Klhl1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Klhl1
Entrez Gene ID	93688
Full Name	kelch-like 1
Synonyms	mKIAA1490
General protein information	Preferred Names kelch-like 1 Names kelch-like protein 1 kelch-l like
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 14 Map Location: 14\|14 E2.1

mRNA and Protein(s)

mRNA	Protein	Name
NM_053105.2	NP_444335.2	kelch-like protein 1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Klhl1	NP_444335.2
Gallus gallus (chicken)	KLHL1	XP_416994.2
Homo sapiens (human)	KLHL1	NP_065917.1
Pan troglodytes (chimpanzee)	KLHL1	XP_509677.2
Canis lupus familiaris (dog)	KLHL1	XP_542606.4
Bos taurus (cattle)	KLHL1	NP_001179984.1
Rattus norvegicus (Norway rat)	Klhl1	NP_001099524.1

Gene Ontology
Bibliography

Related articles in PubMed

Genetic Mapping in Mice Reveals the Involvement of Pcdh9 in Long-Term Social and Object Recognition and Sensorimotor Development.
Bruining H, Matsui A, Oguro-Ando A, Kahn RS, Van't Spijker HM, Akkermans G, Stiedl O, van Engeland H, Koopmans B, van Lith HA, Oppelaar H, Tieland L, Nonkes LJ, Yagi T, Kaneko R, Burbach JP, Yamamoto N, Kas MJ
Biological psychiatry78(7)485-95(2015 Oct)

Calcium current homeostasis and synaptic deficits in hippocampal neurons from Kelch-like 1 knockout mice.
Perissinotti PP, Ethington EA, Almazan E, Mart?nez-Hern?ndez E, Kalil J, Koob MD, Piedras-Renter?a ES
Frontiers in cellular neuroscience8444(2014)

T-type current modulation by the actin-binding protein Kelch-like 1.
Aromolaran KA, Benzow KA, Cribbs LL, Koob MD, Piedras-Renter?a ES
American journal of physiology. Cell physiology298(6)C1353-62(2010 Jun)

Kelch-like 1 protein upregulates T-type currents by an actin-F dependent increase in ?(1H) channels via the recycling endosome.
Aromolaran KA, Benzow KA, Cribbs LL, Koob MD, Piedras-Renter?a ES
Channels (Austin, Tex.)3(6)402-12(2009 Nov)

Identification of Dlk1, Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic dopamine neurons.
Jacobs FM, van der Linden AJ, Wang Y, von Oerthel L, Sul HS, Burbach JP, Smidt MP
Development (Cambridge, England)136(14)2363-73(2009 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

KLHL1 interacts with Cav3.2 and modulates T-type calcium currents by increasing current deactivation kinetics and current density and calcium influx.
Title: T-type current modulation by the actin-binding protein Kelch-like 1.

KLHL1 requires actin-polymerization to increase T-Type Calcium Channel alpha(1H) currents
Title: Kelch-like 1 protein upregulates T-type currents by an actin-F dependent increase in ?(1H) channels via the recycling endosome.

Dlk1 is required to prevent premature expression of Dat in meso-diencephalic dopamine neuronal precursors as part of the multifaceted process of neuronal differentiation driven by Nurr1 and Pitx3.
Title: Identification of Dlk1, Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic dopamine neurons.

KLHL! was widely distributed throughout the mouse brain. In the mouse testis, Sca8 transcript colocalized with Klhl1 mRNA in the spermatogenic cells.
Title: SCA8 mRNA expression suggests an antisense regulation of KLHL1 and correlates to SCA8 pathology.

MRP2/KLHL1 has a role, through its interaction with actin, in the process elongation of oligodendrocytes
Title: Process elongation of oligodendrocytes is promoted by the Kelch-related protein MRP2/KLHL1.

The following Klhl1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Klhl1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu09095	NM_053105.2 Latest version!	Mus musculus kelch-like 1 (Klhl1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$440.30 $629.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Klhl1 ( NM_053105.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_444335.2 Mus musculus kelch-like 1 (Klhl1), mRNA.

