Kndc1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Kndc1
Entrez Gene ID	76484
Full Name	kinase non-catalytic C-lobe domain (KIND) containing 1
Synonyms	2410012C07Rik,B830014K08Rik,VKIND,v-KIND,very-kind
General protein information	Preferred Names kinase non-catalytic C-lobe domain (KIND) containing 1 Names protein very KIND KIND domain-containing protein 1 kinase non-catalytic C-lobe domain-containing protein 1 ras-GEF domain-containing family member 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 7 Map Location: 7\|7 F4

mRNA and Protein(s)

mRNA	Protein	Name
NM_177261.4	NP_796235.4	kinase non-catalytic C-lobe domain-containing protein 1

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	kndc1	XP_002937180.2
Gallus gallus (chicken)	KNDC1	XP_421694.4
Homo sapiens (human)	KNDC1	NP_689856.6
	KNDC1	XP_001114436.2
Mus musculus (house mouse)	Kndc1	NP_796235.4
Rattus norvegicus (Norway rat)	Kndc1	XP_006230568.1

Gene Ontology
Bibliography

Related articles in PubMed

The brain-specific RasGEF very-KIND is required for normal dendritic growth in cerebellar granule cells and proper motor coordination.
Hayashi K, Furuya A, Sakamaki Y, Akagi T, Shinoda Y, Sadakata T, Hashikawa T, Shimizu K, Minami H, Sano Y, Nakayama M, Furuichi T
PloS one12(3)e0173175(2017)

Cerebellar development transcriptome database (CDT-DB): profiling of spatio-temporal gene expression during the postnatal development of mouse cerebellum.
Sato A, Sekine Y, Saruta C, Nishibe H, Morita N, Sato Y, Sadakata T, Shinoda Y, Kojima T, Furuichi T
Neural networks : the official journal of the International Neural Network Society21(8)1056-69(2008 Oct)

Very-KIND, a KIND domain containing RasGEF, controls dendrite growth by linking Ras small GTPases and MAP2.
Huang J, Furuya A, Furuichi T
The Journal of cell biology179(3)539-52(2007 Nov)

A gene-targeting approach for functional characterization of KIAA genes encoding extremely large proteins.
Nakayama M, Iida M, Koseki H, Ohara O
FASEB journal : official publication of the Federation of American Societies for Experimental Biology20(10)1718-20(2006 Aug)

Very-KIND is a novel nervous system specific guanine nucleotide exchange factor for Ras GTPases.
Mees A, Rock R, Ciccarelli FD, Leberfinger CB, Borawski JM, Bork P, Wiese S, Gessler M, Kerkhoff E
Gene expression patterns : GEP6(1)79-85(2005 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

our results suggest that v-KIND is required for compact dendritic growth and proper excitatory synaptic connections in cerebellar granule cells, which are necessary for normal motor coordination and balance.
Title: The brain-specific RasGEF very-KIND is required for normal dendritic growth in cerebellar granule cells and proper motor coordination.

results demonstrate the structural and functional determinant underlying the v-KIND-MAP2 interaction that controls dendrite arborization patterns
Title: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth--structure and function of the second kinase noncatalytic C-lobe domain.

v-KIND mediates a signaling pathway that links Ras and MAP2 to control dendrite growth
Title: Very-KIND, a KIND domain containing RasGEF, controls dendrite growth by linking Ras small GTPases and MAP2.

During mouse embryogenesis the VKIND gene was specifically expressed in the developing nervous system.
Title: Very-KIND is a novel nervous system specific guanine nucleotide exchange factor for Ras GTPases.

The following Kndc1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kndc1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu06130	NM_177261.4 Latest version!	Mus musculus kinase non-catalytic C-lobe domain (KIND) containing 1 (Kndc1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	25	$951.30 $1359.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Kndc1 ( NM_177261.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_796235.4 Mus musculus kinase non-catalytic C-lobe domain (KIND) containing 1 (Kndc1), mRNA.

