Sesn3 cDNA ORF clone, Mus musculus(house mouse)

Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis.
Ro SH, Xue X, Ramakrishnan SK, Cho CS, Namkoong S, Jang I, Semple IA, Ho A, Park HW, Shah YM, Lee JH
eLife5e12204(2016 Feb)

A gene expression resource generated by genome-wide lacZ profiling in the mouse.
Tuck E, Estabel J, Oellrich A, Maguire AK, Adissu HA, Souter L, Siragher E, Lillistone C, Green AL, Wardle-Jones H, Carragher DM, Karp NA, Smedley D, Adams NC, , Bussell JN, Adams DJ, Ram?rez-Solis R, Steel KP, Galli A, White JK
Disease models & mechanisms8(11)1467-78(2015 Nov)

Sesn3 liver-specific knockout mice exhibit insulin resistance and glucose intolerance. Sesn3 interacts with and activates mTORC2 and subsequently stimulates Akt phosphorylation at Ser473.
Title: Sestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signaling.

Study found that Sestrins (1,2 and 3) can inhibit mTORC1 signaling in the absence of AMPK or TSC2. Surprisingly, when coexpressed with a GTP-bound constitutively active form of RagB (RagBQ99L), Sestrins potentiate mTORC1 signaling in the absence of amino acids.
Title: Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling.

Suggest that inhibitory effect of ethanol on Sesn3 may play an important role in the development of ethanol-induced fatty liver.
Title: The inhibitory effect of ethanol on Sestrin3 in the pathogenesis of ethanol-induced liver injury.

Concomitant ablation of Sesn2 and Sesn3 provokes hepatic mTORC1-S6K activation and insulin resistance even in the absence of nutritional overload and obesity.
Title: Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3.

FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor
Title: FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor.