Bmper cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Bmper
Entrez Gene ID	73230
Full Name	BMP-binding endothelial regulator
Synonyms	3110056H04Rik,CV-2,Crim3,Cv2
General protein information	Preferred Names BMP-binding endothelial regulator Names BMP-binding endothelial regulator protein bone morphogenetic protein-binding endothelial cell precursor-derived regulator crossveinless-2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9\|9 A3
Summary	This gene encodes a secreted protein that contains five Von Willebrand factor type C domains and a Von Willebrand factor type D domain and a trypsin inhibitory-like domain. The encoded protein binds to bone morphogenetic proteins (BMP) and regulates their activity. Mutation of the related gene in humans causes diaphanospondylodysostosis. [provided by RefSeq, Mar 2013].

mRNA and Protein(s)

mRNA	Protein	Name
NM_028472.2	NP_082748.1	BMP-binding endothelial regulator protein precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	BMPER	XP_519036.3
Mus musculus (house mouse)	Bmper	NP_082748.1
Danio rerio (zebrafish)	bmper	NP_001018323.1
Rattus norvegicus (Norway rat)	Bmper	NP_001129271.1
Drosophila melanogaster (fruit fly)	cv-2	NP_524809.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006168	XP_316228.4
Homo sapiens (human)	BMPER	NP_597725.1
	BMPER	XP_001105988.1
Gallus gallus (chicken)	BMPER	NP_001007081.1
Canis lupus familiaris (dog)	BMPER	XP_532513.2
Bos taurus (cattle)	BMPER	NP_001071465.1
Xenopus tropicalis (tropical clawed frog)	bmper	NP_001037867.1

Gene Ontology
Bibliography

Related articles in PubMed

A molecular roadmap of the AGM region reveals BMPER as a novel regulator of HSC maturation.
McGarvey AC, Rybtsov S, Souilhol C, Tamagno S, Rice R, Hills D, Godwin D, Rice D, Tomlinson SR, Medvinsky A
The Journal of experimental medicine214(12)3731-3751(2017 Dec)

Delayed Hair Follicle Morphogenesis and Hair Follicle Dystrophy in a Lipoatrophy Mouse Model of Pparg Total Deletion.
Sardella C, Winkler C, Quignodon L, Hardman JA, Toffoli B, Giordano Attianese GMP, Hundt JE, Michalik L, Vinson CR, Paus R, Desvergne B, Gilardi F
The Journal of investigative dermatology(2017 Sep)

von Willebrand factor type C domain-containing proteins regulate bone morphogenetic protein signaling through different recognition mechanisms.
Zhang JL, Huang Y, Qiu LY, Nickel J, Sebald W
The Journal of biological chemistry282(27)20002-14(2007 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CV2 binds directly to BMP10, as determined by co-immunoprecipitation, and inhibits BMP10 from initiating SMAD signaling, as determined by luciferase reporter gene assays. BMP10 and CV2 have important roles in coordinating cardiomyogenesis in progenitor cells.
Title: Combined effects of bone morphogenetic protein 10 and crossveinless-2 on cardiomyocyte differentiation in mouse adipocyte-derived stem cells.

BMPER contributes to the precise control of BMP activity within the aorta-gonad-mesonephros region, enabling the maturation of hematopoietic stem cells within a BMP-negative environment.
Title: A molecular roadmap of the AGM region reveals BMPER as a novel regulator of HSC maturation.

BMPER/low-density lipoprotein receptor-related protein 1 axis plays a pivotal role in pulmonary inflammatory response.
Title: LRP1-Dependent BMPER Signaling Regulates Lipopolysaccharide-Induced Vascular Inflammation.

The proangiogenic BMPER effect in endothelial cells is mediated by inhibition of antiangiogenic thrombospondin-1 and enhanced expression and activation of the FGF signaling pathway that is crucial in the promotion of angiogenesis.
Title: Fibroblast growth factor signaling pathway in endothelial cells is activated by BMPER to promote angiogenesis.

BMPER-induced BMP signaling promotes coronary artery remodeling.
Title: BMPER-induced BMP signaling promotes coronary artery remodeling.

The following Bmper gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Bmper cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu16382	NM_028472.2 Latest version!	Mus musculus BMP-binding endothelial regulator (Bmper), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Bmper ( NM_028472.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_082748.1 Mus musculus BMP-binding endothelial regulator (Bmper), mRNA.

