Epgn cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Epgn
Entrez Gene ID	71920
Full Name	epithelial mitogen
Synonyms	2310069M11Rik,epigen
General protein information	Preferred Names epithelial mitogen Names epigen EPG
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5\|5 E1

mRNA and Protein(s)

mRNA	Protein	Name
NM_053087.2	NP_444317.1	epigen precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	EPGN	XP_003586263.2
Rattus norvegicus (Norway rat)	Epgn	XP_006250820.1
	EPGN	XP_001102155.1
Gallus gallus (chicken)	EPGN	NP_001012404.1
Xenopus tropicalis (tropical clawed frog)	epgn	NP_001135711.2
Mus musculus (house mouse)	Epgn	NP_444317.1
Homo sapiens (human)	EPGN	NP_001257918.1
Pan troglodytes (chimpanzee)	EPGN	NP_001229552.1
Canis lupus familiaris (dog)	EPGN	XP_854753.2

Gene Ontology
Bibliography

Related articles in PubMed

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Overexpression of epigen during embryonic development induces reversible, epidermal growth factor receptor-dependent sebaceous gland hyperplasia.
Dahlhoff M, Frances D, Kloepper JE, Paus R, Sch?fer M, Niemann C, Schneider MR
Molecular and cellular biology34(16)3086-95(2014 Aug)

Rhbdf2 mutations increase its protein stability and drive EGFR hyperactivation through enhanced secretion of amphiregulin.
Hosur V, Johnson KR, Burzenski LM, Stearns TM, Maser RS, Shultz LD
Proceedings of the National Academy of Sciences of the United States of America111(21)E2200-9(2014 May)

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H
Nucleic acids research42(Database issue)D802-9(2014 Jan)

Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation.
Zhou K, Muroyama A, Underwood J, Leylek R, Ray S, Soderling SH, Lechler T
Proceedings of the National Academy of Sciences of the United States of America110(40)E3820-9(2013 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

activation of the EGFR by its ligand epigen during early epidermal development causes hyperplasia of the sebaceous gland and, to a minor extent, hyperplasia of the interfollicular epidermis and increased hair follicles density.
Title: Overexpression of epigen during embryonic development induces reversible, epidermal growth factor receptor-dependent sebaceous gland hyperplasia.

Epigen has non-essential functions or functions that can be compensated by other EGFR ligands during growth and tissue homeostasis.
Title: Genetic deletion of the EGFR ligand epigen does not affect mouse embryonic development and tissue homeostasis.

EPG is an EGF-like growth factor and a low affinity ligand
Title: Epigen, the last ligand of ErbB receptors, reveals intricate relationships between affinity and mitogenicity.

The following Epgn gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Epgn cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu09051	NM_053087.2 Latest version!	Mus musculus epithelial mitogen (Epgn), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Epgn ( NM_053087.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_444317.1 Mus musculus epithelial mitogen (Epgn), mRNA.

Price & Availability↑

CloneID	OMu09051
Clone ID Related Accession (Same CDS sequence)	NM_053087.2
Accession Version	NM_053087.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 459bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	epigen precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC109311.12. On Nov 17, 2006 this sequence version replaced NM_053087.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ291391.1, BC119291.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164134, SAMN01164137 [ECO:0000348] ##Evidence-Data-END##

ATGGCTCTGG GGGTTCTGAT AGCAGTCTGC CTCTTGTTCA AAGCAATGAA GGCAGCACTG 
AGCGAAGAAG CAGAGGTGAT CCCTCCTAGC ACAGCACAGC AGAGCAACTG GACATTTAAC 
AACACCGAAG CTGACTACAT AGAAGAACCT GTAGCTCTGA AGTTCTCTCA TCCTTGTCTG 
GAAGACCATA ATAGTTACTG CATTAATGGA GCATGTGCAT TCCACCATGA GCTGAAGCAA 
GCCATTTGCA GATGCTTTAC TGGTTATACG GGACAACGAT GTGAGCATTT GACCCTAACT 
TCGTATGCTG TGGATTCTTA TGAAAAATAC ATTGCGATTG GGATTGGCGT CGGATTGCTA 
ATTAGTGCTT TTCTTGCTGT CTTCTATTGC TACATAAGAA AAAGGTGTAT AAATCTGAAA 
TCACCCTACA TCATCTGCTC TGGAGGGAGC CCATTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_444317.1
CDS	7..465
Translation	MALGVLIAVCLLFKAMKAALSEEAEVIPPSTAQQSNWTFNNTEADYIEEPVALKFSHPCLEDHNSYCINGACAFHHELKQAICRCFTGYTGQRCEHLTLTSYAVDSYEKYIAIGIGVGLLISAFLAVFYCYIRKRCINLKSPYIICSGGSPL

Target ORF information:

RefSeq Version	NM_053087.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus epithelial mitogen (Epgn), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053087.2

ORF Insert Sequence:

ATGGCTCTGG GGGTTCTGAT AGCAGTCTGC CTCTTGTTCA AAGCAATGAA GGCAGCACTG 
AGCGAAGAAG CAGAGGTGAT CCCTCCTAGC ACAGCACAGC AGAGCAACTG GACATTTAAC 
AACACCGAAG CTGACTACAT AGAAGAACCT GTAGCTCTGA AGTTCTCTCA TCCTTGTCTG 
GAAGACCATA ATAGTTACTG CATTAATGGA GCATGTGCAT TCCACCATGA GCTGAAGCAA 
GCCATTTGCA GATGCTTTAC TGGTTATACG GGACAACGAT GTGAGCATTT GACCCTAACT 
TCGTATGCTG TGGATTCTTA TGAAAAATAC ATTGCGATTG GGATTGGCGT CGGATTGCTA 
ATTAGTGCTT TTCTTGCTGT CTTCTATTGC TACATAAGAA AAAGGTGTAT AAATCTGAAA 
TCACCCTACA TCATCTGCTC TGGAGGGAGC CCATTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Overexpression of epigen during embryonic development induces reversible, epidermal growth factor receptor-dependent sebaceous gland hyperplasia.
Molecular and cellular biology34(16)3086-95(2014 Aug)
Dahlhoff M,Frances D,Kloepper JE,Paus R,Sch?fer M,Niemann C,Schneider MR

Rhbdf2 mutations increase its protein stability and drive EGFR hyperactivation through enhanced secretion of amphiregulin.
Proceedings of the National Academy of Sciences of the United States of America111(21)E2200-9(2014 May)
Hosur V,Johnson KR,Burzenski LM,Stearns TM,Maser RS,Shultz LD

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Nucleic acids research42(Database issue)D802-9(2014 Jan)
Koscielny G,Yaikhom G,Iyer V,Meehan TF,Morgan H,Atienza-Herrero J,Blake A,Chen CK,Easty R,Di Fenza A,Fiegel T,Grifiths M,Horne A,Karp NA,Kurbatova N,Mason JC,Matthews P,Oakley DJ,Qazi A,Regnart J,Retha A,Santos LA,Sneddon DJ,Warren J,Westerberg H,Wilson RJ,Melvin DG,Smedley D,Brown SD,Flicek P,Skarnes WC,Mallon AM,Parkinson H

Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation.
Proceedings of the National Academy of Sciences of the United States of America110(40)E3820-9(2013 Oct)
Zhou K,Muroyama A,Underwood J,Leylek R,Ray S,Soderling SH,Lechler T

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Epgn cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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