Price & Availability↑

CloneID	OMu06130
Clone ID Related Accession (Same CDS sequence)	NM_177261.4
Accession Version	NM_177261.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 5229bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	kinase non-catalytic C-lobe domain-containing protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK147335.1, AK046817.1 and BE994731.1. On Apr 26, 2007 this sequence version replaced NM_177261.3. ##Evidence-Data-START## Transcript exon combination :: AK147335.1, AB257857.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849383 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGGCCA TGGACCCAGC CTCCCGGGGC TTCTACGAGG AAGATGGCAA GGACTTGGAC 
TTCTACGACT TCGAGCCGCT CCCCACCCTG CCGGAGGATG AGGAAAATGT GTCTCTGGCT 
GACATCCTCT CCCTGCGGGA CAGAGGCCTC AGTGAGCAGG AGGCCTGGGC TGTGTGCCTA 
GAGTGCAGCC TGTCCATGCG GAGTGTCGCC CACGCAGCCA TCTTCCAGAC CCTGTGCATC 
ACACCAGACA CCTTGGCCTT CAACACCAGT GGAAACGTGT GCTTCATGGA ACAGCTCAGT 
GATGACCCCG AGGGTGCCTT TGTACCCCCA GAGTTTGACC TGACAGGAAA CACCTTTGAG 
GCTCACATCT ACTCCCTGGG GGCCACACTG AAGGCTGCCC TGGAGTATGT CCCAGAACCA 
GAGCTGGAGC CCAAGCTGAG CACAGACCTG GAGGGACTGC TGAGCCAGAT GCAGGCAGAA 
GACCCCAGAG AGCGGCCGGA CCTGGCGAGC ATCATAGCAC TGTGTGAGGA GAAGATGCAG 
CCTGTGTCCT CATGCCGCCT GTGCCGCAGT CTCTCAGCCA TTGGAAGAAG GGTGCTCTCC 
ATTGAGTCCT TCGGAGCATT CCAGGAGCTC AGCGAGAACA CATGGAGGGG AAGGCCTGCT 
CCAAGAAACG TGGGGCCCAA GAAGATGCCA GGAGACCTCA GCACTGACCC AGAGGCACTG 
TTCCCATCAA AGGGCCTACT CCAGCCTCCT GCTTCCAGGG ATGCCGAGCA GGAGGCTGGG 
CAGAGGCCCA GAGCCCCATC CCCCAAACCA CTGCTGTCAG CCCCTGTGAG AAATGGTGAG 
AACCCAGGAC AGGAAGGGCT GGCTGACCTT GTCCTGGATG CCAGGTGCCC CCTGGGCGAG 
CTGGACAGAG ACAACCTCAG GCGAAGCCGG CTGAAAAAGG CTCAGACGTT TCCCAGGCTA 
CTGCAGGAAA GCACAGAGAC CAGCACCCTC TGCCTGTCAC TGAACGGCTC GAGAAACCAG 
CTGGCCATAT CTGAGTTCTT TCCCCCAGAC CCTAGGAAGC TCTTCCTGGA AGGGAAAAAT 
GGCCTTTCTG GTTTCAAAAC ACAGTCCAAA AGCAGACTGT GGCCAGAGCA GGAGCCTGGA 
GTCCAGTTGG ATAAGACACC AGGTGCAGGC CGCAACCCAC ACAGGAGTCC AGGGGCCTCG 
GGGCAACTAG AGGCTTCATC TCCTAGCCAG GGATCTGTAG AGTACAAACC TTCACCCAGC 
CCTGTAGACG CTGGAGATTC AGACCATGAA GGCCACATAC CTAGGAGTGA AGAGAAGATT 
