Nfatc4 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nfatc4
Entrez Gene ID	73181
Full Name	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4
Synonyms	3110041H08Rik,AW107667,AW546455,Nfat3
General protein information	Preferred Names nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4 Names nuclear factor of activated T-cells, cytoplasmic 4 NF-AT3 NF-ATc4 NFATc4 T-cell transcription factor NFAT3 nfatc4 transcription complex subunit NF-ATc4
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 14 Map Location: 14\|14 C3

mRNA and Protein(s)

mRNA	Protein	Name
NM_023699.3	NP_076188.3	nuclear factor of activated T-cells, cytoplasmic 4 isoform 1
NM_001168346.1	NP_001161818.1	nuclear factor of activated T-cells, cytoplasmic 4 isoform 2

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Nfatc4	NP_076188.3
Xenopus tropicalis (tropical clawed frog)	nfatc4	XP_002934369.1
Pan troglodytes (chimpanzee)	NFATC4	XP_001170041.2
Danio rerio (zebrafish)	nfatc4	XP_690183.5
Homo sapiens (human)	NFATC4	NP_004545.2
Rattus norvegicus (Norway rat)	Nfatc4	NP_001100734.1
Canis lupus familiaris (dog)	NFATC4	XP_537395.2
	LOC714785	XP_002808504.1

Gene Ontology
Bibliography

Related articles in PubMed

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Defining the identity of mouse embryonic dermal fibroblasts.
Budnick I, Hamburg-Shields E, Chen D, Torre E, Jarrell A, Akhtar-Zaidi B, Cordovan O, Spitale RC, Scacheri P, Atit RP
Genesis (New York, N.Y. : 2000)54(8)415-30(2016 Aug)

Neuritin Up-regulates Kv4.2 ?-Subunit of Potassium Channel Expression and Affects Neuronal Excitability by Regulating the Calcium-Calcineurin-NFATc4 Signaling Pathway.
Yao JJ, Zhao QR, Liu DD, Chow CW, Mei YA
The Journal of biological chemistry291(33)17369-81(2016 08)

Motor Nerve Arborization Requires Proteolytic Domain of Damage-Induced Neuronal Endopeptidase (DINE) during Development.
Matsumoto S, Kiryu-Seo S, Kiyama H
The Journal of neuroscience : the official journal of the Society for Neuroscience36(17)4744-57(2016 04)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Ca(2+)/calcineurin (CaN)/nuclear factor of activated T-cells (NFAT) c4 axis is required for neuritin-induced Kv4.2 transcriptional expression and potentiation of IA densities in cerebellum granule neurons.
Title: Neuritin Up-regulates Kv4.2 ?-Subunit of Potassium Channel Expression and Affects Neuronal Excitability by Regulating the Calcium-Calcineurin-NFATc4 Signaling Pathway.

Nfatc4 expression was coordinately upregulated by top hypoxia-activated transcription factors, while NFATc4 target genes were enriched in hypoxic neural stem cells.
Title: Transcriptional Profiling of Hypoxic Neural Stem Cells Identifies Calcineurin-NFATc4 Signaling as a Major Regulator of Neural Stem Cell Biology.

our results suggest that activation of NHE1 induces hypertrophy through the activation of NFAT3/Gata4 and OPN expression
Title: Na(+)/H (+) exchanger isoform 1 induced osteopontin expression in cardiomyocytes involves NFAT3/Gata4.

results indicate that NFAT is a BACE1 transcription factor. Our study suggests that inhibition of NFAT-mediated BACE1 expression may be a valuable drug target for AD therapy
Title: Transcriptional regulation of BACE1 by NFAT3 leads to enhanced amyloidogenic processing.

Nuclear factor of activated T cells is activated in the endothelium of retinal microvessels in diabetic mice
Title: Nuclear factor of activated T cells is activated in the endothelium of retinal microvessels in diabetic mice.

The following Nfatc4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nfatc4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu05661	NM_023699.3 Latest version!	Mus musculus nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4 (Nfatc4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$531.30 $759.00
OMu11370	NM_001168346.1 Latest version!	Mus musculus nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4 (Nfatc4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$524.30 $749.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nfatc4 ( NM_023699.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_076188.3 Mus musculus nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4 (Nfatc4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu05661
Clone ID Related Accession (Same CDS sequence)	NM_023699.3
Accession Version	NM_023699.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2706bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	nuclear factor of activated T-cells, cytoplasmic 4 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CJ067971.1, AK159078.1 and AW493556.1. On Dec 2, 2009 this sequence version replaced NM_023699.2. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC028928.1, AK159078.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGGGGCCG CAAGCTGCGA GGATGAGGAG CTGGAATTTA AGCTGGTGTT CGGAGAGGAA 
AAGGAGCCCC CCCCGCTGGG CCCTGGGGGT CCTGGGGAAG AGCTGGACTC AGAGGATACC 
CCTCCATGCT GTCGTTTGGC CCTGGGGGAA CCCCTTCCTT ATGGTGCTGC CCCTATTGGG 
ATTCCCCGAC CCCCACCCCC TCGGCCAGGG ATGCACTCAC CACCGCCCCG TCCCGCCCCT 
TCACCTGGCA CCTGGGAGAG CCAGCCAGCT AGGTCGGTGA GGCTGGGGGG CCCAGGAGGT 
AATGCAGGGG GTGCTGGGGG TGGTCGTGTT CTTGAGTGTC CCAGCATCCG GATTACCTCC 
ATCTCTCCCA CGCCTGACCC GCCGACCTCG CTAGAGGACA CATCTGAAAC TTGGGGGGAC 
GGCTCTCCTA GAGATTACCC TCCACCAGAA GGCTTTGGGG GCTATCGAGA GGCTGGAGGT 
CAGGGCGGAG GCGCTTTCTT CAGCCCGAGC CCTGGCAGCA GCAGCCTGTC TTCGTGGAGC 
TTCTTCTCGG ACGCCTCCGA CGAGGCAGCC CTGTATGCAG CGTGCGACGA GGTGGAGTCT 
GAACTTAATG AAGCAGCCTC CCGTTTTGGC TTGAGCTCTC CGCTGCCCTC GCCCCGGGCT 
TCTCCTAGGC CATGGACCCC GGAGGATCCC TGGAGCCTAT ACGGTCCAAG CTCGGGAGGC 
CGAGCGCCAG AGGATAGCTG GCTACTCCTC AGCGCTCCTG GGCCCGTCCC AGCCTCCCCT 
CGGCCTGCTT CTCCCTGCGG CAAGCGGCGC TATTCCAGTT CCGGAACCCC ATCTTCGGCC 
TCCCCAGCTT TGTCCCGCCG AGGCAGCCTT GGGGAAGAAG GTCCAGAGCC ACCTCCACCA 
CCCCCGTTGC CTCTGGTCCG GGACCCTAGT TCCCCTGGCC CTTTTGACTA TGTGGGTGCT 
CCACCAACCG AGAGCATCCC TCAGAAAACT CGGAGGACTT CTAGCGAGCA AGCAGTGGCC 
CTGCCTCGGT CTGAAGAGCC TCCCTCGTGC AATGGGAAGC TACCCTCCGG TACAGAGGAC 
TCTGTGGCTG CTCCGGGGGC TCTGCGGAAA GAGGTGGCCG GCATGGATTA CCTAGCAGTG 
CCTTCTCCCC TTGCTTGGTC CAAGGCCCGG ATTGGGGGAC ACAGCCCCAT CTTCAGGACC 
