Lrrc17 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lrrc17
Entrez Gene ID	74511
Full Name	leucine rich repeat containing 17
Synonyms	37kDa,4833425M04Rik,6130400C22Rik,P37nb
General protein information	Preferred Names leucine rich repeat containing 17 Names leucine-rich repeat-containing protein 17 37 kDa leucine-rich repeat (LRR) protein leucine-rich repeat (LRR) protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5\|5 A3

mRNA and Protein(s)

mRNA	Protein	Name
NM_028977.1	NP_083253.1	leucine-rich repeat-containing protein 17 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	LRRC17	XP_001158135.1
Homo sapiens (human)	LRRC17	NP_001026862.1
	LRRC17	XP_001086757.1
Bos taurus (cattle)	LRRC17	NP_001071618.1
Rattus norvegicus (Norway rat)	Lrrc17	NP_001020326.1
Danio rerio (zebrafish)	lrrc17	NP_991102.1
Canis lupus familiaris (dog)	LRRC17	XP_003432345.1
Gallus gallus (chicken)	LRRC17	NP_001185529.1
Xenopus tropicalis (tropical clawed frog)	lrrc17	XP_004913080.1
Mus musculus (house mouse)	Lrrc17	NP_083253.1

Gene Ontology
Bibliography

Related articles in PubMed

Radial glia require PDGFD-PDGFR? signalling in human but not mouse neocortex.
Lui JH, Nowakowski TJ, Pollen AA, Javaherian A, Kriegstein AR, Oldham MC
Nature515(7526)264-8(2014 Nov)

Use of chromosome engineering to model a segmental deletion of chromosome band 7q22 found in myeloid malignancies.
Wong JC, Zhang Y, Lieuw KH, Tran MT, Forgo E, Weinfurtner K, Alzamora P, Kogan SC, Akagi K, Wolff L, Le Beau MM, Killeen N, Shannon K
Blood115(22)4524-32(2010 Jun)

Identification of novel oocyte and granulosa cell markers.
Malcuit C, Trask MC, Santiago L, Beaudoin E, Tremblay KD, Mager J
Gene expression patterns : GEP9(6)404-10(2009 Sep)

Identification of LRRc17 as a negative regulator of receptor activator of NF-kappaB ligand (RANKL)-induced osteoclast differentiation.
Kim T, Kim K, Lee SH, So HS, Lee J, Kim N, Choi Y
The Journal of biological chemistry284(22)15308-16(2009 May)

Candidate gene isolation and comparative analysis of a commonly deleted segment of 7q22 implicated in myeloid malignancies.
Kratz CP, Emerling BM, Donovan S, Laig-Webster M, Taylor BR, Thompson P, Jensen S, Banerjee A, Bonifas J, Makalowski W, Green ED, Le Beau MM, Shannon KM
Genomics77(3)171-80(2001 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results demonstrated a novel inhibitory activity of LRRc17 in RANKL-induced osteoclastogenesis.
Title: Identification of LRRc17 as a negative regulator of receptor activator of NF-kappaB ligand (RANKL)-induced osteoclast differentiation.

The following Lrrc17 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lrrc17 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu06385	NM_028977.1 Latest version!	Mus musculus leucine rich repeat containing 17 (Lrrc17), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lrrc17 ( NM_028977.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_083253.1 Mus musculus leucine rich repeat containing 17 (Lrrc17), mRNA.

