Abcb6 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Abcb6
Entrez Gene ID	74104
Full Name	ATP-binding cassette, sub-family B (MDR/TAP), member 6
Synonyms	1200005B17Rik
General protein information	Preferred Names ATP-binding cassette, sub-family B (MDR/TAP), member 6 Names ATP-binding cassette sub-family B member 6, mitochondrial
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1\|1 C4

mRNA and Protein(s)

mRNA	Protein	Name
NM_023732.3	NP_076221.1	ATP-binding cassette sub-family B member 6, mitochondrial
NM_023732.2	NP_076221.1	ATP-binding cassette sub-family B member 6, mitochondrial
XM_006496552.2	XP_006496615.1	ATP-binding cassette sub-family B member 6, mitochondrial isoform X1
XM_006496552.3	XP_006496615.1	ATP-binding cassette sub-family B member 6, mitochondrial isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ABCB6	XP_001161097.1
	ABCB6	XP_002799099.1
Bos taurus (cattle)	ABCB6	NP_001091625.1
Schizosaccharomyces pombe (fission yeast)	hmt1	NP_588371.3
Magnaporthe oryzae (rice blast fungus)	MGG_05190	XP_003712732.1
Xenopus tropicalis (tropical clawed frog)	abcb6	NP_001072643.1
Homo sapiens (human)	ABCB6	NP_005680.1
Canis lupus familiaris (dog)	ABCB6	XP_005640740.1
Mus musculus (house mouse)	Abcb6	NP_076221.1
Danio rerio (zebrafish)	abcb6a	NP_001139165.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002278	XP_307900.5
Neurospora crassa	NCU00010	XP_956997.2
Rattus norvegicus (Norway rat)	Abcb6	NP_542149.1
Gallus gallus (chicken)	ABCB6	XP_423449.4
Drosophila melanogaster (fruit fly)	Hmt-1	NP_650503.1
Caenorhabditis elegans (roundworm)	hmt-1	NP_001022812.1

Gene Ontology
Bibliography

Related articles in PubMed

The severity of hereditary porphyria is modulated by the porphyrin exporter and Lan antigen ABCB6.
Fukuda Y, Cheong PL, Lynch J, Brighton C, Frase S, Kargas V, Rampersaud E, Wang Y, Sankaran VG, Yu B, Ney PA, Weiss MJ, Vogel P, Bond PJ, Ford RC, Trent RJ, Schuetz JD
Nature communications712353(2016 Aug)

Functional coupling of ATP-binding cassette transporter Abcb6 to cytochrome P450 expression and activity in liver.
Chavan H, Li F, Tessman R, Mickey K, Dorko K, Schmitt T, Kumer S, Gunewardena S, Gaikwad N, Krishnamurthy P
The Journal of biological chemistry290(12)7871-86(2015 Mar)

Deficiency of ATP-binding cassette transporter B6 in megakaryocyte progenitors accelerates atherosclerosis in mice.
Murphy AJ, Sarrazy V, Wang N, Bijl N, Abramowicz S, Westerterp M, Welch CB, Schuetz JD, Yvan-Charvet L
Arteriosclerosis, thrombosis, and vascular biology34(4)751-8(2014 Apr)

Mutations in ABCB6 cause dyschromatosis universalis hereditaria.
Zhang C, Li D, Zhang J, Chen X, Huang M, Archacki S, Tian Y, Ren W, Mei A, Zhang Q, Fang M, Su Z, Yin Y, Liu D, Chen Y, Cui X, Li C, Yang H, Wang Q, Wang J, Liu M, Deng Y
The Journal of investigative dermatology133(9)2221-8(2013 Sep)

Polycyclic aromatic hydrocarbons (PAHs) mediate transcriptional activation of the ATP binding cassette transporter ABCB6 gene via the aryl hydrocarbon receptor (AhR).
Chavan H, Krishnamurthy P
The Journal of biological chemistry287(38)32054-68(2012 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

liver extracts from Abcb6-deficient mice suppress P450 expression in human primary hepatocytes, suggest that this mouse model may provide an opportunity to understand the physiological signals and the mechanisms involved in negative regulation of P450s
Title: Functional coupling of ATP-binding cassette transporter Abcb6 to cytochrome P450 expression and activity in liver.

Identify a new role of ABCB6 in preventing atherosclerosis development by dampening platelet production, reactivity, and chemokine (C-C motif) ligand 5 deposition in atherosclerotic lesions.
Title: Deficiency of ATP-binding cassette transporter B6 in megakaryocyte progenitors accelerates atherosclerosis in mice.

Polycyclic aromatic hydrocarbons (PAHs) mediate transcriptional activation of the ATP binding cassette transporter ABCB6 gene via the aryl hydrocarbon receptor (AhR)
Title: Polycyclic aromatic hydrocarbons (PAHs) mediate transcriptional activation of the ATP binding cassette transporter ABCB6 gene via the aryl hydrocarbon receptor (AhR).

Abcb6 is the sole ATP-dependent porphyrin importer, and loss of Abcb6 produces up-regulation of heme and iron pathways necessary for normal development.
Title: ATP-dependent mitochondrial porphyrin importer ABCB6 protects against phenylhydrazine toxicity.

Conserved intramolecular disulfide bond is critical to trafficking and fate of ATP-binding cassette (ABC) transporters ABCB6 and sulfonylurea receptor 1 (SUR1)/ABCC8.
Title: Conserved intramolecular disulfide bond is critical to trafficking and fate of ATP-binding cassette (ABC) transporters ABCB6 and sulfonylurea receptor 1 (SUR1)/ABCC8.

The following Abcb6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Abcb6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu23042	NM_023732.3 Latest version!	Mus musculus ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Abcb6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$496.30 $709.00
OMu27806	XM_006496552.3 Latest version!	Mus musculus ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Abcb6), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
View Old Accession Versions >>
OMu23042	NM_023732.2	Mus musculus ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Abcb6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$496.30 $709.00
OMu27806	XM_006496552.2	Mus musculus ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Abcb6), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Abcb6 ( XM_006496552.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006496615.1 Mus musculus ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Abcb6), transcript variant X1, mRNA.

