Selenot cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Selenot
Entrez Gene ID	69227
Full Name	selenoprotein T
Synonyms	2810407C02Rik,5730408P04Rik,Selt
General protein information	Preferred Names selenoprotein T Names thioredoxin reductase-like selenoprotein T thioredoxin reductase-like enzyme
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 3 Map Location: 3\|3 D
Summary	This gene encodes a selenoprotein, containing a selenocysteine (Sec) residue at the active site. Sec is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is localized in the endoplasmic reticulum. It belongs to the SelWTH family that possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif found in several redox active proteins. Studies in mice indicate a crucial role for this gene in the protection of dopaminergic neurons against oxidative stress in Parkinson's disease, and in the control of glucose homeostasis in pancreatic beta-cells. A pseudogene of this locus has been identified on chromosome 8. [provided by RefSeq, Aug 2017].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001040396.2	NP_001035486.2	selenoprotein T precursor
NM_001040396.3	NP_001035486.2	thioredoxin reductase-like selenoprotein T precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	SELT	NP_001096573.2
Mus musculus (house mouse)	Selt	NP_001035486.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009202	XP_319979.4
Canis lupus familiaris (dog)	SELT	NP_001157959.1
Homo sapiens (human)	SELT	NP_057359.2
Danio rerio (zebrafish)	selt1a	NP_840075.2
Rattus norvegicus (Norway rat)	Selt	NP_001014275.2
Gallus gallus (chicken)	SELT	NP_001006557.3
Xenopus tropicalis (tropical clawed frog)	selt	NP_988868.2
	SELT	NP_001152886.1
Drosophila melanogaster (fruit fly)	CG3887	NP_608897.1

Gene Ontology
Bibliography

Related articles in PubMed

Selenoprotein T is a novel OST subunit that regulates UPR signaling and hormone secretion.
Hamieh A, Cartier D, Abid H, Calas A, Burel C, Bucharles C, Jehan C, Grumolato L, Landry M, Lerouge P, Anouar Y, Lihrmann I
EMBO reports18(11)1935-1946(2017 Nov)

Selenoprotein T Deficiency Leads to Neurodevelopmental Abnormalities and Hyperactive Behavior in Mice.
Castex MT, Arabo A, B?nard M, Roy V, Le Joncour V, Pr?vost G, Bonnet JJ, Anouar Y, Falluel-Morel A
Molecular neurobiology53(9)5818-5832(2016 Nov)

Selenoprotein Gene Nomenclature.
Gladyshev VN, Arn?r ES, Berry MJ, Brigelius-Floh? R, Bruford EA, Burk RF, Carlson BA, Castellano S, Chavatte L, Conrad M, Copeland PR, Diamond AM, Driscoll DM, Ferreiro A, Floh? L, Green FR, Guig? R, Handy DE, Hatfield DL, Hesketh J, Hoffmann PR, Holmgren A, Hondal RJ, Howard MT, Huang K, Kim HY, Kim IY, K?hrle J, Krol A, Kryukov GV, Lee BJ, Lee BC, Lei XG, Liu Q, Lescure A, Lobanov AV, Loscalzo J, Maiorino M, Mariotti M, Sandeep Prabhu K, Rayman MP, Rozovsky S, Salinas G, Schmidt EE, Schomburg L, Schweizer U, Simonovi? M, Sunde RA, Tsuji PA, Tweedie S, Ursini F, Whanger PD, Zhang Y
The Journal of biological chemistry291(46)24036-24040(2016 Nov)

Selenoprotein T Exerts an Essential Oxidoreductase Activity That Protects Dopaminergic Neurons in Mouse Models of Parkinson's Disease.
Boukhzar L, Hamieh A, Cartier D, Tanguy Y, Alsharif I, Castex M, Arabo A, El Hajji S, Bonnet JJ, Errami M, Falluel-Morel A, Chagraoui A, Lihrmann I, Anouar Y
Antioxidants & redox signaling24(11)557-74(2016 Apr)

The PACAP-regulated gene selenoprotein T is abundantly expressed in mouse and human ?-cells and its targeted inactivation impairs glucose tolerance.
Prevost G, Arabo A, Jian L, Quelennec E, Cartier D, Hassan S, Falluel-Morel A, Tanguy Y, Gargani S, Lihrmann I, Kerr-Conte J, Lefebvre H, Pattou F, Anouar Y
Endocrinology154(10)3796-806(2013 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SelT exerts a neuroprotective role which is essential during brain development, and that its loss impairs mice behavior.
Title: Selenoprotein T Deficiency Leads to Neurodevelopmental Abnormalities and Hyperactive Behavior in Mice.

