Fbxl22 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fbxl22
Entrez Gene ID	74165
Full Name	F-box and leucine-rich repeat protein 22
Synonyms	1110004B15Rik
General protein information	Preferred Names F-box and leucine-rich repeat protein 22 Names F-box and leucine-rich protein 22 F-box/LRR-repeat protein 22
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9\|9 C

mRNA and Protein(s)

mRNA	Protein	Name
NM_175206.4	NP_780415.1	F-box and leucine-rich protein 22

Pathways from BioSystems

Homologies

	FBXL22	XP_001106074.1
Canis lupus familiaris (dog)	FBXL22	XP_853281.1
Danio rerio (zebrafish)	fbxl22	NP_001013297.1
Rattus norvegicus (Norway rat)	Fbxl22	NP_001102239.1
Gallus gallus (chicken)	FBXL22	XP_004943797.1
Mus musculus (house mouse)	Fbxl22	NP_780415.1
Xenopus tropicalis (tropical clawed frog)	fbxl22	XP_002934598.1
Bos taurus (cattle)	FBXL22	NP_001039621.1

Gene Ontology
Bibliography

Related articles in PubMed

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H
Nucleic acids research42(Database issue)D802-9(2014 Jan)

F-box and leucine-rich repeat protein 22 is a cardiac-enriched F-box protein that regulates sarcomeric protein turnover and is essential for maintenance of contractile function in vivo.
Spaich S, Will RD, Just S, Spaich S, Kuhn C, Frank D, Berger IM, Wiemann S, Korn B, Koegl M, Backs J, Katus HA, Rottbauer W, Frey N
Circulation research111(12)1504-16(2012 Dec)

Systematic analysis and nomenclature of mammalian F-box proteins.
Jin J, Cardozo T, Lovering RC, Elledge SJ, Pagano M, Harper JW
Genes & development18(21)2573-80(2004 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Fbxl22 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fbxl22 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu05006	NM_175206.4 Latest version!	Mus musculus F-box and leucine-rich repeat protein 22 (Fbxl22), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fbxl22 ( NM_175206.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_780415.1 Mus musculus F-box and leucine-rich repeat protein 22 (Fbxl22), mRNA.

Price & Availability↑

CloneID	OMu05006
Clone ID Related Accession (Same CDS sequence)	NM_175206.4
Accession Version	NM_175206.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 711bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	F-box and leucine-rich protein 22
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK003404.1 and AK052175.1. On Oct 22, 2009 this sequence version replaced NM_175206.3. ##Evidence-Data-START## Transcript exon combination :: AK052175.1, AK084845.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGCACATAA CCCAGCTCAA TCGGGAGTGT CTGCTGTGTC TCTTCTCCTT CCTGGACAAG 
GACAGCCGGA GGAGCCTCTC CAGGACTTGC TCCCAGCTCC GAGATGTGTT TGAGGACCCC 
ACCCTCTGGC CCCTGCTGCA CTTCCATTCT CTCGCAGAGC TCAAGAAAGA CAACTTCCGG 
CTGAGCCCTG CGCTGCGCAG CCTGTCCATC TGTTGGCATT CCAGCCGTGT GCAGGTGTGC 
AGCATCGAGG ACTGGCTCAA GAGCGCCCTC CAGAGGAGCA TCTGCAGCCA GCACGAGAGC 
CTGGTTAATG ATTTCCTCCT GCAGGTGTGC AACAGGTGCC CCAACCTGAC GTCCGTCACG 
CTGTCGGGCT GCGGCCACGT CACGGACGAC TGCCTGGCGC GCTTGCTGCT CAGCTGCCCG 
CGCCTGCGTA CGCTGCGCCT CGAGAACTGC GCGCGCGTTA CCAACCGCAC GCTGGCGGCC 
GTGGCCGCGC ACGGGCGCGC GCTGCAGACT CTGCACGTGG ACTTCTGCCG CAACGTGAGC 
GCCGCCGGCC TGCTCCGCCT CCGCGCCGCC TGCCCGAACC TGCGCCTCAG CGCCGAACGC 
AGCGCGGCCA TGATACCCGA TCAGCCGCCG CGCGCACGCG TGTGCGCTGC CTCAGCTTTC 
TCGGCTGCAC CGGGGAGACA AAGCATGCCT CACCCCACGG GCTCCTACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_780415.1
CDS	41..751
Translation	MHITQLNRECLLCLFSFLDKDSRRSLSRTCSQLRDVFEDPTLWPLLHFHSLAELKKDNFRLSPALRSLSICWHSSRVQVCSIEDWLKSALQRSICSQHESLVNDFLLQVCNRCPNLTSVTLSGCGHVTDDCLARLLLSCPRLRTLRLENCARVTNRTLAAVAAHGRALQTLHVDFCRNVSAAGLLRLRAACPNLRLSAERSAAMIPDQPPRARVCAASAFSAAPGRQSMPHPTGSY

