Gpr39 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gpr39
Entrez Gene ID	71111
Full Name	G protein-coupled receptor 39
Synonyms	4933415E13Rik
General protein information	Preferred Names G protein-coupled receptor 39 Names G-protein coupled receptor 39
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1\|1 E2.3-E3

mRNA and Protein(s)

mRNA	Protein	Name
NM_027677.2	NP_081953.2	G-protein coupled receptor 39

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	GPR39	XP_515800.2
Bos taurus (cattle)	GPR39	NP_001137216.1
Mus musculus (house mouse)	Gpr39	NP_081953.2
Rattus norvegicus (Norway rat)	Gpr39	NP_001107864.1
Homo sapiens (human)	GPR39	NP_001499.1
Canis lupus familiaris (dog)	GPR39	XP_853332.2
Gallus gallus (chicken)	GPR39	NP_001073574.1
Danio rerio (zebrafish)	gpr39	NP_956711.1

Gene Ontology
Bibliography

Related articles in PubMed

Zac1/GPR39 phosphorylating CaMK-II contributes to the distinct roles of Pax3 and Pax7 in myogenic progression.
Yang Q, Li Y, Zhang X, Chen D
Biochimica et biophysica acta1864(2)407-419(2018 Feb)

Perturbed bone composition and integrity with disorganized osteoblast function in zinc receptor/Gpr39-deficient mice.
Jovanovic M, Schmidt FN, Guterman-Ram G, Khayyeri H, Hiram-Bab S, Orenbuch A, Katchkovsky S, Aflalo A, Isaksson H, Busse B, J?hn K, Levaot N
FASEB journal : official publication of the Federation of American Societies for Experimental Biology(2018 Jan)

The Zn
Sunuwar L, Asraf H, Donowitz M, Sekler I, Hershfinkel M
Biochimica et biophysica acta1863(4)947-960(2017 Apr)

GPR39 is region-specifically expressed in mouse oviduct correlating with the Zn
Qiao J, Zhao H, Zhang Y, Peng H, Chen Q, Zhang H, Zheng X, Jin Y, Ni H, Duan E, Guo Y
Theriogenology8898-105(2017 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study used mice expressing a Gpr39 promoter-driven LacZ reporter system to detect Gpr39 expression in the reproductive system at different phases of the estrous cycle and found an interesting region-specific distribution of Gpr39 in the mouse oviduct epithelium, which was associated with zinc metabolism.
Title: GPR39 is region-specifically expressed in mouse oviduct correlating with the Zn

The zinc sensing receptor, ZnR/GPR39, triggers intracellular Ca(2+) signalling in colonocytes thereby inducing occludin expression. Moreover, ZnR/GPR39 is essential for epithelial barrier recovery in the dextran sodium sulfate (DSS) ulcerative colitis model.
Title: The zinc sensing receptor, ZnR/GPR39, triggers metabotropic calcium signalling in colonocytes and regulates occludin recovery in experimental colitis.

This study has demonstrated the presence of GPR39 and the insulinotropic actions of trace metals on BRIN-BD11 cells and pancreatic beta cells
Title: GPR39 receptors and actions of trace metals on pancreatic beta cell function and glucose homoeostasis.

The results indicate depressive-like behavior in GPR39 Knockout mice with an immune response similar to that observed in depressive disorder.
Title: Immune malfunction in the GPR39 zinc receptor of knockout mice: Its relationship to depressive disorder.

The results of this study indicated that neurons, mZnR/GPR39 activity and subsequent Zn2+-dependent Ca2+ rises, ERK1/2 phosphorylation and up-regulation of NHE activity are all abolished at acidic pHe.
Title: Regulation of neuronal pH by the metabotropic Zn(2+)-sensing Gq-coupled receptor, mZnR/GPR39.

The following Gpr39 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gpr39 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu04489	NM_027677.2 Latest version!	Mus musculus G protein-coupled receptor 39 (Gpr39), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gpr39 ( NM_027677.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_081953.2 Mus musculus G protein-coupled receptor 39 (Gpr39), mRNA.