TCTGCCCTAC CTCCCCTGGA CTGGCCTTTA CCCAGCCAGT ATGAGCAGCT GGAGCTGAGG 
ATCGAGGTAC AGCCTAGAGC ACACCACCGA GCTCACTATG AGACTGAGGG CAGCCGGGGG 
GCTGTCAAGG CTGCTCCTGG AGGCCACCCT GTGGTCAAGC TCCTAGGCTA CAGTGAGAAG 
CCATTGACTC TGCAGATGTT CATTGGCACT GCAGATGAGA GGAGCCTGCG GCCCCATGCC 
TTCTACCAGG TGCACCGGAT TACTGGCAAG ATGGTGGCTA CAGCCAGCTA TGAAGCTGTA 
GTCAGTGGTA CCAAAGTGTT GGAGATGACC TTACTCCCAG AGAACAACAT GGCTGCCAAC 
ATTGACTGTG CTGGAATCCT GAAGCTTCGA AATTCAGACA TTGAGCTACG GAAGGGTGAG 
ACAGACATCG GGCGCAAAAA CACGCGTGTG CGGCTGGTGT TCCGTGTGCA CGTGCCTCAG 
GGCGGCGGGA AGGTCGTGTC TGTGCAGGCA GCATCAGTGC CCATCGAGTG CTCCCAGCGC 
TCGGCCCAGG AGCTGCCCCA GGTGGAGACC TACAGCCCCA GTGCCTGCTC TGTGAGAGGA 
GGGGAGGAGC TAGTGTTGAC TGGTTCCAAC TTCCTGCCAG ACTCTAAAGT GGTGTTCATT 
GAGAGGGGTC CTGATGGAAA ACTGCAGTGG GAGGAAGAGG CAGCGGTGAA CCGACTGCAG 
AGCAGTGAGG TGACATTGAC TCTCACCATC CCCGAGTACA GCAACAAGCG GGTGTCCCGA 
CCAGTCCAGG TCTACTTTTA CGTCTCCAAT GGACGGAGGA AGCGCAGTCC TACCCAAAGT 
TTCAAGTTCC TACCTGTGGT CTTCAAGGAG GAGCCCCTAC CAGACTCATC TCTCCGGGGC 
TTCCCTTCCA CATCGGGTCC CCCCTTTGGC CCTGACGTGG ACTTCTCACC GCCCAGGCCC 
CCTTACCCCT CCTATCCCCA TGAAGACCCT GCTTATGAGA CTCCTTATCT GTCAGAAGGC 
TTTGGTTATA GCACACCCGC TCTGTACCCC CAGACGGGGC CCCCACCGTC CTATAGATCT 
GGCCTGCGGA TGTTCCCTGA GACTGGGGGT ACCACAGGTT GTGCCCGCCT ACCTTCAGTC 
TCTTTCCTTC CGCGCCCCTT TCCTGGTGAT CAATATGGAG GACAGGGCTC CTCTTTTGCC 
CTGGGGCTTC CATTCTCCCC TCCAGCCCCC TTTAGGCCGC CACTGCCTTC CTCCCCACCA 
CTCGAAGACC CCTTCCATCC CCAGAGTGCC ATCCACCCCT TACCTCCTGA GGGCTACAAT 
GAGGTGGGGC CAGGCTATAC CCCTGGGGAG GGGGCTTCGG AGCAGGAGAA AGCCAGGGGT 
GGCTACAGCA GCGGCTTCAG AGACAGTGTA CCTATCCAGG GTATCACCCT GGAGGAAGTG 
AGTGAGATCA TTGGCCGAGA CCTGAGTGGC TTCCCTGCAC GTCCTGGAGA AGAGCCTCCT 
GCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_076188.3
CDS	243..2948
Translation	MGAASCEDEELEFKLVFGEEKEPPPLGPGGPGEELDSEDTPPCCRLALGEPLPYGAAPIGIPRPPPPRPGMHSPPPRPAPSPGTWESQPARSVRLGGPGGNAGGAGGGRVLECPSIRITSISPTPDPPTSLEDTSETWGDGSPRDYPPPEGFGGYREAGGQGGGAFFSPSPGSSSLSSWSFFSDASDEAALYAACDEVESELNEAASRFGLSSPLPSPRASPRPWTPEDPWSLYGPSSGGRAPEDSWLLLSAPGPVPASPRPASPCGKRRYSSSGTPSSASPALSRRGSLGEEGPEPPPPPPLPLVRDPSSPGPFDYVGAPPTESIPQKTRRTSSEQAVALPRSEEPPSCNGKLPSGTEDSVAAPGALRKEVAGMDYLAVPSPLAWSKARIGGHSPIFRTSALPPLDWPLPSQYEQLELRIEVQPRAHHRAHYETEGSRGAVKAAPGGHPVVKLLGYSEKPLTLQMFIGTADERSLRPHAFYQVHRITGKMVATASYEAVVSGTKVLEMTLLPENNMAANIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHVPQGGGKVVSVQAASVPIECSQRSAQELPQVETYSPSACSVRGGEELVLTGSNFLPDSKVVFIERGPDGKLQWEEEAAVNRLQSSEVTLTLTIPEYSNKRVSRPVQVYFYVSNGRRKRSPTQSFKFLPVVFKEEPLPDSSLRGFPSTSGPPFGPDVDFSPPRPPYPSYPHEDPAYETPYLSEGFGYSTPALYPQTGPPPSYRSGLRMFPETGGTTGCARLPSVSFLPRPFPGDQYGGQGSSFALGLPFSPPAPFRPPLPSSPPLEDPFHPQSAIHPLPPEGYNEVGPGYTPGEGASEQEKARGGYSSGFRDSVPIQGITLEEVSEIIGRDLSGFPARPGEEPPA

