Setmar cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Setmar
Entrez Gene ID	74729
Full Name	SET domain without mariner transposase fusion
Synonyms	5830404F24Rik,Etet2
General protein information	Preferred Names SET domain without mariner transposase fusion Names histone-lysine N-methyltransferase SETMAR SET domain and mariner transposase fusion gene-containing protein homolog SET domain without mariner transposase fusion protein epidermal tumor expressed transcript 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6\|6 E1
Summary	This gene encodes a histone-lysine N-methyltransferase that may be involved in the methylation of histone H3. In anthropoid primates this gene is a fusion gene of a SET histone-lysine N-methyltransferase and a mariner (MAR) family transposase. In all other species this gene contains only the SET domain. [provided by RefSeq, Jan 2013].

mRNA and Protein(s)

mRNA	Protein	Name
NM_178391.4	NP_848478.2	histone-lysine N-methyltransferase SETMAR isoform 1
NM_001276356.1	NP_001263285.1	histone-lysine N-methyltransferase SETMAR isoform 2

Pathways from BioSystems

Homologies

Bos taurus (cattle)	SETMAR	NP_001068976.1
Canis lupus familiaris (dog)	SETMAR	NP_001263417.1
Danio rerio (zebrafish)	setmar	NP_001107072.1
Mus musculus (house mouse)	Setmar	NP_848478.2
Rattus norvegicus (Norway rat)	Setmar	NP_001020219.1
Caenorhabditis elegans (roundworm)	set-23	NP_741320.1

Gene Ontology
Bibliography

Related articles in PubMed

Study of the interaction among Notch pathway receptors, correlation with stemness, as well as their interaction with CD44, dipeptidyl peptidase-IV, hepatocyte growth factor receptor and the SETMAR transferase, in colon cancer stem cells.
Apostolou P, Toloudi M, Ioannou E, Kourtidou E, Chatziioannou M, Kopic A, Komiotis D, Kiritsis C, Manta S, Papasotiriou I
Journal of receptor and signal transduction research33(6)353-8(2013 Dec)

The transposase domain protein Metnase/SETMAR suppresses chromosomal translocations.
Wray J, Williamson EA, Chester S, Farrington J, Sterk R, Weinstock DM, Jasin M, Lee SH, Nickoloff JA, Hromas R
Cancer genetics and cytogenetics200(2)184-90(2010 Jul)

Birth of a chimeric primate gene by capture of the transposase gene from a mobile element.
Cordaux R, Udit S, Batzer MA, Feschotte C
Proceedings of the National Academy of Sciences of the United States of America103(21)8101-6(2006 May)

Identification and partial characterization of novel genes by differential display of mRNAs in squamous papillomas induced in skin of SENCAR mice.
Siddiqui J, Haqqi T, Bickers D, Mukhtar H
International journal of oncology9(2)211-6(1996 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The suppression of Notch-1 led to increased expression of Oct4 and Sox2, but in decreased gene expression of cMET, Setmar and CD44.
Title: Study of the interaction among Notch pathway receptors, correlation with stemness, as well as their interaction with CD44, dipeptidyl peptidase-IV, hepatocyte growth factor receptor and the SETMAR transferase, in colon cancer stem cells.

Metnase may have been selected for because it has a function opposing transposases and may thus play a key role in suppressing translocations that underlie oncogenicity.
Title: The transposase domain protein Metnase/SETMAR suppresses chromosomal translocations.