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CloneID	OMu27806
Clone ID Related Accession (Same CDS sequence)	XM_006496552.2 , XM_006496552.3
Accession Version	XM_006496552.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1665bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	ATP-binding cassette sub-family B member 6, mitochondrial isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006496552.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTGAACT TACTGACTGC GAAGGCTCCT TGGAGCTCCC TGGCCTGGAC CGTTACCACC 
TATGTCTTCC TCAAGTTCCT CCAGGGGGGT GGCACTGGCA GTACAGGTTT TGTGAGCAAC 
CTGCGAACCT TCCTATGGAT CCGGGTGCAG CAGTTTACGT CCCGAGGTGT GGAGCTACGT 
CTCTTCTCTC ACCTGCATGA ACTCTCACTG CGCTGGCACC TGGGCCGGCG TACCGGGGAG 
GTGCTTCGGA TCGTGGACCG GGGAACATCT AGTGTCACAG GACTACTCAG CTACCTGGTG 
TTCAGCATCA TCCCCACCCT GGCTGACATC ATCATTGGCA TCATCTACTT CAGCATGTTC 
TTCAATGCCT GGTTTGGCCT CATCGTGTTC CTGTGCATGA GTCTTTACCT CATCCTGACT 
ATCGTGGTCA CCGAGTGGAG AGCCAAGTTT CGCCGTGATA TGAACACACA GGAAAACGCC 
ACCCGGGCAC GAGCAGTAGA CTCTCTGCTC AACTTTGAAA CGGTGAAATA CTATGGTGCC 
GAGGGTTATG AAGTAGACCG CTATCGAGAG GCCATCCTCA AGTTTCAGGG TTTGGAGTGG 
AAGTCAACCG CCTCACTGGT TGTGCTGAAT CAGACACAGA ACCTGGTGAT CGGGCTTGGC 
CTCCTTGCTG GCTCCTTGCT TTGCGCATAC TTCGTCAGTG AGCAGAAGCT ACAGGTTGGG 
GACTTTGTGC TTTTTGGCAC TTACATCACC CAACTGTACA TGCCTCTCAA CTGGTTTGGC 
ACCTACTACA GGATGATCCA GACTAACTTC ATTGACATGG AGAACATGTT TGACTTGCTG 
AAAGAGGAGA CAGAAGTGAA GGATGTTCCT GGTGCAGGGC CCCTTCGTTT TCATAAGGGC 
CGGATTGAGT TTGAAAATGT GCACTTCAGC TACGCTGATG GGCAGGAGAC CTTACAAGAT 
GTGTCCTTCA CTGTGATGCC TGGACAGACG GTGGCTCTGG TAGGTCCATC TGGGGCAGGA 
AAGAGCACAA TTTTGCGCCT GCTATTTCGC TTCTATGACA TCAGCTCTGG CTGCATCCGA 
ATAGATGGAC AGGATATTTC ACAGGTGACC CAGATCTCTC TCCGATCTCA CATTGGAGTT 
GTGCCCCAGG ACACTGTCCT CTTCAACGAC ACCATTGCTA ACAATATCCG CTATGGCCGT 
GTCACAGCTG GGGACAGTGA GGTAGAGGCT GCTGCTCAGG CTGCAGGCAT TCATGATGCC 
ATCTTGTCTT TCCCTGAAGG GTATGAGACA CAGGTCGGGG AGCGGGGTCT GAAGCTGAGT 
GGTGGCGAGA AGCAGCGAGT GGCCATCGCC CGCACCATCC TTAAGGCTCC TGACATCATT 
CTGCTGGATG AGGCCACATC AGCACTGGAT ACATCTAATG AGAGAGCCAT CCAGGCCTCT 
CTGGCCAAAG TCTGCACCAA CCGCACCACC ATCGTCATAG CACACAGGCT CTCAACTGTG 
GTCAATGCTG ACCAGATTCT GGTCATCAAG GACGGTTGCA TCATAGAGAG AGGAAGGCAC 
GAAGCCCTGC TGTCCCGAGG TGGCGTTTAT GCCGAGATGT GGCAGCTGCA GCAGCAAGGA 
CAAGAAACTG TCCCTGAAGA ATCTAAACCT CAGGACACGG CATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006496615.1
CDS	989..2653
Translation	MLNLLTAKAPWSSLAWTVTTYVFLKFLQGGGTGSTGFVSNLRTFLWIRVQQFTSRGVELRLFSHLHELSLRWHLGRRTGEVLRIVDRGTSSVTGLLSYLVFSIIPTLADIIIGIIYFSMFFNAWFGLIVFLCMSLYLILTIVVTEWRAKFRRDMNTQENATRARAVDSLLNFETVKYYGAEGYEVDRYREAILKFQGLEWKSTASLVVLNQTQNLVIGLGLLAGSLLCAYFVSEQKLQVGDFVLFGTYITQLYMPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDVPGAGPLRFHKGRIEFENVHFSYADGQETLQDVSFTVMPGQTVALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQISLRSHIGVVPQDTVLFNDTIANNIRYGRVTAGDSEVEAAAQAAGIHDAILSFPEGYETQVGERGLKLSGGEKQRVAIARTILKAPDIILLDEATSALDTSNERAIQASLAKVCTNRTTIVIAHRLSTVVNADQILVIKDGCIIERGRHEALLSRGGVYAEMWQLQQQGQETVPEESKPQDTA

Target ORF information:

RefSeq Version	XM_006496552.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Abcb6), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006496552.2

ORF Insert Sequence:

ATGTTGAACT TACTGACTGC GAAGGCTCCT TGGAGCTCCC TGGCCTGGAC CGTTACCACC 
TATGTCTTCC TCAAGTTCCT CCAGGGGGGT GGCACTGGCA GTACAGGTTT TGTGAGCAAC 
CTGCGAACCT TCCTATGGAT CCGGGTGCAG CAGTTTACGT CCCGAGGTGT GGAGCTACGT 
CTCTTCTCTC ACCTGCATGA ACTCTCACTG CGCTGGCACC TGGGCCGGCG TACCGGGGAG 
GTGCTTCGGA TCGTGGACCG GGGAACATCT AGTGTCACAG GACTACTCAG CTACCTGGTG 
TTCAGCATCA TCCCCACCCT GGCTGACATC ATCATTGGCA TCATCTACTT CAGCATGTTC 
TTCAATGCCT GGTTTGGCCT CATCGTGTTC CTGTGCATGA GTCTTTACCT CATCCTGACT 
ATCGTGGTCA CCGAGTGGAG AGCCAAGTTT CGCCGTGATA TGAACACACA GGAAAACGCC 
ACCCGGGCAC GAGCAGTAGA CTCTCTGCTC AACTTTGAAA CGGTGAAATA CTATGGTGCC 
GAGGGTTATG AAGTAGACCG CTATCGAGAG GCCATCCTCA AGTTTCAGGG TTTGGAGTGG 
AAGTCAACCG CCTCACTGGT TGTGCTGAAT CAGACACAGA ACCTGGTGAT CGGGCTTGGC 
CTCCTTGCTG GCTCCTTGCT TTGCGCATAC TTCGTCAGTG AGCAGAAGCT ACAGGTTGGG 
GACTTTGTGC TTTTTGGCAC TTACATCACC CAACTGTACA TGCCTCTCAA CTGGTTTGGC 
ACCTACTACA GGATGATCCA GACTAACTTC ATTGACATGG AGAACATGTT TGACTTGCTG 
AAAGAGGAGA CAGAAGTGAA GGATGTTCCT GGTGCAGGGC CCCTTCGTTT TCATAAGGGC 
CGGATTGAGT TTGAAAATGT GCACTTCAGC TACGCTGATG GGCAGGAGAC CTTACAAGAT 
GTGTCCTTCA CTGTGATGCC TGGACAGACG GTGGCTCTGG TAGGTCCATC TGGGGCAGGA 
AAGAGCACAA TTTTGCGCCT GCTATTTCGC TTCTATGACA TCAGCTCTGG CTGCATCCGA 
ATAGATGGAC AGGATATTTC ACAGGTGACC CAGATCTCTC TCCGATCTCA CATTGGAGTT 
GTGCCCCAGG ACACTGTCCT CTTCAACGAC ACCATTGCTA ACAATATCCG CTATGGCCGT 
GTCACAGCTG GGGACAGTGA GGTAGAGGCT GCTGCTCAGG CTGCAGGCAT TCATGATGCC 
ATCTTGTCTT TCCCTGAAGG GTATGAGACA CAGGTCGGGG AGCGGGGTCT GAAGCTGAGT 
GGTGGCGAGA AGCAGCGAGT GGCCATCGCC CGCACCATCC TTAAGGCTCC TGACATCATT 
CTGCTGGATG AGGCCACATC AGCACTGGAT ACATCTAATG AGAGAGCCAT CCAGGCCTCT 
CTGGCCAAAG TCTGCACCAA CCGCACCACC ATCGTCATAG CACACAGGCT CTCAACTGTG 
GTCAATGCTG ACCAGATTCT GGTCATCAAG GACGGTTGCA TCATAGAGAG AGGAAGGCAC 
GAAGCCCTGC TGTCCCGAGG TGGCGTTTAT GCCGAGATGT GGCAGCTGCA GCAGCAAGGA 
CAAGAAACTG TCCCTGAAGA ATCTAAACCT CAGGACACGG CATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Abcb6 ( NM_023732.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_076221.1 Mus musculus ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Abcb6), mRNA.