Target ORF information:

RefSeq Version	NM_023699.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4 (Nfatc4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_023699.3

ORF Insert Sequence:

ATGGGGGCCG CAAGCTGCGA GGATGAGGAG CTGGAATTTA AGCTGGTGTT CGGAGAGGAA 
AAGGAGCCCC CCCCGCTGGG CCCTGGGGGT CCTGGGGAAG AGCTGGACTC AGAGGATACC 
CCTCCATGCT GTCGTTTGGC CCTGGGGGAA CCCCTTCCTT ATGGTGCTGC CCCTATTGGG 
ATTCCCCGAC CCCCACCCCC TCGGCCAGGG ATGCACTCAC CACCGCCCCG TCCCGCCCCT 
TCACCTGGCA CCTGGGAGAG CCAGCCAGCT AGGTCGGTGA GGCTGGGGGG CCCAGGAGGT 
AATGCAGGGG GTGCTGGGGG TGGTCGTGTT CTTGAGTGTC CCAGCATCCG GATTACCTCC 
ATCTCTCCCA CGCCTGACCC GCCGACCTCG CTAGAGGACA CATCTGAAAC TTGGGGGGAC 
GGCTCTCCTA GAGATTACCC TCCACCAGAA GGCTTTGGGG GCTATCGAGA GGCTGGAGGT 
CAGGGCGGAG GCGCTTTCTT CAGCCCGAGC CCTGGCAGCA GCAGCCTGTC TTCGTGGAGC 
TTCTTCTCGG ACGCCTCCGA CGAGGCAGCC CTGTATGCAG CGTGCGACGA GGTGGAGTCT 
GAACTTAATG AAGCAGCCTC CCGTTTTGGC TTGAGCTCTC CGCTGCCCTC GCCCCGGGCT 
TCTCCTAGGC CATGGACCCC GGAGGATCCC TGGAGCCTAT ACGGTCCAAG CTCGGGAGGC 
CGAGCGCCAG AGGATAGCTG GCTACTCCTC AGCGCTCCTG GGCCCGTCCC AGCCTCCCCT 
CGGCCTGCTT CTCCCTGCGG CAAGCGGCGC TATTCCAGTT CCGGAACCCC ATCTTCGGCC 
TCCCCAGCTT TGTCCCGCCG AGGCAGCCTT GGGGAAGAAG GTCCAGAGCC ACCTCCACCA 
CCCCCGTTGC CTCTGGTCCG GGACCCTAGT TCCCCTGGCC CTTTTGACTA TGTGGGTGCT 
CCACCAACCG AGAGCATCCC TCAGAAAACT CGGAGGACTT CTAGCGAGCA AGCAGTGGCC 
CTGCCTCGGT CTGAAGAGCC TCCCTCGTGC AATGGGAAGC TACCCTCCGG TACAGAGGAC 
TCTGTGGCTG CTCCGGGGGC TCTGCGGAAA GAGGTGGCCG GCATGGATTA CCTAGCAGTG 
CCTTCTCCCC TTGCTTGGTC CAAGGCCCGG ATTGGGGGAC ACAGCCCCAT CTTCAGGACC 
TCTGCCCTAC CTCCCCTGGA CTGGCCTTTA CCCAGCCAGT ATGAGCAGCT GGAGCTGAGG 
ATCGAGGTAC AGCCTAGAGC ACACCACCGA GCTCACTATG AGACTGAGGG CAGCCGGGGG 
GCTGTCAAGG CTGCTCCTGG AGGCCACCCT GTGGTCAAGC TCCTAGGCTA CAGTGAGAAG 
CCATTGACTC TGCAGATGTT CATTGGCACT GCAGATGAGA GGAGCCTGCG GCCCCATGCC 
TTCTACCAGG TGCACCGGAT TACTGGCAAG ATGGTGGCTA CAGCCAGCTA TGAAGCTGTA 
GTCAGTGGTA CCAAAGTGTT GGAGATGACC TTACTCCCAG AGAACAACAT GGCTGCCAAC 
ATTGACTGTG CTGGAATCCT GAAGCTTCGA AATTCAGACA TTGAGCTACG GAAGGGTGAG 
ACAGACATCG GGCGCAAAAA CACGCGTGTG CGGCTGGTGT TCCGTGTGCA CGTGCCTCAG 
GGCGGCGGGA AGGTCGTGTC TGTGCAGGCA GCATCAGTGC CCATCGAGTG CTCCCAGCGC 
TCGGCCCAGG AGCTGCCCCA GGTGGAGACC TACAGCCCCA GTGCCTGCTC TGTGAGAGGA 
GGGGAGGAGC TAGTGTTGAC TGGTTCCAAC TTCCTGCCAG ACTCTAAAGT GGTGTTCATT 
GAGAGGGGTC CTGATGGAAA ACTGCAGTGG GAGGAAGAGG CAGCGGTGAA CCGACTGCAG 
AGCAGTGAGG TGACATTGAC TCTCACCATC CCCGAGTACA GCAACAAGCG GGTGTCCCGA 
CCAGTCCAGG TCTACTTTTA CGTCTCCAAT GGACGGAGGA AGCGCAGTCC TACCCAAAGT 
TTCAAGTTCC TACCTGTGGT CTTCAAGGAG GAGCCCCTAC CAGACTCATC TCTCCGGGGC 
TTCCCTTCCA CATCGGGTCC CCCCTTTGGC CCTGACGTGG ACTTCTCACC GCCCAGGCCC 
CCTTACCCCT CCTATCCCCA TGAAGACCCT GCTTATGAGA CTCCTTATCT GTCAGAAGGC 
