F13a1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	F13a1
Entrez Gene ID	74145
Full Name	coagulation factor XIII, A1 subunit
Synonyms	1200014I03Rik,AI462306,F13a
General protein information	Preferred Names coagulation factor XIII, A1 subunit Names coagulation factor XIII A chain coagulation factor XIII, alpha subunit coagulation factor XIIIa protein-glutamine gamma-glutamyltransferase A chain transglutaminase A chain
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 13 Map Location: 13\|13 A3.3
Summary	This gene encodes subunit A of the coagulation factor XIII that catalyzes the final step of the blood coagulation pathway. The encoded protein associates with subunit B to form a heterotetrameric proenzyme that undergoes thrombin-mediated proteolysis to generate active factor XIIIa. The transglutaminase activity of factor XIIIa is required for the calcium-dependent crosslinking of fibrin, leading to the formation of a clot. Mice lacking the encoded protein display impaired reproduction and reduced survival due to bleeding episodes, hematothorax, hematoperitoneum and subcutaneous hemorrhage. Additionally, mice lacking the encoded protein exhibit impaired wound healing and inadequate healing of myocardial infarction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].

mRNA and Protein(s)

mRNA	Protein	Name
NM_028784.3	NP_083060.2	coagulation factor XIII A chain
NM_001166391.1	NP_001159863.1	coagulation factor XIII A chain

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	F13A1	NP_990016.1
Rattus norvegicus (Norway rat)	F13a1	NP_067730.2
Xenopus tropicalis (tropical clawed frog)	f13a1	XP_002936471.1
Canis lupus familiaris (dog)	F13A1	XP_535876.2
Mus musculus (house mouse)	F13a1	NP_083060.2
Danio rerio (zebrafish)	f13a1b	NP_001070622.1
Homo sapiens (human)	F13A1	NP_000120.2
	F13A1	XP_001096779.2
Bos taurus (cattle)	F13A1	NP_001161366.1

Gene Ontology
Bibliography

Related articles in PubMed

Cre/lox Studies Identify Resident Macrophages as the Major Source of Circulating Coagulation Factor XIII-A.
Beckers CML, Simpson KR, Griffin KJ, Brown JM, Cheah LT, Smith KA, Vacher J, Cordell PA, Kearney MT, Grant PJ, Pease RJ
Arteriosclerosis, thrombosis, and vascular biology37(8)1494-1502(2017 Aug)

Thrombin promotes diet-induced obesity through fibrin-driven inflammation.
Kopec AK, Abrahams SR, Thornton S, Palumbo JS, Mullins ES, Divanovic S, Weiler H, Owens AP 3rd, Mackman N, Goss A, van Ryn J, Luyendyk JP, Flick MJ
The Journal of clinical investigation127(8)3152-3166(2017 Aug)

Transglutaminases factor XIII-A and TG2 regulate resorption, adipogenesis and plasma fibronectin homeostasis in bone and bone marrow.
Mousa A, Cui C, Song A, Myneni VD, Sun H, Li JJ, Murshed M, Melino G, Kaartinen MT
Cell death and differentiation24(5)844-854(2017 May)

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.
Naba A, Clauser KR, Mani DR, Carr SA, Hynes RO
Scientific reports740495(2017 Jan)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Suggest that resident macrophages maintain plasma FXIII-A and exclude the platelet lineage as a major contributor.
Title: Cre/lox Studies Identify Resident Macrophages as the Major Source of Circulating Coagulation Factor XIII-A.

Mast cells have the ability to produce and degrade FXIIIA depending on their chymase expression profile: mast cells expressing chymase degrade FXIIIA, whereas mast cells that do not express chymase mainly produce FXIIIA
Title: Proteome analysis of mast cell releasates reveals a role for chymase in the regulation of coagulation factor XIIIA levels via proteolytic degradation.

A lack of factor XIII leads to prolonged clotting times, increased signs of inflammation, and elevated bacterial dissemination in streptococcal skin diseases.
Title: Local activation of coagulation factor XIII reduces systemic complications and improves the survival of mice after Streptococcus pyogenes M1 skin infection.