Price & Availability↑

CloneID	OMu23042
Clone ID Related Accession (Same CDS sequence)	NM_023732.3 , NM_023732.2
Accession Version	NM_023732.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2529bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Mus musculus(house mouse)
Product	ATP-binding cassette sub-family B member 6, mitochondrial
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK151165.1, AK004605.1, AI843102.1 and AC166150.2. On Sep 1, 2015 this sequence version replaced NM_023732.2. ##Evidence-Data-START## Transcript exon combination :: BC006634.1, AK151165.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGTGACTG TGGGCAACTA CTGCGAGACC GAAGGGCCGG CGGGGCCCGC TTGGACTCAG 
AATGGCTTGA GTCCCTGCTT CTTCTTCACG CTAGTGCCCT CGACACTCCT GACTCTGGGG 
GTACTGGCCT TGGTGCTGGT TCTTCCCCGC AGGCGTCGGG AGGTGCCTGC TGGCCCAGAA 
GAGCTGTCTT GGGCGGCTGG CCCTCGGGTG GCCCCATATG TGCTGCAGCT GTTTCTGGCC 
ACACTTCAGA TGGCACTGCC CCTGGCTGGT CTGGCTGGCC GAGTGGGCAC TGCTCGGGGG 
GTCCGTCTGC CAGGCTACCT ACTGCTGGCT TCTGTGCTGG AGAGTCTGGC CAGCGTCTGT 
GGCTTGTGGC TGCTCGTGGT GGAACGGAGC CAGGCACGGC AGAGTCTGGC AATGGGCGTC 
TGGATGAAGT TCAGGCATAG CTTGGGTCTC CTGCTCCTCT GGACTGTGAC ATTTGCAGCC 
GAGAACTTGG CCCTAGTATC TTGGAACAGC CCGCAGTGGT GGTGGGCCAG AGCAGATCTG 
GGCCAGCAGG TTCAATTTGG CCTGTGGGTC CTGCGTTATG TGACCTCTGG AGGGCTATTT 
ATCTTGGGGC TCTGGGCCCC AGGACTTCGC CCCCAGTCTT ATACTCTACA CGTTCATGAA 
GAAGACCAAG ATGTAGGAGG GAACCAGGGC CGCTCAACAG ACCGACGATC CACCTGGAGA 
GACCTTGGCC GGAAGCTTCG ACTGCTGAGT AGCTACTTGT GGCCTCGGGG AAGTCCATCA 
CTACAGCTGA TAGTGCTCAT ATGCCTGGGA CTCATGGGGT TGGAACGAGC ACTCAATGTG 
TTGGTCCCCA TCTTCTATAG GGACATTGTG AACTTACTGA CTGCGAAGGC TCCTTGGAGC 
TCCCTGGCCT GGACCGTTAC CACCTATGTC TTCCTCAAGT TCCTCCAGGG GGGTGGCACT 
GGCAGTACAG GTTTTGTGAG CAACCTGCGA ACCTTCCTAT GGATCCGGGT GCAGCAGTTT 
ACGTCCCGAG GTGTGGAGCT ACGTCTCTTC TCTCACCTGC ATGAACTCTC ACTGCGCTGG 
CACCTGGGCC GGCGTACCGG GGAGGTGCTT CGGATCGTGG ACCGGGGAAC ATCTAGTGTC 
ACAGGACTAC TCAGCTACCT GGTGTTCAGC ATCATCCCCA CCCTGGCTGA CATCATCATT 
GGCATCATCT ACTTCAGCAT GTTCTTCAAT GCCTGGTTTG GCCTCATCGT GTTCCTGTGC 
ATGAGTCTTT ACCTCATCCT GACTATCGTG GTCACCGAGT GGAGAGCCAA GTTTCGCCGT 
GATATGAACA CACAGGAAAA CGCCACCCGG GCACGAGCAG TAGACTCTCT GCTCAACTTT 
GAAACGGTGA AATACTATGG TGCCGAGGGT TATGAAGTAG ACCGCTATCG AGAGGCCATC 
CTCAAGTTTC AGGGTTTGGA GTGGAAGTCA ACCGCCTCAC TGGTTGTGCT GAATCAGACA 
CAGAACCTGG TGATCGGGCT TGGCCTCCTT GCTGGCTCCT TGCTTTGCGC ATACTTCGTC 
AGTGAGCAGA AGCTACAGGT TGGGGACTTT GTGCTTTTTG GCACTTACAT CACCCAACTG 
TACATGCCTC TCAACTGGTT TGGCACCTAC TACAGGATGA TCCAGACTAA CTTCATTGAC 
ATGGAGAACA TGTTTGACTT GCTGAAAGAG GAGACAGAAG TGAAGGATGT TCCTGGTGCA 
GGGCCCCTTC GTTTTCATAA GGGCCGGATT GAGTTTGAAA ATGTGCACTT CAGCTACGCT 
GATGGGCAGG AGACCTTACA AGATGTGTCC TTCACTGTGA TGCCTGGACA GACGGTGGCT 
CTGGTAGGTC CATCTGGGGC AGGAAAGAGC ACAATTTTGC GCCTGCTATT TCGCTTCTAT 
GACATCAGCT CTGGCTGCAT CCGAATAGAT GGACAGGATA TTTCACAGGT GACCCAGATC 
TCTCTCCGAT CTCACATTGG AGTTGTGCCC CAGGACACTG TCCTCTTCAA CGACACCATT 
GCTAACAATA TCCGCTATGG CCGTGTCACA GCTGGGGACA GTGAGGTAGA GGCTGCTGCT 
CAGGCTGCAG GCATTCATGA TGCCATCTTG TCTTTCCCTG AAGGGTATGA GACACAGGTC 
GGGGAGCGGG GTCTGAAGCT GAGTGGTGGC GAGAAGCAGC GAGTGGCCAT CGCCCGCACC 
ATCCTTAAGG CTCCTGACAT CATTCTGCTG GATGAGGCCA CATCAGCACT GGATACATCT 
AATGAGAGAG CCATCCAGGC CTCTCTGGCC AAAGTCTGCA CCAACCGCAC CACCATCGTC 
ATAGCACACA GGCTCTCAAC TGTGGTCAAT GCTGACCAGA TTCTGGTCAT CAAGGACGGT 
TGCATCATAG AGAGAGGAAG GCACGAAGCC CTGCTGTCCC GAGGTGGCGT TTATGCCGAG 
ATGTGGCAGC TGCAGCAGCA AGGACAAGAA ACTGTCCCTG AAGAATCTAA ACCTCAGGAC 
ACGGCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_076221.1
CDS	275..2803
Translation	MVTVGNYCETEGPAGPAWTQNGLSPCFFFTLVPSTLLTLGVLALVLVLPRRRREVPAGPEELSWAAGPRVAPYVLQLFLATLQMALPLAGLAGRVGTARGVRLPGYLLLASVLESLASVCGLWLLVVERSQARQSLAMGVWMKFRHSLGLLLLWTVTFAAENLALVSWNSPQWWWARADLGQQVQFGLWVLRYVTSGGLFILGLWAPGLRPQSYTLHVHEEDQDVGGNQGRSTDRRSTWRDLGRKLRLLSSYLWPRGSPSLQLIVLICLGLMGLERALNVLVPIFYRDIVNLLTAKAPWSSLAWTVTTYVFLKFLQGGGTGSTGFVSNLRTFLWIRVQQFTSRGVELRLFSHLHELSLRWHLGRRTGEVLRIVDRGTSSVTGLLSYLVFSIIPTLADIIIGIIYFSMFFNAWFGLIVFLCMSLYLILTIVVTEWRAKFRRDMNTQENATRARAVDSLLNFETVKYYGAEGYEVDRYREAILKFQGLEWKSTASLVVLNQTQNLVIGLGLLAGSLLCAYFVSEQKLQVGDFVLFGTYITQLYMPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDVPGAGPLRFHKGRIEFENVHFSYADGQETLQDVSFTVMPGQTVALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQISLRSHIGVVPQDTVLFNDTIANNIRYGRVTAGDSEVEAAAQAAGIHDAILSFPEGYETQVGERGLKLSGGEKQRVAIARTILKAPDIILLDEATSALDTSNERAIQASLAKVCTNRTTIVIAHRLSTVVNADQILVIKDGCIIERGRHEALLSRGGVYAEMWQLQQQGQETVPEESKPQDTA

