Mzb1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mzb1
Entrez Gene ID	69816
Full Name	marginal zone B and B1 cell-specific protein 1
Synonyms	2010001M09Rik,AV064572,PACAP,pERp1
General protein information	Preferred Names marginal zone B and B1 cell-specific protein 1 Names marginal zone B- and B1-cell-specific protein plasma cell-induced ER protein 1 plasma cell-induced resident ER protein plasma cell-induced resident endoplasmic reticulum protein proapoptotic caspase adapter protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 18 Map Location: 18\|18 B2

mRNA and Protein(s)

mRNA	Protein	Name
NM_027222.3	NP_081498.2	marginal zone B- and B1-cell-specific protein precursor
XM_017317978.1	XP_017173467.1	marginal zone B- and B1-cell-specific protein isoform X1
XM_017317978.2	XP_017173467.1	marginal zone B- and B1-cell-specific protein isoform X1

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	LOC100859189	XP_003642115.1
Mus musculus (house mouse)	Mzb1	NP_081498.2
Rattus norvegicus (Norway rat)	Mzb1	NP_001019411.1
Bos taurus (cattle)	MZB1	NP_001092400.1
Homo sapiens (human)	MZB1	NP_057543.2
Pan troglodytes (chimpanzee)	MZB1	XP_001172512.1
	MZB1	XP_001082403.1
Canis lupus familiaris (dog)	MZB1	XP_003433803.2

Gene Ontology
Bibliography

Related articles in PubMed

MZB1 is a GRP94 cochaperone that enables proper immunoglobulin heavy chain biosynthesis upon ER stress.
Rosenbaum M, Andreani V, Kapoor T, Herp S, Flach H, Duchniewicz M, Grosschedl R
Genes & development28(11)1165-78(2014 Jun)

Transgenic expression of microRNA-185 causes a developmental arrest of T cells by targeting multiple genes including Mzb1.
Belkaya S, Murray SE, Eitson JL, de la Morena MT, Forman JA, van Oers NS
The Journal of biological chemistry288(42)30752-62(2013 Oct)

Novel hormone-regulated genes in visceral adipose tissue: cloning and identification of proinflammatory cytokine-like mouse and human MEDA-7: implications for obesity, insulin resistance and the metabolic syndrome.
Zhang H, Chen X, Sairam MR
Diabetologia54(9)2368-80(2011 Sep)

Mzb1 protein regulates calcium homeostasis, antibody secretion, and integrin activation in innate-like B cells.
Flach H, Rosenbaum M, Duchniewicz M, Kim S, Zhang SL, Cahalan MD, Mittler G, Grosschedl R
Immunity33(5)723-35(2010 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

MZB1 seems to act as a substrate-specific cochaperone of GRP94 that enables proper biosynthesis of microHCs under conditions of ER stress.
Title: MZB1 is a GRP94 cochaperone that enables proper immunoglobulin heavy chain biosynthesis upon ER stress.

miR-185 regulates T cell development through its targeting of several mRNAs including Mzb1.
Title: Transgenic expression of microRNA-185 causes a developmental arrest of T cells by targeting multiple genes including Mzb1.

Mzb1 helps to diversify peripheral B cell functions by regulating Ca(2+) stores, antibody secretion, and integrin activation.
Title: Mzb1 protein regulates calcium homeostasis, antibody secretion, and integrin activation in innate-like B cells.

Data suggest that pERp1 is either a unique type of oxidoreductase or a previously unidentified class of molecular chaperone that is dedicated to enhancing the oxidative folding of Ig precursors.
Title: pERp1 is significantly up-regulated during plasma cell differentiation and contributes to the oxidative folding of immunoglobulin.

In a mouse model of asthma 2010001M09Rik (Mzb1) was unaltered 24 hours after allergen exposure, however, by 72 hours a marked increase in 2010001M09Rik mRNA was detected in lung tissue from disease-susceptible C57BL/6 and BALB/c mice.
Title: Expression of survivin in lung eosinophils is associated with pathology in a mouse model of allergic asthma.

The following Mzb1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mzb1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu03895	NM_027222.3 Latest version!	Mus musculus marginal zone B and B1 cell-specific protein 1 (Mzb1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu79837	XM_017317978.2 Latest version!	Mus musculus marginal zone B and B1 cell-specific protein 1 (Mzb1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OMu79837	XM_017317978.1	Mus musculus marginal zone B and B1 cell-specific protein 1 (Mzb1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mzb1 ( XM_017317978.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017173467.1 Mus musculus marginal zone B and B1 cell-specific protein 1 (Mzb1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu79837
Clone ID Related Accession (Same CDS sequence)	XM_017317978.1 , XM_017317978.2
Accession Version	XM_017317978.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 393bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	marginal zone B- and B1-cell-specific protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000084.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGGCAAC GTCTGGCGAA AGCAGAGGCT AAATCTCACA CTCCAGACGC CAGTGGATTG 
CAGGAGCTGA GTGAATCCAC GTACACAGAT GTCCTGGACC AGACCTGCTC TCAGAACTGG 
CAGTCCTATG GAGTTCATGA AGTGAACCAG ATGAAGCGTC TCACGGGCCC AGGACTTAGC 
AAGGGGCCAG AGCCAAGAAT CAGCGTGATG ATTTCTGGGG GTCCCTGGCC CAATAGGCTC 
TCCAAGACGT GTTTCCACTA CCTGGGTGAG TTTGGAGAGG ACCAGATCTA TGAAGCCTAC 
CGCCAAGGCC AAGCGAATCT GGAGGCGCTG CTCTGTGGGG GCACCCATGG GCCCTGCTCA 
CAGGAGATCC TGGCCCAGAG AGAAGAGCTT TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017173467.1
CDS	650..1042
Translation	MGQRLAKAEAKSHTPDASGLQELSESTYTDVLDQTCSQNWQSYGVHEVNQMKRLTGPGLSKGPEPRISVMISGGPWPNRLSKTCFHYLGEFGEDQIYEAYRQGQANLEALLCGGTHGPCSQEILAQREEL