These findings provide insight into assembly of the fibrinogen/FXIII-A2B2 complex in both physiologic and therapeutic situations.
Title: The interaction between fibrinogen and zymogen FXIII-A2B2 is mediated by fibrinogen residues ?390-396 and the FXIII-B subunits.

These findings expose a newly recognized, essential role for fibrin crosslinking during whole blood clot formation and consolidation and establish FXIIIa activity as a key determinant of thrombus composition and size.
Title: Factor XIIIa-dependent retention of red blood cells in clots is mediated by fibrin ?-chain crosslinking.

The following F13a1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the F13a1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu06120	NM_001166391.1 Latest version!	Mus musculus coagulation factor XIII, A1 subunit (F13a1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$433.30 $619.00
OMu06120	NM_028784.3 Latest version!	Mus musculus coagulation factor XIII, A1 subunit (F13a1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$433.30 $619.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

F13a1 ( NM_028784.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_083060.2 Mus musculus coagulation factor XIII, A1 subunit (F13a1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu06120
Clone ID Related Accession (Same CDS sequence)	NM_028784.3 , NM_001166391.1
Accession Version	NM_028784.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2199bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	coagulation factor XIII A chain
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK049092.1, BM239113.2 and AV249730.1. On Oct 22, 2009 this sequence version replaced NM_028784.2. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC040274.1, AK049092.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849382 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCAGATA CTCCAGCAAG CACCTTTGGG GGGAGGCGAG CAGTCCCGCC CAATAACTCC 
AATGCTGCAG AAGTGGACCT CCCAACTGAG GAGCTACAAG GCCTGGTGCC AAGGGGTGTC 
AACCTGAAAG ATTACCTGAA TGTCACAGCT GTTCACCTGT TCAAGGAGAG ATGGGACAGT 
AACAAGATTG ATCACCACAC AGACAAATAT GACAACAATA AGTTGATTGT CCGCAGAGGG 
CAGACCTTCT ACATCCAGAT TGACTTCAAC CGTCCCTATG ACCCCAGGAA GGATCTCTTC 
AGAGTGGAAT ATGTCATTGG TCGCTACCCT CAGGAGAACA AGGGCACCTA CATCCCTGTG 
CCTGTAGTGA AAGAGCTGCA AAGCGGAAAG TGGGGAGCCA AGGTTATCAT GAATGAGGAC 
CGGTCGGTGC GACTTTCCGT TCAGTCTTCT CCGGAATGCA TTGTGGGGAA ATTCCGCATG 
TATGTTGCAG TCTGGACTCC CTATGGCATC CTGCGTACTC GAAGAGACCC AGAAACAGAC 
ACATATATTC TCTTCAACCC TTGGTGTGAA GAGGACGCTG TGTATCTGGA TGATGAGAAG 
GAAAGAGAAG AGTACGTCCT GAATGACATT GGAGTGATAT TTTATGGGGA CTTCAAAGAC 
ATCAAGAGCA GAAGCTGGAG CTATGGCCAG TTCGAAGACG GCATCCTGGA TACTTGCTTG 
TATGTGATGG ACAAAGCTGA GATGGACCTT TCTGGCAGAG GCAACCCCAT CAAAGTCAGC 
CGAGTTGGAT CAGCAATGGT GAATGCCAAG GATGATGAAG GTGTTCTTGT TGGATCATGG 
GACAATGTCT ATGCCTACGG CATCCCTCCA TCAGCCTGGA CAGGAAGTGT TGACATTCTA 
CTAGAATACA GAAGCTCGGA AACACCAGTC CGATATGGCC AGTGTTGGGT TTTTGCTGGT 
GTCTTTAACA CATTTTTAAG ATGCCTTGGA ATCCCTGCAC GAGTCATTAC CAATTACTTC 
TCGGCCCACG ACAATGATGC CAATCTGCAA ATGGACATCT TCCTGGAAGA AGATGGGAAT 
GTGAGCTCCA AACTCACCAA GGATTCGGTG TGGAACTACC ACTGCTGGAA CGAAGCGTGG 
ATGACAAGGC CTGATCTTCC TGTTGGATTT GGAGGCTGGC AAGCTGTGGA CAGCACACCC 
CAGGAAAACA GTGATGGCAT GTACCGCTGT GGCCCTGCCT CTGTCCAAGC CGTTAAGCAT 
GGCCATGTCT GCTTCCAGTT TGATGCCCCG TTTGTTTTTG CAGAGGTCAA CAGTGATCTT 
GTTTACATCA CAGCTAAGCA AGATGGCACT CACGTGGTGG AAGCCGTGGA TGCCACCCAT 
ATCGGGAAGC TAATTGTGAC CAAGCAAATT GGAGGAGATG GCATGCAGGA TATCACGGAT 
ACTTACAAAT TTCAAGAAGG CCAAGAAGAA GAGAGACTAG CCCTTGAAAC TGCTCTGATG 
TATGGAGCCA AGAAGACCCT CAACACTGAA GGTGTTGTCA AATCAAGGTC TGATGTGACC 
ATGAACTTTG ATGTGGAAAA TGCTGTGCTG GGAAAGGACT TCAAAGTGAC TATCACCTTC 
CAGAACAATA GCTCCAATCT GTACACCATC CTGGCCTATC TTTCTGGCAA CATCACCTTC 
TACACTGGGG TATCCAAGAA AGAGTTCAAG AAGGAGTCCT TTGAAGAGAC GCTGGATCCC 
TTTTCCTCCA AGAAAAAGGA GGTGCTGGTC AGAGCGGGCG AGTACATGAG CCACCTTCTA 
GAACAGGGCT TCTTGCACTT CTTCGTCACG GCACGCATCA ACGAGTCCAG GGATGTCCTG 
GCCAAACAAA AGTCCATAAT ACTGACTATC CCCAAGATCA CCATCAAGGT CCGAGGTGCT 
GCCATGGTTG GCTCTGATAT GGTTGTGACT GTTGAGTTCA CTAATCCTTT AAAAGAAACA 
CTACAAAATG TCTGGATTCA TTTGGATGGT CCTGGAGTGA TGAGACCCAA GAGAAAGGTG 
TTCCGTGAAA TCCGGCCCAA CACCACGGTG CAGTGGGAAG AAGTCTGTCG GCCTTGGGTC 
TCTGGCCATC GGAAGCTGAT TGCCAGCATG ACCAGTGACT CCCTGAGACA TGTGTATGGA 
GAGCTGGATC TTCAGATTCA AAGACGACCT ACTATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_083060.2
CDS	94..2292
Translation	MSDTPASTFGGRRAVPPNNSNAAEVDLPTEELQGLVPRGVNLKDYLNVTAVHLFKERWDSNKIDHHTDKYDNNKLIVRRGQTFYIQIDFNRPYDPRKDLFRVEYVIGRYPQENKGTYIPVPVVKELQSGKWGAKVIMNEDRSVRLSVQSSPECIVGKFRMYVAVWTPYGILRTRRDPETDTYILFNPWCEEDAVYLDDEKEREEYVLNDIGVIFYGDFKDIKSRSWSYGQFEDGILDTCLYVMDKAEMDLSGRGNPIKVSRVGSAMVNAKDDEGVLVGSWDNVYAYGIPPSAWTGSVDILLEYRSSETPVRYGQCWVFAGVFNTFLRCLGIPARVITNYFSAHDNDANLQMDIFLEEDGNVSSKLTKDSVWNYHCWNEAWMTRPDLPVGFGGWQAVDSTPQENSDGMYRCGPASVQAVKHGHVCFQFDAPFVFAEVNSDLVYITAKQDGTHVVEAVDATHIGKLIVTKQIGGDGMQDITDTYKFQEGQEEERLALETALMYGAKKTLNTEGVVKSRSDVTMNFDVENAVLGKDFKVTITFQNNSSNLYTILAYLSGNITFYTGVSKKEFKKESFEETLDPFSSKKKEVLVRAGEYMSHLLEQGFLHFFVTARINESRDVLAKQKSIILTIPKITIKVRGAAMVGSDMVVTVEFTNPLKETLQNVWIHLDGPGVMRPKRKVFREIRPNTTVQWEEVCRPWVSGHRKLIASMTSDSLRHVYGELDLQIQRRPTM