Target ORF information:

RefSeq Version	NM_023732.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Abcb6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_023732.3

ORF Insert Sequence:

ATGGTGACTG TGGGCAACTA CTGCGAGACC GAAGGGCCGG CGGGGCCCGC TTGGACTCAG 
AATGGCTTGA GTCCCTGCTT CTTCTTCACG CTAGTGCCCT CGACACTCCT GACTCTGGGG 
GTACTGGCCT TGGTGCTGGT TCTTCCCCGC AGGCGTCGGG AGGTGCCTGC TGGCCCAGAA 
GAGCTGTCTT GGGCGGCTGG CCCTCGGGTG GCCCCATATG TGCTGCAGCT GTTTCTGGCC 
ACACTTCAGA TGGCACTGCC CCTGGCTGGT CTGGCTGGCC GAGTGGGCAC TGCTCGGGGG 
GTCCGTCTGC CAGGCTACCT ACTGCTGGCT TCTGTGCTGG AGAGTCTGGC CAGCGTCTGT 
GGCTTGTGGC TGCTCGTGGT GGAACGGAGC CAGGCACGGC AGAGTCTGGC AATGGGCGTC 
TGGATGAAGT TCAGGCATAG CTTGGGTCTC CTGCTCCTCT GGACTGTGAC ATTTGCAGCC 
GAGAACTTGG CCCTAGTATC TTGGAACAGC CCGCAGTGGT GGTGGGCCAG AGCAGATCTG 
GGCCAGCAGG TTCAATTTGG CCTGTGGGTC CTGCGTTATG TGACCTCTGG AGGGCTATTT 
ATCTTGGGGC TCTGGGCCCC AGGACTTCGC CCCCAGTCTT ATACTCTACA CGTTCATGAA 
GAAGACCAAG ATGTAGGAGG GAACCAGGGC CGCTCAACAG ACCGACGATC CACCTGGAGA 
GACCTTGGCC GGAAGCTTCG ACTGCTGAGT AGCTACTTGT GGCCTCGGGG AAGTCCATCA 
CTACAGCTGA TAGTGCTCAT ATGCCTGGGA CTCATGGGGT TGGAACGAGC ACTCAATGTG 
TTGGTCCCCA TCTTCTATAG GGACATTGTG AACTTACTGA CTGCGAAGGC TCCTTGGAGC 
TCCCTGGCCT GGACCGTTAC CACCTATGTC TTCCTCAAGT TCCTCCAGGG GGGTGGCACT 
GGCAGTACAG GTTTTGTGAG CAACCTGCGA ACCTTCCTAT GGATCCGGGT GCAGCAGTTT 
ACGTCCCGAG GTGTGGAGCT ACGTCTCTTC TCTCACCTGC ATGAACTCTC ACTGCGCTGG 
CACCTGGGCC GGCGTACCGG GGAGGTGCTT CGGATCGTGG ACCGGGGAAC ATCTAGTGTC 
ACAGGACTAC TCAGCTACCT GGTGTTCAGC ATCATCCCCA CCCTGGCTGA CATCATCATT 
GGCATCATCT ACTTCAGCAT GTTCTTCAAT GCCTGGTTTG GCCTCATCGT GTTCCTGTGC 
ATGAGTCTTT ACCTCATCCT GACTATCGTG GTCACCGAGT GGAGAGCCAA GTTTCGCCGT 
GATATGAACA CACAGGAAAA CGCCACCCGG GCACGAGCAG TAGACTCTCT GCTCAACTTT 
GAAACGGTGA AATACTATGG TGCCGAGGGT TATGAAGTAG ACCGCTATCG AGAGGCCATC 
CTCAAGTTTC AGGGTTTGGA GTGGAAGTCA ACCGCCTCAC TGGTTGTGCT GAATCAGACA 
CAGAACCTGG TGATCGGGCT TGGCCTCCTT GCTGGCTCCT TGCTTTGCGC ATACTTCGTC 
AGTGAGCAGA AGCTACAGGT TGGGGACTTT GTGCTTTTTG GCACTTACAT CACCCAACTG 
TACATGCCTC TCAACTGGTT TGGCACCTAC TACAGGATGA TCCAGACTAA CTTCATTGAC 
ATGGAGAACA TGTTTGACTT GCTGAAAGAG GAGACAGAAG TGAAGGATGT TCCTGGTGCA 
GGGCCCCTTC GTTTTCATAA GGGCCGGATT GAGTTTGAAA ATGTGCACTT CAGCTACGCT 
GATGGGCAGG AGACCTTACA AGATGTGTCC TTCACTGTGA TGCCTGGACA GACGGTGGCT 
CTGGTAGGTC CATCTGGGGC AGGAAAGAGC ACAATTTTGC GCCTGCTATT TCGCTTCTAT 
GACATCAGCT CTGGCTGCAT CCGAATAGAT GGACAGGATA TTTCACAGGT GACCCAGATC 
TCTCTCCGAT CTCACATTGG AGTTGTGCCC CAGGACACTG TCCTCTTCAA CGACACCATT 
GCTAACAATA TCCGCTATGG CCGTGTCACA GCTGGGGACA GTGAGGTAGA GGCTGCTGCT 
CAGGCTGCAG GCATTCATGA TGCCATCTTG TCTTTCCCTG AAGGGTATGA GACACAGGTC 
GGGGAGCGGG GTCTGAAGCT GAGTGGTGGC GAGAAGCAGC GAGTGGCCAT CGCCCGCACC 
ATCCTTAAGG CTCCTGACAT CATTCTGCTG GATGAGGCCA CATCAGCACT GGATACATCT 
AATGAGAGAG CCATCCAGGC CTCTCTGGCC AAAGTCTGCA CCAACCGCAC CACCATCGTC 
ATAGCACACA GGCTCTCAAC TGTGGTCAAT GCTGACCAGA TTCTGGTCAT CAAGGACGGT 
TGCATCATAG AGAGAGGAAG GCACGAAGCC CTGCTGTCCC GAGGTGGCGT TTATGCCGAG 
ATGTGGCAGC TGCAGCAGCA AGGACAAGAA ACTGTCCCTG AAGAATCTAA ACCTCAGGAC 
ACGGCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Abcb6 ( NM_023732.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_076221.1 Mus musculus ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Abcb6), mRNA.

