H4c14 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	H4c14
Entrez Gene ID	97122
Full Name	histone cluster 2, H4
Synonyms	H4,X04652
General protein information	Preferred Names histone cluster 2, H4 Names histone H4 histone 2, H4
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3\|3 F2.1
Summary	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. [provided by RefSeq, Aug 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_033596.3	NP_291074.1	histone H4

Pathways from BioSystems

Homologies

Homo sapiens (human)	HIST1H4C	NP_003533.1
Caenorhabditis elegans (roundworm)	his-38	NP_509231.1
Oryza sativa (rice)	Os09g0433600	NP_001063245.1
Pan troglodytes (chimpanzee)	LOC465305	XP_003313563.1
	LOC695214	XP_001083731.1
Bos taurus (cattle)	LOC526789	XP_002684676.1
Mus musculus (house mouse)	Hist2h4	NP_291074.1
Gallus gallus (chicken)	HIST1H46L6	XP_001233180.1
Arabidopsis thaliana (thale cress)	AT3G46320	NP_850660.1
Rattus norvegicus (Norway rat)	LOC100912489	XP_006237606.1
Drosophila melanogaster (fruit fly)	His4:CG33897	NP_001027312.1
Canis lupus familiaris (dog)	LOC100855431	XP_003639662.1
Danio rerio (zebrafish)	si:ch211-113a14.17	XP_688877.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003909	XP_318361.3
Xenopus tropicalis (tropical clawed frog)	hist1h4a	NP_001016869.1

Gene Ontology
Bibliography

Related articles in PubMed

Fidelity of histone gene regulation is obligatory for genome replication and stability.
Ghule PN, Xie RL, Medina R, Colby JL, Jones SN, Lian JB, Stein JL, van Wijnen AJ, Stein GS
Molecular and cellular biology34(14)2650-9(2014 Jul)

Functional coupling of transcription factor HiNF-P and histone H4 gene expression during pre- and post-natal mouse development.
Liu LJ, Xie R, Hussain S, Lian JB, Rivera-Perez J, Jones SN, Stein JL, Stein GS, van Wijnen AJ
Gene483(1-2)1-10(2011 Sep)

The histone gene activator HINFP is a nonredundant cyclin E/CDK2 effector during early embryonic cell cycles.
Xie R, Medina R, Zhang Y, Hussain S, Colby J, Ghule P, Sundararajan S, Keeler M, Liu LJ, van der Deen M, Mitra P, Lian JB, Rivera-Perez JA, Jones SN, Stein JL, van Wijnen AJ, Stein GS
Proceedings of the National Academy of Sciences of the United States of America106(30)12359-64(2009 Jul)

The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism.
Aqeilan RI, Hassan MQ, de Bruin A, Hagan JP, Volinia S, Palumbo T, Hussain S, Lee SH, Gaur T, Stein GS, Lian JB, Croce CM
The Journal of biological chemistry283(31)21629-39(2008 Aug)

Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.
Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, Guarente LP, Farese RV Jr, Weissman S, Verdin E, Schwer B
Molecular and cellular biology27(24)8807-14(2007 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results show that deregulation of histone H4 results in catastrophic cellular and molecular defects that lead to genomic instability.
Title: Fidelity of histone gene regulation is obligatory for genome replication and stability.

The in vivo co-expression of Hinfp and histone H4 genes is consistent with the biological function of Hinfp as a principal transcriptional regulator of histone H4 gene expression during mouse development.
Title: Functional coupling of transcription factor HiNF-P and histone H4 gene expression during pre- and post-natal mouse development.

Data indicate that the CDK2/cyclin E/p220(NPAT)/HINFP/histone gene signaling pathway at the G1/S phase transition is an essential, nonredundant cell cycle regulatory mechanism that is established early in embryogenesis.
Title: The histone gene activator HINFP is a nonredundant cyclin E/CDK2 effector during early embryonic cell cycles.

