Lonp1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lonp1
Entrez Gene ID	74142
Full Name	lon peptidase 1, mitochondrial
Synonyms	1200017E13Rik,LON,Prss15
General protein information	Preferred Names lon peptidase 1, mitochondrial Names lon protease homolog, mitochondrial LONP lon protease-like protein mitochondrial ATP-dependent protease Lon protease, serine, 15 serine protease 15
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 17 Map Location: 17\|17 D

mRNA and Protein(s)

mRNA	Protein	Name
NM_028782.2	NP_083058.2	lon protease homolog, mitochondrial precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	LONP1	XP_001143873.1
Canis lupus familiaris (dog)	LONP1	XP_854391.2
Mus musculus (house mouse)	Lonp1	NP_083058.2
Rattus norvegicus (Norway rat)	Lonp1	NP_596895.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010451	XP_311497.4
Caenorhabditis elegans (roundworm)	C34B2.6	NP_492796.1
Homo sapiens (human)	LONP1	NP_004784.2
Bos taurus (cattle)	LONP1	NP_001015569.2
Danio rerio (zebrafish)	lonp1	XP_691712.4
Saccharomyces cerevisiae (baker's yeast)	PIM1	NP_009531.1
Kluyveromyces lactis	KLLA0E10407g	XP_454420.1
Magnaporthe oryzae (rice blast fungus)	MGG_11141	XP_003714792.1
Xenopus tropicalis (tropical clawed frog)	LOC100492505	XP_002938599.1
	LONP1	XP_001088663.2
Gallus gallus (chicken)	LONP1	XP_001232112.2
Oryza sativa (rice)	Os07g0689300	NP_001175344.1
Schizosaccharomyces pombe (fission yeast)	lon1	NP_593035.1
Drosophila melanogaster (fruit fly)	Lon	NP_649133.1
Neurospora crassa	NCU05261	XP_961826.1
Arabidopsis thaliana (thale cress)	LON1	NP_568490.3

Gene Ontology
Bibliography

Related articles in PubMed

Dysfunction of mitochondrial Lon protease and identification of oxidized protein in mouse brain following exposure to MPTP: Implications for Parkinson disease.
Bulteau AL, Mena NP, Auch?re F, Lee I, Prigent A, Lobsiger CS, Camadro JM, Hirsch EC
Free radical biology & medicine108236-246(2017 Jul)

Mitochondrial LON protease-dependent degradation of cytochrome c oxidase subunits under hypoxia and myocardial ischemia.
Sepuri NBV, Angireddy R, Srinivasan S, Guha M, Spear J, Lu B, Anandatheerthavarada HK, Suzuki CK, Avadhani NG
Biochimica et biophysica acta1858(7)519-528(2017 07)

Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury.
Wu Y, Wei FY, Kawarada L, Suzuki T, Araki K, Komohara Y, Fujimura A, Kaitsuka T, Takeya M, Oike Y, Suzuki T, Tomizawa K
PLoS genetics12(9)e1006355(2016 Sep)

ATP-Dependent Lon Protease Contributes to Helicobacter pylori-Induced Gastric Carcinogenesis.
Luo B, Wang M, Hou N, Hu X, Jia G, Qin X, Zuo X, Liu Y, Luo K, Song W, Wang K, Pang M
Neoplasia (New York, N.Y.)18(4)242-52(2016 04)

HtrA2/Omi influences the stability of LON protease 1 and prohibitin, proteins involved in mitochondrial homeostasis.
Goo HG, Rhim H, Kang S
Experimental cell research328(2)456-65(2014 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Lon preferentially degrades the phosphorylated subunits of CcO and plays a role in the regulation of CcO activity in hypoxia and ischemia/reperfusion injury.
Title: Mitochondrial LON protease-dependent degradation of cytochrome c oxidase subunits under hypoxia and myocardial ischemia.

Lon protease (Lonp1), which is a key inductive of mitochondrial unfolded protein response (UPR(mt)) and is required to maintain the mitochondrial quality, was greatly induced in H. pylori infected gastric epithelial cells.
Title: ATP-Dependent Lon Protease Contributes to Helicobacter pylori-Induced Gastric Carcinogenesis.

LONP1 knockdown inhibits cellular proliferation and tumor and metastasis formation, whereas its overexpression increases tumorigenesis.
Title: ATP-dependent Lon protease controls tumor bioenergetics by reprogramming mitochondrial activity.