The SelT play a crucial role in the protection of dopaminergic neurons against oxidative stress and cell death, providing insight into the molecular underpinnings of this stress in PD.
Title: Selenoprotein T Exerts an Essential Oxidoreductase Activity That Protects Dopaminergic Neurons in Mouse Models of Parkinson's Disease.

Data suggest SelT is expressed in pancreatic beta- and delta-cells; inactivation of SelT in beta-cells leads to glucose intolerance via impaired glucose homeostasis and PACAP (pituitary adenylate cyclase-activating polypeptide) insulinotropic effect.
Title: The PACAP-regulated gene selenoprotein T is abundantly expressed in mouse and human ?-cells and its targeted inactivation impairs glucose tolerance.

Data show that the loss of SelT elevates expression of another selenoprotein, selenoprotein W, suggesting that SepW1 may functionally compensate for SelT.
Title: Selenoprotein T deficiency alters cell adhesion and elevates selenoprotein W expression in murine fibroblast cells.

The following Selenot gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Selenot cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu18803	NM_001040396.3 Latest version!	Mus musculus selenoprotein T (Selenot), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OMu18803	NM_001040396.2	Mus musculus selenoprotein T (Selt), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Selenot ( NM_001040396.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001035486.2 Mus musculus selenoprotein T (Selt), mRNA.

Price & Availability↑

CloneID	OMu18803
Clone ID Related Accession (Same CDS sequence)	NM_001040396.2 , NM_001040396.3
Accession Version	NM_001040396.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 588bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-07-09
Organism	Mus musculus(House mouse)
Product	selenoprotein T precursor
Comment

ATGAGGCTCC TGCTGCTTCT GCTGGTGGCG GCGTCGGCGG TGGTCCGCAG CGAGGCCTCT 
GCCAACCTGG GCGGCGTGCC CAGCAAGAGA TTAAAGATGC AGTACGCCAC CGGGCCGCTG 
CTCAAGTTCC AGATTTGTGT ATCCTGAGGG TACCGGCGGG TGTTTGAGGA GTACATGCGG 
GTTATCAGCC AGCGGTATCC AGACATCCGC ATTGAAGGCG AGAATTATCT CCCTCAACCA 
ATTTATAGAC ACATAGCATC TTTCCTGTCA GTCTTCAAAC TAGTATTAAT AGGCTTAATA 
ATTGTTGGCA AAGATCCTTT TGCTTTTTTC GGCATGCAAG CTCCTAGCAT CTGGCAGTGG 
GGCCAAGAAA ATAAGGTTTA TGCATGTATG ATGGTTTTCT TCCTGAGCAA CATGATTGAG 
AACCAGTGTA TGTCAACAGG TGCATTTGAG ATAACTTTAA ATGATGTGCC AGTGTGGTCT 
AAGCTGGAAT CTGGACATCT TCCATCCATG CAACAACTTG TTCAAATTCT TGACAATGAA 
ATGAAACTCA ATGTGCATAT GGATTCAATC CCACATCATC GATCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001035486.2
Translation	MRLLLLLLVAASAVVRSEASANLGGVPSKRLKMQYATGPLLKFQICVS*GYRRVFEEYMRVISQRYPDIRIEGENYLPQPIYRHIASFLSVFKLVLIGLIIVGKDPFAFFGMQAPSIWQWGQENKVYACMMVFFLSNMIENQCMSTGAFEITLNDVPVWSKLESGHLPSMQQLVQILDNEMKLNVHMDSIPHHRS

Target ORF information:

RefSeq Version	NM_001040396.2
Organism	Mus musculus(House mouse)
Definition	Mus musculus selenoprotein T (Selt), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001040396.2