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CloneID	OMu23042
Clone ID Related Accession (Same CDS sequence)	NM_023732.3 , NM_023732.2
Accession Version	NM_023732.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2529bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-14
Organism	Mus musculus(House mouse)
Product	ATP-binding cassette sub-family B member 6, mitochondrial
Comment

ATGGTGACTG TGGGCAACTA CTGCGAGACC GAAGGGCCGG CGGGGCCCGC TTGGACTCAG 
AATGGCTTGA GTCCCTGCTT CTTCTTCACG CTAGTGCCCT CGACACTCCT GACTCTGGGG 
GTACTGGCCT TGGTGCTGGT TCTTCCCCGC AGGCGTCGGG AGGTGCCTGC TGGCCCAGAA 
GAGCTGTCTT GGGCGGCTGG CCCTCGGGTG GCCCCATATG TGCTGCAGCT GTTTCTGGCC 
ACACTTCAGA TGGCACTGCC CCTGGCTGGT CTGGCTGGCC GAGTGGGCAC TGCTCGGGGG 
GTCCGTCTGC CAGGCTACCT ACTGCTGGCT TCTGTGCTGG AGAGTCTGGC CAGCGTCTGT 
GGCTTGTGGC TGCTCGTGGT GGAACGGAGC CAGGCACGGC AGAGTCTGGC AATGGGCGTC 
TGGATGAAGT TCAGGCATAG CTTGGGTCTC CTGCTCCTCT GGACTGTGAC ATTTGCAGCC 
GAGAACTTGG CCCTAGTATC TTGGAACAGC CCGCAGTGGT GGTGGGCCAG AGCAGATCTG 
GGCCAGCAGG TTCAATTTGG CCTGTGGGTC CTGCGTTATG TGACCTCTGG AGGGCTATTT 
ATCTTGGGGC TCTGGGCCCC AGGACTTCGC CCCCAGTCTT ATACTCTACA CGTTCATGAA 
GAAGACCAAG ATGTAGGAGG GAACCAGGGC CGCTCAACAG ACCGACGATC CACCTGGAGA 
GACCTTGGCC GGAAGCTTCG ACTGCTGAGT AGCTACTTGT GGCCTCGGGG AAGTCCATCA 
CTACAGCTGA TAGTGCTCAT ATGCCTGGGA CTCATGGGGT TGGAACGAGC ACTCAATGTG 
TTGGTCCCCA TCTTCTATAG GGACATTGTG AACTTACTGA CTGCGAAGGC TCCTTGGAGC 
TCCCTGGCCT GGACCGTTAC CACCTATGTC TTCCTCAAGT TCCTCCAGGG GGGTGGCACT 
GGCAGTACAG GTTTTGTGAG CAACCTGCGA ACCTTCCTAT GGATCCGGGT GCAGCAGTTT 
ACGTCCCGAG GTGTGGAGCT ACGTCTCTTC TCTCACCTGC ATGAACTCTC ACTGCGCTGG 
CACCTGGGCC GGCGTACCGG GGAGGTGCTT CGGATCGTGG ACCGGGGAAC ATCTAGTGTC 
ACAGGACTAC TCAGCTACCT GGTGTTCAGC ATCATCCCCA CCCTGGCTGA CATCATCATT 
GGCATCATCT ACTTCAGCAT GTTCTTCAAT GCCTGGTTTG GCCTCATCGT GTTCCTGTGC 
ATGAGTCTTT ACCTCATCCT GACTATCGTG GTCACCGAGT GGAGAGCCAA GTTTCGCCGT 
GATATGAACA CACAGGAAAA CGCCACCCGG GCACGAGCAG TAGACTCTCT GCTCAACTTT 
GAAACGGTGA AATACTATGG TGCCGAGGGT TATGAAGTAG ACCGCTATCG AGAGGCCATC 
CTCAAGTTTC AGGGTTTGGA GTGGAAGTCA ACCGCCTCAC TGGTTGTGCT GAATCAGACA 
CAGAACCTGG TGATCGGGCT TGGCCTCCTT GCTGGCTCCT TGCTTTGCGC ATACTTCGTC 
AGTGAGCAGA AGCTACAGGT TGGGGACTTT GTGCTTTTTG GCACTTACAT CACCCAACTG 
TACATGCCTC TCAACTGGTT TGGCACCTAC TACAGGATGA TCCAGACTAA CTTCATTGAC 
ATGGAGAACA TGTTTGACTT GCTGAAAGAG GAGACAGAAG TGAAGGATGT TCCTGGTGCA 
GGGCCCCTTC GTTTTCATAA GGGCCGGATT GAGTTTGAAA ATGTGCACTT CAGCTACGCT 
GATGGGCAGG AGACCTTACA AGATGTGTCC TTCACTGTGA TGCCTGGACA GACGGTGGCT 
CTGGTAGGTC CATCTGGGGC AGGAAAGAGC ACAATTTTGC GCCTGCTATT TCGCTTCTAT 
GACATCAGCT CTGGCTGCAT CCGAATAGAT GGACAGGATA TTTCACAGGT GACCCAGATC 
TCTCTCCGAT CTCACATTGG AGTTGTGCCC CAGGACACTG TCCTCTTCAA CGACACCATT 
GCTAACAATA TCCGCTATGG CCGTGTCACA GCTGGGGACA GTGAGGTAGA GGCTGCTGCT 
CAGGCTGCAG GCATTCATGA TGCCATCTTG TCTTTCCCTG AAGGGTATGA GACACAGGTC 
GGGGAGCGGG GTCTGAAGCT GAGTGGTGGC GAGAAGCAGC GAGTGGCCAT CGCCCGCACC 
ATCCTTAAGG CTCCTGACAT CATTCTGCTG GATGAGGCCA CATCAGCACT GGATACATCT 
AATGAGAGAG CCATCCAGGC CTCTCTGGCC AAAGTCTGCA CCAACCGCAC CACCATCGTC 
ATAGCACACA GGCTCTCAAC TGTGGTCAAT GCTGACCAGA TTCTGGTCAT CAAGGACGGT 
TGCATCATAG AGAGAGGAAG GCACGAAGCC CTGCTGTCCC GAGGTGGCGT TTATGCCGAG 
ATGTGGCAGC TGCAGCAGCA AGGACAAGAA ACTGTCCCTG AAGAATCTAA ACCTCAGGAC 
ACGGCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