Target ORF information:

RefSeq Version	NM_028784.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus coagulation factor XIII, A1 subunit (F13a1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_028784.3

ORF Insert Sequence:

ATGTCAGATA CTCCAGCAAG CACCTTTGGG GGGAGGCGAG CAGTCCCGCC CAATAACTCC 
AATGCTGCAG AAGTGGACCT CCCAACTGAG GAGCTACAAG GCCTGGTGCC AAGGGGTGTC 
AACCTGAAAG ATTACCTGAA TGTCACAGCT GTTCACCTGT TCAAGGAGAG ATGGGACAGT 
AACAAGATTG ATCACCACAC AGACAAATAT GACAACAATA AGTTGATTGT CCGCAGAGGG 
CAGACCTTCT ACATCCAGAT TGACTTCAAC CGTCCCTATG ACCCCAGGAA GGATCTCTTC 
AGAGTGGAAT ATGTCATTGG TCGCTACCCT CAGGAGAACA AGGGCACCTA CATCCCTGTG 
CCTGTAGTGA AAGAGCTGCA AAGCGGAAAG TGGGGAGCCA AGGTTATCAT GAATGAGGAC 
CGGTCGGTGC GACTTTCCGT TCAGTCTTCT CCGGAATGCA TTGTGGGGAA ATTCCGCATG 
TATGTTGCAG TCTGGACTCC CTATGGCATC CTGCGTACTC GAAGAGACCC AGAAACAGAC 
ACATATATTC TCTTCAACCC TTGGTGTGAA GAGGACGCTG TGTATCTGGA TGATGAGAAG 
GAAAGAGAAG AGTACGTCCT GAATGACATT GGAGTGATAT TTTATGGGGA CTTCAAAGAC 
ATCAAGAGCA GAAGCTGGAG CTATGGCCAG TTCGAAGACG GCATCCTGGA TACTTGCTTG 
TATGTGATGG ACAAAGCTGA GATGGACCTT TCTGGCAGAG GCAACCCCAT CAAAGTCAGC 
CGAGTTGGAT CAGCAATGGT GAATGCCAAG GATGATGAAG GTGTTCTTGT TGGATCATGG 
GACAATGTCT ATGCCTACGG CATCCCTCCA TCAGCCTGGA CAGGAAGTGT TGACATTCTA 
CTAGAATACA GAAGCTCGGA AACACCAGTC CGATATGGCC AGTGTTGGGT TTTTGCTGGT 
GTCTTTAACA CATTTTTAAG ATGCCTTGGA ATCCCTGCAC GAGTCATTAC CAATTACTTC 
TCGGCCCACG ACAATGATGC CAATCTGCAA ATGGACATCT TCCTGGAAGA AGATGGGAAT 
GTGAGCTCCA AACTCACCAA GGATTCGGTG TGGAACTACC ACTGCTGGAA CGAAGCGTGG 
ATGACAAGGC CTGATCTTCC TGTTGGATTT GGAGGCTGGC AAGCTGTGGA CAGCACACCC 
CAGGAAAACA GTGATGGCAT GTACCGCTGT GGCCCTGCCT CTGTCCAAGC CGTTAAGCAT 
GGCCATGTCT GCTTCCAGTT TGATGCCCCG TTTGTTTTTG CAGAGGTCAA CAGTGATCTT 
GTTTACATCA CAGCTAAGCA AGATGGCACT CACGTGGTGG AAGCCGTGGA TGCCACCCAT 
ATCGGGAAGC TAATTGTGAC CAAGCAAATT GGAGGAGATG GCATGCAGGA TATCACGGAT 
ACTTACAAAT TTCAAGAAGG CCAAGAAGAA GAGAGACTAG CCCTTGAAAC TGCTCTGATG 
TATGGAGCCA AGAAGACCCT CAACACTGAA GGTGTTGTCA AATCAAGGTC TGATGTGACC 
ATGAACTTTG ATGTGGAAAA TGCTGTGCTG GGAAAGGACT TCAAAGTGAC TATCACCTTC 
CAGAACAATA GCTCCAATCT GTACACCATC CTGGCCTATC TTTCTGGCAA CATCACCTTC 
TACACTGGGG TATCCAAGAA AGAGTTCAAG AAGGAGTCCT TTGAAGAGAC GCTGGATCCC 
TTTTCCTCCA AGAAAAAGGA GGTGCTGGTC AGAGCGGGCG AGTACATGAG CCACCTTCTA 
GAACAGGGCT TCTTGCACTT CTTCGTCACG GCACGCATCA ACGAGTCCAG GGATGTCCTG 
GCCAAACAAA AGTCCATAAT ACTGACTATC CCCAAGATCA CCATCAAGGT CCGAGGTGCT 
GCCATGGTTG GCTCTGATAT GGTTGTGACT GTTGAGTTCA CTAATCCTTT AAAAGAAACA 
CTACAAAATG TCTGGATTCA TTTGGATGGT CCTGGAGTGA TGAGACCCAA GAGAAAGGTG 
TTCCGTGAAA TCCGGCCCAA CACCACGGTG CAGTGGGAAG AAGTCTGTCG GCCTTGGGTC 
TCTGGCCATC GGAAGCTGAT TGCCAGCATG ACCAGTGACT CCCTGAGACA TGTGTATGGA 
GAGCTGGATC TTCAGATTCA AAGACGACCT ACTATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

