Ly6k cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ly6k
Entrez Gene ID	76486
Full Name	lymphocyte antigen 6 complex, locus K
Synonyms	2410015A16Rik,3110035B01Rik,mLy-6K
General protein information	Preferred Names lymphocyte antigen 6 complex, locus K Names lymphocyte antigen 6K ly-6K
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 15 Map Location: 15\|15 D3

mRNA and Protein(s)

mRNA	Protein	Name
NM_029627.2	NP_083903.1	lymphocyte antigen 6K precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Ly6k	NP_083903.1
Rattus norvegicus (Norway rat)	LOC100910068	XP_006241816.1
Rattus norvegicus (Norway rat)	Ly6k	XP_006241818.1

Gene Ontology
Bibliography

Related articles in PubMed

Organization, evolution and functions of the human and mouse Ly6/uPAR family genes.
Loughner CL, Bruford EA, McAndrews MS, Delp EE, Swamynathan S, Swamynathan SK
Human genomics1010(2016 Apr)

TEX101, a glycoprotein essential for sperm fertility, is required for stable expression of Ly6k on testicular germ cells.
Endo S, Yoshitake H, Tsukamoto H, Matsuura H, Kato K, Sakuraba M, Takamori K, Fujiwara H, Takeda S, Araki Y
Scientific reports623616(2016 Mar)

GPI-anchored protein complex, LY6K/TEX101, is required for sperm migration into the oviduct and male fertility in mice.
Fujihara Y, Okabe M, Ikawa M
Biology of reproduction90(3)60(2014 Mar)

Molecular expression of Ly6k, a putative glycosylphosphatidyl-inositol-anchored membrane protein on the mouse testicular germ cells.
Maruyama M, Yoshitake H, Tsukamoto H, Takamori K, Araki Y
Biochemical and biophysical research communications402(1)75-81(2010 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study demonstrated that both TEX101 and Ly6k contribute mutually for their protein expression in the testicular germ cells, suggesting that the expression-balance of these two proteins is essential for fertile sperm formation.
Title: TEX101, a glycoprotein essential for sperm fertility, is required for stable expression of Ly6k on testicular germ cells.

LY6K is a newly identified factor involved in sperm fertilizing ability
Title: GPI-anchored protein complex, LY6K/TEX101, is required for sperm migration into the oviduct and male fertility in mice.

This information is essential for the molecular classification of Ly6k, and may help uncover the detailed physiological role of Ly6k in gametogenesis, or cancer biology.
Title: Molecular expression of Ly6k, a putative glycosylphosphatidyl-inositol-anchored membrane protein on the mouse testicular germ cells.

This study confirmed the biological interaction between TEX101 and Ly6k.
Title: TEX101, a germ cell-marker glycoprotein, is associated with lymphocyte antigen 6 complex locus k within the mouse testis.

Expression profiling confirmed that mLy-6K is expressed by plasma cells but not B cells or tissues not containing plasma cells.
Title: Identification of Ly-6K as a novel marker for mouse plasma cells.

The following Ly6k gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ly6k cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu07244	NM_029627.2 Latest version!	Mus musculus lymphocyte antigen 6 complex, locus K (Ly6k), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ly6k ( NM_029627.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_083903.1 Mus musculus lymphocyte antigen 6 complex, locus K (Ly6k), mRNA.

