Psmb11 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Psmb11
Entrez Gene ID	73902
Full Name	proteasome (prosome, macropain) subunit, beta type, 11
Synonyms	5830406J20Rik,beta5t
General protein information	Preferred Names proteasome (prosome, macropain) subunit, beta type, 11 Names proteasome subunit beta type-11 proteasome beta 11 subunit proteasome subunit beta-5t proteasome subunit beta5t
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 14 Map Location: 14\|14 C2

mRNA and Protein(s)

mRNA	Protein	Name
NM_175204.4	NP_780413.1	proteasome subunit beta type-11

Pathways from BioSystems

Homologies

	PSMB11	XP_002805028.1
Bos taurus (cattle)	PSMB11	NP_001092856.1
Mus musculus (house mouse)	Psmb11	NP_780413.1
Danio rerio (zebrafish)	psmb11b	XP_002667581.3
Pan troglodytes (chimpanzee)	PSMB11	XP_522799.2
Rattus norvegicus (Norway rat)	Psmb11	NP_001099502.1
Danio rerio (zebrafish)	si:ch211-14a17.13	NP_001007179.1
Homo sapiens (human)	PSMB11	NP_001093250.1
Canis lupus familiaris (dog)	PSMB11	XP_003639262.1
Xenopus tropicalis (tropical clawed frog)	psmb11	XP_002941563.1

Gene Ontology
Bibliography

Related articles in PubMed

A human PSMB11 variant affects thymoproteasome processing and CD8+ T cell production.
Ohigashi I, Ohte Y, Setoh K, Nakase H, Maekawa A, Kiyonari H, Hamazaki Y, Sekai M, Sudo T, Tabara Y, Sawai H, Omae Y, Yuliwulandari R, Tanaka Y, Mizokami M, Inoue H, Kasahara M, Minato N, Tokunaga K, Tanaka K, Matsuda F, Murata S, Takahama Y
JCI insight2(10)(2017 May)

Foxn1-?5t transcriptional axis controls CD8
Uddin MM, Ohigashi I, Motosugi R, Nakayama T, Sakata M, Hamazaki J, Nishito Y, Rode I, Tanaka K, Takemoto T, Murata S, Takahama Y
Nature communications814419(2017 Feb)

Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence.
Nowell CS, Bredenkamp N, Tet?lin S, Jin X, Tischner C, Vaidya H, Sheridan JM, Stenhouse FH, Heussen R, Smith AJ, Blackburn CC
PLoS genetics7(11)e1002348(2011 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

beta5t-containing thymoproteasomes contribute to the positive selection of CD8+ T cells by preferentially producing low-affinity TCR ligand peptides.
Title: Thymoproteasomes produce unique peptide motifs for positive selection of CD8(+) T cells.

The current data showed that impaired proteasomal function causes photoreceptor degeneration.
Title: Decreased proteasomal activity causes photoreceptor degeneration in mice.

Results indicate that the majority of thymic medullary epithelial cells (mTECs) are derived from beta5t-expressing progenitor cells.
Title: Aire-expressing thymic medullary epithelial cells originate from ?5t-expressing progenitor cells.

Thymoproteasome subunit-beta5T generates peptide-MHC complexes specialized for positive selection.
Title: Thymoproteasome subunit-?5T generates peptide-MHC complexes specialized for positive selection.

results indicate that beta5t expression in thymic cortical epithelial cells is dependent on Foxn1 but independent of thymocyte crosstalk or thymic medulla formation
Title: Ontogeny of thymic cortical epithelial cells expressing the thymoproteasome subunit ?5t.

The following Psmb11 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Psmb11 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu58562	NM_175204.4 Latest version!	Mus musculus proteasome (prosome, macropain) subunit, beta type, 11 (Psmb11), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Psmb11 ( NM_175204.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_780413.1 Mus musculus proteasome (prosome, macropain) subunit, beta type, 11 (Psmb11), mRNA.