CCAGAAGAAT CCAGACAACC TGGAAGCACA GCCACTGAAC AGAGCCTGTC CCTGAAGGAC 
CTTCTGTCTA AGCTAGGCCG GCCCTTCAGG GAGTACGAGC TGTGGGCACT GTGCCTCTCC 
TGCCTTAGCA CTCTGCAGAC ACACAAGGAG CACCCAGCTC ACCTGTGCCT GGACAACGTG 
TTGGTGGCCG AGGACGGGAC AGTGTTCTTC GGACCGCCCC CTGCCAATGG CGCCTACAAC 
TCACTCTTCT TGGCTCCCGA AGTGTCAGAA GAGAAGCTGG TGACAGAGAA GGCCTCTGTG 
TACTGTGTGG CTGCGGTTCT GTGGACAGCA GCCAAGTTCA GCGTACCCCG AGACCACAAA 
CTGGCCCTGC CACGTAGACT CAAAACACTC CTTCTGGACA TGGCCAGACG CCATGCCTCA 
GAACGGCCAT CTGCAGCCGA GGCCATCAAG GTGTGCAGCA GCTACCTCCT TCAGCGAGGC 
ATGGACAGCA GCAAGATTCT AGCCCACCTG CGGGCATCCA CCTGCAAGGT TCACCCAGAG 
GAGGAGACCA TCGGCCTCCA GAACGCCTTC TCAGTGGTTG AACTGAAATC CACCACGGCA 
CCTGCTCCTG AGAGTAGTCC CGGCTTCCTG CAGGTCAGCA ATGATACCAA GCTGGTCGCT 
GTCCCAGGGC CTGTGCCTGG TCTGCCCCCC TGCTGCAAAG AAGCCTGTGA GCTGCCAGCA 
GCCTTCACCT CTGAGGCCAC TCACTTTAAG CCCATAGTCC TGGCTCAGGA CGCAAGTGTT 
ACCAGAGACC AGCTTGCCTT GCCCTCAGAG TCAAATGAGA AACCCAAAGA GGGAAGTGGT 
CATCTGGACA GGGAGGGAAC AAGAAAGCAG GCAGCCCTGG AGCTTGTTGA GGCCACTGAC 
CTAAAGATGT CCAACCAGCT GTCACCTGGT CCAGAGCTGC AGGGAGCAAC TCCAGACCCT 
GATGGTGACT CAGGGTCCCC CAGCTCAGCC ACGGAATGTT CCTGCCCCCA TGGCCCTGCT 
CTGGTCACCC AGCAAAAAGG AACATCAGGG ACACCCAGCT CTCCTGCCTC TTCCCTGCCC 
CCTGAGCACA GGCCAGATGG TGAGGGACCA CTAGGCACCA CTGTGCTCCC AGGGCCCACC 
TCAGCCAGCC AGGGCTCTCG ACACCCATGT AAGCCACCCA GGGGTAAGGC TGCAGCGAGT 
CCAAGCAGCC CTAGGGGCTC GGATGGTCAT CCTGAGAAGC CTCGGCCAGC AGACCGCAAG 
CTCTGTCCAT CCAGTGTAGA TACCTCATCC CCCCCTAAGA TGACAGCCTG CCCCTCGCTT 
CAGGAAGCCA TGCGCCTCAT CCAGGAGGAA TTTGCCTTTG ATGGCTACAT GGACAACGGG 
CTAGAGGCAC TGATCATGGG GGAGTATATT TACGCCTTGA AAGACCTCAC CTTCGCCACC 
TTCTGTGGTG CCATATCTGA GAAGTTCTGT GACCTATACT GGGATGAGCA GCTGCTAAAG 
AACCTCTTCA AGGTGGTCAA TGGGCCAGCC TCACCCTCTG AGAGCACTTC TGAGGAGCCT 
GGATCCCAGC CAGAACACTC ACCCAGCAGA TGCTCACTAT CCAGCAAAAG GCCTTCCCTG 
CATGGACTCG GCAAGGAGAA GCCAGCCACG ACCTGGGGCA GCGGGGGACC CTGCTCCCCC 
ACAGCACTAT CAGATATAGA CTCCGACACG CTCTCTCAGG GAAACTTTGA GGTTGGATTT 
CGGTCTCAGA AGTCAATAAA AGTCACGCGA GAGCAGCAAC CAGAGGCCGA AGTGGGTGGG 
CAGCCAGGTC CAAGCCAGGA CTCAACCAGC CATGCCTCGG ACACAGTGGC CCGGCTAGCT 