NP_076221.1

Translation

MVTVGNYCETEGPAGPAWTQNGLSPCFFFTLVPSTLLTLGVLALVLVLPRRRREVPAGPEELSWAAGPRVAPYVLQLFLATLQMALPLAGLAGRVGTARGVRLPGYLLLASVLESLASVCGLWLLVVERSQARQSLAMGVWMKFRHSLGLLLLWTVTFAAENLALVSWNSPQWWWARADLGQQVQFGLWVLRYVTSGGLFILGLWAPGLRPQSYTLHVHEEDQDVGGNQGRSTDRRSTWRDLGRKLRLLSSYLWPRGSPSLQLIVLICLGLMGLERALNVLVPIFYRDIVNLLTAKAPWSSLAWTVTTYVFLKFLQGGGTGSTGFVSNLRTFLWIRVQQFTSRGVELRLFSHLHELSLRWHLGRRTGEVLRIVDRGTSSVTGLLSYLVFSIIPTLADIIIGIIYFSMFFNAWFGLIVFLCMSLYLILTIVVTEWRAKFRRDMNTQENATRARAVDSLLNFETVKYYGAEGYEVDRYREAILKFQGLEWKSTASLVVLNQTQNLVIGLGLLAGSLLCAYFVSEQKLQVGDFVLFGTYITQLYMPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDVPGAGPLRFHKGRIEFENVHFSYADGQETLQDVSFTVMPGQTVALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQISLRSHIGVVPQDTVLFNDTIANNIRYGRVTAGDSEVEAAAQAAGIHDAILSFPEGYETQVGERGLKLSGGEKQRVAIARTILKAPDIILLDEATSALDTSNERAIQASLAKVCTNRTTIVIAHRLSTVVNADQILVIKDGCIIERGRHEALLSRGGVYAEMWQLQQQGQETVPEESKPQDTA

Target ORF information:

RefSeq Version	NM_023732.2
Organism	Mus musculus(House mouse)
Definition	Mus musculus ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Abcb6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_023732.2

ORF Insert Sequence:

ATGGTGACTG TGGGCAACTA CTGCGAGACC GAAGGGCCGG CGGGGCCCGC TTGGACTCAG 
AATGGCTTGA GTCCCTGCTT CTTCTTCACG CTAGTGCCCT CGACACTCCT GACTCTGGGG 
GTACTGGCCT TGGTGCTGGT TCTTCCCCGC AGGCGTCGGG AGGTGCCTGC TGGCCCAGAA 
GAGCTGTCTT GGGCGGCTGG CCCTCGGGTG GCCCCATATG TGCTGCAGCT GTTTCTGGCC 
ACACTTCAGA TGGCACTGCC CCTGGCTGGT CTGGCTGGCC GAGTGGGCAC TGCTCGGGGG 
GTCCGTCTGC CAGGCTACCT ACTGCTGGCT TCTGTGCTGG AGAGTCTGGC CAGCGTCTGT 
GGCTTGTGGC TGCTCGTGGT GGAACGGAGC CAGGCACGGC AGAGTCTGGC AATGGGCGTC 
TGGATGAAGT TCAGGCATAG CTTGGGTCTC CTGCTCCTCT GGACTGTGAC ATTTGCAGCC 
GAGAACTTGG CCCTAGTATC TTGGAACAGC CCGCAGTGGT GGTGGGCCAG AGCAGATCTG 
GGCCAGCAGG TTCAATTTGG CCTGTGGGTC CTGCGTTATG TGACCTCTGG AGGGCTATTT 
ATCTTGGGGC TCTGGGCCCC AGGACTTCGC CCCCAGTCTT ATACTCTACA CGTTCATGAA 
GAAGACCAAG ATGTAGGAGG GAACCAGGGC CGCTCAACAG ACCGACGATC CACCTGGAGA 
GACCTTGGCC GGAAGCTTCG ACTGCTGAGT AGCTACTTGT GGCCTCGGGG AAGTCCATCA 
CTACAGCTGA TAGTGCTCAT ATGCCTGGGA CTCATGGGGT TGGAACGAGC ACTCAATGTG 
TTGGTCCCCA TCTTCTATAG GGACATTGTG AACTTACTGA CTGCGAAGGC TCCTTGGAGC 
TCCCTGGCCT GGACCGTTAC CACCTATGTC TTCCTCAAGT TCCTCCAGGG GGGTGGCACT 
GGCAGTACAG GTTTTGTGAG CAACCTGCGA ACCTTCCTAT GGATCCGGGT GCAGCAGTTT 
ACGTCCCGAG GTGTGGAGCT ACGTCTCTTC TCTCACCTGC ATGAACTCTC ACTGCGCTGG 
CACCTGGGCC GGCGTACCGG GGAGGTGCTT CGGATCGTGG ACCGGGGAAC ATCTAGTGTC 
ACAGGACTAC TCAGCTACCT GGTGTTCAGC ATCATCCCCA CCCTGGCTGA CATCATCATT 
GGCATCATCT ACTTCAGCAT GTTCTTCAAT GCCTGGTTTG GCCTCATCGT GTTCCTGTGC 
ATGAGTCTTT ACCTCATCCT GACTATCGTG GTCACCGAGT GGAGAGCCAA GTTTCGCCGT 
GATATGAACA CACAGGAAAA CGCCACCCGG GCACGAGCAG TAGACTCTCT GCTCAACTTT 
GAAACGGTGA AATACTATGG TGCCGAGGGT TATGAAGTAG ACCGCTATCG AGAGGCCATC 
CTCAAGTTTC AGGGTTTGGA GTGGAAGTCA ACCGCCTCAC TGGTTGTGCT GAATCAGACA 
CAGAACCTGG TGATCGGGCT TGGCCTCCTT GCTGGCTCCT TGCTTTGCGC ATACTTCGTC 
AGTGAGCAGA AGCTACAGGT TGGGGACTTT GTGCTTTTTG GCACTTACAT CACCCAACTG 
TACATGCCTC TCAACTGGTT TGGCACCTAC TACAGGATGA TCCAGACTAA CTTCATTGAC 
ATGGAGAACA TGTTTGACTT GCTGAAAGAG GAGACAGAAG TGAAGGATGT TCCTGGTGCA 
GGGCCCCTTC GTTTTCATAA GGGCCGGATT GAGTTTGAAA ATGTGCACTT CAGCTACGCT 
GATGGGCAGG AGACCTTACA AGATGTGTCC TTCACTGTGA TGCCTGGACA GACGGTGGCT 
CTGGTAGGTC CATCTGGGGC AGGAAAGAGC ACAATTTTGC GCCTGCTATT TCGCTTCTAT 
GACATCAGCT CTGGCTGCAT CCGAATAGAT GGACAGGATA TTTCACAGGT GACCCAGATC 
TCTCTCCGAT CTCACATTGG AGTTGTGCCC CAGGACACTG TCCTCTTCAA CGACACCATT 
GCTAACAATA TCCGCTATGG CCGTGTCACA GCTGGGGACA GTGAGGTAGA GGCTGCTGCT 
CAGGCTGCAG GCATTCATGA TGCCATCTTG TCTTTCCCTG AAGGGTATGA GACACAGGTC 
GGGGAGCGGG GTCTGAAGCT GAGTGGTGGC GAGAAGCAGC GAGTGGCCAT CGCCCGCACC 
ATCCTTAAGG CTCCTGACAT CATTCTGCTG GATGAGGCCA CATCAGCACT GGATACATCT 
AATGAGAGAG CCATCCAGGC CTCTCTGGCC AAAGTCTGCA CCAACCGCAC CACCATCGTC 
ATAGCACACA GGCTCTCAAC TGTGGTCAAT GCTGACCAGA TTCTGGTCAT CAAGGACGGT 
TGCATCATAG AGAGAGGAAG GCACGAAGCC CTGCTGTCCC GAGGTGGCGT TTATGCCGAG 
ATGTGGCAGC TGCAGCAGCA AGGACAAGAA ACTGTCCCTG AAGAATCTAA ACCTCAGGAC 
ACGGCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Abcb6 ( XM_006496552.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006496615.1 Mus musculus ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Abcb6), transcript variant X1, mRNA.