TTTGGTTATA GCACACCCGC TCTGTACCCC CAGACGGGGC CCCCACCGTC CTATAGATCT 
GGCCTGCGGA TGTTCCCTGA GACTGGGGGT ACCACAGGTT GTGCCCGCCT ACCTTCAGTC 
TCTTTCCTTC CGCGCCCCTT TCCTGGTGAT CAATATGGAG GACAGGGCTC CTCTTTTGCC 
CTGGGGCTTC CATTCTCCCC TCCAGCCCCC TTTAGGCCGC CACTGCCTTC CTCCCCACCA 
CTCGAAGACC CCTTCCATCC CCAGAGTGCC ATCCACCCCT TACCTCCTGA GGGCTACAAT 
GAGGTGGGGC CAGGCTATAC CCCTGGGGAG GGGGCTTCGG AGCAGGAGAA AGCCAGGGGT 
GGCTACAGCA GCGGCTTCAG AGACAGTGTA CCTATCCAGG GTATCACCCT GGAGGAAGTG 
AGTGAGATCA TTGGCCGAGA CCTGAGTGGC TTCCCTGCAC GTCCTGGAGA AGAGCCTCCT 
GCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Nfatc4 ( NM_001168346.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001161818.1 Mus musculus nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4 (Nfatc4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu11370
Clone ID Related Accession (Same CDS sequence)	NM_001168346.1
Accession Version	NM_001168346.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2673bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	nuclear factor of activated T-cells, cytoplasmic 4 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CJ067971.1, EU887657.1 and AW493556.1. Transcript Variant: This variant (2) has an additional segment in the 3' region, as compared to variant 1. The resulting isoform (2) is shorter and has a different C-terminus, as compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: EU887657.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGGGGCCG CAAGCTGCGA GGATGAGGAG CTGGAATTTA AGCTGGTGTT CGGAGAGGAA 
AAGGAGCCCC CCCCGCTGGG CCCTGGGGGT CCTGGGGAAG AGCTGGACTC AGAGGATACC 
CCTCCATGCT GTCGTTTGGC CCTGGGGGAA CCCCTTCCTT ATGGTGCTGC CCCTATTGGG 
ATTCCCCGAC CCCCACCCCC TCGGCCAGGG ATGCACTCAC CACCGCCCCG TCCCGCCCCT 
TCACCTGGCA CCTGGGAGAG CCAGCCAGCT AGGTCGGTGA GGCTGGGGGG CCCAGGAGGT 
AATGCAGGGG GTGCTGGGGG TGGTCGTGTT CTTGAGTGTC CCAGCATCCG GATTACCTCC 
ATCTCTCCCA CGCCTGACCC GCCGACCTCG CTAGAGGACA CATCTGAAAC TTGGGGGGAC 
GGCTCTCCTA GAGATTACCC TCCACCAGAA GGCTTTGGGG GCTATCGAGA GGCTGGAGGT 
CAGGGCGGAG GCGCTTTCTT CAGCCCGAGC CCTGGCAGCA GCAGCCTGTC TTCGTGGAGC 
TTCTTCTCGG ACGCCTCCGA CGAGGCAGCC CTGTATGCAG CGTGCGACGA GGTGGAGTCT 
GAACTTAATG AAGCAGCCTC CCGTTTTGGC TTGAGCTCTC CGCTGCCCTC GCCCCGGGCT 
TCTCCTAGGC CATGGACCCC GGAGGATCCC TGGAGCCTAT ACGGTCCAAG CTCGGGAGGC 
CGAGCGCCAG AGGATAGCTG GCTACTCCTC AGCGCTCCTG GGCCCGTCCC AGCCTCCCCT 
CGGCCTGCTT CTCCCTGCGG CAAGCGGCGC TATTCCAGTT CCGGAACCCC ATCTTCGGCC 
TCCCCAGCTT TGTCCCGCCG AGGCAGCCTT GGGGAAGAAG GTCCAGAGCC ACCTCCACCA 
CCCCCGTTGC CTCTGGTCCG GGACCCTAGT TCCCCTGGCC CTTTTGACTA TGTGGGTGCT 
CCACCAACCG AGAGCATCCC TCAGAAAACT CGGAGGACTT CTAGCGAGCA AGCAGTGGCC 
CTGCCTCGGT CTGAAGAGCC TCCCTCGTGC AATGGGAAGC TACCCTCCGG TACAGAGGAC 
TCTGTGGCTG CTCCGGGGGC TCTGCGGAAA GAGGTGGCCG GCATGGATTA CCTAGCAGTG 
