Trip13 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Trip13
Entrez Gene ID	69716
Full Name	thyroid hormone receptor interactor 13
Synonyms	2410002G23Rik,D13Ertd328e
General protein information	Preferred Names thyroid hormone receptor interactor 13 Names pachytene checkpoint protein 2 homolog TR-interacting protein 13 TRIP-13 thyroid receptor-interacting protein 13
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 13 Map Location: 13 C1\|13 40.15 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_027182.2	NP_081458.1	pachytene checkpoint protein 2 homolog

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	TRIP13	XP_003310659.1
Xenopus tropicalis (tropical clawed frog)	trip13	NP_989228.1
Rattus norvegicus (Norway rat)	Trip13	NP_001011930.1
Saccharomyces cerevisiae (baker's yeast)	PCH2	NP_009745.2
Eremothecium gossypii	AGOS_AEL258W	NP_984603.2
Homo sapiens (human)	TRIP13	NP_004228.1
Bos taurus (cattle)	TRIP13	XP_002696498.1
Gallus gallus (chicken)	TRIP13	XP_004935129.1
Canis lupus familiaris (dog)	TRIP13	XP_851775.1
Mus musculus (house mouse)	Trip13	NP_081458.1
Danio rerio (zebrafish)	trip13	NP_956876.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001522	XP_321602.5
Oryza sativa (rice)	Os04g0479000	NP_001053091.1
Drosophila melanogaster (fruit fly)	pch2	NP_524282.4
Arabidopsis thaliana (thale cress)	AT4G24710	NP_194202.3

Gene Ontology
Bibliography

Related articles in PubMed

The DNA Damage Checkpoint Eliminates Mouse Oocytes with Chromosome Synapsis Failure.
Rinaldi VD, Bolcun-Filas E, Kogo H, Kurahashi H, Schimenti JC
Molecular cell67(6)1026-1036.e2(2017 Sep)

p53 and TAp63 participate in the recombination-dependent pachytene arrest in mouse spermatocytes.
Marcet-Ortega M, Pacheco S, Mart?nez-Marchal A, Castillo H, Flores E, Jasin M, Keeney S, Roig I
PLoS genetics13(6)e1006845(2017 Jun)

TRIP13 impairs mitotic checkpoint surveillance and is associated with poor prognosis in multiple myeloma.
Tao Y, Yang G, Yang H, Song D, Hu L, Xie B, Wang H, Gao L, Gao M, Xu H, Xu Z, Wu X, Zhang Y, Zhu W, Zhan F, Shi J
Oncotarget8(16)26718-26731(2017 Apr)

TRIP13-deficient tubular epithelial cells are susceptible to apoptosis following acute kidney injury.
Pressly JD, Hama T, Brien SO, Regner KR, Park F
Scientific reports743196(2017 Mar)

Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program.
Sundberg JP, Dadras SS, Silva KA, Kennedy VE, Garland G, Murray SA, Sundberg BA, Schofield PN, Pratt CH
PloS one12(7)e0180682(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TRIP13-deficient spermatocytes also progress to an H1t-positive stage if ATM activity is attenuated by hypomorphic mutations in Mre11 or Nbs1 or by elimination of the ATM-effector kinase CHK2
Title: The ATM signaling cascade promotes recombination-dependent pachytene arrest in mouse spermatocytes.

TRIP13 promotes error-prone non-homologous end joining and induces chemoresistance in head and neck cancer.
Title: TRIP13 promotes error-prone nonhomologous end joining and induces chemoresistance in head and neck cancer.

TRIP13 is required for recombination and normal higher-order chromosome structure during meiosis.
Title: Mouse TRIP13/PCH2 is required for recombination and normal higher-order chromosome structure during meiosis.

HORMAD1 and HORMAD2 are depleted from synapsed chromosome axes with the help of TRIP13.
Title: Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal proteins, are depleted from synapsed chromosome axes with the help of TRIP13 AAA-ATPase.

results demonstrate that in mice, the primary meiotic function of TRIP13 is in recombination itself
Title: Mouse pachytene checkpoint 2 (trip13) is required for completing meiotic recombination but not synapsis.

The following Trip13 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Trip13 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu19205	NM_027182.2 Latest version!	Mus musculus thyroid hormone receptor interactor 13 (Trip13), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Trip13 ( NM_027182.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_081458.1 Mus musculus thyroid hormone receptor interactor 13 (Trip13), mRNA.