The following H4c14 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the H4c14 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu16737	NM_033596.3 Latest version!	Mus musculus H4 clustered histone 14 (H4c14), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

H4c14 ( NM_033596.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_291074.1 Mus musculus H4 clustered histone 14 (H4c14), mRNA.

Price & Availability↑

CloneID	OMu16737
Clone ID Related Accession (Same CDS sequence)	NM_033596.3
Accession Version	NM_033596.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 312bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Mus musculus(house mouse)
Product	histone H4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC125099.3. On Mar 12, 2014 this sequence version replaced NM_033596.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCTGGCA GAGGAAAGGG TGGAAAGGGT CTAGGCAAGG GTGGCGCCAA GCGCCATCGC 
AAAGTCTTGC GTGACAACAT CCAGGGTATC ACCAAGCCCG CCATCCGCCG CCTGGCTCGG 
CGCGGTGGGG TCAAGCGCAT CTCCGGCCTC ATCTACGAGG AGACCCGTGG TGTGCTGAAG 
GTGTTCCTGG AGAACGTCAT CCGCGACGCA GTCACCTACA CCGAGCACGC CAAGCGCAAG 
ACCGTCACCG CTATGGATGT GGTGTACGCT CTCAAGCGCC AGGGCCGCAC CCTCTACGGC 
TTCGGAGGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_291074.1
CDS	14..325
Translation	MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG

Target ORF information:

RefSeq Version	NM_033596.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus H4 clustered histone 14 (H4c14), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033596.3

ORF Insert Sequence:

ATGTCTGGCA GAGGAAAGGG TGGAAAGGGT CTAGGCAAGG GTGGCGCCAA GCGCCATCGC 
AAAGTCTTGC GTGACAACAT CCAGGGTATC ACCAAGCCCG CCATCCGCCG CCTGGCTCGG 
CGCGGTGGGG TCAAGCGCAT CTCCGGCCTC ATCTACGAGG AGACCCGTGG TGTGCTGAAG 
GTGTTCCTGG AGAACGTCAT CCGCGACGCA GTCACCTACA CCGAGCACGC CAAGCGCAAG 
ACCGTCACCG CTATGGATGT GGTGTACGCT CTCAAGCGCC AGGGCCGCAC CCTCTACGGC 
TTCGGAGGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Fidelity of histone gene regulation is obligatory for genome replication and stability.
Molecular and cellular biology34(14)2650-9(2014 Jul)
Ghule PN,Xie RL,Medina R,Colby JL,Jones SN,Lian JB,Stein JL,van Wijnen AJ,Stein GS

Functional coupling of transcription factor HiNF-P and histone H4 gene expression during pre- and post-natal mouse development.
Gene483(1-2)1-10(2011 Sep)
Liu LJ,Xie R,Hussain S,Lian JB,Rivera-Perez J,Jones SN,Stein JL,Stein GS,van Wijnen AJ

The histone gene activator HINFP is a nonredundant cyclin E/CDK2 effector during early embryonic cell cycles.
Proceedings of the National Academy of Sciences of the United States of America106(30)12359-64(2009 Jul)
Xie R,Medina R,Zhang Y,Hussain S,Colby J,Ghule P,Sundararajan S,Keeler M,Liu LJ,van der Deen M,Mitra P,Lian JB,Rivera-Perez JA,Jones SN,Stein JL,van Wijnen AJ,Stein GS

The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism.
The Journal of biological chemistry283(31)21629-39(2008 Aug)
Aqeilan RI,Hassan MQ,de Bruin A,Hagan JP,Volinia S,Palumbo T,Hussain S,Lee SH,Gaur T,Stein GS,Lian JB,Croce CM

Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.
Molecular and cellular biology27(24)8807-14(2007 Dec)
Lombard DB,Alt FW,Cheng HL,Bunkenborg J,Streeper RS,Mostoslavsky R,Kim J,Yancopoulos G,Valenzuela D,Murphy A,Yang Y,Chen Y,Hirschey MD,Bronson RT,Haigis M,Guarente LP,Farese RV Jr,Weissman S,Verdin E,Schwer B

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H4c14 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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