The following Setmar gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Setmar cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu07287	NM_178391.4 Latest version!	Mus musculus SET domain without mariner transposase fusion (Setmar), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OMu07561	NM_001276356.1 Latest version!	Mus musculus SET domain without mariner transposase fusion (Setmar), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Setmar ( NM_178391.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_848478.2 Mus musculus SET domain without mariner transposase fusion (Setmar), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu07287
Clone ID Related Accession (Same CDS sequence)	NM_178391.4
Accession Version	NM_178391.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 930bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-08
Organism	Mus musculus(house mouse)
Product	histone-lysine N-methyltransferase SETMAR isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC153916.2 and AK017895.1. On Feb 1, 2013 this sequence version replaced NM_178391.3. Transcript Variant: This variant (1) encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK017895.1, BC045208.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGTCTGCGG AAGGTGTGGA GAAGCTTTCT CTCGAGATAG CAGCATCTGA GGAGGAATCT 
GTAGCCCCGA CAGAACAACA AGATGTAGCG TGCGGCCTGG AGAACTTGCC TGTGAGCTTG 
TGGCCTTTGG GGGCGGAGCC CAGGCCTAAA CCTTTCCAGT ATACTCCTGA TCATGTTGCT 
GGACCTGGAG CAGACATTGA CCCCACACAA ATAACCTTCC CTGGATGTGC TTGCATCGAA 
ACTCCATGTG TCCCTGGCAC TTGCTCTTGT CTTCGCCATG AGAATAACTA CGATGACAAT 
TTATGCCTTA GGGATGTGGG ATCCGAAGGA AAGTACGCCA AGCCAGTTTT TGAATGCAAT 
GTTCTGTGCC AGTGTGGCAT GCGCTGCAGA AATAGGGTGG TCCAGAATGG CCTACACTTC 
CTTCTCCAGG TGTTCCAGAC AGAGAAAAAA GGCTGGGGAC TTCGGACTTT GGAATTTATA 
CCCAAGGGAA GATTTGTCTG TGAGTATGCT GGGGAGGTGT TAGGATTCTC TGAAGTGCAA 
AGAAGAATTC ACCTACAAAC ATCACATGAC TCAAATTACA TCATCGCTGT CAGAGAACAC 
ATTTACAGTG GACAGATCAT GGAAACATTT GTCGACCCTA CCTACATAGG AAATATTGGG 
AGATTCCTCA ACCATTCTTG TGAACCAAAT CTGTTGATGA TTCCTGTCCG AATTGACTCA 
ATGGTACCCA AGCTGGCACT TTTCGCAGCC AAAGATATTT TGCCAGGAGA AGAACTCTCT 
TACGACTATT CAGGAAGATT CCTTAACCAA GTAAGTAGTA AAGACAAAGA AAAGATAGAC 
TGTAGCCCAC CACGAAAGCC TTGTTACTGT GGGGCCCAGT CATGCACCAC TTTCCTGCCC 
TATGACAGTT CACTATATAT GGCCCCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_848478.2
CDS	37..966
Translation	MSAEGVEKLSLEIAASEEESVAPTEQQDVACGLENLPVSLWPLGAEPRPKPFQYTPDHVAGPGADIDPTQITFPGCACIETPCVPGTCSCLRHENNYDDNLCLRDVGSEGKYAKPVFECNVLCQCGMRCRNRVVQNGLHFLLQVFQTEKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTSHDSNYIIAVREHIYSGQIMETFVDPTYIGNIGRFLNHSCEPNLLMIPVRIDSMVPKLALFAAKDILPGEELSYDYSGRFLNQVSSKDKEKIDCSPPRKPCYCGAQSCTTFLPYDSSLYMAP

Target ORF information:

RefSeq Version	NM_178391.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus SET domain without mariner transposase fusion (Setmar), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_178391.4

ORF Insert Sequence:

ATGTCTGCGG AAGGTGTGGA GAAGCTTTCT CTCGAGATAG CAGCATCTGA GGAGGAATCT 
GTAGCCCCGA CAGAACAACA AGATGTAGCG TGCGGCCTGG AGAACTTGCC TGTGAGCTTG 
TGGCCTTTGG GGGCGGAGCC CAGGCCTAAA CCTTTCCAGT ATACTCCTGA TCATGTTGCT 
GGACCTGGAG CAGACATTGA CCCCACACAA ATAACCTTCC CTGGATGTGC TTGCATCGAA 
ACTCCATGTG TCCCTGGCAC TTGCTCTTGT CTTCGCCATG AGAATAACTA CGATGACAAT 
TTATGCCTTA GGGATGTGGG ATCCGAAGGA AAGTACGCCA AGCCAGTTTT TGAATGCAAT 
GTTCTGTGCC AGTGTGGCAT GCGCTGCAGA AATAGGGTGG TCCAGAATGG CCTACACTTC 
CTTCTCCAGG TGTTCCAGAC AGAGAAAAAA GGCTGGGGAC TTCGGACTTT GGAATTTATA 
CCCAAGGGAA GATTTGTCTG TGAGTATGCT GGGGAGGTGT TAGGATTCTC TGAAGTGCAA 
AGAAGAATTC ACCTACAAAC ATCACATGAC TCAAATTACA TCATCGCTGT CAGAGAACAC 
ATTTACAGTG GACAGATCAT GGAAACATTT GTCGACCCTA CCTACATAGG AAATATTGGG 
AGATTCCTCA ACCATTCTTG TGAACCAAAT CTGTTGATGA TTCCTGTCCG AATTGACTCA 
ATGGTACCCA AGCTGGCACT TTTCGCAGCC AAAGATATTT TGCCAGGAGA AGAACTCTCT 
TACGACTATT CAGGAAGATT CCTTAACCAA GTAAGTAGTA AAGACAAAGA AAAGATAGAC 
TGTAGCCCAC CACGAAAGCC TTGTTACTGT GGGGCCCAGT CATGCACCAC TTTCCTGCCC 
TATGACAGTT CACTATATAT GGCCCCTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Setmar ( NM_001276356.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001263285.1 Mus musculus SET domain without mariner transposase fusion (Setmar), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu07561
Clone ID Related Accession (Same CDS sequence)	NM_001276356.1
Accession Version	NM_001276356.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 825bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-08
Organism	Mus musculus(house mouse)
Product	histone-lysine N-methyltransferase SETMAR isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC153916.2. Transcript Variant: This variant (2) uses an alternate internal exon, compared to variant 1. This difference results in a distinct 5' UTR and causes translation initiation at an alternate start codon, compared to variant 1. The encoded protein (isoform 2) is shorter and has a distinct N-terminus compared to isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BE912497.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849377 [ECO:0000348] ##Evidence-Data-END##

ATGGACAGGA GCATCTCTTT CATCCCTGTA GGACATCCCT GCACAGCTAA AGTGTATACT 
CCTGATCATG TTGCTGGACC TGGAGCAGAC ATTGACCCCA CACAAATAAC CTTCCCTGGA 
TGTGCTTGCA TCGAAACTCC ATGTGTCCCT GGCACTTGCT CTTGTCTTCG CCATGAGAAT 
AACTACGATG ACAATTTATG CCTTAGGGAT GTGGGATCCG AAGGAAAGTA CGCCAAGCCA 
GTTTTTGAAT GCAATGTTCT GTGCCAGTGT GGCATGCGCT GCAGAAATAG GGTGGTCCAG 
AATGGCCTAC ACTTCCTTCT CCAGGTGTTC CAGACAGAGA AAAAAGGCTG GGGACTTCGG 
ACTTTGGAAT TTATACCCAA GGGAAGATTT GTCTGTGAGT ATGCTGGGGA GGTGTTAGGA 
TTCTCTGAAG TGCAAAGAAG AATTCACCTA CAAACATCAC ATGACTCAAA TTACATCATC 
GCTGTCAGAG AACACATTTA CAGTGGACAG ATCATGGAAA CATTTGTCGA CCCTACCTAC 
ATAGGAAATA TTGGGAGATT CCTCAACCAT TCTTGTGAAC CAAATCTGTT GATGATTCCT 
GTCCGAATTG ACTCAATGGT ACCCAAGCTG GCACTTTTCG CAGCCAAAGA TATTTTGCCA 
GGAGAAGAAC TCTCTTACGA CTATTCAGGA AGATTCCTTA ACCAAGTAAG TAGTAAAGAC 
AAAGAAAAGA TAGACTGTAG CCCACCACGA AAGCCTTGTT ACTGTGGGGC CCAGTCATGC 
ACCACTTTCC TGCCCTATGA CAGTTCACTA TATATGGCCC CTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001263285.1
CDS	295..1119
Translation	MDRSISFIPVGHPCTAKVYTPDHVAGPGADIDPTQITFPGCACIETPCVPGTCSCLRHENNYDDNLCLRDVGSEGKYAKPVFECNVLCQCGMRCRNRVVQNGLHFLLQVFQTEKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEVQRRIHLQTSHDSNYIIAVREHIYSGQIMETFVDPTYIGNIGRFLNHSCEPNLLMIPVRIDSMVPKLALFAAKDILPGEELSYDYSGRFLNQVSSKDKEKIDCSPPRKPCYCGAQSCTTFLPYDSSLYMAP