AGATCTGAGG ACGGTGGCCC AGCTGGGTCT CCAGGGGCAT CTGATTTCCA GAACTGCAGC 
CCTGGCTGGT CCAGTGCCTT CTATGAGGCT GACTGCTTTG GAGCCGATGT CTACAACTAC 
GTGAAGGATC TGGAGAGGCA GAAGACCAAC GGGCACACAG AACTGGAAGC CCAGAGTCCA 
GAGCTGGAGC AGCAGCTCAT GATAGAGAAG AGAAACTATA GGAAGACCCT GAAGTTTTAC 
CAGAAACTCT TACAGAAGGA AAAACGGAAC AAAGGCTCTG AGGTCAGGAC CATGTTGTCT 
AAACTTCGAG GACAGCTGGA TGAAATGAAG TCCAAGGTGC AGTTCCTGAG CCTGGTCAAG 
AAGTACCTCC AGGTCATGTA TGCAGAACGC TGGGGGCTGG AGCCCTGTGC TCTGCCGGTG 
ATTGTGAACA TCGCAGCAGC CCCCTGTGAC ACACTGGATT TCAGCCCCCT GGATGAGTCT 
TCTTCCCTCA TCTTCTACAA TGTCAACAAG CACCCAGGCA GCGGCCGACA GAAGAAGGCT 
CGCATCCTAC AGGCTGGTAC ACCACTGGGG CTCATGGCCT ACCTCTACTC CAGTGATGCT 
TTCCTCGAGG GCTACGTGCA GCAGTTTCTC TACACTTTCC GGTACTTTTG CACACCGCAC 
GACTTCCTGC ACTTCCTCCT GGACCGCATC AGCAGCACTT TATCCAGGGC TCACCAGGAT 
CCTACCTCGA CTTTTACCAA GATCTACAGG CGAAGCCTCT GCGTCCTGCA GGCCTGGGTG 
GAAGACTGCT ACACCGTGGA CTTCATAAGG AACGCGGGGC TGCTGGGACA GCTGGAGGAC 
TTCATCTCTT CCAAGATCCT ACCTCTAGAT GGCACTGCCG AGCACCTGCT GGCCCTCTTA 
GAGGTGGGCA CTGAGCGGCG GGCTGACAGT GCCTCTCGAG GTGCAGACCT GGAGGACCCT 
AAGGAGGCAG AGGAGGACAC CAGACCCTTT AATGCCCTCT GCAAGAGGTT CTCAGAGGAT 
GGCATCACCC GGAAGAGCTT CTCTTGGAGA CTGCCTCGGG GCAACGGGCT AGTGCTGCCA 
CATCATAAGG AGCGCCAGTA CACCATTGCA TCCGCCCTGC CTAAGCCCTG CTTCTTCGAA 
GACTTCTATG GCCCCTATGC CAAAGCCAGT GAGAAGGGTC CTTACTTCTT GACAGAGTAC 
AGCACCAACC AGCTCTTCAC TCAGCTAACA CTACTGCAGC AGGAATTGTT TCAAAAGTGC 
CACCCTGTCC ACTTCCTAAA TTCACGAGCC CTGGGTGTCA TGGACAAAAG TGCAGCCATT 
CCCAAAGCCA GCTCTTCTGA GTCTCTTTCT GCCAAAACCT GCAGCCTCTT CCTACCCAAT 
TACGTCCAGG ACAAATATCT GCTACAGCTT TTAAGAAACG CAGATGATGT CAGTACCTGG 
GTGGCTGCTG AAATTGTGAC CAGTCATACC TCCAAGCTTC AGGTGAACTT GCTGTCCAAA 
TTCCTGCTGA TTGCAAAATC TTGCTACGAA CAGAGGAACT TTGCAACGGC CATGCAAATC 
CTGGGCGGGC TGGAGCACCT GGCTGTGAGG CAGTCCCCTG CTTGGAGAAT CCTGCCTGCG 
AAGATTGCTG AGGTCATGGA AGAGCTGAAA GCTGTGGAGG TATTCCTGAA GAGTGACAGC 
CTGTGTCTGA TGGAAGGAAG GCGCTTCCGG GCCCAGCCTA CTCTACCCTC CGCCCACCTG 
CTGGCCATGC ACATCCAGCA GCTGGAGACA GGAGGTTTCA CCATGACTAA TGGAGCCCAT 