Price & Availability↑

CloneID	OMu06385
Clone ID Related Accession (Same CDS sequence)	NM_028977.1
Accession Version	NM_028977.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1332bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-17
Organism	Mus musculus(house mouse)
Product	leucine-rich repeat-containing protein 17 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CF914556.1, AK018071.1 and CD741871.1. On or before Nov 30, 2007 this sequence version replaced XM_904948.2, XM_919092.2. ##Evidence-Data-START## Transcript exon combination :: BC030317.1, AK018071.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGCGCATAG TGGCCATCTT GCTTCTGTTC TGCCTTTGCA GAGCTGCTGA GCCTCGCAAG 
TCCAGCCCTG GTGTTTTGAG AAGCCAAGGC AATCCCAGCC GCAGCCACGG CCGTGGTGGC 
AGGAGGGGCT CCAGCCCAGT CAAACGCTAT GCACCAGGCC TGCCTTGTGA TGTGTACACT 
TATCTCCATG AAAAATACCT AGACTGCCAA GAAAGGAAAC TAGTCTATGT GTTGCCTGAC 
TGGCCTCAAG ATTTGCTGCA CATGCTGCTA GCAAGAAACA AAATCCGCGT GTTAAAGAAC 
AACATGTTTG CTAAGTTTAA AAGGCTGAAG AGCCTGGACC TGCAGCAGAA CGAGATCTCC 
AAAATTGAGA GCGAGGCGTT CTTTGGTTTA AATAAACTTA CCACCCTCTT GTTGCAGCAC 
AACCAGATCA AGGTGCTGAC AGAGGAGGCG TTCATTTACA CGCCGCTCCT GAGCTACCTG 
CGGCTCTATG ACAACCCCTG GCACTGCACT TGTGAGCTAG AGACGCTCAT TTCCATGCTG 
CAGATTCCAC GGAACCGGAA TCTGGGGAAC TACGCCAAGT GCGGAAGCCC ACCAGCACTG 
AGAAATAAAA AGTTGCTGCA GCTAAAACCT CAAGAGCTGT GTGATGAAGA GGAGAAGGAG 
CAACTGGACC CCAAACCCCA AGTGTCGGGG ATACCCGCAG TCATCAGGCC AGAAGCAGAC 
TCCACTCTGT GCCACAATTA CGTGTTTCCC ATACAAACCC TAGACTGCAA GAGGAAAGAG 
TTGAAGAAAG TCCCAAGCAA CATCCCTCCA GACATAGTGA AGCTTGACCT GTCATCCAAC 
AAAATCAGAC AGCTCCGACC CAAGGAGTTT GAAGATGTTC ACGAACTAAA GAAGTTAAAC 
CTAAGCAGCA ATGGCATTGA GTTTATAGAT CCTGCTGCCT TTTTAGGGCT CATACACCTA 
GAAGAGCTCG ACTTATCAAA CAACAGCCTG CAGAACTTTG ACTATGGCGT GTTAGAGGAT 
TTGTACTTTC TGAAACTCCT GTGGCTCAGA GATAACCCTT GGAGGTGTGA CTACAGCATC 
CACTACCTCT ACTACTGGTT AAAGCACCAC TACAACGTCC ACTATAACGG TCTGGAATGC 
AAAACGCCGG AAGAATACAA AGGGTGGTCT GTGGGGAAAT ACGTACGGAG TTACTATGAA 
GAATGCCCCA AGGACAAGCT GCCAGCCTAC CCTGAGACGT TTGACCAGGA CACAGAAGAT 
GATGAATGGC AGAAAATACA CAGAGATCAC CCAGCAAAGA AGCACAGAGT GAGAATCACC 
ATTGTGGGGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_083253.1
CDS	316..1647
Translation	MRIVAILLLFCLCRAAEPRKSSPGVLRSQGNPSRSHGRGGRRGSSPVKRYAPGLPCDVYTYLHEKYLDCQERKLVYVLPDWPQDLLHMLLARNKIRVLKNNMFAKFKRLKSLDLQQNEISKIESEAFFGLNKLTTLLLQHNQIKVLTEEAFIYTPLLSYLRLYDNPWHCTCELETLISMLQIPRNRNLGNYAKCGSPPALRNKKLLQLKPQELCDEEEKEQLDPKPQVSGIPAVIRPEADSTLCHNYVFPIQTLDCKRKELKKVPSNIPPDIVKLDLSSNKIRQLRPKEFEDVHELKKLNLSSNGIEFIDPAAFLGLIHLEELDLSNNSLQNFDYGVLEDLYFLKLLWLRDNPWRCDYSIHYLYYWLKHHYNVHYNGLECKTPEEYKGWSVGKYVRSYYEECPKDKLPAYPETFDQDTEDDEWQKIHRDHPAKKHRVRITIVG

Target ORF information:

RefSeq Version	NM_028977.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus leucine rich repeat containing 17 (Lrrc17), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_028977.1

ORF Insert Sequence:

ATGCGCATAG TGGCCATCTT GCTTCTGTTC TGCCTTTGCA GAGCTGCTGA GCCTCGCAAG 
TCCAGCCCTG GTGTTTTGAG AAGCCAAGGC AATCCCAGCC GCAGCCACGG CCGTGGTGGC 
AGGAGGGGCT CCAGCCCAGT CAAACGCTAT GCACCAGGCC TGCCTTGTGA TGTGTACACT 
TATCTCCATG AAAAATACCT AGACTGCCAA GAAAGGAAAC TAGTCTATGT GTTGCCTGAC 
TGGCCTCAAG ATTTGCTGCA CATGCTGCTA GCAAGAAACA AAATCCGCGT GTTAAAGAAC 
AACATGTTTG CTAAGTTTAA AAGGCTGAAG AGCCTGGACC TGCAGCAGAA CGAGATCTCC 
AAAATTGAGA GCGAGGCGTT CTTTGGTTTA AATAAACTTA CCACCCTCTT GTTGCAGCAC 
AACCAGATCA AGGTGCTGAC AGAGGAGGCG TTCATTTACA CGCCGCTCCT GAGCTACCTG 
CGGCTCTATG ACAACCCCTG GCACTGCACT TGTGAGCTAG AGACGCTCAT TTCCATGCTG 
CAGATTCCAC GGAACCGGAA TCTGGGGAAC TACGCCAAGT GCGGAAGCCC ACCAGCACTG 
AGAAATAAAA AGTTGCTGCA GCTAAAACCT CAAGAGCTGT GTGATGAAGA GGAGAAGGAG 
CAACTGGACC CCAAACCCCA AGTGTCGGGG ATACCCGCAG TCATCAGGCC AGAAGCAGAC 
TCCACTCTGT GCCACAATTA CGTGTTTCCC ATACAAACCC TAGACTGCAA GAGGAAAGAG 
TTGAAGAAAG TCCCAAGCAA CATCCCTCCA GACATAGTGA AGCTTGACCT GTCATCCAAC 
AAAATCAGAC AGCTCCGACC CAAGGAGTTT GAAGATGTTC ACGAACTAAA GAAGTTAAAC 
CTAAGCAGCA ATGGCATTGA GTTTATAGAT CCTGCTGCCT TTTTAGGGCT CATACACCTA 
GAAGAGCTCG ACTTATCAAA CAACAGCCTG CAGAACTTTG ACTATGGCGT GTTAGAGGAT 
TTGTACTTTC TGAAACTCCT GTGGCTCAGA GATAACCCTT GGAGGTGTGA CTACAGCATC 
CACTACCTCT ACTACTGGTT AAAGCACCAC TACAACGTCC ACTATAACGG TCTGGAATGC 
AAAACGCCGG AAGAATACAA AGGGTGGTCT GTGGGGAAAT ACGTACGGAG TTACTATGAA 
GAATGCCCCA AGGACAAGCT GCCAGCCTAC CCTGAGACGT TTGACCAGGA CACAGAAGAT 
GATGAATGGC AGAAAATACA CAGAGATCAC CCAGCAAAGA AGCACAGAGT GAGAATCACC 
ATTGTGGGGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Radial glia require PDGFD-PDGFR? signalling in human but not mouse neocortex.
Nature515(7526)264-8(2014 Nov)
Lui JH,Nowakowski TJ,Pollen AA,Javaherian A,Kriegstein AR,Oldham MC

Use of chromosome engineering to model a segmental deletion of chromosome band 7q22 found in myeloid malignancies.
Blood115(22)4524-32(2010 Jun)
Wong JC,Zhang Y,Lieuw KH,Tran MT,Forgo E,Weinfurtner K,Alzamora P,Kogan SC,Akagi K,Wolff L,Le Beau MM,Killeen N,Shannon K

Identification of novel oocyte and granulosa cell markers.
Gene expression patterns : GEP9(6)404-10(2009 Sep)
Malcuit C,Trask MC,Santiago L,Beaudoin E,Tremblay KD,Mager J

Identification of LRRc17 as a negative regulator of receptor activator of NF-kappaB ligand (RANKL)-induced osteoclast differentiation.
The Journal of biological chemistry284(22)15308-16(2009 May)
Kim T,Kim K,Lee SH,So HS,Lee J,Kim N,Choi Y

Candidate gene isolation and comparative analysis of a commonly deleted segment of 7q22 implicated in myeloid malignancies.
Genomics77(3)171-80(2001 Oct)
Kratz CP,Emerling BM,Donovan S,Laig-Webster M,Taylor BR,Thompson P,Jensen S,Banerjee A,Bonifas J,Makalowski W,Green ED,Le Beau MM,Shannon KM