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CloneID	OMu27806
Clone ID Related Accession (Same CDS sequence)	XM_006496552.2 , XM_006496552.3
Accession Version	XM_006496552.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1665bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	ATP-binding cassette sub-family B member 6, mitochondrial isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006496552.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTGAACT TACTGACTGC GAAGGCTCCT TGGAGCTCCC TGGCCTGGAC CGTTACCACC 
TATGTCTTCC TCAAGTTCCT CCAGGGGGGT GGCACTGGCA GTACAGGTTT TGTGAGCAAC 
CTGCGAACCT TCCTATGGAT CCGGGTGCAG CAGTTTACGT CCCGAGGTGT GGAGCTACGT 
CTCTTCTCTC ACCTGCATGA ACTCTCACTG CGCTGGCACC TGGGCCGGCG TACCGGGGAG 
GTGCTTCGGA TCGTGGACCG GGGAACATCT AGTGTCACAG GACTACTCAG CTACCTGGTG 
TTCAGCATCA TCCCCACCCT GGCTGACATC ATCATTGGCA TCATCTACTT CAGCATGTTC 
TTCAATGCCT GGTTTGGCCT CATCGTGTTC CTGTGCATGA GTCTTTACCT CATCCTGACT 
ATCGTGGTCA CCGAGTGGAG AGCCAAGTTT CGCCGTGATA TGAACACACA GGAAAACGCC 
ACCCGGGCAC GAGCAGTAGA CTCTCTGCTC AACTTTGAAA CGGTGAAATA CTATGGTGCC 
GAGGGTTATG AAGTAGACCG CTATCGAGAG GCCATCCTCA AGTTTCAGGG TTTGGAGTGG 
AAGTCAACCG CCTCACTGGT TGTGCTGAAT CAGACACAGA ACCTGGTGAT CGGGCTTGGC 
CTCCTTGCTG GCTCCTTGCT TTGCGCATAC TTCGTCAGTG AGCAGAAGCT ACAGGTTGGG 
GACTTTGTGC TTTTTGGCAC TTACATCACC CAACTGTACA TGCCTCTCAA CTGGTTTGGC 
ACCTACTACA GGATGATCCA GACTAACTTC ATTGACATGG AGAACATGTT TGACTTGCTG 
AAAGAGGAGA CAGAAGTGAA GGATGTTCCT GGTGCAGGGC CCCTTCGTTT TCATAAGGGC 
CGGATTGAGT TTGAAAATGT GCACTTCAGC TACGCTGATG GGCAGGAGAC CTTACAAGAT 
GTGTCCTTCA CTGTGATGCC TGGACAGACG GTGGCTCTGG TAGGTCCATC TGGGGCAGGA 
AAGAGCACAA TTTTGCGCCT GCTATTTCGC TTCTATGACA TCAGCTCTGG CTGCATCCGA 
ATAGATGGAC AGGATATTTC ACAGGTGACC CAGATCTCTC TCCGATCTCA CATTGGAGTT 
GTGCCCCAGG ACACTGTCCT CTTCAACGAC ACCATTGCTA ACAATATCCG CTATGGCCGT 
GTCACAGCTG GGGACAGTGA GGTAGAGGCT GCTGCTCAGG CTGCAGGCAT TCATGATGCC 
ATCTTGTCTT TCCCTGAAGG GTATGAGACA CAGGTCGGGG AGCGGGGTCT GAAGCTGAGT 
GGTGGCGAGA AGCAGCGAGT GGCCATCGCC CGCACCATCC TTAAGGCTCC TGACATCATT 
CTGCTGGATG AGGCCACATC AGCACTGGAT ACATCTAATG AGAGAGCCAT CCAGGCCTCT 
CTGGCCAAAG TCTGCACCAA CCGCACCACC ATCGTCATAG CACACAGGCT CTCAACTGTG 
GTCAATGCTG ACCAGATTCT GGTCATCAAG GACGGTTGCA TCATAGAGAG AGGAAGGCAC 
GAAGCCCTGC TGTCCCGAGG TGGCGTTTAT GCCGAGATGT GGCAGCTGCA GCAGCAAGGA 
CAAGAAACTG TCCCTGAAGA ATCTAAACCT CAGGACACGG CATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006496615.1
CDS	995..2659
Translation	MLNLLTAKAPWSSLAWTVTTYVFLKFLQGGGTGSTGFVSNLRTFLWIRVQQFTSRGVELRLFSHLHELSLRWHLGRRTGEVLRIVDRGTSSVTGLLSYLVFSIIPTLADIIIGIIYFSMFFNAWFGLIVFLCMSLYLILTIVVTEWRAKFRRDMNTQENATRARAVDSLLNFETVKYYGAEGYEVDRYREAILKFQGLEWKSTASLVVLNQTQNLVIGLGLLAGSLLCAYFVSEQKLQVGDFVLFGTYITQLYMPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDVPGAGPLRFHKGRIEFENVHFSYADGQETLQDVSFTVMPGQTVALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQISLRSHIGVVPQDTVLFNDTIANNIRYGRVTAGDSEVEAAAQAAGIHDAILSFPEGYETQVGERGLKLSGGEKQRVAIARTILKAPDIILLDEATSALDTSNERAIQASLAKVCTNRTTIVIAHRLSTVVNADQILVIKDGCIIERGRHEALLSRGGVYAEMWQLQQQGQETVPEESKPQDTA