AGATGGAGCA AACTGAGAAA CATCGCCAAG GTGGCAAGCC AGGTGCACGC GTTCCAGGAG 
AACCCGTACA CATTCAGCCC GGACCCCAAG CTACAGGCCC ACCTCAAGCA GAGGATCGCC 
CGCTTTAGCG GCGCTGATGT CTCCATTTTA GCAGCTGATA ACAGGGCCAA CTTCCACCAG 
ATCCCAGGAG AGAAACACTC ACGGAAGATC CAAGACAAGC TGAGGAGAAT GAAGGCCACA 
TTCCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_796235.4
CDS	492..5720
Translation	MQAMDPASRGFYEEDGKDLDFYDFEPLPTLPEDEENVSLADILSLRDRGLSEQEAWAVCLECSLSMRSVAHAAIFQTLCITPDTLAFNTSGNVCFMEQLSDDPEGAFVPPEFDLTGNTFEAHIYSLGATLKAALEYVPEPELEPKLSTDLEGLLSQMQAEDPRERPDLASIIALCEEKMQPVSSCRLCRSLSAIGRRVLSIESFGAFQELSENTWRGRPAPRNVGPKKMPGDLSTDPEALFPSKGLLQPPASRDAEQEAGQRPRAPSPKPLLSAPVRNGENPGQEGLADLVLDARCPLGELDRDNLRRSRLKKAQTFPRLLQESTETSTLCLSLNGSRNQLAISEFFPPDPRKLFLEGKNGLSGFKTQSKSRLWPEQEPGVQLDKTPGAGRNPHRSPGASGQLEASSPSQGSVEYKPSPSPVDAGDSDHEGHIPRSEEKIPEESRQPGSTATEQSLSLKDLLSKLGRPFREYELWALCLSCLSTLQTHKEHPAHLCLDNVLVAEDGTVFFGPPPANGAYNSLFLAPEVSEEKLVTEKASVYCVAAVLWTAAKFSVPRDHKLALPRRLKTLLLDMARRHASERPSAAEAIKVCSSYLLQRGMDSSKILAHLRASTCKVHPEEETIGLQNAFSVVELKSTTAPAPESSPGFLQVSNDTKLVAVPGPVPGLPPCCKEACELPAAFTSEATHFKPIVLAQDASVTRDQLALPSESNEKPKEGSGHLDREGTRKQAALELVEATDLKMSNQLSPGPELQGATPDPDGDSGSPSSATECSCPHGPALVTQQKGTSGTPSSPASSLPPEHRPDGEGPLGTTVLPGPTSASQGSRHPCKPPRGKAAASPSSPRGSDGHPEKPRPADRKLCPSSVDTSSPPKMTACPSLQEAMRLIQEEFAFDGYMDNGLEALIMGEYIYALKDLTFATFCGAISEKFCDLYWDEQLLKNLFKVVNGPASPSESTSEEPGSQPEHSPSRCSLSSKRPSLHGLGKEKPATTWGSGGPCSPTALSDIDSDTLSQGNFEVGFRSQKSIKVTREQQPEAEVGGQPGPSQDSTSHASDTVARLARSEDGGPAGSPGASDFQNCSPGWSSAFYEADCFGADVYNYVKDLERQKTNGHTELEAQSPELEQQLMIEKRNYRKTLKFYQKLLQKEKRNKGSEVRTMLSKLRGQLDEMKSKVQFLSLVKKYLQVMYAERWGLEPCALPVIVNIAAAPCDTLDFSPLDESSSLIFYNVNKHPGSGRQKKARILQAGTPLGLMAYLYSSDAFLEGYVQQFLYTFRYFCTPHDFLHFLLDRISSTLSRAHQDPTSTFTKIYRRSLCVLQAWVEDCYTVDFIRNAGLLGQLEDFISSKILPLDGTAEHLLALLEVGTERRADSASRGADLEDPKEAEEDTRPFNALCKRFSEDGITRKSFSWRLPRGNGLVLPHHKERQYTIASALPKPCFFEDFYGPYAKASEKGPYFLTEYSTNQLFTQLTLLQQELFQKCHPVHFLNSRALGVMDKSAAIPKASSSESLSAKTCSLFLPNYVQDKYLLQLLRNADDVSTWVAAEIVTSHTSKLQVNLLSKFLLIAKSCYEQRNFATAMQILGGLEHLAVRQSPAWRILPAKIAEVMEELKAVEVFLKSDSLCLMEGRRFRAQPTLPSAHLLAMHIQQLETGGFTMTNGAHRWSKLRNIAKVASQVHAFQENPYTFSPDPKLQAHLKQRIARFSGADVSILAADNRANFHQIPGEKHSRKIQDKLRRMKATFQ