The correlative effect of Lon and ClpP upregulation on loss of mitochondrial Fe-S proteins during the progression of the disease may suggest that Fe-S proteins are potential targets of Lon and ClpP proteases in FRDA.
Title: Frataxin deficiency causes upregulation of mitochondrial Lon and ClpP proteases and severe loss of mitochondrial Fe-S proteins.

Modulation of Lon protease activity during aging and oxidative stress.
Title: Modulation of Lon protease activity and aconitase turnover during aging and oxidative stress.

The following Lonp1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lonp1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu18824	NM_028782.2 Latest version!	Mus musculus lon peptidase 1, mitochondrial (Lonp1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lonp1 ( NM_028782.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_083058.2 Mus musculus lon peptidase 1, mitochondrial (Lonp1), mRNA.

Price & Availability↑

CloneID	OMu18824
Clone ID Related Accession (Same CDS sequence)	NM_028782.2
Accession Version	NM_028782.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2850bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-02
Organism	Mus musculus(house mouse)
Product	lon protease homolog, mitochondrial precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY247676.1, AK160071.1 and CK428749.1. On Oct 13, 2006 this sequence version replaced NM_028782.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK004820.1, AK131910.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCGA GCACAGGCTA CGTGCGGCTC TGGGCCGCTG CGCGGTGCTG GGTTCTGCGG 
CGGCCGCTGC TGGCTGTCAC CGGAGGCCGG GTCCCGAGCG CGTCCGGGTC GTGGCTGCGC 
CGAGGATGTC GGGCCTGCGA CATGTCAGCT CCCTGGGGCG GCCGCGTTCT TCCCGGCGGG 
GTCCAGTGGC GGGGGCTGTG GGACTCGGGC AACCGCGGTG GCAGCGACGA GACCTCCGAG 
GGCGGTGCGG AGGACGGGGC CACGGCGAGC ACCGGGGAAG GCCCGGTCGT CACAGCGCTC 
GCGCCCATGA CCGTCCCGGA TGTGTTTCCT CACCTGCCGC TCATCGCCAT CACCCGCAAC 
CCTGTGTTCC CGCGCTTTAT CAAGATCGTG GAGGTTAAAA ATAAGAAGTT GGTTGAGCTC 
CTGAGAAGGA AAGTCCGACT TGCACAGCCC TATGTTGGCG TCTTCCTAAA GAGAGATGAC 
AACAATGAGT CGGACGTGGT GGAGAGCCTG GATGAAATCT ACCATACGGG AACATTCGCT 
CAGATTCATG AGATGCAGGA CCTCGGAGAC AAGTTGCGAA TGATTGTCAC TGGCCACAGA 
AGGATTCACA TCAGCCGGCA GCTGGAGGTG GAACCAGAGG GGCTTGAGCC AGAGGCAGAG 
AAACAAAAGT CCAGGAGGAA GCTGAAGCGA GGCAAGAAAG AGGTGGAGGA TGAGCTGGGC 
CCCAAGCCCC AGCTGGAGAT GGTGACCGAG GCTGCCACTG ACACATCCAA GGAGGTGCTC 
ATGGTGGAGG TTGAGAATGT AGCCCATGAA GACTTCCAGG TCACAGAGGA AGTGAAGGCC 
CTGACTGCAG AGATTGTGAA GACCATTCGG GATATCATCG CCTTGAACCC TCTGTACAGA 
GAGTCCGTGC TGCAGATGAT GCAGGCAGGC CAGCGTGTGG TGGACAACCC CATCTACTTG 
AGCGACATGG GTGCGGCACT CACTGGGGCG GAGTCCCATG AGCTGCAAGA TGTTCTGGAA 
GAGACCAACA TCCTTAAGCG GCTCTATAAG GCCCTGTCTC TCTTGAAGAA GGAGTTTGAG 
TTGAGCAAGC TTCAGCAACG CCTAGGCCGT GAGGTAGAGG AGAAGATCAA GCAGACACAC 
AGGAAGTACC TGCTGCAGGA GCAGTTGAAG ATCATCAAGA AGGAATTGGG GCTGGAGAAA 