Target ORF information:

RefSeq Version	XM_006496552.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Abcb6), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006496552.3

ORF Insert Sequence:

ATGTTGAACT TACTGACTGC GAAGGCTCCT TGGAGCTCCC TGGCCTGGAC CGTTACCACC 
TATGTCTTCC TCAAGTTCCT CCAGGGGGGT GGCACTGGCA GTACAGGTTT TGTGAGCAAC 
CTGCGAACCT TCCTATGGAT CCGGGTGCAG CAGTTTACGT CCCGAGGTGT GGAGCTACGT 
CTCTTCTCTC ACCTGCATGA ACTCTCACTG CGCTGGCACC TGGGCCGGCG TACCGGGGAG 
GTGCTTCGGA TCGTGGACCG GGGAACATCT AGTGTCACAG GACTACTCAG CTACCTGGTG 
TTCAGCATCA TCCCCACCCT GGCTGACATC ATCATTGGCA TCATCTACTT CAGCATGTTC 
TTCAATGCCT GGTTTGGCCT CATCGTGTTC CTGTGCATGA GTCTTTACCT CATCCTGACT 
ATCGTGGTCA CCGAGTGGAG AGCCAAGTTT CGCCGTGATA TGAACACACA GGAAAACGCC 
ACCCGGGCAC GAGCAGTAGA CTCTCTGCTC AACTTTGAAA CGGTGAAATA CTATGGTGCC 
GAGGGTTATG AAGTAGACCG CTATCGAGAG GCCATCCTCA AGTTTCAGGG TTTGGAGTGG 
AAGTCAACCG CCTCACTGGT TGTGCTGAAT CAGACACAGA ACCTGGTGAT CGGGCTTGGC 
CTCCTTGCTG GCTCCTTGCT TTGCGCATAC TTCGTCAGTG AGCAGAAGCT ACAGGTTGGG 
GACTTTGTGC TTTTTGGCAC TTACATCACC CAACTGTACA TGCCTCTCAA CTGGTTTGGC 
ACCTACTACA GGATGATCCA GACTAACTTC ATTGACATGG AGAACATGTT TGACTTGCTG 
AAAGAGGAGA CAGAAGTGAA GGATGTTCCT GGTGCAGGGC CCCTTCGTTT TCATAAGGGC 
CGGATTGAGT TTGAAAATGT GCACTTCAGC TACGCTGATG GGCAGGAGAC CTTACAAGAT 
GTGTCCTTCA CTGTGATGCC TGGACAGACG GTGGCTCTGG TAGGTCCATC TGGGGCAGGA 
AAGAGCACAA TTTTGCGCCT GCTATTTCGC TTCTATGACA TCAGCTCTGG CTGCATCCGA 
ATAGATGGAC AGGATATTTC ACAGGTGACC CAGATCTCTC TCCGATCTCA CATTGGAGTT 
GTGCCCCAGG ACACTGTCCT CTTCAACGAC ACCATTGCTA ACAATATCCG CTATGGCCGT 
GTCACAGCTG GGGACAGTGA GGTAGAGGCT GCTGCTCAGG CTGCAGGCAT TCATGATGCC 
ATCTTGTCTT TCCCTGAAGG GTATGAGACA CAGGTCGGGG AGCGGGGTCT GAAGCTGAGT 
GGTGGCGAGA AGCAGCGAGT GGCCATCGCC CGCACCATCC TTAAGGCTCC TGACATCATT 
CTGCTGGATG AGGCCACATC AGCACTGGAT ACATCTAATG AGAGAGCCAT CCAGGCCTCT 
CTGGCCAAAG TCTGCACCAA CCGCACCACC ATCGTCATAG CACACAGGCT CTCAACTGTG 
GTCAATGCTG ACCAGATTCT GGTCATCAAG GACGGTTGCA TCATAGAGAG AGGAAGGCAC 
GAAGCCCTGC TGTCCCGAGG TGGCGTTTAT GCCGAGATGT GGCAGCTGCA GCAGCAAGGA 
CAAGAAACTG TCCCTGAAGA ATCTAAACCT CAGGACACGG CATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The severity of hereditary porphyria is modulated by the porphyrin exporter and Lan antigen ABCB6.
Nature communications712353(2016 Aug)
Fukuda Y,Cheong PL,Lynch J,Brighton C,Frase S,Kargas V,Rampersaud E,Wang Y,Sankaran VG,Yu B,Ney PA,Weiss MJ,Vogel P,Bond PJ,Ford RC,Trent RJ,Schuetz JD

Functional coupling of ATP-binding cassette transporter Abcb6 to cytochrome P450 expression and activity in liver.
The Journal of biological chemistry290(12)7871-86(2015 Mar)
Chavan H,Li F,Tessman R,Mickey K,Dorko K,Schmitt T,Kumer S,Gunewardena S,Gaikwad N,Krishnamurthy P

Deficiency of ATP-binding cassette transporter B6 in megakaryocyte progenitors accelerates atherosclerosis in mice.
Arteriosclerosis, thrombosis, and vascular biology34(4)751-8(2014 Apr)
Murphy AJ,Sarrazy V,Wang N,Bijl N,Abramowicz S,Westerterp M,Welch CB,Schuetz JD,Yvan-Charvet L

Mutations in ABCB6 cause dyschromatosis universalis hereditaria.
The Journal of investigative dermatology133(9)2221-8(2013 Sep)
Zhang C,Li D,Zhang J,Chen X,Huang M,Archacki S,Tian Y,Ren W,Mei A,Zhang Q,Fang M,Su Z,Yin Y,Liu D,Chen Y,Cui X,Li C,Yang H,Wang Q,Wang J,Liu M,Deng Y

Polycyclic aromatic hydrocarbons (PAHs) mediate transcriptional activation of the ATP binding cassette transporter ABCB6 gene via the aryl hydrocarbon receptor (AhR).
The Journal of biological chemistry287(38)32054-68(2012 Sep)
Chavan H,Krishnamurthy P

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Abcb6 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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