Price & Availability↑

CloneID	OMu09095
Clone ID Related Accession (Same CDS sequence)	NM_053105.2
Accession Version	NM_053105.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2256bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Mus musculus(house mouse)
Product	kelch-like protein 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC094584.1. On May 15, 2005 this sequence version replaced NM_053105.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC094584.1, SRR1660815.90469.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164139 [ECO:0000348] ##Evidence-Data-END##

ATGTCCGGCT CCGGGAGAAA AGACTTCGAT GTGAAGCACA TCCTGCGACT CCGCTGGAAA 
CTCTTCAGCC ATCCCTCGCC GGCCTCCAGT AGCCCAGCGG GGGGCAGCTG CCTGCAACAG 
GACAGCGGAG GAGGCAGCTT TGAGCACTGG GGTCCTAGCC AGAGTCGGCT GCTCAAAAAC 
CAGGAAAAGG GCAGTGTGAG CGCTTTCTGG AAAAAGCCTT CTTCCTCCTC TTCCTCCTCC 
TCTTCCTCCT CGTCTTCTGC TTCATCTTCT CCTTTCAATC CGCTGAATGG CACCTTACTA 
CCAGTTGCCA CGAGGCTGCA GCAAGGGGCT CCCGGGCAGG GCACCCAGCA GCCCGCCAGG 
ACTCTTTTCT ACGTGGAGTC CCTAGAGGAG GAGGTAGTGA CAGGCATGGA CTTTTCTGGA 
CCAGAGGACA AAGGATTGGC CCTGAAAGAG CTCCAAGCGG AGCCTGCCAG CTCTATCCAG 
GCAACAGGTG AAGGATGTGG ACACAGGTTG ACATCGACCA ATCATTCACT GACACCTCAA 
AGTGATTTGG ATTCCAGCAG CTCCGAAGAA TTCTATCAAG CTGTTCACCA TGCTGAGCAA 
TCATTTAGAA AGATGGAGAA TTATTTAAAG CAACAGCAGC TCTGTGATGT CATCCTGATA 
GTTGGAAATC GAAAGATACC TGCTCATAGG CTTGTTCTGA GTTCTGTCTC TGACTATTTT 
GCTGCCATGT TTACAAGTGA TGTCTGTGAA GCCAAGCAAG AGGAGATCAA GATGGAAGGC 
ATAGACCCAA ATGCACTCTG GGATCTTGTT CAATTTGCAT ATACAGGTTG CTTGGAATTA 
AAAGAAGACA CTATTGAAAA CCTTCTTGCA GCTGCTTGCC TTCTCCAGCT CCCTCAAGTG 
GTCGAAGTGT GTTGTCACTT CCTCATGAAA CTTCTGCATC CATCCAACTG TTTAGGAATA 
AGGGCATTTG CTGATGCTCA AGGATGCATT GAATTAATGA AGGTGGCACA CAGCTACACC 
ATGGAAAACA TAATGGAAGT AATCAGAAAT CAAGAGTTTT TACTCCTTCC AGCTGAAGAG 
CTCCATAAAC TACTGGCCAG TGATGATGTA AATGTTCCTG ATGAAGAGAC CATTTTCCAT 
GCACTGATGA TGTGGGTCAA GTATGACATG CAGCGGAGAT GTAGTGACCT GAGTATGCTC 
CTTGCCTTCA TAAGATTACC ACTGCTTCCA CCACAGATAC TGGCTGACCT TGAAAACCAT 
GCACTATTCA AGAATGATTT GGAATGTCAA AAACTGATTC TGGAAGCAAT GAAATATCAT 
CTATTGCCCG AAAGAAGAAC TTTAATGCAA AGTCCAAGAA CTAAGCCCAG AAAATCTACA 
GTTGGAACTC TTTATGCAGT GGGGGGAATG GATAATAACA AAGGGGCTAC AACCATAGAG 
AAGTATGACC TCCGAACAAA TCTGTGGATT CAGGCTGGAA TGATGAATGG CAGAAGGCTT 
CAGTTCGGTG TGGCTGTCAT TGATGACAAG CTCTTTGTAA TTGGAGGTCG AGATGGCTTA 
AAGACTTTGA ACACTGTTGA ATGTTACAAT CCCAAAACCA AGACATGGAC TGTTTTGCCA 
CCAATGTCAA CACATAGGCA TGGTCTAGGA GTAACTGTAC TGGAAGGGCC TATCTATGCA 
GTGGGAGGCC ATGACGGCTG GAGCTATCTG AACACAGTGG AAAGGTGGGA TCCCCAGAGC 
CAGCAGTGGA CATATGTAGC CAGTATGTCC ATTGCTCGGA GCACGGTTGG AGTAGCAGCA 
CTGAATGGAA AGTTGTACTC CGTTGGGGGT CGAGATGGAA GTTCCTGTCT GAGTTCAATG 
GAATACTATG ATCCTCATAC AAATAAGTGG AGCATGTGCG CACCGATGTG TAAGAGGAGA 
GGGGGTGTTG GAGTGGCCAC CTGTGATGGT TTCCTGTATG CAGTGGGTGG CCATGATGCT 
CCTGCTTCAA ACCACTGTTC CAGGCTCCTG GACTACGTGG AAAGGTATGA TCCAAAAACA 
GATACATGGA CCATGGTGGC TCCTTTGAGT ATGCCTAGAG ATGCTGTTGG TGTCTGTCTC 
CTTGGTGACA GGCTATATGC TGTTGGGGGC TATGATGGGC AGACTTACCT CAACACCATG 
GAGTCCTATG ATCCACAAAC TAATGAGTGG ACACAGATGG CTTCATTGAA TATTGGGAGA 
GCAGGTGCCT GTGTGGTTGT CATCAAGCAA CCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_444335.2
CDS	718..2973
Translation	MSGSGRKDFDVKHILRLRWKLFSHPSPASSSPAGGSCLQQDSGGGSFEHWGPSQSRLLKNQEKGSVSAFWKKPSSSSSSSSSSSSSASSSPFNPLNGTLLPVATRLQQGAPGQGTQQPARTLFYVESLEEEVVTGMDFSGPEDKGLALKELQAEPASSIQATGEGCGHRLTSTNHSLTPQSDLDSSSSEEFYQAVHHAEQSFRKMENYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQRRCSDLSMLLAFIRLPLLPPQILADLENHALFKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPRKSTVGTLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTYVASMSIARSTVGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWSMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQMASLNIGRAGACVVVIKQP

Target ORF information:

RefSeq Version	NM_053105.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus kelch-like 1 (Klhl1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053105.2

ORF Insert Sequence:

ATGTCCGGCT CCGGGAGAAA AGACTTCGAT GTGAAGCACA TCCTGCGACT CCGCTGGAAA 
CTCTTCAGCC ATCCCTCGCC GGCCTCCAGT AGCCCAGCGG GGGGCAGCTG CCTGCAACAG 
GACAGCGGAG GAGGCAGCTT TGAGCACTGG GGTCCTAGCC AGAGTCGGCT GCTCAAAAAC 
CAGGAAAAGG GCAGTGTGAG CGCTTTCTGG AAAAAGCCTT CTTCCTCCTC TTCCTCCTCC 
TCTTCCTCCT CGTCTTCTGC TTCATCTTCT CCTTTCAATC CGCTGAATGG CACCTTACTA 
CCAGTTGCCA CGAGGCTGCA GCAAGGGGCT CCCGGGCAGG GCACCCAGCA GCCCGCCAGG 
ACTCTTTTCT ACGTGGAGTC CCTAGAGGAG GAGGTAGTGA CAGGCATGGA CTTTTCTGGA 
CCAGAGGACA AAGGATTGGC CCTGAAAGAG CTCCAAGCGG AGCCTGCCAG CTCTATCCAG 
GCAACAGGTG AAGGATGTGG ACACAGGTTG ACATCGACCA ATCATTCACT GACACCTCAA 
AGTGATTTGG ATTCCAGCAG CTCCGAAGAA TTCTATCAAG CTGTTCACCA TGCTGAGCAA 
TCATTTAGAA AGATGGAGAA TTATTTAAAG CAACAGCAGC TCTGTGATGT CATCCTGATA 
GTTGGAAATC GAAAGATACC TGCTCATAGG CTTGTTCTGA GTTCTGTCTC TGACTATTTT 
GCTGCCATGT TTACAAGTGA TGTCTGTGAA GCCAAGCAAG AGGAGATCAA GATGGAAGGC 
ATAGACCCAA ATGCACTCTG GGATCTTGTT CAATTTGCAT ATACAGGTTG CTTGGAATTA 
AAAGAAGACA CTATTGAAAA CCTTCTTGCA GCTGCTTGCC TTCTCCAGCT CCCTCAAGTG 
GTCGAAGTGT GTTGTCACTT CCTCATGAAA CTTCTGCATC CATCCAACTG TTTAGGAATA 
AGGGCATTTG CTGATGCTCA AGGATGCATT GAATTAATGA AGGTGGCACA CAGCTACACC 
ATGGAAAACA TAATGGAAGT AATCAGAAAT CAAGAGTTTT TACTCCTTCC AGCTGAAGAG 
CTCCATAAAC TACTGGCCAG TGATGATGTA AATGTTCCTG ATGAAGAGAC CATTTTCCAT 
GCACTGATGA TGTGGGTCAA GTATGACATG CAGCGGAGAT GTAGTGACCT GAGTATGCTC 
CTTGCCTTCA TAAGATTACC ACTGCTTCCA CCACAGATAC TGGCTGACCT TGAAAACCAT 
GCACTATTCA AGAATGATTT GGAATGTCAA AAACTGATTC TGGAAGCAAT GAAATATCAT 
CTATTGCCCG AAAGAAGAAC TTTAATGCAA AGTCCAAGAA CTAAGCCCAG AAAATCTACA 
GTTGGAACTC TTTATGCAGT GGGGGGAATG GATAATAACA AAGGGGCTAC AACCATAGAG 
AAGTATGACC TCCGAACAAA TCTGTGGATT CAGGCTGGAA TGATGAATGG CAGAAGGCTT 
CAGTTCGGTG TGGCTGTCAT TGATGACAAG CTCTTTGTAA TTGGAGGTCG AGATGGCTTA 
AAGACTTTGA ACACTGTTGA ATGTTACAAT CCCAAAACCA AGACATGGAC TGTTTTGCCA 
CCAATGTCAA CACATAGGCA TGGTCTAGGA GTAACTGTAC TGGAAGGGCC TATCTATGCA 