F13a1 ( NM_001166391.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001159863.1 Mus musculus coagulation factor XIII, A1 subunit (F13a1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu06120
Clone ID Related Accession (Same CDS sequence)	NM_028784.3 , NM_001166391.1
Accession Version	NM_001166391.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2199bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	coagulation factor XIII A chain
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK030914.1, AK049092.1, BM239113.2 and AV249730.1. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK030914.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCAGATA CTCCAGCAAG CACCTTTGGG GGGAGGCGAG CAGTCCCGCC CAATAACTCC 
AATGCTGCAG AAGTGGACCT CCCAACTGAG GAGCTACAAG GCCTGGTGCC AAGGGGTGTC 
AACCTGAAAG ATTACCTGAA TGTCACAGCT GTTCACCTGT TCAAGGAGAG ATGGGACAGT 
AACAAGATTG ATCACCACAC AGACAAATAT GACAACAATA AGTTGATTGT CCGCAGAGGG 
CAGACCTTCT ACATCCAGAT TGACTTCAAC CGTCCCTATG ACCCCAGGAA GGATCTCTTC 
AGAGTGGAAT ATGTCATTGG TCGCTACCCT CAGGAGAACA AGGGCACCTA CATCCCTGTG 
CCTGTAGTGA AAGAGCTGCA AAGCGGAAAG TGGGGAGCCA AGGTTATCAT GAATGAGGAC 
CGGTCGGTGC GACTTTCCGT TCAGTCTTCT CCGGAATGCA TTGTGGGGAA ATTCCGCATG 
TATGTTGCAG TCTGGACTCC CTATGGCATC CTGCGTACTC GAAGAGACCC AGAAACAGAC 
ACATATATTC TCTTCAACCC TTGGTGTGAA GAGGACGCTG TGTATCTGGA TGATGAGAAG 
GAAAGAGAAG AGTACGTCCT GAATGACATT GGAGTGATAT TTTATGGGGA CTTCAAAGAC 
ATCAAGAGCA GAAGCTGGAG CTATGGCCAG TTCGAAGACG GCATCCTGGA TACTTGCTTG 
TATGTGATGG ACAAAGCTGA GATGGACCTT TCTGGCAGAG GCAACCCCAT CAAAGTCAGC 
CGAGTTGGAT CAGCAATGGT GAATGCCAAG GATGATGAAG GTGTTCTTGT TGGATCATGG 
GACAATGTCT ATGCCTACGG CATCCCTCCA TCAGCCTGGA CAGGAAGTGT TGACATTCTA 
CTAGAATACA GAAGCTCGGA AACACCAGTC CGATATGGCC AGTGTTGGGT TTTTGCTGGT 
GTCTTTAACA CATTTTTAAG ATGCCTTGGA ATCCCTGCAC GAGTCATTAC CAATTACTTC 
TCGGCCCACG ACAATGATGC CAATCTGCAA ATGGACATCT TCCTGGAAGA AGATGGGAAT 
GTGAGCTCCA AACTCACCAA GGATTCGGTG TGGAACTACC ACTGCTGGAA CGAAGCGTGG 