Price & Availability↑

CloneID	OMu16382
Clone ID Related Accession (Same CDS sequence)	NM_028472.2
Accession Version	NM_028472.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2058bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-11
Organism	Mus musculus(house mouse)
Product	BMP-binding endothelial regulator protein precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF454954.1 and AC154737.3. On Mar 21, 2013 this sequence version replaced NM_028472.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF454954.1, AY263358.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTCTGGT TCTTCAGCGT CAGGGCTCTG GCTGAGCGTC CTTGCCGACG CTCGCCTGGG 
ATTACCTGCT GCGTCTTGCT GCTGCTCAAT TGCTCCGGGG TCCCCATGTC TCTGGCTTCC 
TCCTTCCTGA CAGGGTCTGT TGCAAAATGT GAAAATGAAG GGGAGGTCCT CCAAATTCCA 
TTTATCACAG ACAACCCTTG CATAATGTGT GTGTGTTTGA ACAAAGAGGT GACTTGTAAG 
AGGGAGAAGT GCCCTGTGCT GTCACGGGAC TGTGCGCTGG CCATCAAGCA GAGAGGCGCC 
TGCTGTGAAC GATGCAAAGG TTGTACCCAT GAAGGAAGAA CCTACAACAG TTCCTTCAAG 
TGGCAAACCC CGGCTGAGCC ATGTGTCCTT CGGCAGTGCC AGGAGGGTGT GGTGACAGAG 
TCTGAGGTGC GCTGTGTTGT TCATTGTAAA AATCCCGCAG AGCATCAAGG AGCCTGCTGC 
CCTACCTGCC CAGGCTGTGT GTTTGAAGGT GTGCAATACC GGGAAGGAGA AGAATTTCAG 
CCAGAAGGAA ACAAATGTAT TACATGCTCC TGCGTTGGAG GCAGGACACA GTGCGTGAGA 
GAAGTCTGTC CCATTCTCTC TTGTCCCCAG CACCTTAGTC ACACACCCTC AGGACAGTGC 
TGCCCCAAAT GTTTGGGTCA GAGAAAAGTA TTCGACCTTC CCTTTGGGAG CTGCCTGTTT 
CGCAGTGATG TTTATGACAA TGGAGCCTCA TTTGTCTATG ATAACTGCAC AGTATGCACT 
TGCAAGGACT CAACAATGGT TTGTAAGAAG AAGTGCTCCC ACCCTGGTGT CTGTAACAGT 
GATGAGGATG CCTGTTGTGA AGACTGTCTC TTACGGGTGC CCCCTGAAGA CATCAAAGTG 
TGCAAGTTCG GTAGCAAGAT TTTCAGGGAT GGAGAGATGT GGTCCTCAGT CAACTGCAGC 
ATCTGTGCTT GTGTGAAGGG GAAGACAGAG TGTCGAAAGA AGCAGTGTGT TCCTGTCAGC 
AGCTGCCCAC AGGGTAAAAT TCTCAACAGG AAAGGATGCT GTCCTATCTG CACTGAAAAA 
CCTGGTGTGT GCACAGTATT CGGAGATCCC CACTACAACA CTTTTGATGG GCGGACATTT 