Target ORF information:

RefSeq Version	NM_001276356.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus SET domain without mariner transposase fusion (Setmar), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001276356.1

ORF Insert Sequence:

ATGGACAGGA GCATCTCTTT CATCCCTGTA GGACATCCCT GCACAGCTAA AGTGTATACT 
CCTGATCATG TTGCTGGACC TGGAGCAGAC ATTGACCCCA CACAAATAAC CTTCCCTGGA 
TGTGCTTGCA TCGAAACTCC ATGTGTCCCT GGCACTTGCT CTTGTCTTCG CCATGAGAAT 
AACTACGATG ACAATTTATG CCTTAGGGAT GTGGGATCCG AAGGAAAGTA CGCCAAGCCA 
GTTTTTGAAT GCAATGTTCT GTGCCAGTGT GGCATGCGCT GCAGAAATAG GGTGGTCCAG 
AATGGCCTAC ACTTCCTTCT CCAGGTGTTC CAGACAGAGA AAAAAGGCTG GGGACTTCGG 
ACTTTGGAAT TTATACCCAA GGGAAGATTT GTCTGTGAGT ATGCTGGGGA GGTGTTAGGA 
TTCTCTGAAG TGCAAAGAAG AATTCACCTA CAAACATCAC ATGACTCAAA TTACATCATC 
GCTGTCAGAG AACACATTTA CAGTGGACAG ATCATGGAAA CATTTGTCGA CCCTACCTAC 
ATAGGAAATA TTGGGAGATT CCTCAACCAT TCTTGTGAAC CAAATCTGTT GATGATTCCT 
GTCCGAATTG ACTCAATGGT ACCCAAGCTG GCACTTTTCG CAGCCAAAGA TATTTTGCCA 
GGAGAAGAAC TCTCTTACGA CTATTCAGGA AGATTCCTTA ACCAAGTAAG TAGTAAAGAC 
AAAGAAAAGA TAGACTGTAG CCCACCACGA AAGCCTTGTT ACTGTGGGGC CCAGTCATGC 
ACCACTTTCC TGCCCTATGA CAGTTCACTA TATATGGCCC CTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Study of the interaction among Notch pathway receptors, correlation with stemness, as well as their interaction with CD44, dipeptidyl peptidase-IV, hepatocyte growth factor receptor and the SETMAR transferase, in colon cancer stem cells.
Journal of receptor and signal transduction research33(6)353-8(2013 Dec)
Apostolou P,Toloudi M,Ioannou E,Kourtidou E,Chatziioannou M,Kopic A,Komiotis D,Kiritsis C,Manta S,Papasotiriou I

The transposase domain protein Metnase/SETMAR suppresses chromosomal translocations.
Cancer genetics and cytogenetics200(2)184-90(2010 Jul)
Wray J,Williamson EA,Chester S,Farrington J,Sterk R,Weinstock DM,Jasin M,Lee SH,Nickoloff JA,Hromas R

Birth of a chimeric primate gene by capture of the transposase gene from a mobile element.
Proceedings of the National Academy of Sciences of the United States of America103(21)8101-6(2006 May)
Cordaux R,Udit S,Batzer MA,Feschotte C

Identification and partial characterization of novel genes by differential display of mRNAs in squamous papillomas induced in skin of SENCAR mice.
International journal of oncology9(2)211-6(1996 Aug)
Siddiqui J,Haqqi T,Bickers D,Mukhtar H

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Setmar cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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