GATGATAAAG ATGCCATTGA GGAGAAGTTC CGGGAACGCC TCAGGGAGCT TGTGGTTCCC 
AAGCATGTGA TGGACGTGGT GGATGAGGAG CTGAGCAAGC TTGCTCTACT GGACAACCAC 
TCCTCTGAGT TCAATGTCAC TCGAAACTAC CTGGACTGGC TGACATCCAT CCCATGGGGC 
CGGCAGAGTG ATGAGAACTT GGACTTGGCT CGGGCCCAGG CTGTGCTGGA GGAGGACCAC 
TACGGCATGG AGGATGTGAA GAAGCGTGTC CTGGAGTTCA TTGCAGTCAG CCAGCTCAGA 
GGCTCCACAC AAGGCAAGAT CCTCTGCTTC CACGGCCCAC CGGGGGTGGG CAAGACCAGC 
ATTGCACGCT CCATTGCCCG TGCCCTTGGC CGAGAATACT TCCGTTTCAG TGTTGGTGGC 
ATGACAGATG TGGCAGAAAT CAAGGGGCAC AGGCGTACCT ACGTGGGGGC CATGCCTGGG 
AAGATCATCC AGTGTCTGAA GAAGACCAAG ACAGAGAACC CGCTAGTGCT CATTGATGAG 
GTGGACAAGA TTGGCCGAGG CTACCAAGGG GACCCGTCAT CAGCACTGCT GGAGTTGCTG 
GACCCTGAGC AGAATGCCAA CTTCCTGGAC CACTACCTGG ATGTGCCAGT GGATCTGTCC 
AAGGTGCTAT TCATCTGCAC GGCCAATGTC ATTGACACCA TCCCAGAACC ACTGAGGGAC 
CGCATGGAGA TGATCAATGT GTCTGGCTAT GTAGCACAGG AGAAGCTGGC CATCGCAGAG 
CGGTACCTGG TGCCACAGGC CCGCACCCTG TGTGGCCTAG ATGAGAGCAA GGCCCAGCTG 
TCAGCAGCAG TGCTCACACT GCTCATCAAG CAATACTGCA GGGAGAGTGG TGTGCGCAAC 
CTACAGAAGC AGGTGGAGAA GGTGCTGCGC AAGGCTGCAT ACAAGATCGT AAGTGGGGAG 
GCCCAGACAG TACAGGTGAC ACCTGAGAAC CTACAAGACT TTGTTGGGAA GCCTGTGTTC 
ACAGTGGAGC GCATGTACGA AGTCACACCT CCTGGCGTGG TCATGGGTTT GGCCTGGACT 
GCCATGGGGG GCTCTACATT GTTTGTGGAG ACATCTTTGA GGCGGCCCCA GCCTAGTGGC 
AGCAAGGAGG ACAAGGATGG CAGCCTAGAG GTGACAGGTC AGCTGGGAGA TGTGATGAAA 
GAGAGTGCCC GCATAGCCTA CACCTATGCT CGTGCCTTCC TGATGGAGCA GGACCCTGAA 
AATGACTTCC TAGTCACCTC ACACATCCAC CTGCATGTGC CTGAGGGTGC TACCCCCAAG 
GATGGTCCCA GCGCAGGCTG TACTATTGTC ACTGCACTGC TGTCCCTGGC TCTGGGCCAG 
CCAGTGTTGC AGAACCTGGC TATGACTGGG GAGGTCTCCC TCACTGGCAA GGTGTTGCCT 
GTGGGTGGCA TCAAGGAGAA GACCATTGCG GCTAAGCGTG CAGGTGTGAC CTGCATCATT 
CTGCCTGCTG AGAACAGAAA GGACTACTCG GATTTAGCTC CTTTTATCAC AGAGGGCCTT 
GAAGTTCACT TCGTGGAACA CTATCGGGAC ATATTCCCCA TTGCCTTCCC CCGGCGAGAG 
CACAGGGAGG CACTGGCCGT GGAGAGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_083058.2
CDS	31..2880
Translation	MAASTGYVRLWAAARCWVLRRPLLAVTGGRVPSASGSWLRRGCRACDMSAPWGGRVLPGGVQWRGLWDSGNRGGSDETSEGGAEDGATASTGEGPVVTALAPMTVPDVFPHLPLIAITRNPVFPRFIKIVEVKNKKLVELLRRKVRLAQPYVGVFLKRDDNNESDVVESLDEIYHTGTFAQIHEMQDLGDKLRMIVTGHRRIHISRQLEVEPEGLEPEAEKQKSRRKLKRGKKEVEDELGPKPQLEMVTEAATDTSKEVLMVEVENVAHEDFQVTEEVKALTAEIVKTIRDIIALNPLYRESVLQMMQAGQRVVDNPIYLSDMGAALTGAESHELQDVLEETNILKRLYKALSLLKKEFELSKLQQRLGREVEEKIKQTHRKYLLQEQLKIIKKELGLEKDDKDAIEEKFRERLRELVVPKHVMDVVDEELSKLALLDNHSSEFNVTRNYLDWLTSIPWGRQSDENLDLARAQAVLEEDHYGMEDVKKRVLEFIAVSQLRGSTQGKILCFHGPPGVGKTSIARSIARALGREYFRFSVGGMTDVAEIKGHRRTYVGAMPGKIIQCLKKTKTENPLVLIDEVDKIGRGYQGDPSSALLELLDPEQNANFLDHYLDVPVDLSKVLFICTANVIDTIPEPLRDRMEMINVSGYVAQEKLAIAERYLVPQARTLCGLDESKAQLSAAVLTLLIKQYCRESGVRNLQKQVEKVLRKAAYKIVSGEAQTVQVTPENLQDFVGKPVFTVERMYEVTPPGVVMGLAWTAMGGSTLFVETSLRRPQPSGSKEDKDGSLEVTGQLGDVMKESARIAYTYARAFLMEQDPENDFLVTSHIHLHVPEGATPKDGPSAGCTIVTALLSLALGQPVLQNLAMTGEVSLTGKVLPVGGIKEKTIAAKRAGVTCIILPAENRKDYSDLAPFITEGLEVHFVEHYRDIFPIAFPRREHREALAVER