GTGGGAGGCC ATGACGGCTG GAGCTATCTG AACACAGTGG AAAGGTGGGA TCCCCAGAGC 
CAGCAGTGGA CATATGTAGC CAGTATGTCC ATTGCTCGGA GCACGGTTGG AGTAGCAGCA 
CTGAATGGAA AGTTGTACTC CGTTGGGGGT CGAGATGGAA GTTCCTGTCT GAGTTCAATG 
GAATACTATG ATCCTCATAC AAATAAGTGG AGCATGTGCG CACCGATGTG TAAGAGGAGA 
GGGGGTGTTG GAGTGGCCAC CTGTGATGGT TTCCTGTATG CAGTGGGTGG CCATGATGCT 
CCTGCTTCAA ACCACTGTTC CAGGCTCCTG GACTACGTGG AAAGGTATGA TCCAAAAACA 
GATACATGGA CCATGGTGGC TCCTTTGAGT ATGCCTAGAG ATGCTGTTGG TGTCTGTCTC 
CTTGGTGACA GGCTATATGC TGTTGGGGGC TATGATGGGC AGACTTACCT CAACACCATG 
GAGTCCTATG ATCCACAAAC TAATGAGTGG ACACAGATGG CTTCATTGAA TATTGGGAGA 
GCAGGTGCCT GTGTGGTTGT CATCAAGCAA CCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genetic Mapping in Mice Reveals the Involvement of Pcdh9 in Long-Term Social and Object Recognition and Sensorimotor Development.
Biological psychiatry78(7)485-95(2015 Oct)
Bruining H,Matsui A,Oguro-Ando A,Kahn RS,Van't Spijker HM,Akkermans G,Stiedl O,van Engeland H,Koopmans B,van Lith HA,Oppelaar H,Tieland L,Nonkes LJ,Yagi T,Kaneko R,Burbach JP,Yamamoto N,Kas MJ

Calcium current homeostasis and synaptic deficits in hippocampal neurons from Kelch-like 1 knockout mice.
Frontiers in cellular neuroscience8444(2014)
Perissinotti PP,Ethington EA,Almazan E,Mart?nez-Hern?ndez E,Kalil J,Koob MD,Piedras-Renter?a ES

T-type current modulation by the actin-binding protein Kelch-like 1.
American journal of physiology. Cell physiology298(6)C1353-62(2010 Jun)
Aromolaran KA,Benzow KA,Cribbs LL,Koob MD,Piedras-Renter?a ES

Kelch-like 1 protein upregulates T-type currents by an actin-F dependent increase in ?(1H) channels via the recycling endosome.
Channels (Austin, Tex.)3(6)402-12(2009 Nov)
Aromolaran KA,Benzow KA,Cribbs LL,Koob MD,Piedras-Renter?a ES

Identification of Dlk1, Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic dopamine neurons.
Development (Cambridge, England)136(14)2363-73(2009 Jul)
Jacobs FM,van der Linden AJ,Wang Y,von Oerthel L,Sul HS,Burbach JP,Smidt MP

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Klhl1 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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