Price & Availability↑

CloneID	OMu04489
Clone ID Related Accession (Same CDS sequence)	NM_027677.2
Accession Version	NM_027677.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1371bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Mus musculus(house mouse)
Product	G-protein coupled receptor 39
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC140425.3 and AC153655.4. On Apr 9, 2009 this sequence version replaced NM_027677.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC085285.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849376 [ECO:0000348] ##Evidence-Data-END##

ATGGCTTCAT CCAGTGGCTC CAACCACATC TGCTCCCGTG TCATCGATCA CAGCCATGTT 
CCTGAATTTG AGGTGGCCAC TTGGATCAAA ATCACCCTCA TCTTGGTGTA CCTGATCATC 
TTTGTGGTAG GCATCTTGGG CAACAGCGTC ACCATCAGGG TTACGCAGGT ATTGCAGAAG 
AAGGGCTATT TGCAGAAGGA GGTGACAGAT CACATGGTCA GTTTGGCTTG TTCAGATATC 
TTGGTCTTTT TGATTGGCAT GCCCATGGAG TTCTACAGCA TCATTTGGAA CCCCCTGACC 
ACACCCAGCT ATGCTCTGTC CTGTAAGCTC CACACGTTCC TCTTTGAGAC GTGCAGCTAC 
GCCACACTGC TGCACGTGCT GACCCTCAGC TTTGAGCGCT ACATTGCCAT TTGTCATCCC 
TTCAAGTATA AAGCAGTGTC TGGACCTCGC CAGGTGAAAC TGCTGATTGG CTTTGTATGG 
GTCACCTCCG CCCTGGTGGC ACTGCCTTTG CTCTTTGCCA TGGGTATCGA GTACCCTCTG 
GTAAACGTAC CCACTCACAA GGGACTCAAC TGCAACCTCT CTCGCACCCG CCACCACGAT 
GAACCTGGAA ACTCCAATAT GTCCATCTGC ACGAACCTCT CCAACCGTTG GGAGGTCTTC 
CAGTCCAGCA TCTTTGGGGC CTTTGCTGTT TACCTGGTGG TCCTGGCGTC TGTGGCTTTC 
ATGTGTTGGA ATATGATGAA AGTGCTAATG AAGAGCAAGC AGGGCACTCT TGCAGGGACC 
GGGCCACAGC TCCAGCTGAG GAAGTCAGAG AGTGAGGAGA GCCGGACAGC AAGAAGACAG 
ACCATCATAT TCCTGAGACT GATTGTGGTG ACGTTGGCCG TGTGTTGGAT GCCCAATCAG 
ATCCGACGGA TCATGGCTGC AGCAAAACCC AAACATGACT GGACCAGAAC GTACTTCAGG 
GCATACATGA TCCTCCTGCC CTTCTCTGAT ACCTTCTTCT ACCTCAGCTC TGTGGTCAAC 
CCTCTCCTCT ACAACGTGTC CTCTCAGCAG TTCCGGAAGG TGTTCTGGCA GGTGCTCTGC 
TGCCGCCTGA CTCTGCAGCA TGCCAACCAA GAGAAACGCC AGCGTGCCCG CTTCATCTCC 
ACCAAGGACA GCACCAGCTC AGCCCGCAGC CCCCTCATCT TCCTAGCCTC CCGGCGCAGT 
AACTCTTCCT CCAGGAGAAC TAACAAGGTT TTCTTAAGCA CTTTTCAGAC TGAGGCCAAG 
CCTGGAGAGG CTAAGCCCCA GCCCTTGAGT CCTGAGTCAC CACAGACTGG CTCAGAGACC 
AAACCAGCTG GGTCCACCCC AGAAAATAGT TTACAGGAGC AGGAAGTATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_081953.2
CDS	342..1712
Translation	MASSSGSNHICSRVIDHSHVPEFEVATWIKITLILVYLIIFVVGILGNSVTIRVTQVLQKKGYLQKEVTDHMVSLACSDILVFLIGMPMEFYSIIWNPLTTPSYALSCKLHTFLFETCSYATLLHVLTLSFERYIAICHPFKYKAVSGPRQVKLLIGFVWVTSALVALPLLFAMGIEYPLVNVPTHKGLNCNLSRTRHHDEPGNSNMSICTNLSNRWEVFQSSIFGAFAVYLVVLASVAFMCWNMMKVLMKSKQGTLAGTGPQLQLRKSESEESRTARRQTIIFLRLIVVTLAVCWMPNQIRRIMAAAKPKHDWTRTYFRAYMILLPFSDTFFYLSSVVNPLLYNVSSQQFRKVFWQVLCCRLTLQHANQEKRQRARFISTKDSTSSARSPLIFLASRRSNSSSRRTNKVFLSTFQTEAKPGEAKPQPLSPESPQTGSETKPAGSTPENSLQEQEV

Target ORF information:

RefSeq Version	NM_027677.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus G protein-coupled receptor 39 (Gpr39), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_027677.2