Price & Availability↑

CloneID	OMu19205
Clone ID Related Accession (Same CDS sequence)	NM_027182.2
Accession Version	NM_027182.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1299bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	pachytene checkpoint protein 2 homolog
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AK146877.1. On Apr 6, 2007 this sequence version replaced NM_027182.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK146877.1, AK142463.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGGACGAGG CGGTGGGCGA CCTGAAGCAA GCGCTTCCCT GTGTTGCCGA ATCGCCCGCG 
GTCCATGTGG AGGTTCTGCA GCGCAGCGGA AGCACTGCAA AAAAAGAAGA TATAAAGTCG 
AGTGTTTACA GGCTGCTCAA CCGGCATAAT ATTGTGTTTG GAGATTACGT CTGGACTGAG 
TTTGATGATC CTTTTCTAAG CAGAAATGTT CAGTCAGTGT CTATTGTTGA CACAGAACTA 
AAGGCTAAAG ACCCTCAGCC CATTGATCTG AGTGCATGCA CCATTGCACT TCACATCTTC 
CAGCTGAATG AAGAAGGCCC CAGCAGTGAG AATTTGGATG AAGAAACAGA AAATATAATT 
GCAGCAAGTC ACTGGGTTCT GCCTGCAGCT GAATTTCATG GACTTTGGGA TAGCCTCGTG 
TATGATGTGG AGGTCAAATC ACATCTCCTT GATTATGTGA TGACCACCGT ACTCTTCTCA 
GACAAGAACG TGGACAGCAA CCTCATCACC TGGAACCGGG TGGTGCTGCT GCACGGTCCT 
CCGGGTACTG GAAAAACATC CCTTTGTAAG GCATTAGCCC AAAAACTGAC CATCAGACTG 
TCGAGCAGGT ACCGGTATGG CCAGTTGATT GAAATAAACA GCCACAGCCT ATTTTCTAAG 
TGGTTTTCAG AAAGTGGCAA ATTGGTAACT AAGATGTTCC AGAAGATTCA GGACTTGATT 
GATGATAAGG AAGCTTTGGT GTTTGTTCTG ATTGATGAGG TGGAGAGTCT CACAGCTGCT 
CGAAATGCTT GCAGGGCAGG CGCAGAGCCA TCAGATGCTA TCCGAGTAGT CAATGCTGTG 
TTGACTCAGA TTGACCAGAT TAAAAGGCAT TCCAATGTGG TGATTCTGAC CACTTCCAAC 
ATCACTGAGA AGATTGATGT GGCTTTCGTG GATAGAGCTG ACATCAAGCA ATACATTGGC 
CCCCCCTCTG CAGCAGCCAT CTTCAAAATC TACCTGTCTT GTTTAGAAGA ACTGATGAAG 
TGCCAGATCA TATATCCTCG TCAGCAGCTG TTGACCCTTC GGGAGCTGGA AATGATTGGC 
TTCATTGAAA ATAATGTGTC AAAGTTGAGC CTCCTTTTGA GTGAAATTTC AAGGAAGAGT 
GAGGGCCTCA GTGGCCGGGT CTTGAGGAAA CTTCCTTTCC TGGCTCATGC TCTCTACATC 
CAGGCCCCCA GCGTCACCAT CGAGGGTTTC CTCCAGGCCC TATCTCTGGC AGTGGACAAA 
CAGTTTGAGG AGAAAAAGAA ACTTTCAGCT TATGTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_081458.1
CDS	187..1485
Translation	MDEAVGDLKQALPCVAESPAVHVEVLQRSGSTAKKEDIKSSVYRLLNRHNIVFGDYVWTEFDDPFLSRNVQSVSIVDTELKAKDPQPIDLSACTIALHIFQLNEEGPSSENLDEETENIIAASHWVLPAAEFHGLWDSLVYDVEVKSHLLDYVMTTVLFSDKNVDSNLITWNRVVLLHGPPGTGKTSLCKALAQKLTIRLSSRYRYGQLIEINSHSLFSKWFSESGKLVTKMFQKIQDLIDDKEALVFVLIDEVESLTAARNACRAGAEPSDAIRVVNAVLTQIDQIKRHSNVVILTTSNITEKIDVAFVDRADIKQYIGPPSAAAIFKIYLSCLEELMKCQIIYPRQQLLTLRELEMIGFIENNVSKLSLLLSEISRKSEGLSGRVLRKLPFLAHALYIQAPSVTIEGFLQALSLAVDKQFEEKKKLSAYV

Target ORF information:

RefSeq Version	NM_027182.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus thyroid hormone receptor interactor 13 (Trip13), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_027182.2

ORF Insert Sequence:

ATGGACGAGG CGGTGGGCGA CCTGAAGCAA GCGCTTCCCT GTGTTGCCGA ATCGCCCGCG 
GTCCATGTGG AGGTTCTGCA GCGCAGCGGA AGCACTGCAA AAAAAGAAGA TATAAAGTCG 
AGTGTTTACA GGCTGCTCAA CCGGCATAAT ATTGTGTTTG GAGATTACGT CTGGACTGAG 
TTTGATGATC CTTTTCTAAG CAGAAATGTT CAGTCAGTGT CTATTGTTGA CACAGAACTA 
AAGGCTAAAG ACCCTCAGCC CATTGATCTG AGTGCATGCA CCATTGCACT TCACATCTTC 
CAGCTGAATG AAGAAGGCCC CAGCAGTGAG AATTTGGATG AAGAAACAGA AAATATAATT 
GCAGCAAGTC ACTGGGTTCT GCCTGCAGCT GAATTTCATG GACTTTGGGA TAGCCTCGTG 
TATGATGTGG AGGTCAAATC ACATCTCCTT GATTATGTGA TGACCACCGT ACTCTTCTCA 
GACAAGAACG TGGACAGCAA CCTCATCACC TGGAACCGGG TGGTGCTGCT GCACGGTCCT 
CCGGGTACTG GAAAAACATC CCTTTGTAAG GCATTAGCCC AAAAACTGAC CATCAGACTG 
TCGAGCAGGT ACCGGTATGG CCAGTTGATT GAAATAAACA GCCACAGCCT ATTTTCTAAG 
TGGTTTTCAG AAAGTGGCAA ATTGGTAACT AAGATGTTCC AGAAGATTCA GGACTTGATT 
GATGATAAGG AAGCTTTGGT GTTTGTTCTG ATTGATGAGG TGGAGAGTCT CACAGCTGCT 
CGAAATGCTT GCAGGGCAGG CGCAGAGCCA TCAGATGCTA TCCGAGTAGT CAATGCTGTG 
TTGACTCAGA TTGACCAGAT TAAAAGGCAT TCCAATGTGG TGATTCTGAC CACTTCCAAC 
ATCACTGAGA AGATTGATGT GGCTTTCGTG GATAGAGCTG ACATCAAGCA ATACATTGGC 
CCCCCCTCTG CAGCAGCCAT CTTCAAAATC TACCTGTCTT GTTTAGAAGA ACTGATGAAG 
TGCCAGATCA TATATCCTCG TCAGCAGCTG TTGACCCTTC GGGAGCTGGA AATGATTGGC 
TTCATTGAAA ATAATGTGTC AAAGTTGAGC CTCCTTTTGA GTGAAATTTC AAGGAAGAGT 
GAGGGCCTCA GTGGCCGGGT CTTGAGGAAA CTTCCTTTCC TGGCTCATGC TCTCTACATC 
CAGGCCCCCA GCGTCACCAT CGAGGGTTTC CTCCAGGCCC TATCTCTGGC AGTGGACAAA 
CAGTTTGAGG AGAAAAAGAA ACTTTCAGCT TATGTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The DNA Damage Checkpoint Eliminates Mouse Oocytes with Chromosome Synapsis Failure.
Molecular cell67(6)1026-1036.e2(2017 Sep)
Rinaldi VD,Bolcun-Filas E,Kogo H,Kurahashi H,Schimenti JC

p53 and TAp63 participate in the recombination-dependent pachytene arrest in mouse spermatocytes.
PLoS genetics13(6)e1006845(2017 Jun)
Marcet-Ortega M,Pacheco S,Mart?nez-Marchal A,Castillo H,Flores E,Jasin M,Keeney S,Roig I

TRIP13 impairs mitotic checkpoint surveillance and is associated with poor prognosis in multiple myeloma.
Oncotarget8(16)26718-26731(2017 Apr)
Tao Y,Yang G,Yang H,Song D,Hu L,Xie B,Wang H,Gao L,Gao M,Xu H,Xu Z,Wu X,Zhang Y,Zhu W,Zhan F,Shi J

TRIP13-deficient tubular epithelial cells are susceptible to apoptosis following acute kidney injury.
Scientific reports743196(2017 Mar)
Pressly JD,Hama T,Brien SO,Regner KR,Park F

Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program.
PloS one12(7)e0180682(2017)
Sundberg JP,Dadras SS,Silva KA,Kennedy VE,Garland G,Murray SA,Sundberg BA,Schofield PN,Pratt CH

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Trip13 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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