Price & Availability↑

CloneID	OMu58562
Clone ID Related Accession (Same CDS sequence)	NM_175204.4
Accession Version	NM_175204.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 909bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	proteasome subunit beta type-11
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK162727.1 and CT009512.6. On Sep 12, 2009 this sequence version replaced NM_175204.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AK162727.1 [ECO:0000345] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTCTTC AGGATGTGTG CAAGTGGCAG ACTCCCGACA CTCCCAGACC ATCCATTCAC 
TTGCCTCAGG CCGGTGGCTG GGCTGTACCC CGGGGCTGTG ACCCTCAAAC CTTCCTGCAG 
ATCCATGGCC CCAGGCTGGC TCATGGCACC ACTACCCTGG CTTTTCGCTT TCGTCACGGT 
GTCATCGCTG CGGCTGATAC TCGGTCCTCC TGTGGCAGCT ATGTGGCATG TCCAGCCTCA 
CGGAAGGTCA TTCCTGTGCA CCAGCGTCTC CTGGGTACCA CCTCTGGGAC CTCTGCTGAC 
TGTGCCACAT GGTACCGGGT GCTACGGCGG GAGCTGCGGC TTCGGGAACT GAGGGAAGGC 
CAGCTGCCCA GTGTGGCAGG CACGGCCAAA CTCTTGGCAG CTATGATGTC CTGCTACCGC 
GGTCTGGATC TGTGTGTGGC CACTGCCCTC TGTGGCTGGG ACCACTCTGG CCCTGCTCTC 
TTCTATGTCT ACAGCGATGG CACTTGTCTG CAGGGAGATA TCTTCTCAGT AGGCTCTGGG 
TCTCCCTACG CCTATGGTGT GCTTGATCGT GGCTACCACT ATGACATGAC CATCCAGGAA 
GCCTACACCC TGGCCCGCTG TGCTGTGGCC CATGCCACCC ACCGTGATGC TTATTCAGGG 
GGCTCAGTGG ACCTCTTCCA CGTTCGGGAG AGCGGATGGG AGTATGTATC CCGCAGTGAT 
GCTTGCGTGC TGTATAGGGA GCTGCAGAAA GCCCGGAGCT TGGAGCAGGA GCTGGAGGCA 
AAAGCTTGTG GAATCTATCC TGAGCCTGCC ACGCCGCAAG GTGCTCGAGA ATGTAAAGAA 
CTCTTTGTGG AGCAAGAGGA GGTGACGCCA GAAGACTGCG CGATAATAAT GAAGACTGAA 
ACAATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_780413.1
CDS	18..926
Translation	MALQDVCKWQTPDTPRPSIHLPQAGGWAVPRGCDPQTFLQIHGPRLAHGTTTLAFRFRHGVIAAADTRSSCGSYVACPASRKVIPVHQRLLGTTSGTSADCATWYRVLRRELRLRELREGQLPSVAGTAKLLAAMMSCYRGLDLCVATALCGWDHSGPALFYVYSDGTCLQGDIFSVGSGSPYAYGVLDRGYHYDMTIQEAYTLARCAVAHATHRDAYSGGSVDLFHVRESGWEYVSRSDACVLYRELQKARSLEQELEAKACGIYPEPATPQGARECKELFVEQEEVTPEDCAIIMKTETM

Target ORF information:

RefSeq Version	NM_175204.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus proteasome (prosome, macropain) subunit, beta type, 11 (Psmb11), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_175204.4

ORF Insert Sequence:

ATGGCTCTTC AGGATGTGTG CAAGTGGCAG ACTCCCGACA CTCCCAGACC ATCCATTCAC 
TTGCCTCAGG CCGGTGGCTG GGCTGTACCC CGGGGCTGTG ACCCTCAAAC CTTCCTGCAG 
ATCCATGGCC CCAGGCTGGC TCATGGCACC ACTACCCTGG CTTTTCGCTT TCGTCACGGT 
GTCATCGCTG CGGCTGATAC TCGGTCCTCC TGTGGCAGCT ATGTGGCATG TCCAGCCTCA 
CGGAAGGTCA TTCCTGTGCA CCAGCGTCTC CTGGGTACCA CCTCTGGGAC CTCTGCTGAC 
TGTGCCACAT GGTACCGGGT GCTACGGCGG GAGCTGCGGC TTCGGGAACT GAGGGAAGGC 
CAGCTGCCCA GTGTGGCAGG CACGGCCAAA CTCTTGGCAG CTATGATGTC CTGCTACCGC 
GGTCTGGATC TGTGTGTGGC CACTGCCCTC TGTGGCTGGG ACCACTCTGG CCCTGCTCTC 
TTCTATGTCT ACAGCGATGG CACTTGTCTG CAGGGAGATA TCTTCTCAGT AGGCTCTGGG 
TCTCCCTACG CCTATGGTGT GCTTGATCGT GGCTACCACT ATGACATGAC CATCCAGGAA 
GCCTACACCC TGGCCCGCTG TGCTGTGGCC CATGCCACCC ACCGTGATGC TTATTCAGGG 
GGCTCAGTGG ACCTCTTCCA CGTTCGGGAG AGCGGATGGG AGTATGTATC CCGCAGTGAT 
GCTTGCGTGC TGTATAGGGA GCTGCAGAAA GCCCGGAGCT TGGAGCAGGA GCTGGAGGCA 
AAAGCTTGTG GAATCTATCC TGAGCCTGCC ACGCCGCAAG GTGCTCGAGA ATGTAAAGAA 
CTCTTTGTGG AGCAAGAGGA GGTGACGCCA GAAGACTGCG CGATAATAAT GAAGACTGAA 
ACAATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A human PSMB11 variant affects thymoproteasome processing and CD8+ T cell production.
JCI insight2(10)(2017 May)
Ohigashi I,Ohte Y,Setoh K,Nakase H,Maekawa A,Kiyonari H,Hamazaki Y,Sekai M,Sudo T,Tabara Y,Sawai H,Omae Y,Yuliwulandari R,Tanaka Y,Mizokami M,Inoue H,Kasahara M,Minato N,Tokunaga K,Tanaka K,Matsuda F,Murata S,Takahama Y

Foxn1-?5t transcriptional axis controls CD8
Nature communications814419(2017 Feb)
Uddin MM,Ohigashi I,Motosugi R,Nakayama T,Sakata M,Hamazaki J,Nishito Y,Rode I,Tanaka K,Takemoto T,Murata S,Takahama Y

Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence.
PLoS genetics7(11)e1002348(2011 Nov)
Nowell CS,Bredenkamp N,Tet?lin S,Jin X,Tischner C,Vaidya H,Sheridan JM,Stenhouse FH,Heussen R,Smith AJ,Blackburn CC

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Psmb11 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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