AACTTTCAGG GGACGTGTCA GTATGTTTTG ACAAAAGACT GCTCCTCCCC AGCCTCACCC 
TTCCAGGTGC TGGTGAAGAA TGATGCACGG AGGACCCGTT CCTTCTCCTG GACCAAGTCT 
GTGGAGCTGA TGCTGGGCGA AAGCACAGTC AGCCTGCAGC AGCACCTCAC TGTGCGCTGG 
AATGGCTCTC GCATTGCCCT TCCCTGCCAC ACACCCCACT TCCACATCGA CCTGGACGGC 
TACCTTTTGA AAGTGACTAC CAGAGCAGGT TTGGAGATAT CGTGGGATGG AGACAGTTTT 
GTGGAGGTCA TGGCTGCCCC TCATCTCAAG GGCAAGCTCT GTGGTCTTTG TGGCAACTAC 
AATGGTCATA AACGTGATGA CTTGATTGGT GGAGATGGGA ACTTCAAGTT TGACGTGGAT 
GACTTTGCTG AATCGTGGAG GGTGGAATCC AACGAATTCT GCAACCGACC ACAGAGAAAA 
CCAGTACCTG AGCTCTGTCA AGGCACAGTG AAGGTGAAGC TTCGAGCCCA TCGAGAATGC 
CAGAAACTCA AGTCCTGGGA GTTCCAGACC TGCCACTCTA CAGTGGACTA TACCACTTTC 
TACCGGTCCT GTGTAACAGA CATGTGTGAA TGTCCAGTCC ATAAAAACTG TTACTGTGAG 
TCATTTCTGG CGTATACCCG TGCCTGTCAG AGAGAGGGAA TCAAAGTGCA CTGGGAACCT 
CAGCAGAGCT GTGCAGCCAC CCAGTGCAAA CATGGTGCTG TGTATGATAC CTGTGGCCCA 
GGATGTGTGA AGACATGTGA TAACTGGAAT GAGATCGGCC CATGCAATAA GCCCTGCATT 
GCAGGTTGCC ACTGCCCAGC AAATCTGGTC CTTCATAAGG GAAGGTGCAT CAAGCCAGTC 
CTCTGTCCTC AGCGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_082748.1
CDS	566..2623
Translation	MLWFFSVRALAERPCRRSPGITCCVLLLLNCSGVPMSLASSFLTGSVAKCENEGEVLQIPFITDNPCIMCVCLNKEVTCKREKCPVLSRDCALAIKQRGACCERCKGCTHEGRTYNSSFKWQTPAEPCVLRQCQEGVVTESEVRCVVHCKNPAEHQGACCPTCPGCVFEGVQYREGEEFQPEGNKCITCSCVGGRTQCVREVCPILSCPQHLSHTPSGQCCPKCLGQRKVFDLPFGSCLFRSDVYDNGASFVYDNCTVCTCKDSTMVCKKKCSHPGVCNSDEDACCEDCLLRVPPEDIKVCKFGSKIFRDGEMWSSVNCSICACVKGKTECRKKQCVPVSSCPQGKILNRKGCCPICTEKPGVCTVFGDPHYNTFDGRTFNFQGTCQYVLTKDCSSPASPFQVLVKNDARRTRSFSWTKSVELMLGESTVSLQQHLTVRWNGSRIALPCHTPHFHIDLDGYLLKVTTRAGLEISWDGDSFVEVMAAPHLKGKLCGLCGNYNGHKRDDLIGGDGNFKFDVDDFAESWRVESNEFCNRPQRKPVPELCQGTVKVKLRAHRECQKLKSWEFQTCHSTVDYTTFYRSCVTDMCECPVHKNCYCESFLAYTRACQREGIKVHWEPQQSCAATQCKHGAVYDTCGPGCVKTCDNWNEIGPCNKPCIAGCHCPANLVLHKGRCIKPVLCPQR