ORF Insert Sequence:

ATGAGGCTCC TGCTGCTTCT GCTGGTGGCG GCGTCGGCGG TGGTCCGCAG CGAGGCCTCT 
GCCAACCTGG GCGGCGTGCC CAGCAAGAGA TTAAAGATGC AGTACGCCAC CGGGCCGCTG 
CTCAAGTTCC AGATTTGTGT ATCCTGAGGG TACCGGCGGG TGTTTGAGGA GTACATGCGG 
GTTATCAGCC AGCGGTATCC AGACATCCGC ATTGAAGGCG AGAATTATCT CCCTCAACCA 
ATTTATAGAC ACATAGCATC TTTCCTGTCA GTCTTCAAAC TAGTATTAAT AGGCTTAATA 
ATTGTTGGCA AAGATCCTTT TGCTTTTTTC GGCATGCAAG CTCCTAGCAT CTGGCAGTGG 
GGCCAAGAAA ATAAGGTTTA TGCATGTATG ATGGTTTTCT TCCTGAGCAA CATGATTGAG 
AACCAGTGTA TGTCAACAGG TGCATTTGAG ATAACTTTAA ATGATGTGCC AGTGTGGTCT 
AAGCTGGAAT CTGGACATCT TCCATCCATG CAACAACTTG TTCAAATTCT TGACAATGAA 
ATGAAACTCA ATGTGCATAT GGATTCAATC CCACATCATC GATCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Selenot ( NM_001040396.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001035486.2 Mus musculus selenoprotein T (Selenot), mRNA.

Price & Availability↑

CloneID	OMu18803
Clone ID Related Accession (Same CDS sequence)	NM_001040396.2 , NM_001040396.3
Accession Version	NM_001040396.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 588bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-22
Organism	Mus musculus(house mouse)
Product	thioredoxin reductase-like selenoprotein T precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY123391.1, AK013022.1, AK047958.1, BF660234.1 and AA155383.1. On Apr 19, 2017 this sequence version replaced NM_001040396.2. ##Evidence-Data-START## Transcript exon combination :: SRR1660819.105941.1, AK047958.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGGCTCC TGCTGCTTCT GCTGGTGGCG GCGTCGGCGG TGGTCCGCAG CGAGGCCTCT 
GCCAACCTGG GCGGCGTGCC CAGCAAGAGA TTAAAGATGC AGTACGCCAC CGGGCCGCTG 
CTCAAGTTCC AGATTTGTGT ATCCTGAGGG TACCGGCGGG TGTTTGAGGA GTACATGCGG 
GTTATCAGCC AGCGGTATCC AGACATCCGC ATTGAAGGCG AGAATTATCT CCCTCAACCA 
ATTTATAGAC ACATAGCATC TTTCCTGTCA GTCTTCAAAC TAGTATTAAT AGGCTTAATA 
ATTGTTGGCA AAGATCCTTT TGCTTTTTTC GGCATGCAAG CTCCTAGCAT CTGGCAGTGG 
GGCCAAGAAA ATAAGGTTTA TGCATGTATG ATGGTTTTCT TCCTGAGCAA CATGATTGAG 
AACCAGTGTA TGTCAACAGG TGCATTTGAG ATAACTTTAA ATGATGTGCC AGTGTGGTCT 
AAGCTGGAAT CTGGACATCT TCCATCCATG CAACAACTTG TTCAAATTCT TGACAATGAA 
ATGAAACTCA ATGTGCATAT GGATTCAATC CCACATCATC GATCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001035486.2
CDS	102..689
Translation	MRLLLLLLVAASAVVRSEASANLGGVPSKRLKMQYATGPLLKFQICVS*GYRRVFEEYMRVISQRYPDIRIEGENYLPQPIYRHIASFLSVFKLVLIGLIIVGKDPFAFFGMQAPSIWQWGQENKVYACMMVFFLSNMIENQCMSTGAFEITLNDVPVWSKLESGHLPSMQQLVQILDNEMKLNVHMDSIPHHRS

Target ORF information:

RefSeq Version	NM_001040396.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus selenoprotein T (Selenot), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001040396.3

ORF Insert Sequence:

ATGAGGCTCC TGCTGCTTCT GCTGGTGGCG GCGTCGGCGG TGGTCCGCAG CGAGGCCTCT 
GCCAACCTGG GCGGCGTGCC CAGCAAGAGA TTAAAGATGC AGTACGCCAC CGGGCCGCTG 
CTCAAGTTCC AGATTTGTGT ATCCTGAGGG TACCGGCGGG TGTTTGAGGA GTACATGCGG 
GTTATCAGCC AGCGGTATCC AGACATCCGC ATTGAAGGCG AGAATTATCT CCCTCAACCA 
ATTTATAGAC ACATAGCATC TTTCCTGTCA GTCTTCAAAC TAGTATTAAT AGGCTTAATA 
ATTGTTGGCA AAGATCCTTT TGCTTTTTTC GGCATGCAAG CTCCTAGCAT CTGGCAGTGG 
GGCCAAGAAA ATAAGGTTTA TGCATGTATG ATGGTTTTCT TCCTGAGCAA CATGATTGAG 
AACCAGTGTA TGTCAACAGG TGCATTTGAG ATAACTTTAA ATGATGTGCC AGTGTGGTCT 
AAGCTGGAAT CTGGACATCT TCCATCCATG CAACAACTTG TTCAAATTCT TGACAATGAA 
ATGAAACTCA ATGTGCATAT GGATTCAATC CCACATCATC GATCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Selenoprotein T is a novel OST subunit that regulates UPR signaling and hormone secretion.
EMBO reports18(11)1935-1946(2017 Nov)
Hamieh A,Cartier D,Abid H,Calas A,Burel C,Bucharles C,Jehan C,Grumolato L,Landry M,Lerouge P,Anouar Y,Lihrmann I

Selenoprotein T Deficiency Leads to Neurodevelopmental Abnormalities and Hyperactive Behavior in Mice.
Molecular neurobiology53(9)5818-5832(2016 Nov)
Castex MT,Arabo A,B?nard M,Roy V,Le Joncour V,Pr?vost G,Bonnet JJ,Anouar Y,Falluel-Morel A

Selenoprotein Gene Nomenclature.
The Journal of biological chemistry291(46)24036-24040(2016 Nov)
Gladyshev VN,Arn?r ES,Berry MJ,Brigelius-Floh? R,Bruford EA,Burk RF,Carlson BA,Castellano S,Chavatte L,Conrad M,Copeland PR,Diamond AM,Driscoll DM,Ferreiro A,Floh? L,Green FR,Guig? R,Handy DE,Hatfield DL,Hesketh J,Hoffmann PR,Holmgren A,Hondal RJ,Howard MT,Huang K,Kim HY,Kim IY,K?hrle J,Krol A,Kryukov GV,Lee BJ,Lee BC,Lei XG,Liu Q,Lescure A,Lobanov AV,Loscalzo J,Maiorino M,Mariotti M,Sandeep Prabhu K,Rayman MP,Rozovsky S,Salinas G,Schmidt EE,Schomburg L,Schweizer U,Simonovi? M,Sunde RA,Tsuji PA,Tweedie S,Ursini F,Whanger PD,Zhang Y

Selenoprotein T Exerts an Essential Oxidoreductase Activity That Protects Dopaminergic Neurons in Mouse Models of Parkinson's Disease.
Antioxidants & redox signaling24(11)557-74(2016 Apr)
Boukhzar L,Hamieh A,Cartier D,Tanguy Y,Alsharif I,Castex M,Arabo A,El Hajji S,Bonnet JJ,Errami M,Falluel-Morel A,Chagraoui A,Lihrmann I,Anouar Y

The PACAP-regulated gene selenoprotein T is abundantly expressed in mouse and human ?-cells and its targeted inactivation impairs glucose tolerance.
Endocrinology154(10)3796-806(2013 Oct)
Prevost G,Arabo A,Jian L,Quelennec E,Cartier D,Hassan S,Falluel-Morel A,Tanguy Y,Gargani S,Lihrmann I,Kerr-Conte J,Lefebvre H,Pattou F,Anouar Y

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Selenot cDNA ORF clone, Mus musculus(house mouse)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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