CCTTCTCCCC TTGCTTGGTC CAAGGCCCGG ATTGGGGGAC ACAGCCCCAT CTTCAGGACC 
TCTGCCCTAC CTCCCCTGGA CTGGCCTTTA CCCAGCCAGT ATGAGCAGCT GGAGCTGAGG 
ATCGAGGTAC AGCCTAGAGC ACACCACCGA GCTCACTATG AGACTGAGGG CAGCCGGGGG 
GCTGTCAAGG CTGCTCCTGG AGGCCACCCT GTGGTCAAGC TCCTAGGCTA CAGTGAGAAG 
CCATTGACTC TGCAGATGTT CATTGGCACT GCAGATGAGA GGAGCCTGCG GCCCCATGCC 
TTCTACCAGG TGCACCGGAT TACTGGCAAG ATGGTGGCTA CAGCCAGCTA TGAAGCTGTA 
GTCAGTGGTA CCAAAGTGTT GGAGATGACC TTACTCCCAG AGAACAACAT GGCTGCCAAC 
ATTGACTGTG CTGGAATCCT GAAGCTTCGA AATTCAGACA TTGAGCTACG GAAGGGTGAG 
ACAGACATCG GGCGCAAAAA CACGCGTGTG CGGCTGGTGT TCCGTGTGCA CGTGCCTCAG 
GGCGGCGGGA AGGTCGTGTC TGTGCAGGCA GCATCAGTGC CCATCGAGTG CTCCCAGCGC 
TCGGCCCAGG AGCTGCCCCA GGTGGAGACC TACAGCCCCA GTGCCTGCTC TGTGAGAGGA 
GGGGAGGAGC TAGTGTTGAC TGGTTCCAAC TTCCTGCCAG ACTCTAAAGT GGTGTTCATT 
GAGAGGGGTC CTGATGGAAA ACTGCAGTGG GAGGAAGAGG CAGCGGTGAA CCGACTGCAG 
AGCAGTGAGG TGACATTGAC TCTCACCATC CCCGAGTACA GCAACAAGCG GGTGTCCCGA 
CCAGTCCAGG TCTACTTTTA CGTCTCCAAT GGACGGAGGA AGCGCAGTCC TACCCAAAGT 
TTCAAGTTCC TACCTGTGGT CTTCAAGGAG GAGCCCCTAC CAGACTCATC TCTCCGGGGC 
TTCCCTTCCA CATCGGGTCC CCCCTTTGGC CCTGACGTGG ACTTCTCACC GCCCAGGCCC 
CCTTACCCCT CCTATCCCCA TGAAGACCCT GCTTATGAGA CTCCTTATCT GTCAGAAGGC 
TTTGGTTATA GCACACCCGC TCTGTACCCC CAGACGGGGC CCCCACCGTC CTATAGATCT 
GGCCTGCGGA TGTTCCCTGA GACTGGGGGT ACCACAGGTT GTGCCCGCCT ACCTTCAGTC 
TCTTTCCTTC CGCGCCCCTT TCCTGGTGAT CAATATGGAG GACAGGGCTC CTCTTTTGCC 
CTGGGGCTTC CATTCTCCCC TCCAGCCCCC TTTAGGCCGC CACTGCCTTC CTCCCCACCA 
CTCGAAGACC CCTTCCATCC CCAGAGTGCC ATCCACCCCT TACCTCCTGA GGGCTACAAT 
GAGGTGGGGC CAGGCTATAC CCCTGGGGAG GGGGCTTCGG AGCAGGAGAA AGCCAGGGGT 
GGCTACAGCA GCGGCTTCAG AGACAGTGTA CCTATCCAGG GTATCACCCT GGAGGAAGGT 
GGGTGTGGGA CTGGGGGCTG CGAGTGTAAG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001161818.1
CDS	243..2915
Translation	MGAASCEDEELEFKLVFGEEKEPPPLGPGGPGEELDSEDTPPCCRLALGEPLPYGAAPIGIPRPPPPRPGMHSPPPRPAPSPGTWESQPARSVRLGGPGGNAGGAGGGRVLECPSIRITSISPTPDPPTSLEDTSETWGDGSPRDYPPPEGFGGYREAGGQGGGAFFSPSPGSSSLSSWSFFSDASDEAALYAACDEVESELNEAASRFGLSSPLPSPRASPRPWTPEDPWSLYGPSSGGRAPEDSWLLLSAPGPVPASPRPASPCGKRRYSSSGTPSSASPALSRRGSLGEEGPEPPPPPPLPLVRDPSSPGPFDYVGAPPTESIPQKTRRTSSEQAVALPRSEEPPSCNGKLPSGTEDSVAAPGALRKEVAGMDYLAVPSPLAWSKARIGGHSPIFRTSALPPLDWPLPSQYEQLELRIEVQPRAHHRAHYETEGSRGAVKAAPGGHPVVKLLGYSEKPLTLQMFIGTADERSLRPHAFYQVHRITGKMVATASYEAVVSGTKVLEMTLLPENNMAANIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHVPQGGGKVVSVQAASVPIECSQRSAQELPQVETYSPSACSVRGGEELVLTGSNFLPDSKVVFIERGPDGKLQWEEEAAVNRLQSSEVTLTLTIPEYSNKRVSRPVQVYFYVSNGRRKRSPTQSFKFLPVVFKEEPLPDSSLRGFPSTSGPPFGPDVDFSPPRPPYPSYPHEDPAYETPYLSEGFGYSTPALYPQTGPPPSYRSGLRMFPETGGTTGCARLPSVSFLPRPFPGDQYGGQGSSFALGLPFSPPAPFRPPLPSSPPLEDPFHPQSAIHPLPPEGYNEVGPGYTPGEGASEQEKARGGYSSGFRDSVPIQGITLEEGGCGTGGCECK