Target ORF information:

RefSeq Version	NM_028472.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus BMP-binding endothelial regulator (Bmper), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_028472.2

ORF Insert Sequence:

ATGCTCTGGT TCTTCAGCGT CAGGGCTCTG GCTGAGCGTC CTTGCCGACG CTCGCCTGGG 
ATTACCTGCT GCGTCTTGCT GCTGCTCAAT TGCTCCGGGG TCCCCATGTC TCTGGCTTCC 
TCCTTCCTGA CAGGGTCTGT TGCAAAATGT GAAAATGAAG GGGAGGTCCT CCAAATTCCA 
TTTATCACAG ACAACCCTTG CATAATGTGT GTGTGTTTGA ACAAAGAGGT GACTTGTAAG 
AGGGAGAAGT GCCCTGTGCT GTCACGGGAC TGTGCGCTGG CCATCAAGCA GAGAGGCGCC 
TGCTGTGAAC GATGCAAAGG TTGTACCCAT GAAGGAAGAA CCTACAACAG TTCCTTCAAG 
TGGCAAACCC CGGCTGAGCC ATGTGTCCTT CGGCAGTGCC AGGAGGGTGT GGTGACAGAG 
TCTGAGGTGC GCTGTGTTGT TCATTGTAAA AATCCCGCAG AGCATCAAGG AGCCTGCTGC 
CCTACCTGCC CAGGCTGTGT GTTTGAAGGT GTGCAATACC GGGAAGGAGA AGAATTTCAG 
CCAGAAGGAA ACAAATGTAT TACATGCTCC TGCGTTGGAG GCAGGACACA GTGCGTGAGA 
GAAGTCTGTC CCATTCTCTC TTGTCCCCAG CACCTTAGTC ACACACCCTC AGGACAGTGC 
TGCCCCAAAT GTTTGGGTCA GAGAAAAGTA TTCGACCTTC CCTTTGGGAG CTGCCTGTTT 
CGCAGTGATG TTTATGACAA TGGAGCCTCA TTTGTCTATG ATAACTGCAC AGTATGCACT 
TGCAAGGACT CAACAATGGT TTGTAAGAAG AAGTGCTCCC ACCCTGGTGT CTGTAACAGT 
GATGAGGATG CCTGTTGTGA AGACTGTCTC TTACGGGTGC CCCCTGAAGA CATCAAAGTG 
TGCAAGTTCG GTAGCAAGAT TTTCAGGGAT GGAGAGATGT GGTCCTCAGT CAACTGCAGC 
ATCTGTGCTT GTGTGAAGGG GAAGACAGAG TGTCGAAAGA AGCAGTGTGT TCCTGTCAGC 
AGCTGCCCAC AGGGTAAAAT TCTCAACAGG AAAGGATGCT GTCCTATCTG CACTGAAAAA 
CCTGGTGTGT GCACAGTATT CGGAGATCCC CACTACAACA CTTTTGATGG GCGGACATTT 
AACTTTCAGG GGACGTGTCA GTATGTTTTG ACAAAAGACT GCTCCTCCCC AGCCTCACCC 
TTCCAGGTGC TGGTGAAGAA TGATGCACGG AGGACCCGTT CCTTCTCCTG GACCAAGTCT 
GTGGAGCTGA TGCTGGGCGA AAGCACAGTC AGCCTGCAGC AGCACCTCAC TGTGCGCTGG 
AATGGCTCTC GCATTGCCCT TCCCTGCCAC ACACCCCACT TCCACATCGA CCTGGACGGC 
TACCTTTTGA AAGTGACTAC CAGAGCAGGT TTGGAGATAT CGTGGGATGG AGACAGTTTT 
GTGGAGGTCA TGGCTGCCCC TCATCTCAAG GGCAAGCTCT GTGGTCTTTG TGGCAACTAC 
AATGGTCATA AACGTGATGA CTTGATTGGT GGAGATGGGA ACTTCAAGTT TGACGTGGAT 
GACTTTGCTG AATCGTGGAG GGTGGAATCC AACGAATTCT GCAACCGACC ACAGAGAAAA 
CCAGTACCTG AGCTCTGTCA AGGCACAGTG AAGGTGAAGC TTCGAGCCCA TCGAGAATGC 
CAGAAACTCA AGTCCTGGGA GTTCCAGACC TGCCACTCTA CAGTGGACTA TACCACTTTC 
TACCGGTCCT GTGTAACAGA CATGTGTGAA TGTCCAGTCC ATAAAAACTG TTACTGTGAG 
TCATTTCTGG CGTATACCCG TGCCTGTCAG AGAGAGGGAA TCAAAGTGCA CTGGGAACCT 
CAGCAGAGCT GTGCAGCCAC CCAGTGCAAA CATGGTGCTG TGTATGATAC CTGTGGCCCA 
GGATGTGTGA AGACATGTGA TAACTGGAAT GAGATCGGCC CATGCAATAA GCCCTGCATT 
GCAGGTTGCC ACTGCCCAGC AAATCTGGTC CTTCATAAGG GAAGGTGCAT CAAGCCAGTC 
CTCTGTCCTC AGCGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A molecular roadmap of the AGM region reveals BMPER as a novel regulator of HSC maturation.
The Journal of experimental medicine214(12)3731-3751(2017 Dec)
McGarvey AC,Rybtsov S,Souilhol C,Tamagno S,Rice R,Hills D,Godwin D,Rice D,Tomlinson SR,Medvinsky A

Delayed Hair Follicle Morphogenesis and Hair Follicle Dystrophy in a Lipoatrophy Mouse Model of Pparg Total Deletion.
The Journal of investigative dermatology(2017 Sep)
Sardella C,Winkler C,Quignodon L,Hardman JA,Toffoli B,Giordano Attianese GMP,Hundt JE,Michalik L,Vinson CR,Paus R,Desvergne B,Gilardi F

von Willebrand factor type C domain-containing proteins regulate bone morphogenetic protein signaling through different recognition mechanisms.
The Journal of biological chemistry282(27)20002-14(2007 Jul)
Zhang JL,Huang Y,Qiu LY,Nickel J,Sebald W

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Bmper cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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