Price & Availability↑

CloneID	OMu07244
Clone ID Related Accession (Same CDS sequence)	NM_029627.2
Accession Version	NM_029627.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 465bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-17
Organism	Mus musculus(house mouse)
Product	lymphocyte antigen 6K precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AK010485.1. On Jun 30, 2008 this sequence version replaced NM_029627.1. ##Evidence-Data-START## Transcript exon combination :: AK010485.1, BY709908.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849383, SAMN00849384 [ECO:0000348] ##Evidence-Data-END##

ATGGCGTTCC TAGTGGCCTT GCTCGTAGTT CTGGGCTTAC AGTTGGTGCA GAGTAACGCG 
CTCACCTGCC ATGTGTGTGA GGCGCAGAAC AGCTATGCCT GCTCGAATCC GTCCCAGTGC 
CCTGGAGAAA AGAAATTCTG TTTGTTGGCC GTCACACGAA TTTTTGAACG TTTCTTCTAT 
GTGTCGAAAC AGTGCACCCG AAGGTGTCCA ACCCCCGTAG TCAGCCCGCC TAGCACTAAT 
CCACCATCTG AGCCTAAGGA GTTTCTGATA GAAAAACCCA TGCCCTTCCT ATTTTATAAG 
TGCTGTCAAT GGGACTCATG TAATGGTGAG GGGCCACCCA CTGACCAGCT CTTAAAGGAA 
CAACCTGGGA AAGCCAGTGG GAGAAGACAT AGATACATTG AGCTGTTACT GACTGGCTTC 
ATGGTCCTTA CTGCTAATGG CCTCTCAGCC CTCTGCCTGC TGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_083903.1
CDS	219..683
Translation	MAFLVALLVVLGLQLVQSNALTCHVCEAQNSYACSNPSQCPGEKKFCLLAVTRIFERFFYVSKQCTRRCPTPVVSPPSTNPPSEPKEFLIEKPMPFLFYKCCQWDSCNGEGPPTDQLLKEQPGKASGRRHRYIELLLTGFMVLTANGLSALCLL

Target ORF information:

RefSeq Version	NM_029627.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus lymphocyte antigen 6 complex, locus K (Ly6k), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_029627.2

ORF Insert Sequence:

ATGGCGTTCC TAGTGGCCTT GCTCGTAGTT CTGGGCTTAC AGTTGGTGCA GAGTAACGCG 
CTCACCTGCC ATGTGTGTGA GGCGCAGAAC AGCTATGCCT GCTCGAATCC GTCCCAGTGC 
CCTGGAGAAA AGAAATTCTG TTTGTTGGCC GTCACACGAA TTTTTGAACG TTTCTTCTAT 
GTGTCGAAAC AGTGCACCCG AAGGTGTCCA ACCCCCGTAG TCAGCCCGCC TAGCACTAAT 
CCACCATCTG AGCCTAAGGA GTTTCTGATA GAAAAACCCA TGCCCTTCCT ATTTTATAAG 
TGCTGTCAAT GGGACTCATG TAATGGTGAG GGGCCACCCA CTGACCAGCT CTTAAAGGAA 
CAACCTGGGA AAGCCAGTGG GAGAAGACAT AGATACATTG AGCTGTTACT GACTGGCTTC 
ATGGTCCTTA CTGCTAATGG CCTCTCAGCC CTCTGCCTGC TGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Organization, evolution and functions of the human and mouse Ly6/uPAR family genes.
Human genomics1010(2016 Apr)
Loughner CL,Bruford EA,McAndrews MS,Delp EE,Swamynathan S,Swamynathan SK

TEX101, a glycoprotein essential for sperm fertility, is required for stable expression of Ly6k on testicular germ cells.
Scientific reports623616(2016 Mar)
Endo S,Yoshitake H,Tsukamoto H,Matsuura H,Kato K,Sakuraba M,Takamori K,Fujiwara H,Takeda S,Araki Y

GPI-anchored protein complex, LY6K/TEX101, is required for sperm migration into the oviduct and male fertility in mice.
Biology of reproduction90(3)60(2014 Mar)
Fujihara Y,Okabe M,Ikawa M

Molecular expression of Ly6k, a putative glycosylphosphatidyl-inositol-anchored membrane protein on the mouse testicular germ cells.
Biochemical and biophysical research communications402(1)75-81(2010 Nov)
Maruyama M,Yoshitake H,Tsukamoto H,Takamori K,Araki Y

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Ly6k cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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