Target ORF information:

RefSeq Version	NM_028782.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus lon peptidase 1, mitochondrial (Lonp1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_028782.2

ORF Insert Sequence:

ATGGCGGCGA GCACAGGCTA CGTGCGGCTC TGGGCCGCTG CGCGGTGCTG GGTTCTGCGG 
CGGCCGCTGC TGGCTGTCAC CGGAGGCCGG GTCCCGAGCG CGTCCGGGTC GTGGCTGCGC 
CGAGGATGTC GGGCCTGCGA CATGTCAGCT CCCTGGGGCG GCCGCGTTCT TCCCGGCGGG 
GTCCAGTGGC GGGGGCTGTG GGACTCGGGC AACCGCGGTG GCAGCGACGA GACCTCCGAG 
GGCGGTGCGG AGGACGGGGC CACGGCGAGC ACCGGGGAAG GCCCGGTCGT CACAGCGCTC 
GCGCCCATGA CCGTCCCGGA TGTGTTTCCT CACCTGCCGC TCATCGCCAT CACCCGCAAC 
CCTGTGTTCC CGCGCTTTAT CAAGATCGTG GAGGTTAAAA ATAAGAAGTT GGTTGAGCTC 
CTGAGAAGGA AAGTCCGACT TGCACAGCCC TATGTTGGCG TCTTCCTAAA GAGAGATGAC 
AACAATGAGT CGGACGTGGT GGAGAGCCTG GATGAAATCT ACCATACGGG AACATTCGCT 
CAGATTCATG AGATGCAGGA CCTCGGAGAC AAGTTGCGAA TGATTGTCAC TGGCCACAGA 
AGGATTCACA TCAGCCGGCA GCTGGAGGTG GAACCAGAGG GGCTTGAGCC AGAGGCAGAG 
AAACAAAAGT CCAGGAGGAA GCTGAAGCGA GGCAAGAAAG AGGTGGAGGA TGAGCTGGGC 
CCCAAGCCCC AGCTGGAGAT GGTGACCGAG GCTGCCACTG ACACATCCAA GGAGGTGCTC 
ATGGTGGAGG TTGAGAATGT AGCCCATGAA GACTTCCAGG TCACAGAGGA AGTGAAGGCC 
CTGACTGCAG AGATTGTGAA GACCATTCGG GATATCATCG CCTTGAACCC TCTGTACAGA 
GAGTCCGTGC TGCAGATGAT GCAGGCAGGC CAGCGTGTGG TGGACAACCC CATCTACTTG 
AGCGACATGG GTGCGGCACT CACTGGGGCG GAGTCCCATG AGCTGCAAGA TGTTCTGGAA 
GAGACCAACA TCCTTAAGCG GCTCTATAAG GCCCTGTCTC TCTTGAAGAA GGAGTTTGAG 
TTGAGCAAGC TTCAGCAACG CCTAGGCCGT GAGGTAGAGG AGAAGATCAA GCAGACACAC 
AGGAAGTACC TGCTGCAGGA GCAGTTGAAG ATCATCAAGA AGGAATTGGG GCTGGAGAAA 
GATGATAAAG ATGCCATTGA GGAGAAGTTC CGGGAACGCC TCAGGGAGCT TGTGGTTCCC 
AAGCATGTGA TGGACGTGGT GGATGAGGAG CTGAGCAAGC TTGCTCTACT GGACAACCAC 
