovich KA, Selker EU, Read ND, Jaffe D, FitzHugh W, Ma LJ, Smirnov S, Purcell S, Rehman B, Elkins T, Engels R, Wang S, Nielsen CB, Butler J, Endrizzi M, Qui D, Ianakiev P, Bell-Pedersen D, Nelson MA, Werner-Washburne M, Selitrennikoff CP, Kinsey JA, Braun EL, Zelter A, Schulte U, Kothe GO, Jedd G, Mewes W, Staben C, Marcotte E, Greenberg D, Roy A, Foley K, Naylor J, Stange-Thomann N, Barrett R, Gnerre S, Kamal M, Kamvysselis M, Mauceli E, Bielke C, Rudd S, Frishman D, Krystofova S, Rasmussen C, Metzenberg RL, Perkins DD, Kroken S, Cogoni C, Macino G, Catcheside D, Li W, Pratt RJ, Osmani SA, DeSouza CP, Glass L, Orbach MJ, Berglund JA, Voelker R, Yarden O, Plamann M, Seiler S, Dunlap J, Radford A, Aramayo R, Natvig DO, Alex LA, Mannhaupt G, Ebbole DJ, Freitag M, Paulsen I, Sachs MS, Lander ES, Nusbaum C, Birren B
Nature422(6934)859-68(2003 Apr)

VVD photocycle length appears sculpted to establish a VVD-WCC reservoir of sufficient size to sustain photoadaptation while maintaining sensitivity to changing light intensity.
Title: Biological Significance of Photoreceptor Photocycle Length: VIVID Photocycle Governs the Dynamic VIVID-White Collar Complex Pool Mediating Photo-adaptation and Response to Changes in Light Intensity.

VVD acts as an inhibitor of WCC-driven gene expression and, at the same time, as a positive regulator that maintains the responsiveness of the photosystem.
Title: The Neurospora photoreceptor VIVID exerts negative and positive control on light sensing to achieve adaptation.

WC-1, part of White Collar Complex (WCC), and VVD contain a flavin-binding light-oxygen-voltage (LOV) domain; VVD-mediated desensitization and stabilization of the light activated WCC explain how Neurospora can robustly entrain photoperiods.
Title: Photoadaptation in Neurospora by competitive interaction of activating and inhibitory LOV domains.

Data support a reaction scheme that describes the mechanism for light-induced dimerization of VVD.
Title: Illuminating solution responses of a LOV domain protein with photocoupled small-angle X-ray scattering.

VIVID (VVD) buffers the circadian system against temperature fluctuations. In vvd-null mutants, the circadian period of clock-controlled events such as asexual sporulation is temperature compensated, but the phase of this clock time marker is not.
Title: The PAS/LOV protein VIVID controls temperature compensation of circadian clock phase and development in Neurospora crassa.