Target ORF information:

RefSeq Version	NM_177261.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus kinase non-catalytic C-lobe domain (KIND) containing 1 (Kndc1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_177261.4

ORF Insert Sequence:

ATGCAGGCCA TGGACCCAGC CTCCCGGGGC TTCTACGAGG AAGATGGCAA GGACTTGGAC 
TTCTACGACT TCGAGCCGCT CCCCACCCTG CCGGAGGATG AGGAAAATGT GTCTCTGGCT 
GACATCCTCT CCCTGCGGGA CAGAGGCCTC AGTGAGCAGG AGGCCTGGGC TGTGTGCCTA 
GAGTGCAGCC TGTCCATGCG GAGTGTCGCC CACGCAGCCA TCTTCCAGAC CCTGTGCATC 
ACACCAGACA CCTTGGCCTT CAACACCAGT GGAAACGTGT GCTTCATGGA ACAGCTCAGT 
GATGACCCCG AGGGTGCCTT TGTACCCCCA GAGTTTGACC TGACAGGAAA CACCTTTGAG 
GCTCACATCT ACTCCCTGGG GGCCACACTG AAGGCTGCCC TGGAGTATGT CCCAGAACCA 
GAGCTGGAGC CCAAGCTGAG CACAGACCTG GAGGGACTGC TGAGCCAGAT GCAGGCAGAA 
GACCCCAGAG AGCGGCCGGA CCTGGCGAGC ATCATAGCAC TGTGTGAGGA GAAGATGCAG 
CCTGTGTCCT CATGCCGCCT GTGCCGCAGT CTCTCAGCCA TTGGAAGAAG GGTGCTCTCC 
ATTGAGTCCT TCGGAGCATT CCAGGAGCTC AGCGAGAACA CATGGAGGGG AAGGCCTGCT 
CCAAGAAACG TGGGGCCCAA GAAGATGCCA GGAGACCTCA GCACTGACCC AGAGGCACTG 
TTCCCATCAA AGGGCCTACT CCAGCCTCCT GCTTCCAGGG ATGCCGAGCA GGAGGCTGGG 
CAGAGGCCCA GAGCCCCATC CCCCAAACCA CTGCTGTCAG CCCCTGTGAG AAATGGTGAG 
AACCCAGGAC AGGAAGGGCT GGCTGACCTT GTCCTGGATG CCAGGTGCCC CCTGGGCGAG 
CTGGACAGAG ACAACCTCAG GCGAAGCCGG CTGAAAAAGG CTCAGACGTT TCCCAGGCTA 
CTGCAGGAAA GCACAGAGAC CAGCACCCTC TGCCTGTCAC TGAACGGCTC GAGAAACCAG 
CTGGCCATAT CTGAGTTCTT TCCCCCAGAC CCTAGGAAGC TCTTCCTGGA AGGGAAAAAT 
GGCCTTTCTG GTTTCAAAAC ACAGTCCAAA AGCAGACTGT GGCCAGAGCA GGAGCCTGGA 
GTCCAGTTGG ATAAGACACC AGGTGCAGGC CGCAACCCAC ACAGGAGTCC AGGGGCCTCG 
GGGCAACTAG AGGCTTCATC TCCTAGCCAG GGATCTGTAG AGTACAAACC TTCACCCAGC 
CCTGTAGACG CTGGAGATTC AGACCATGAA GGCCACATAC CTAGGAGTGA AGAGAAGATT 
CCAGAAGAAT CCAGACAACC TGGAAGCACA GCCACTGAAC AGAGCCTGTC CCTGAAGGAC 
CTTCTGTCTA AGCTAGGCCG GCCCTTCAGG GAGTACGAGC TGTGGGCACT GTGCCTCTCC 
TGCCTTAGCA CTCTGCAGAC ACACAAGGAG CACCCAGCTC ACCTGTGCCT GGACAACGTG 
TTGGTGGCCG AGGACGGGAC AGTGTTCTTC GGACCGCCCC CTGCCAATGG CGCCTACAAC 
TCACTCTTCT TGGCTCCCGA AGTGTCAGAA GAGAAGCTGG TGACAGAGAA GGCCTCTGTG 
TACTGTGTGG CTGCGGTTCT GTGGACAGCA GCCAAGTTCA GCGTACCCCG AGACCACAAA 
CTGGCCCTGC CACGTAGACT CAAAACACTC CTTCTGGACA TGGCCAGACG CCATGCCTCA 
GAACGGCCAT CTGCAGCCGA GGCCATCAAG GTGTGCAGCA GCTACCTCCT TCAGCGAGGC 
ATGGACAGCA GCAAGATTCT AGCCCACCTG CGGGCATCCA CCTGCAAGGT TCACCCAGAG 
GAGGAGACCA TCGGCCTCCA GAACGCCTTC TCAGTGGTTG AACTGAAATC CACCACGGCA 
CCTGCTCCTG AGAGTAGTCC CGGCTTCCTG CAGGTCAGCA ATGATACCAA GCTGGTCGCT 
GTCCCAGGGC CTGTGCCTGG TCTGCCCCCC TGCTGCAAAG AAGCCTGTGA GCTGCCAGCA 