TCCTCTGAGT TCAATGTCAC TCGAAACTAC CTGGACTGGC TGACATCCAT CCCATGGGGC 
CGGCAGAGTG ATGAGAACTT GGACTTGGCT CGGGCCCAGG CTGTGCTGGA GGAGGACCAC 
TACGGCATGG AGGATGTGAA GAAGCGTGTC CTGGAGTTCA TTGCAGTCAG CCAGCTCAGA 
GGCTCCACAC AAGGCAAGAT CCTCTGCTTC CACGGCCCAC CGGGGGTGGG CAAGACCAGC 
ATTGCACGCT CCATTGCCCG TGCCCTTGGC CGAGAATACT TCCGTTTCAG TGTTGGTGGC 
ATGACAGATG TGGCAGAAAT CAAGGGGCAC AGGCGTACCT ACGTGGGGGC CATGCCTGGG 
AAGATCATCC AGTGTCTGAA GAAGACCAAG ACAGAGAACC CGCTAGTGCT CATTGATGAG 
GTGGACAAGA TTGGCCGAGG CTACCAAGGG GACCCGTCAT CAGCACTGCT GGAGTTGCTG 
GACCCTGAGC AGAATGCCAA CTTCCTGGAC CACTACCTGG ATGTGCCAGT GGATCTGTCC 
AAGGTGCTAT TCATCTGCAC GGCCAATGTC ATTGACACCA TCCCAGAACC ACTGAGGGAC 
CGCATGGAGA TGATCAATGT GTCTGGCTAT GTAGCACAGG AGAAGCTGGC CATCGCAGAG 
CGGTACCTGG TGCCACAGGC CCGCACCCTG TGTGGCCTAG ATGAGAGCAA GGCCCAGCTG 
TCAGCAGCAG TGCTCACACT GCTCATCAAG CAATACTGCA GGGAGAGTGG TGTGCGCAAC 
CTACAGAAGC AGGTGGAGAA GGTGCTGCGC AAGGCTGCAT ACAAGATCGT AAGTGGGGAG 
GCCCAGACAG TACAGGTGAC ACCTGAGAAC CTACAAGACT TTGTTGGGAA GCCTGTGTTC 
ACAGTGGAGC GCATGTACGA AGTCACACCT CCTGGCGTGG TCATGGGTTT GGCCTGGACT 
GCCATGGGGG GCTCTACATT GTTTGTGGAG ACATCTTTGA GGCGGCCCCA GCCTAGTGGC 
AGCAAGGAGG ACAAGGATGG CAGCCTAGAG GTGACAGGTC AGCTGGGAGA TGTGATGAAA 
GAGAGTGCCC GCATAGCCTA CACCTATGCT CGTGCCTTCC TGATGGAGCA GGACCCTGAA 
AATGACTTCC TAGTCACCTC ACACATCCAC CTGCATGTGC CTGAGGGTGC TACCCCCAAG 
GATGGTCCCA GCGCAGGCTG TACTATTGTC ACTGCACTGC TGTCCCTGGC TCTGGGCCAG 
CCAGTGTTGC AGAACCTGGC TATGACTGGG GAGGTCTCCC TCACTGGCAA GGTGTTGCCT 
GTGGGTGGCA TCAAGGAGAA GACCATTGCG GCTAAGCGTG CAGGTGTGAC CTGCATCATT 
CTGCCTGCTG AGAACAGAAA GGACTACTCG GATTTAGCTC CTTTTATCAC AGAGGGCCTT 
GAAGTTCACT TCGTGGAACA CTATCGGGAC ATATTCCCCA TTGCCTTCCC CCGGCGAGAG 
CACAGGGAGG CACTGGCCGT GGAGAGATGA