Ift57 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ift57
Entrez Gene ID	73916
Full Name	intraflagellar transport 57
Synonyms	4833420A15Rik,Esrrbl1,Hippi,MHS4R2
General protein information	Preferred Names intraflagellar transport 57 Names intraflagellar transport protein 57 homolog HIP1-interacting protein Vestrogen-related receptor beta like 1 estrogen-related receptor beta like 1 huntingtin-interacting protein-1 protein interactor intraflagellar transport 57 homolog
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 16 Map Location: 16\|16 B5

mRNA and Protein(s)

mRNA	Protein	Name
NM_028680.3	NP_082956.2	intraflagellar transport protein 57 homolog

Pathways from BioSystems

Homologies

	IFT57	XP_002802678.1
Bos taurus (cattle)	IFT57	NP_001098873.1
Mus musculus (house mouse)	Ift57	NP_082956.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008872	XP_319614.4
Homo sapiens (human)	IFT57	NP_060480.1
Danio rerio (zebrafish)	ift57	NP_001001832.1
Canis lupus familiaris (dog)	IFT57	XP_535730.3
Gallus gallus (chicken)	IFT57	XP_004938345.1
Pan troglodytes (chimpanzee)	IFT57	XP_003309965.1
Rattus norvegicus (Norway rat)	Ift57	NP_001100563.1
Drosophila melanogaster (fruit fly)	Che-13	NP_608792.1
Caenorhabditis elegans (roundworm)	che-13	NP_001251397.1
Xenopus tropicalis (tropical clawed frog)	ift57	NP_001016561.1

Gene Ontology
Bibliography

Related articles in PubMed

The intraflagellar transport protein IFT27 promotes BBSome exit from cilia through the GTPase ARL6/BBS3.
Liew GM, Ye F, Nager AR, Murphy JP, Lee JS, Aguiar M, Breslow DK, Gygi SP, Nachury MV
Developmental cell31(3)265-78(2014 Nov)

TTC26/DYF13 is an intraflagellar transport protein required for transport of motility-related proteins into flagella.
Ishikawa H, Ide T, Yagi T, Jiang X, Hirono M, Sasaki H, Yanagisawa H, Wemmer KA, Stainier DY, Qin H, Kamiya R, Marshall WF
eLife3e01566(2014 Jan)

Centrosomal protein DZIP1 regulates Hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesis.
Wang C, Low WC, Liu A, Wang B
The Journal of biological chemistry288(41)29518-29(2013 Oct)

Interaction of mouse TTC30/DYF-1 with multiple intraflagellar transport complex B proteins and KIF17.
Howard PW, Jue SF, Maurer RA
Experimental cell research319(14)2275-81(2013 Aug)

The BBSome controls IFT assembly and turnaround in cilia.
Wei Q, Zhang Y, Li Y, Zhang Q, Ling K, Hu J
Nature cell biology14(9)950-7(2012 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

novel transcription regulatory mechanism of REST by HIPPI may contribute to the deregulation of transcription observed in the cell model of Huntington disease.
Title: Regulation of RE1 protein silencing transcription factor (REST) expression by HIP1 protein interactor (HIPPI).

These findings suggest that Rybp and Hippi may functionally interact in the apoptotic processes that accompany normal murine neural development.
Title: Rybp interacts with Hippi and enhances Hippi-mediated apoptosis.

Sonic hedgehog (Shh) pathway is downregulated in the neural tube in the absence of Hippi, which results in failure to establish ventral neural cell fate.
Title: Hippi is essential for node cilia assembly and Sonic hedgehog signaling.

Hip-1 and Hippi cooperate to induce neuronal apoptosis in a caspase-8-dependent manner.
Title: Hip, hip, hippi!

Results show that pro-apoptotic Hippi-Hip-1 heterodimers can recruit procaspase-8 into a complex of Hippi, Hip-1 and procaspase-8, and launch apoptosis through components of the 'extrinsic' cell-death pathway.
Title: Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi.

The following Ift57 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ift57 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu05954	NM_028680.3 Latest version!	Mus musculus intraflagellar transport 57 (Ift57), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ift57 ( NM_028680.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_082956.2 Mus musculus intraflagellar transport 57 (Ift57), mRNA.