ATGACAAGGC CTGATCTTCC TGTTGGATTT GGAGGCTGGC AAGCTGTGGA CAGCACACCC 
CAGGAAAACA GTGATGGCAT GTACCGCTGT GGCCCTGCCT CTGTCCAAGC CGTTAAGCAT 
GGCCATGTCT GCTTCCAGTT TGATGCCCCG TTTGTTTTTG CAGAGGTCAA CAGTGATCTT 
GTTTACATCA CAGCTAAGCA AGATGGCACT CACGTGGTGG AAGCCGTGGA TGCCACCCAT 
ATCGGGAAGC TAATTGTGAC CAAGCAAATT GGAGGAGATG GCATGCAGGA TATCACGGAT 
ACTTACAAAT TTCAAGAAGG CCAAGAAGAA GAGAGACTAG CCCTTGAAAC TGCTCTGATG 
TATGGAGCCA AGAAGACCCT CAACACTGAA GGTGTTGTCA AATCAAGGTC TGATGTGACC 
ATGAACTTTG ATGTGGAAAA TGCTGTGCTG GGAAAGGACT TCAAAGTGAC TATCACCTTC 
CAGAACAATA GCTCCAATCT GTACACCATC CTGGCCTATC TTTCTGGCAA CATCACCTTC 
TACACTGGGG TATCCAAGAA AGAGTTCAAG AAGGAGTCCT TTGAAGAGAC GCTGGATCCC 
TTTTCCTCCA AGAAAAAGGA GGTGCTGGTC AGAGCGGGCG AGTACATGAG CCACCTTCTA 
GAACAGGGCT TCTTGCACTT CTTCGTCACG GCACGCATCA ACGAGTCCAG GGATGTCCTG 
GCCAAACAAA AGTCCATAAT ACTGACTATC CCCAAGATCA CCATCAAGGT CCGAGGTGCT 
GCCATGGTTG GCTCTGATAT GGTTGTGACT GTTGAGTTCA CTAATCCTTT AAAAGAAACA 
CTACAAAATG TCTGGATTCA TTTGGATGGT CCTGGAGTGA TGAGACCCAA GAGAAAGGTG 
TTCCGTGAAA TCCGGCCCAA CACCACGGTG CAGTGGGAAG AAGTCTGTCG GCCTTGGGTC 
TCTGGCCATC GGAAGCTGAT TGCCAGCATG ACCAGTGACT CCCTGAGACA TGTGTATGGA 
GAGCTGGATC TTCAGATTCA AAGACGACCT ACTATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001159863.1
CDS	69..2267
Translation	MSDTPASTFGGRRAVPPNNSNAAEVDLPTEELQGLVPRGVNLKDYLNVTAVHLFKERWDSNKIDHHTDKYDNNKLIVRRGQTFYIQIDFNRPYDPRKDLFRVEYVIGRYPQENKGTYIPVPVVKELQSGKWGAKVIMNEDRSVRLSVQSSPECIVGKFRMYVAVWTPYGILRTRRDPETDTYILFNPWCEEDAVYLDDEKEREEYVLNDIGVIFYGDFKDIKSRSWSYGQFEDGILDTCLYVMDKAEMDLSGRGNPIKVSRVGSAMVNAKDDEGVLVGSWDNVYAYGIPPSAWTGSVDILLEYRSSETPVRYGQCWVFAGVFNTFLRCLGIPARVITNYFSAHDNDANLQMDIFLEEDGNVSSKLTKDSVWNYHCWNEAWMTRPDLPVGFGGWQAVDSTPQENSDGMYRCGPASVQAVKHGHVCFQFDAPFVFAEVNSDLVYITAKQDGTHVVEAVDATHIGKLIVTKQIGGDGMQDITDTYKFQEGQEEERLALETALMYGAKKTLNTEGVVKSRSDVTMNFDVENAVLGKDFKVTITFQNNSSNLYTILAYLSGNITFYTGVSKKEFKKESFEETLDPFSSKKKEVLVRAGEYMSHLLEQGFLHFFVTARINESRDVLAKQKSIILTIPKITIKVRGAAMVGSDMVVTVEFTNPLKETLQNVWIHLDGPGVMRPKRKVFREIRPNTTVQWEEVCRPWVSGHRKLIASMTSDSLRHVYGELDLQIQRRPTM