Target ORF information:

RefSeq Version	NM_175206.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus F-box and leucine-rich repeat protein 22 (Fbxl22), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_175206.4

ORF Insert Sequence:

ATGCACATAA CCCAGCTCAA TCGGGAGTGT CTGCTGTGTC TCTTCTCCTT CCTGGACAAG 
GACAGCCGGA GGAGCCTCTC CAGGACTTGC TCCCAGCTCC GAGATGTGTT TGAGGACCCC 
ACCCTCTGGC CCCTGCTGCA CTTCCATTCT CTCGCAGAGC TCAAGAAAGA CAACTTCCGG 
CTGAGCCCTG CGCTGCGCAG CCTGTCCATC TGTTGGCATT CCAGCCGTGT GCAGGTGTGC 
AGCATCGAGG ACTGGCTCAA GAGCGCCCTC CAGAGGAGCA TCTGCAGCCA GCACGAGAGC 
CTGGTTAATG ATTTCCTCCT GCAGGTGTGC AACAGGTGCC CCAACCTGAC GTCCGTCACG 
CTGTCGGGCT GCGGCCACGT CACGGACGAC TGCCTGGCGC GCTTGCTGCT CAGCTGCCCG 
CGCCTGCGTA CGCTGCGCCT CGAGAACTGC GCGCGCGTTA CCAACCGCAC GCTGGCGGCC 
GTGGCCGCGC ACGGGCGCGC GCTGCAGACT CTGCACGTGG ACTTCTGCCG CAACGTGAGC 
GCCGCCGGCC TGCTCCGCCT CCGCGCCGCC TGCCCGAACC TGCGCCTCAG CGCCGAACGC 
AGCGCGGCCA TGATACCCGA TCAGCCGCCG CGCGCACGCG TGTGCGCTGC CTCAGCTTTC 
TCGGCTGCAC CGGGGAGACA AAGCATGCCT CACCCCACGG GCTCCTACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Nucleic acids research42(Database issue)D802-9(2014 Jan)
Koscielny G,Yaikhom G,Iyer V,Meehan TF,Morgan H,Atienza-Herrero J,Blake A,Chen CK,Easty R,Di Fenza A,Fiegel T,Grifiths M,Horne A,Karp NA,Kurbatova N,Mason JC,Matthews P,Oakley DJ,Qazi A,Regnart J,Retha A,Santos LA,Sneddon DJ,Warren J,Westerberg H,Wilson RJ,Melvin DG,Smedley D,Brown SD,Flicek P,Skarnes WC,Mallon AM,Parkinson H

F-box and leucine-rich repeat protein 22 is a cardiac-enriched F-box protein that regulates sarcomeric protein turnover and is essential for maintenance of contractile function in vivo.
Circulation research111(12)1504-16(2012 Dec)
Spaich S,Will RD,Just S,Spaich S,Kuhn C,Frank D,Berger IM,Wiemann S,Korn B,Koegl M,Backs J,Katus HA,Rottbauer W,Frey N

Systematic analysis and nomenclature of mammalian F-box proteins.
Genes & development18(21)2573-80(2004 Nov)
Jin J,Cardozo T,Lovering RC,Elledge SJ,Pagano M,Harper JW

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Fbxl22 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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