GCCTTCACCT CTGAGGCCAC TCACTTTAAG CCCATAGTCC TGGCTCAGGA CGCAAGTGTT 
ACCAGAGACC AGCTTGCCTT GCCCTCAGAG TCAAATGAGA AACCCAAAGA GGGAAGTGGT 
CATCTGGACA GGGAGGGAAC AAGAAAGCAG GCAGCCCTGG AGCTTGTTGA GGCCACTGAC 
CTAAAGATGT CCAACCAGCT GTCACCTGGT CCAGAGCTGC AGGGAGCAAC TCCAGACCCT 
GATGGTGACT CAGGGTCCCC CAGCTCAGCC ACGGAATGTT CCTGCCCCCA TGGCCCTGCT 
CTGGTCACCC AGCAAAAAGG AACATCAGGG ACACCCAGCT CTCCTGCCTC TTCCCTGCCC 
CCTGAGCACA GGCCAGATGG TGAGGGACCA CTAGGCACCA CTGTGCTCCC AGGGCCCACC 
TCAGCCAGCC AGGGCTCTCG ACACCCATGT AAGCCACCCA GGGGTAAGGC TGCAGCGAGT 
CCAAGCAGCC CTAGGGGCTC GGATGGTCAT CCTGAGAAGC CTCGGCCAGC AGACCGCAAG 
CTCTGTCCAT CCAGTGTAGA TACCTCATCC CCCCCTAAGA TGACAGCCTG CCCCTCGCTT 
CAGGAAGCCA TGCGCCTCAT CCAGGAGGAA TTTGCCTTTG ATGGCTACAT GGACAACGGG 
CTAGAGGCAC TGATCATGGG GGAGTATATT TACGCCTTGA AAGACCTCAC CTTCGCCACC 
TTCTGTGGTG CCATATCTGA GAAGTTCTGT GACCTATACT GGGATGAGCA GCTGCTAAAG 
AACCTCTTCA AGGTGGTCAA TGGGCCAGCC TCACCCTCTG AGAGCACTTC TGAGGAGCCT 
GGATCCCAGC CAGAACACTC ACCCAGCAGA TGCTCACTAT CCAGCAAAAG GCCTTCCCTG 
CATGGACTCG GCAAGGAGAA GCCAGCCACG ACCTGGGGCA GCGGGGGACC CTGCTCCCCC 
ACAGCACTAT CAGATATAGA CTCCGACACG CTCTCTCAGG GAAACTTTGA GGTTGGATTT 
CGGTCTCAGA AGTCAATAAA AGTCACGCGA GAGCAGCAAC CAGAGGCCGA AGTGGGTGGG 
CAGCCAGGTC CAAGCCAGGA CTCAACCAGC CATGCCTCGG ACACAGTGGC CCGGCTAGCT 
AGATCTGAGG ACGGTGGCCC AGCTGGGTCT CCAGGGGCAT CTGATTTCCA GAACTGCAGC 
CCTGGCTGGT CCAGTGCCTT CTATGAGGCT GACTGCTTTG GAGCCGATGT CTACAACTAC 
GTGAAGGATC TGGAGAGGCA GAAGACCAAC GGGCACACAG AACTGGAAGC CCAGAGTCCA 
GAGCTGGAGC AGCAGCTCAT GATAGAGAAG AGAAACTATA GGAAGACCCT GAAGTTTTAC 
CAGAAACTCT TACAGAAGGA AAAACGGAAC AAAGGCTCTG AGGTCAGGAC CATGTTGTCT 
AAACTTCGAG GACAGCTGGA TGAAATGAAG TCCAAGGTGC AGTTCCTGAG CCTGGTCAAG 
AAGTACCTCC AGGTCATGTA TGCAGAACGC TGGGGGCTGG AGCCCTGTGC TCTGCCGGTG 
ATTGTGAACA TCGCAGCAGC CCCCTGTGAC ACACTGGATT TCAGCCCCCT GGATGAGTCT 
TCTTCCCTCA TCTTCTACAA TGTCAACAAG CACCCAGGCA GCGGCCGACA GAAGAAGGCT 
CGCATCCTAC AGGCTGGTAC ACCACTGGGG CTCATGGCCT ACCTCTACTC CAGTGATGCT 
TTCCTCGAGG GCTACGTGCA GCAGTTTCTC TACACTTTCC GGTACTTTTG CACACCGCAC 
GACTTCCTGC ACTTCCTCCT GGACCGCATC AGCAGCACTT TATCCAGGGC TCACCAGGAT 
CCTACCTCGA CTTTTACCAA GATCTACAGG CGAAGCCTCT GCGTCCTGCA GGCCTGGGTG 
GAAGACTGCT ACACCGTGGA CTTCATAAGG AACGCGGGGC TGCTGGGACA GCTGGAGGAC 
TTCATCTCTT CCAAGATCCT ACCTCTAGAT GGCACTGCCG AGCACCTGCT GGCCCTCTTA 
GAGGTGGGCA CTGAGCGGCG GGCTGACAGT GCCTCTCGAG GTGCAGACCT GGAGGACCCT 
AAGGAGGCAG AGGAGGACAC CAGACCCTTT AATGCCCTCT GCAAGAGGTT CTCAGAGGAT 
GGCATCACCC GGAAGAGCTT CTCTTGGAGA CTGCCTCGGG GCAACGGGCT AGTGCTGCCA 
CATCATAAGG AGCGCCAGTA CACCATTGCA TCCGCCCTGC CTAAGCCCTG CTTCTTCGAA 