Target ORF information:

RefSeq Version	NM_001168346.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4 (Nfatc4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001168346.1

ORF Insert Sequence:

ATGGGGGCCG CAAGCTGCGA GGATGAGGAG CTGGAATTTA AGCTGGTGTT CGGAGAGGAA 
AAGGAGCCCC CCCCGCTGGG CCCTGGGGGT CCTGGGGAAG AGCTGGACTC AGAGGATACC 
CCTCCATGCT GTCGTTTGGC CCTGGGGGAA CCCCTTCCTT ATGGTGCTGC CCCTATTGGG 
ATTCCCCGAC CCCCACCCCC TCGGCCAGGG ATGCACTCAC CACCGCCCCG TCCCGCCCCT 
TCACCTGGCA CCTGGGAGAG CCAGCCAGCT AGGTCGGTGA GGCTGGGGGG CCCAGGAGGT 
AATGCAGGGG GTGCTGGGGG TGGTCGTGTT CTTGAGTGTC CCAGCATCCG GATTACCTCC 
ATCTCTCCCA CGCCTGACCC GCCGACCTCG CTAGAGGACA CATCTGAAAC TTGGGGGGAC 
GGCTCTCCTA GAGATTACCC TCCACCAGAA GGCTTTGGGG GCTATCGAGA GGCTGGAGGT 
CAGGGCGGAG GCGCTTTCTT CAGCCCGAGC CCTGGCAGCA GCAGCCTGTC TTCGTGGAGC 
TTCTTCTCGG ACGCCTCCGA CGAGGCAGCC CTGTATGCAG CGTGCGACGA GGTGGAGTCT 
GAACTTAATG AAGCAGCCTC CCGTTTTGGC TTGAGCTCTC CGCTGCCCTC GCCCCGGGCT 
TCTCCTAGGC CATGGACCCC GGAGGATCCC TGGAGCCTAT ACGGTCCAAG CTCGGGAGGC 
CGAGCGCCAG AGGATAGCTG GCTACTCCTC AGCGCTCCTG GGCCCGTCCC AGCCTCCCCT 
CGGCCTGCTT CTCCCTGCGG CAAGCGGCGC TATTCCAGTT CCGGAACCCC ATCTTCGGCC 
TCCCCAGCTT TGTCCCGCCG AGGCAGCCTT GGGGAAGAAG GTCCAGAGCC ACCTCCACCA 
CCCCCGTTGC CTCTGGTCCG GGACCCTAGT TCCCCTGGCC CTTTTGACTA TGTGGGTGCT 
CCACCAACCG AGAGCATCCC TCAGAAAACT CGGAGGACTT CTAGCGAGCA AGCAGTGGCC 
CTGCCTCGGT CTGAAGAGCC TCCCTCGTGC AATGGGAAGC TACCCTCCGG TACAGAGGAC 
TCTGTGGCTG CTCCGGGGGC TCTGCGGAAA GAGGTGGCCG GCATGGATTA CCTAGCAGTG 
CCTTCTCCCC TTGCTTGGTC CAAGGCCCGG ATTGGGGGAC ACAGCCCCAT CTTCAGGACC 
TCTGCCCTAC CTCCCCTGGA CTGGCCTTTA CCCAGCCAGT ATGAGCAGCT GGAGCTGAGG 
ATCGAGGTAC AGCCTAGAGC ACACCACCGA GCTCACTATG AGACTGAGGG CAGCCGGGGG 
GCTGTCAAGG CTGCTCCTGG AGGCCACCCT GTGGTCAAGC TCCTAGGCTA CAGTGAGAAG 
CCATTGACTC TGCAGATGTT CATTGGCACT GCAGATGAGA GGAGCCTGCG GCCCCATGCC 
TTCTACCAGG TGCACCGGAT TACTGGCAAG ATGGTGGCTA CAGCCAGCTA TGAAGCTGTA 
GTCAGTGGTA CCAAAGTGTT GGAGATGACC TTACTCCCAG AGAACAACAT GGCTGCCAAC 
ATTGACTGTG CTGGAATCCT GAAGCTTCGA AATTCAGACA TTGAGCTACG GAAGGGTGAG 
ACAGACATCG GGCGCAAAAA CACGCGTGTG CGGCTGGTGT TCCGTGTGCA CGTGCCTCAG 