Target ORF information:

RefSeq Version	NM_001166391.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus coagulation factor XIII, A1 subunit (F13a1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001166391.1

ORF Insert Sequence:

ATGTCAGATA CTCCAGCAAG CACCTTTGGG GGGAGGCGAG CAGTCCCGCC CAATAACTCC 
AATGCTGCAG AAGTGGACCT CCCAACTGAG GAGCTACAAG GCCTGGTGCC AAGGGGTGTC 
AACCTGAAAG ATTACCTGAA TGTCACAGCT GTTCACCTGT TCAAGGAGAG ATGGGACAGT 
AACAAGATTG ATCACCACAC AGACAAATAT GACAACAATA AGTTGATTGT CCGCAGAGGG 
CAGACCTTCT ACATCCAGAT TGACTTCAAC CGTCCCTATG ACCCCAGGAA GGATCTCTTC 
AGAGTGGAAT ATGTCATTGG TCGCTACCCT CAGGAGAACA AGGGCACCTA CATCCCTGTG 
CCTGTAGTGA AAGAGCTGCA AAGCGGAAAG TGGGGAGCCA AGGTTATCAT GAATGAGGAC 
CGGTCGGTGC GACTTTCCGT TCAGTCTTCT CCGGAATGCA TTGTGGGGAA ATTCCGCATG 
TATGTTGCAG TCTGGACTCC CTATGGCATC CTGCGTACTC GAAGAGACCC AGAAACAGAC 
ACATATATTC TCTTCAACCC TTGGTGTGAA GAGGACGCTG TGTATCTGGA TGATGAGAAG 
GAAAGAGAAG AGTACGTCCT GAATGACATT GGAGTGATAT TTTATGGGGA CTTCAAAGAC 
ATCAAGAGCA GAAGCTGGAG CTATGGCCAG TTCGAAGACG GCATCCTGGA TACTTGCTTG 
TATGTGATGG ACAAAGCTGA GATGGACCTT TCTGGCAGAG GCAACCCCAT CAAAGTCAGC 
CGAGTTGGAT CAGCAATGGT GAATGCCAAG GATGATGAAG GTGTTCTTGT TGGATCATGG 
GACAATGTCT ATGCCTACGG CATCCCTCCA TCAGCCTGGA CAGGAAGTGT TGACATTCTA 
CTAGAATACA GAAGCTCGGA AACACCAGTC CGATATGGCC AGTGTTGGGT TTTTGCTGGT 
GTCTTTAACA CATTTTTAAG ATGCCTTGGA ATCCCTGCAC GAGTCATTAC CAATTACTTC 
TCGGCCCACG ACAATGATGC CAATCTGCAA ATGGACATCT TCCTGGAAGA AGATGGGAAT 
GTGAGCTCCA AACTCACCAA GGATTCGGTG TGGAACTACC ACTGCTGGAA CGAAGCGTGG 
ATGACAAGGC CTGATCTTCC TGTTGGATTT GGAGGCTGGC AAGCTGTGGA CAGCACACCC 
CAGGAAAACA GTGATGGCAT GTACCGCTGT GGCCCTGCCT CTGTCCAAGC CGTTAAGCAT 
GGCCATGTCT GCTTCCAGTT TGATGCCCCG TTTGTTTTTG CAGAGGTCAA CAGTGATCTT 
GTTTACATCA CAGCTAAGCA AGATGGCACT CACGTGGTGG AAGCCGTGGA TGCCACCCAT 
ATCGGGAAGC TAATTGTGAC CAAGCAAATT GGAGGAGATG GCATGCAGGA TATCACGGAT 
ACTTACAAAT TTCAAGAAGG CCAAGAAGAA GAGAGACTAG CCCTTGAAAC TGCTCTGATG 
TATGGAGCCA AGAAGACCCT CAACACTGAA GGTGTTGTCA AATCAAGGTC TGATGTGACC 