Price & Availability↑

CloneID	OMu05954
Clone ID Related Accession (Same CDS sequence)	NM_028680.3
Accession Version	NM_028680.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1290bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	intraflagellar transport protein 57 homolog
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AK047217.1. On Apr 6, 2007 this sequence version replaced NM_028680.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK047217.1, BC138143.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849381 [ECO:0000348] ##Evidence-Data-END##

ATGGCCGCCG CGGCCGCGGT GATCCCGCCG TCGGGCTTGG ACGATGGGGT GTCTCGGGCT 
CGCGGGGAAG GCGCAGGGGA GGCTGTGGTG GAGCGCGGGC CAGGAGCGGC CTACCACATG 
TTCGTGGTGA TGGAAGACTT AGTGGAGAAG CTGAAGCTGC TCCGCTACGA GGAGGAGCTA 
CTCCGAAAGA GCAATCTGAA GCCCCCGTCC AGACACTACT TTGCTCTGCC TACCAACCCA 
GGCGAGCAGT TCTACATGTT TTGCACTCTT GCTGCGTGGC TGATCAACAA AACTGGCCGT 
GCCTTTGAGC AGCCTCAAGA ATACGACGAT CCCAATGCAA CTATATCTAA TATACTCTCT 
GAGCTTCGCT CTTTTGGGAG AACTGCAGAT TTTCCTCCTT CAAAATTAAA GTCTGGTTAC 
GGAGAACAAG TGTGCTATGT TCTTGATTGC TTAGCTGAAG AAGCTTTAAA ATATATTGGT 
TTCACTTGGA AAAGGCCATC ATACCCAGTG GAAGAACTAG AAGAAGAAAC TGTTCCAGAA 
GATGATGCCG AGTTAACATT AAGTAAAGTG GATGAAGAAT TTGTGGAAGA GGAGACAGAT 
AATGAAGAAA ACTTTATTGA TCTCAACGTT TTAAAGGCCC AGACCTATCG CTTGGACACA 
AACGAGTCTG CCAAACAAGA AGATATTTTG GAATCTACGA CAGATGCTGC GGAATGGAGC 
CTAGAAGTTG AGCGTGTACT ACCGCAGCTG AAAGTCACGA TTAGGACTGA CAATAAGGAT 
TGGAGGATCC ATGTTGACCA AATGCACCAG CACAAAAGTG GGATTGAATC TGCTCTGAAG 
GAGACCAAGG GGTTTTTGGA CAAGCTCCAT AATGAAATTA GCAGGACTCT GGAAAAGATT 
GGCAGCCGAG AAAAGTACAT TAACAATCAA CTTGAGCACT TGGTTCAAGA ATATCGTGGG 
GCCCAAGCCC AGCTAAGTGA GGCAAGGGAG CGCTACCAGC AGGGCAATGG CGGAGTAACT 
GAACGGACCA GACTCCTCTC TGAGGTTACA GAAGAATTAG AAAAGGTAAA GCAAGAAATG 
GAAGAGAAGG GCAGCAGCAT GACGGACGGC ACTCCTTTGG TGAAGATTAA GCAGAGCTTA 
ACCAAGCTGA AGCAAGAAAC TGTTCAGATG GACATTAGAA TCGGTGTGGT GGAGCACACG 
CTACTTCAGT CAAAACTCAA GGAGAAGTGC AACATGACCA GGGACATGCA TGCAGCTGTC 
ACCCCAGAGT CAGCAATTGG CTTCTATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_082956.2
CDS	45..1334
Translation	MAAAAAVIPPSGLDDGVSRARGEGAGEAVVERGPGAAYHMFVVMEDLVEKLKLLRYEEELLRKSNLKPPSRHYFALPTNPGEQFYMFCTLAAWLINKTGRAFEQPQEYDDPNATISNILSELRSFGRTADFPPSKLKSGYGEQVCYVLDCLAEEALKYIGFTWKRPSYPVEELEEETVPEDDAELTLSKVDEEFVEEETDNEENFIDLNVLKAQTYRLDTNESAKQEDILESTTDAAEWSLEVERVLPQLKVTIRTDNKDWRIHVDQMHQHKSGIESALKETKGFLDKLHNEISRTLEKIGSREKYINNQLEHLVQEYRGAQAQLSEARERYQQGNGGVTERTRLLSEVTEELEKVKQEMEEKGSSMTDGTPLVKIKQSLTKLKQETVQMDIRIGVVEHTLLQSKLKEKCNMTRDMHAAVTPESAIGFY

Target ORF information:

RefSeq Version	NM_028680.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus intraflagellar transport 57 (Ift57), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_028680.3

ORF Insert Sequence:

ATGGCCGCCG CGGCCGCGGT GATCCCGCCG TCGGGCTTGG ACGATGGGGT GTCTCGGGCT 
CGCGGGGAAG GCGCAGGGGA GGCTGTGGTG GAGCGCGGGC CAGGAGCGGC CTACCACATG 
TTCGTGGTGA TGGAAGACTT AGTGGAGAAG CTGAAGCTGC TCCGCTACGA GGAGGAGCTA 
CTCCGAAAGA GCAATCTGAA GCCCCCGTCC AGACACTACT TTGCTCTGCC TACCAACCCA 
GGCGAGCAGT TCTACATGTT TTGCACTCTT GCTGCGTGGC TGATCAACAA AACTGGCCGT 
GCCTTTGAGC AGCCTCAAGA ATACGACGAT CCCAATGCAA CTATATCTAA TATACTCTCT 
GAGCTTCGCT CTTTTGGGAG AACTGCAGAT TTTCCTCCTT CAAAATTAAA GTCTGGTTAC 
GGAGAACAAG TGTGCTATGT TCTTGATTGC TTAGCTGAAG AAGCTTTAAA ATATATTGGT 
TTCACTTGGA AAAGGCCATC ATACCCAGTG GAAGAACTAG AAGAAGAAAC TGTTCCAGAA 
GATGATGCCG AGTTAACATT AAGTAAAGTG GATGAAGAAT TTGTGGAAGA GGAGACAGAT 
AATGAAGAAA ACTTTATTGA TCTCAACGTT TTAAAGGCCC AGACCTATCG CTTGGACACA 
AACGAGTCTG CCAAACAAGA AGATATTTTG GAATCTACGA CAGATGCTGC GGAATGGAGC 
CTAGAAGTTG AGCGTGTACT ACCGCAGCTG AAAGTCACGA TTAGGACTGA CAATAAGGAT 
TGGAGGATCC ATGTTGACCA AATGCACCAG CACAAAAGTG GGATTGAATC TGCTCTGAAG 
GAGACCAAGG GGTTTTTGGA CAAGCTCCAT AATGAAATTA GCAGGACTCT GGAAAAGATT 
GGCAGCCGAG AAAAGTACAT TAACAATCAA CTTGAGCACT TGGTTCAAGA ATATCGTGGG 
GCCCAAGCCC AGCTAAGTGA GGCAAGGGAG CGCTACCAGC AGGGCAATGG CGGAGTAACT 
GAACGGACCA GACTCCTCTC TGAGGTTACA GAAGAATTAG AAAAGGTAAA GCAAGAAATG 
GAAGAGAAGG GCAGCAGCAT GACGGACGGC ACTCCTTTGG TGAAGATTAA GCAGAGCTTA 
ACCAAGCTGA AGCAAGAAAC TGTTCAGATG GACATTAGAA TCGGTGTGGT GGAGCACACG 
CTACTTCAGT CAAAACTCAA GGAGAAGTGC AACATGACCA GGGACATGCA TGCAGCTGTC 
ACCCCAGAGT CAGCAATTGG CTTCTATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The intraflagellar transport protein IFT27 promotes BBSome exit from cilia through the GTPase ARL6/BBS3.
Developmental cell31(3)265-78(2014 Nov)
Liew GM,Ye F,Nager AR,Murphy JP,Lee JS,Aguiar M,Breslow DK,Gygi SP,Nachury MV

TTC26/DYF13 is an intraflagellar transport protein required for transport of motility-related proteins into flagella.
eLife3e01566(2014 Jan)
Ishikawa H,Ide T,Yagi T,Jiang X,Hirono M,Sasaki H,Yanagisawa H,Wemmer KA,Stainier DY,Qin H,Kamiya R,Marshall WF

Centrosomal protein DZIP1 regulates Hedgehog signaling by promoting cytoplasmic retention of transcription factor GLI3 and affecting ciliogenesis.
The Journal of biological chemistry288(41)29518-29(2013 Oct)
Wang C,Low WC,Liu A,Wang B

Interaction of mouse TTC30/DYF-1 with multiple intraflagellar transport complex B proteins and KIF17.
Experimental cell research319(14)2275-81(2013 Aug)
Howard PW,Jue SF,Maurer RA

The BBSome controls IFT assembly and turnaround in cilia.
Nature cell biology14(9)950-7(2012 Sep)
Wei Q,Zhang Y,Li Y,Zhang Q,Ling K,Hu J

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Ift57 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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