GGCGGCGGGA AGGTCGTGTC TGTGCAGGCA GCATCAGTGC CCATCGAGTG CTCCCAGCGC 
TCGGCCCAGG AGCTGCCCCA GGTGGAGACC TACAGCCCCA GTGCCTGCTC TGTGAGAGGA 
GGGGAGGAGC TAGTGTTGAC TGGTTCCAAC TTCCTGCCAG ACTCTAAAGT GGTGTTCATT 
GAGAGGGGTC CTGATGGAAA ACTGCAGTGG GAGGAAGAGG CAGCGGTGAA CCGACTGCAG 
AGCAGTGAGG TGACATTGAC TCTCACCATC CCCGAGTACA GCAACAAGCG GGTGTCCCGA 
CCAGTCCAGG TCTACTTTTA CGTCTCCAAT GGACGGAGGA AGCGCAGTCC TACCCAAAGT 
TTCAAGTTCC TACCTGTGGT CTTCAAGGAG GAGCCCCTAC CAGACTCATC TCTCCGGGGC 
TTCCCTTCCA CATCGGGTCC CCCCTTTGGC CCTGACGTGG ACTTCTCACC GCCCAGGCCC 
CCTTACCCCT CCTATCCCCA TGAAGACCCT GCTTATGAGA CTCCTTATCT GTCAGAAGGC 
TTTGGTTATA GCACACCCGC TCTGTACCCC CAGACGGGGC CCCCACCGTC CTATAGATCT 
GGCCTGCGGA TGTTCCCTGA GACTGGGGGT ACCACAGGTT GTGCCCGCCT ACCTTCAGTC 
TCTTTCCTTC CGCGCCCCTT TCCTGGTGAT CAATATGGAG GACAGGGCTC CTCTTTTGCC 
CTGGGGCTTC CATTCTCCCC TCCAGCCCCC TTTAGGCCGC CACTGCCTTC CTCCCCACCA 
CTCGAAGACC CCTTCCATCC CCAGAGTGCC ATCCACCCCT TACCTCCTGA GGGCTACAAT 
GAGGTGGGGC CAGGCTATAC CCCTGGGGAG GGGGCTTCGG AGCAGGAGAA AGCCAGGGGT 
GGCTACAGCA GCGGCTTCAG AGACAGTGTA CCTATCCAGG GTATCACCCT GGAGGAAGGT 
GGGTGTGGGA CTGGGGGCTG CGAGTGTAAG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Defining the identity of mouse embryonic dermal fibroblasts.
Genesis (New York, N.Y. : 2000)54(8)415-30(2016 Aug)
Budnick I,Hamburg-Shields E,Chen D,Torre E,Jarrell A,Akhtar-Zaidi B,Cordovan O,Spitale RC,Scacheri P,Atit RP

Neuritin Up-regulates Kv4.2 ?-Subunit of Potassium Channel Expression and Affects Neuronal Excitability by Regulating the Calcium-Calcineurin-NFATc4 Signaling Pathway.
The Journal of biological chemistry291(33)17369-81(2016 08)
Yao JJ,Zhao QR,Liu DD,Chow CW,Mei YA

Motor Nerve Arborization Requires Proteolytic Domain of Damage-Induced Neuronal Endopeptidase (DINE) during Development.
The Journal of neuroscience : the official journal of the Society for Neuroscience36(17)4744-57(2016 04)
Matsumoto S,Kiryu-Seo S,Kiyama H

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Nfatc4 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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