ATGAACTTTG ATGTGGAAAA TGCTGTGCTG GGAAAGGACT TCAAAGTGAC TATCACCTTC 
CAGAACAATA GCTCCAATCT GTACACCATC CTGGCCTATC TTTCTGGCAA CATCACCTTC 
TACACTGGGG TATCCAAGAA AGAGTTCAAG AAGGAGTCCT TTGAAGAGAC GCTGGATCCC 
TTTTCCTCCA AGAAAAAGGA GGTGCTGGTC AGAGCGGGCG AGTACATGAG CCACCTTCTA 
GAACAGGGCT TCTTGCACTT CTTCGTCACG GCACGCATCA ACGAGTCCAG GGATGTCCTG 
GCCAAACAAA AGTCCATAAT ACTGACTATC CCCAAGATCA CCATCAAGGT CCGAGGTGCT 
GCCATGGTTG GCTCTGATAT GGTTGTGACT GTTGAGTTCA CTAATCCTTT AAAAGAAACA 
CTACAAAATG TCTGGATTCA TTTGGATGGT CCTGGAGTGA TGAGACCCAA GAGAAAGGTG 
TTCCGTGAAA TCCGGCCCAA CACCACGGTG CAGTGGGAAG AAGTCTGTCG GCCTTGGGTC 
TCTGGCCATC GGAAGCTGAT TGCCAGCATG ACCAGTGACT CCCTGAGACA TGTGTATGGA 
GAGCTGGATC TTCAGATTCA AAGACGACCT ACTATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cre/lox Studies Identify Resident Macrophages as the Major Source of Circulating Coagulation Factor XIII-A.
Arteriosclerosis, thrombosis, and vascular biology37(8)1494-1502(2017 Aug)
Beckers CML,Simpson KR,Griffin KJ,Brown JM,Cheah LT,Smith KA,Vacher J,Cordell PA,Kearney MT,Grant PJ,Pease RJ

Thrombin promotes diet-induced obesity through fibrin-driven inflammation.
The Journal of clinical investigation127(8)3152-3166(2017 Aug)
Kopec AK,Abrahams SR,Thornton S,Palumbo JS,Mullins ES,Divanovic S,Weiler H,Owens AP 3rd,Mackman N,Goss A,van Ryn J,Luyendyk JP,Flick MJ

Transglutaminases factor XIII-A and TG2 regulate resorption, adipogenesis and plasma fibronectin homeostasis in bone and bone marrow.
Cell death and differentiation24(5)844-854(2017 May)
Mousa A,Cui C,Song A,Myneni VD,Sun H,Li JJ,Murshed M,Melino G,Kaartinen MT

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.
Scientific reports740495(2017 Jan)
Naba A,Clauser KR,Mani DR,Carr SA,Hynes RO

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

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F13a1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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