ORF Insert Sequence:

ATGGCTTCAT CCAGTGGCTC CAACCACATC TGCTCCCGTG TCATCGATCA CAGCCATGTT 
CCTGAATTTG AGGTGGCCAC TTGGATCAAA ATCACCCTCA TCTTGGTGTA CCTGATCATC 
TTTGTGGTAG GCATCTTGGG CAACAGCGTC ACCATCAGGG TTACGCAGGT ATTGCAGAAG 
AAGGGCTATT TGCAGAAGGA GGTGACAGAT CACATGGTCA GTTTGGCTTG TTCAGATATC 
TTGGTCTTTT TGATTGGCAT GCCCATGGAG TTCTACAGCA TCATTTGGAA CCCCCTGACC 
ACACCCAGCT ATGCTCTGTC CTGTAAGCTC CACACGTTCC TCTTTGAGAC GTGCAGCTAC 
GCCACACTGC TGCACGTGCT GACCCTCAGC TTTGAGCGCT ACATTGCCAT TTGTCATCCC 
TTCAAGTATA AAGCAGTGTC TGGACCTCGC CAGGTGAAAC TGCTGATTGG CTTTGTATGG 
GTCACCTCCG CCCTGGTGGC ACTGCCTTTG CTCTTTGCCA TGGGTATCGA GTACCCTCTG 
GTAAACGTAC CCACTCACAA GGGACTCAAC TGCAACCTCT CTCGCACCCG CCACCACGAT 
GAACCTGGAA ACTCCAATAT GTCCATCTGC ACGAACCTCT CCAACCGTTG GGAGGTCTTC 
CAGTCCAGCA TCTTTGGGGC CTTTGCTGTT TACCTGGTGG TCCTGGCGTC TGTGGCTTTC 
ATGTGTTGGA ATATGATGAA AGTGCTAATG AAGAGCAAGC AGGGCACTCT TGCAGGGACC 
GGGCCACAGC TCCAGCTGAG GAAGTCAGAG AGTGAGGAGA GCCGGACAGC AAGAAGACAG 
ACCATCATAT TCCTGAGACT GATTGTGGTG ACGTTGGCCG TGTGTTGGAT GCCCAATCAG 
ATCCGACGGA TCATGGCTGC AGCAAAACCC AAACATGACT GGACCAGAAC GTACTTCAGG 
GCATACATGA TCCTCCTGCC CTTCTCTGAT ACCTTCTTCT ACCTCAGCTC TGTGGTCAAC 
CCTCTCCTCT ACAACGTGTC CTCTCAGCAG TTCCGGAAGG TGTTCTGGCA GGTGCTCTGC 
TGCCGCCTGA CTCTGCAGCA TGCCAACCAA GAGAAACGCC AGCGTGCCCG CTTCATCTCC 
ACCAAGGACA GCACCAGCTC AGCCCGCAGC CCCCTCATCT TCCTAGCCTC CCGGCGCAGT 
AACTCTTCCT CCAGGAGAAC TAACAAGGTT TTCTTAAGCA CTTTTCAGAC TGAGGCCAAG 
CCTGGAGAGG CTAAGCCCCA GCCCTTGAGT CCTGAGTCAC CACAGACTGG CTCAGAGACC 
AAACCAGCTG GGTCCACCCC AGAAAATAGT TTACAGGAGC AGGAAGTATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Zac1/GPR39 phosphorylating CaMK-II contributes to the distinct roles of Pax3 and Pax7 in myogenic progression.
Biochimica et biophysica acta1864(2)407-419(2018 Feb)
Yang Q,Li Y,Zhang X,Chen D

Perturbed bone composition and integrity with disorganized osteoblast function in zinc receptor/Gpr39-deficient mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology(2018 Jan)
Jovanovic M,Schmidt FN,Guterman-Ram G,Khayyeri H,Hiram-Bab S,Orenbuch A,Katchkovsky S,Aflalo A,Isaksson H,Busse B,J?hn K,Levaot N

The Zn
Biochimica et biophysica acta1863(4)947-960(2017 Apr)
Sunuwar L,Asraf H,Donowitz M,Sekler I,Hershfinkel M

GPR39 is region-specifically expressed in mouse oviduct correlating with the Zn
Theriogenology8898-105(2017 Jan)
Qiao J,Zhao H,Zhang Y,Peng H,Chen Q,Zhang H,Zheng X,Jin Y,Ni H,Duan E,Guo Y

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Gpr39 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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