Target ORF information:

RefSeq Version	XM_017317978.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus marginal zone B and B1 cell-specific protein 1 (Mzb1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017317978.1

ORF Insert Sequence:

ATGGGGCAAC GTCTGGCGAA AGCAGAGGCT AAATCTCACA CTCCAGACGC CAGTGGATTG 
CAGGAGCTGA GTGAATCCAC GTACACAGAT GTCCTGGACC AGACCTGCTC TCAGAACTGG 
CAGTCCTATG GAGTTCATGA AGTGAACCAG ATGAAGCGTC TCACGGGCCC AGGACTTAGC 
AAGGGGCCAG AGCCAAGAAT CAGCGTGATG ATTTCTGGGG GTCCCTGGCC CAATAGGCTC 
TCCAAGACGT GTTTCCACTA CCTGGGTGAG TTTGGAGAGG ACCAGATCTA TGAAGCCTAC 
CGCCAAGGCC AAGCGAATCT GGAGGCGCTG CTCTGTGGGG GCACCCATGG GCCCTGCTCA 
CAGGAGATCC TGGCCCAGAG AGAAGAGCTT TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mzb1 ( NM_027222.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_081498.2 Mus musculus marginal zone B and B1 cell-specific protein 1 (Mzb1), mRNA.

Price & Availability↑

CloneID	OMu03895
Clone ID Related Accession (Same CDS sequence)	NM_027222.3
Accession Version	NM_027222.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 567bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	marginal zone B- and B1-cell-specific protein precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK008016.1, BC064044.1 and AA866731.1. On Sep 9, 2009 this sequence version replaced NM_027222.2. ##Evidence-Data-START## Transcript exon combination :: BC064044.1, AK008016.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGACTGC CTCTGCCACT GTTGCTACTG TTCGGGTGCA GGGCTATCCT GGGGAGCGCC 
GGGGATAGGG TTTCCCTCTC GGCTTCGGCT CCCACACTGG ATGATGAAGA GAAGTACTCG 
GCTCATATGC CGGCTCACCT GCGCTGCGAT GCCTGCCGGG CTGTGGCCTT CCAGATGGGG 
CAACGTCTGG CGAAAGCAGA GGCTAAATCT CACACTCCAG ACGCCAGTGG ATTGCAGGAG 
CTGAGTGAAT CCACGTACAC AGATGTCCTG GACCAGACCT GCTCTCAGAA CTGGCAGTCC 
TATGGAGTTC ATGAAGTGAA CCAGATGAAG CGTCTCACGG GCCCAGGACT TAGCAAGGGG 
CCAGAGCCAA GAATCAGCGT GATGATTTCT GGGGGTCCCT GGCCCAATAG GCTCTCCAAG 
ACGTGTTTCC ACTACCTGGG TGAGTTTGGA GAGGACCAGA TCTATGAAGC CTACCGCCAA 
GGCCAAGCGA ATCTGGAGGC GCTGCTCTGT GGGGGCACCC ATGGGCCCTG CTCACAGGAG 
ATCCTGGCCC AGAGAGAAGA GCTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_081498.2
CDS	35..601
Translation	MRLPLPLLLLFGCRAILGSAGDRVSLSASAPTLDDEEKYSAHMPAHLRCDACRAVAFQMGQRLAKAEAKSHTPDASGLQELSESTYTDVLDQTCSQNWQSYGVHEVNQMKRLTGPGLSKGPEPRISVMISGGPWPNRLSKTCFHYLGEFGEDQIYEAYRQGQANLEALLCGGTHGPCSQEILAQREEL

Target ORF information:

RefSeq Version	NM_027222.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus marginal zone B and B1 cell-specific protein 1 (Mzb1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_027222.3

ORF Insert Sequence:

ATGAGACTGC CTCTGCCACT GTTGCTACTG TTCGGGTGCA GGGCTATCCT GGGGAGCGCC 
GGGGATAGGG TTTCCCTCTC GGCTTCGGCT CCCACACTGG ATGATGAAGA GAAGTACTCG 
GCTCATATGC CGGCTCACCT GCGCTGCGAT GCCTGCCGGG CTGTGGCCTT CCAGATGGGG 
CAACGTCTGG CGAAAGCAGA GGCTAAATCT CACACTCCAG ACGCCAGTGG ATTGCAGGAG 
CTGAGTGAAT CCACGTACAC AGATGTCCTG GACCAGACCT GCTCTCAGAA CTGGCAGTCC 
TATGGAGTTC ATGAAGTGAA CCAGATGAAG CGTCTCACGG GCCCAGGACT TAGCAAGGGG 
CCAGAGCCAA GAATCAGCGT GATGATTTCT GGGGGTCCCT GGCCCAATAG GCTCTCCAAG 
ACGTGTTTCC ACTACCTGGG TGAGTTTGGA GAGGACCAGA TCTATGAAGC CTACCGCCAA 
GGCCAAGCGA ATCTGGAGGC GCTGCTCTGT GGGGGCACCC ATGGGCCCTG CTCACAGGAG 
ATCCTGGCCC AGAGAGAAGA GCTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mzb1 ( XM_017317978.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017173467.1 Mus musculus marginal zone B and B1 cell-specific protein 1 (Mzb1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu79837
Clone ID Related Accession (Same CDS sequence)	XM_017317978.1 , XM_017317978.2
Accession Version	XM_017317978.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 393bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	marginal zone B- and B1-cell-specific protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000084.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_017317978.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGGCAAC GTCTGGCGAA AGCAGAGGCT AAATCTCACA CTCCAGACGC CAGTGGATTG 
CAGGAGCTGA GTGAATCCAC GTACACAGAT GTCCTGGACC AGACCTGCTC TCAGAACTGG 
CAGTCCTATG GAGTTCATGA AGTGAACCAG ATGAAGCGTC TCACGGGCCC AGGACTTAGC 
AAGGGGCCAG AGCCAAGAAT CAGCGTGATG ATTTCTGGGG GTCCCTGGCC CAATAGGCTC 
TCCAAGACGT GTTTCCACTA CCTGGGTGAG TTTGGAGAGG ACCAGATCTA TGAAGCCTAC 
CGCCAAGGCC AAGCGAATCT GGAGGCGCTG CTCTGTGGGG GCACCCATGG GCCCTGCTCA 
CAGGAGATCC TGGCCCAGAG AGAAGAGCTT TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017173467.1
CDS	919..1311
Translation	MGQRLAKAEAKSHTPDASGLQELSESTYTDVLDQTCSQNWQSYGVHEVNQMKRLTGPGLSKGPEPRISVMISGGPWPNRLSKTCFHYLGEFGEDQIYEAYRQGQANLEALLCGGTHGPCSQEILAQREEL

Target ORF information:

RefSeq Version	XM_017317978.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus marginal zone B and B1 cell-specific protein 1 (Mzb1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017317978.2

ORF Insert Sequence:

ATGGGGCAAC GTCTGGCGAA AGCAGAGGCT AAATCTCACA CTCCAGACGC CAGTGGATTG 
CAGGAGCTGA GTGAATCCAC GTACACAGAT GTCCTGGACC AGACCTGCTC TCAGAACTGG 
CAGTCCTATG GAGTTCATGA AGTGAACCAG ATGAAGCGTC TCACGGGCCC AGGACTTAGC 
AAGGGGCCAG AGCCAAGAAT CAGCGTGATG ATTTCTGGGG GTCCCTGGCC CAATAGGCTC 
TCCAAGACGT GTTTCCACTA CCTGGGTGAG TTTGGAGAGG ACCAGATCTA TGAAGCCTAC 
CGCCAAGGCC AAGCGAATCT GGAGGCGCTG CTCTGTGGGG GCACCCATGG GCCCTGCTCA 
CAGGAGATCC TGGCCCAGAG AGAAGAGCTT TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MZB1 is a GRP94 cochaperone that enables proper immunoglobulin heavy chain biosynthesis upon ER stress.
Genes & development28(11)1165-78(2014 Jun)
Rosenbaum M,Andreani V,Kapoor T,Herp S,Flach H,Duchniewicz M,Grosschedl R

Transgenic expression of microRNA-185 causes a developmental arrest of T cells by targeting multiple genes including Mzb1.
The Journal of biological chemistry288(42)30752-62(2013 Oct)
Belkaya S,Murray SE,Eitson JL,de la Morena MT,Forman JA,van Oers NS

Novel hormone-regulated genes in visceral adipose tissue: cloning and identification of proinflammatory cytokine-like mouse and human MEDA-7: implications for obesity, insulin resistance and the metabolic syndrome.
Diabetologia54(9)2368-80(2011 Sep)
Zhang H,Chen X,Sairam MR

Mzb1 protein regulates calcium homeostasis, antibody secretion, and integrin activation in innate-like B cells.
Immunity33(5)723-35(2010 Nov)
Flach H,Rosenbaum M,Duchniewicz M,Kim S,Zhang SL,Cahalan MD,Mittler G,Grosschedl R

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Mzb1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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