GACTTCTATG GCCCCTATGC CAAAGCCAGT GAGAAGGGTC CTTACTTCTT GACAGAGTAC 
AGCACCAACC AGCTCTTCAC TCAGCTAACA CTACTGCAGC AGGAATTGTT TCAAAAGTGC 
CACCCTGTCC ACTTCCTAAA TTCACGAGCC CTGGGTGTCA TGGACAAAAG TGCAGCCATT 
CCCAAAGCCA GCTCTTCTGA GTCTCTTTCT GCCAAAACCT GCAGCCTCTT CCTACCCAAT 
TACGTCCAGG ACAAATATCT GCTACAGCTT TTAAGAAACG CAGATGATGT CAGTACCTGG 
GTGGCTGCTG AAATTGTGAC CAGTCATACC TCCAAGCTTC AGGTGAACTT GCTGTCCAAA 
TTCCTGCTGA TTGCAAAATC TTGCTACGAA CAGAGGAACT TTGCAACGGC CATGCAAATC 
CTGGGCGGGC TGGAGCACCT GGCTGTGAGG CAGTCCCCTG CTTGGAGAAT CCTGCCTGCG 
AAGATTGCTG AGGTCATGGA AGAGCTGAAA GCTGTGGAGG TATTCCTGAA GAGTGACAGC 
CTGTGTCTGA TGGAAGGAAG GCGCTTCCGG GCCCAGCCTA CTCTACCCTC CGCCCACCTG 
CTGGCCATGC ACATCCAGCA GCTGGAGACA GGAGGTTTCA CCATGACTAA TGGAGCCCAT 
AGATGGAGCA AACTGAGAAA CATCGCCAAG GTGGCAAGCC AGGTGCACGC GTTCCAGGAG 
AACCCGTACA CATTCAGCCC GGACCCCAAG CTACAGGCCC ACCTCAAGCA GAGGATCGCC 
CGCTTTAGCG GCGCTGATGT CTCCATTTTA GCAGCTGATA ACAGGGCCAA CTTCCACCAG 
ATCCCAGGAG AGAAACACTC ACGGAAGATC CAAGACAAGC TGAGGAGAAT GAAGGCCACA 
TTCCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The brain-specific RasGEF very-KIND is required for normal dendritic growth in cerebellar granule cells and proper motor coordination.
PloS one12(3)e0173175(2017)
Hayashi K,Furuya A,Sakamaki Y,Akagi T,Shinoda Y,Sadakata T,Hashikawa T,Shimizu K,Minami H,Sano Y,Nakayama M,Furuichi T

Cerebellar development transcriptome database (CDT-DB): profiling of spatio-temporal gene expression during the postnatal development of mouse cerebellum.
Neural networks : the official journal of the International Neural Network Society21(8)1056-69(2008 Oct)
Sato A,Sekine Y,Saruta C,Nishibe H,Morita N,Sato Y,Sadakata T,Shinoda Y,Kojima T,Furuichi T

Very-KIND, a KIND domain containing RasGEF, controls dendrite growth by linking Ras small GTPases and MAP2.
The Journal of cell biology179(3)539-52(2007 Nov)
Huang J,Furuya A,Furuichi T

A gene-targeting approach for functional characterization of KIAA genes encoding extremely large proteins.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology20(10)1718-20(2006 Aug)
Nakayama M,Iida M,Koseki H,Ohara O

Very-KIND is a novel nervous system specific guanine nucleotide exchange factor for Ras GTPases.
Gene expression patterns : GEP6(1)79-85(2005 Dec)
Mees A,Rock R,Ciccarelli FD,Leberfinger CB,Borawski JM,Bork P,Wiese S,Gessler M,Kerkhoff E

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Kndc1 cDNA ORF clone, Mus musculus(house mouse)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

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