Mrln cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mrln
Entrez Gene ID	69563
Full Name	myoregulin
Synonyms	2310015B20Rik,Linc-RAM,Mln
General protein information	Preferred Names myoregulin Names myoregulin
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 10 Map Location: 10\|10 B5.3
Summary	This gene encodes a small peptide that shares structural similarity to the small peptides sarcolipin and phospholamban, which are key regulators of sarcoplasmic reticulum Ca(2+)-ATPases (SERCAs). This protein is thought to have a similar function to these peptides, regulating Ca(2+) reuptake in the sarcoplasmic reticulum by inhibiting the Ca(2+) pump activity of SERCAs. [provided by RefSeq, Feb 2015].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017314076.1	XP_017169565.1	myoregulin isoform X1
NM_001304739.1	NP_001291668.1	myoregulin

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Long non-coding RNA Linc-RAM enhances myogenic differentiation by interacting with MyoD.
Yu X, Zhang Y, Li T, Ma Z, Jia H, Chen Q, Zhao Y, Zhai L, Zhong R, Li C, Zou X, Meng J, Chen AK, Puri PL, Chen M, Zhu D
Nature communications814016(2017 Jan)

Widespread control of calcium signaling by a family of SERCA-inhibiting micropeptides.
Anderson DM, Makarewich CA, Anderson KM, Shelton JM, Bezprozvannaya S, Bassel-Duby R, Olson EN
Science signaling9(457)ra119(2016 Dec)

A micropeptide encoded by a putative long noncoding RNA regulates muscle performance.
Anderson DM, Anderson KM, Chang CL, Makarewich CA, Nelson BR, McAnally JR, Kasaragod P, Shelton JM, Liou J, Bassel-Duby R, Olson EN
Cell160(4)595-606(2015 Feb)

Identification of candidate long non-coding RNAs in response to myocardial infarction.
Zangrando J, Zhang L, Vausort M, Maskali F, Marie PY, Wagner DR, Devaux Y
BMC genomics15460(2014 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The human and mouse MLN genes consist of three exons that span 16.5 and 15.0 kb, respectively, with the ORF located in exon 3; findings identify MLN as an important regulator of skeletal muscle physiology.
Title: A micropeptide encoded by a putative long noncoding RNA regulates muscle performance.

The following Mrln gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mrln cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu70433	NM_001304739.1 Latest version!	Mus musculus myoregulin (Mrln), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu70433	XM_017314076.1 Latest version!	Mus musculus myoregulin (Mrln), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mrln ( NM_001304739.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001291668.1 Mus musculus myoregulin (Mrln), mRNA.

Price & Availability↑

CloneID	OMu70433
Clone ID Related Accession (Same CDS sequence)	XM_017314076.1 , NM_001304739.1
Accession Version	NM_001304739.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 141bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Mus musculus(house mouse)
Product	myoregulin
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY282836.1, AK009351.1 and AC122923.4. On Feb 6, 2015 this sequence version replaced NR_038041.1. ##Evidence-Data-START## Transcript exon combination :: BX523793.1, AK009351.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121

ATGAGTGGCA AGAGCTGGGT ACTGATCTCT ACTACTTCGC CCCAGAGCCT GGAAGATGAG 
ATTCTGGGAC GGCTTCTGAA AATTCTCTTC GTTTTGTTCG TTGACTTAAT GTCCATTATG 
TATGTCGTCA TAACGTCCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001291668.1
CDS	231..371
Translation	MSGKSWVLISTTSPQSLEDEILGRLLKILFVLFVDLMSIMYVVITS

Target ORF information:

RefSeq Version	NM_001304739.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus myoregulin (Mrln), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001304739.1

ORF Insert Sequence:

1
61
121

ATGAGTGGCA AGAGCTGGGT ACTGATCTCT ACTACTTCGC CCCAGAGCCT GGAAGATGAG 
ATTCTGGGAC GGCTTCTGAA AATTCTCTTC GTTTTGTTCG TTGACTTAAT GTCCATTATG 
TATGTCGTCA TAACGTCCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mrln ( XM_017314076.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_017169565.1 Mus musculus myoregulin (Mrln), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu70433
Clone ID Related Accession (Same CDS sequence)	XM_017314076.1 , NM_001304739.1
Accession Version	XM_017314076.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 141bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	myoregulin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121

ATGAGTGGCA AGAGCTGGGT ACTGATCTCT ACTACTTCGC CCCAGAGCCT GGAAGATGAG 
ATTCTGGGAC GGCTTCTGAA AATTCTCTTC GTTTTGTTCG TTGACTTAAT GTCCATTATG 
TATGTCGTCA TAACGTCCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017169565.1
CDS	169..309
Translation	MSGKSWVLISTTSPQSLEDEILGRLLKILFVLFVDLMSIMYVVITS

Target ORF information:

RefSeq Version	XM_017314076.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus myoregulin (Mrln), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017314076.1

ORF Insert Sequence:

1
61
121

ATGAGTGGCA AGAGCTGGGT ACTGATCTCT ACTACTTCGC CCCAGAGCCT GGAAGATGAG 
ATTCTGGGAC GGCTTCTGAA AATTCTCTTC GTTTTGTTCG TTGACTTAAT GTCCATTATG 
TATGTCGTCA TAACGTCCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Long non-coding RNA Linc-RAM enhances myogenic differentiation by interacting with MyoD.
Nature communications814016(2017 Jan)
Yu X,Zhang Y,Li T,Ma Z,Jia H,Chen Q,Zhao Y,Zhai L,Zhong R,Li C,Zou X,Meng J,Chen AK,Puri PL,Chen M,Zhu D

Widespread control of calcium signaling by a family of SERCA-inhibiting micropeptides.
Science signaling9(457)ra119(2016 Dec)
Anderson DM,Makarewich CA,Anderson KM,Shelton JM,Bezprozvannaya S,Bassel-Duby R,Olson EN

A micropeptide encoded by a putative long noncoding RNA regulates muscle performance.
Cell160(4)595-606(2015 Feb)
Anderson DM,Anderson KM,Chang CL,Makarewich CA,Nelson BR,McAnally JR,Kasaragod P,Shelton JM,Liou J,Bassel-Duby R,Olson EN

Identification of candidate long non-coding RNAs in response to myocardial infarction.
BMC genomics15460(2014 Jun)
Zangrando J,Zhang L,Vausort M,Maskali F,Marie PY,Wagner DR,Devaux Y

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Mrln cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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