Scgb3a1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Scgb3a1
Entrez Gene ID	68662
Full Name	secretoglobin, family 3A, member 1
Synonyms	HIN-1,LuLeu2,Pnsp2,UGRP2,Utgrp2
General protein information	Preferred Names secretoglobin, family 3A, member 1 Names secretoglobin family 3A member 1 cytokine HIN-1 high in normal 1 pneumo secretory protein 2 uteroglobin related protein 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11 B1.2\|11 29.75 cM
Summary	This gene encodes a small secreted protein that may function in the inhibition of cell growth. Expression of the related gene in humans is downregulated via DNA methylation in breast cancers and other tumor types. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013].

mRNA and Protein(s)

mRNA	Protein	Name
NM_170727.2	NP_733923.1	secretoglobin family 3A member 1 isoform b
NM_054037.2	NP_473378.1	secretoglobin family 3A member 1 isoform a precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	SCGB3A1	NP_443095.2
Rattus norvegicus (Norway rat)	Scgb3a1	NP_001013198.1
Mus musculus (house mouse)	Scgb3a1	NP_473378.1
Pan troglodytes (chimpanzee)	SCGB3A1	XP_003311046.2
	LOC716331	XP_001106992.2

Gene Ontology
Bibliography

Related articles in PubMed

In utero exposure to arsenic alters lung development and genes related to immune and mucociliary function in mice.
Ramsey KA, Bosco A, McKenna KL, Carter KW, Elliot JG, Berry LJ, Sly PD, Larcombe AN, Zosky GR
Environmental health perspectives121(2)244-50(2013 Feb)

RNAi screen reveals potentially novel roles of cytokines in myoblast differentiation.
Ge Y, Waldemer RJ, Nalluri R, Nuzzi PD, Chen J
PloS one8(7)e68068(2013)

Neonatal hyperoxic exposure persistently alters lung secretoglobins and annexin A1.
Raffay TM, Locy ML, Hill CL, Jindal NS, Rogers LK, Welty SE, Tipple TE
BioMed research international2013408485(2013)

Induction of uteroglobin-related protein 2 (Ugrp2) expression by EGF and TGFalpha.
Yamada A, Kimura S
FEBS letters579(10)2221-5(2005 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Neonatal hyperoxia followed by RA recovery was associated with decreased lung CCSP and SCGB3A1 protein but not mRNA expression.
Title: Neonatal hyperoxic exposure persistently alters lung secretoglobins and annexin A1.

The differential expression of mRNA by both airway level and lung region was determined for uteroglobin-related protein 2.
Title: Site-specific differences in gene expression of secreted proteins in the mouse lung: comparison of methods to show differences by location.

The expression of SCGB3A1 and SCGB3A2 are bidirectionally regulated by oncostatin M (OSM) when examined in a mouse transformed Clara cell line.
Title: Oncostatin M regulates secretoglobin 3A1 and 3A2 expression in a bidirectional manner.

Expression of SCGB3A1 was down-regulated by IFN-gamma in a time- and dose-dependent manner in the murine transformed Clara Cells line.
Title: IFN-gamma down-regulates Secretoglobin 3A1 gene expression.

ubiquitous transcription factor NF-Y binds to and activates expression of the Scgb3a1 gene and tissue-specific expression of the gene is associated with CpG methylation of the promoter
Title: Regulation of mouse Scgb3a1 gene expression by NF-Y and association of CpG methylation with its tissue-specific expression.

The following Scgb3a1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Scgb3a1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu03143	NM_170727.2 Latest version!	Mus musculus secretoglobin, family 3A, member 1 (Scgb3a1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OMu09038	NM_054037.2 Latest version!	Mus musculus secretoglobin, family 3A, member 1 (Scgb3a1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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2-4 Clone	40% OFF
5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Scgb3a1 ( NM_170727.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_733923.1 Mus musculus secretoglobin, family 3A, member 1 (Scgb3a1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu03143
Clone ID Related Accession (Same CDS sequence)	NM_170727.2
Accession Version	NM_170727.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 285bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	secretoglobin family 3A member 1 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AV578532.1 and AF313457.1. On Jan 17, 2013 this sequence version replaced NM_170727.1. Transcript Variant: This variant (2, also known as type B) differs in the 5' UTR and contains an alternate exon in the 5' coding region, compared to variant 1. It initiates translation at an alternate start codon. The encoded isoform (b) is shorter and has a distinct N-terminus, compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF313457.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCCCAC AATCAGCAAG GCACAGTGTT GCTTTCTTCA TGGACTCATT GGCCAAGCCT 
GCGGTAGAAC CCGTGGCCGC CCTTGCTCCA GCTGCAGAGG CTGTGGCAGG GGCTGTGCCT 
AGCCTACCAT TAAGCCACTT GGCCATCCTG AGGTTCATCC TGGCCAGCAT GGGCATCCCA 
TTGGATCCTC TCATAGAGGG ATCCAGGAAG TGTGTCACCG AGCTGGGCCC TGAGGCTGTA 
GGAGCTGTGA AGTCACTGCT GGGGGTCCTG ACAATGTTCG GTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_733923.1
CDS	202..486
Translation	MSPQSARHSVAFFMDSLAKPAVEPVAALAPAAEAVAGAVPSLPLSHLAILRFILASMGIPLDPLIEGSRKCVTELGPEAVGAVKSLLGVLTMFG

Target ORF information:

RefSeq Version	NM_170727.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus secretoglobin, family 3A, member 1 (Scgb3a1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_170727.2

ORF Insert Sequence:

ATGTCCCCAC AATCAGCAAG GCACAGTGTT GCTTTCTTCA TGGACTCATT GGCCAAGCCT 
GCGGTAGAAC CCGTGGCCGC CCTTGCTCCA GCTGCAGAGG CTGTGGCAGG GGCTGTGCCT 
AGCCTACCAT TAAGCCACTT GGCCATCCTG AGGTTCATCC TGGCCAGCAT GGGCATCCCA 
TTGGATCCTC TCATAGAGGG ATCCAGGAAG TGTGTCACCG AGCTGGGCCC TGAGGCTGTA 
GGAGCTGTGA AGTCACTGCT GGGGGTCCTG ACAATGTTCG GTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Scgb3a1 ( NM_054037.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_473378.1 Mus musculus secretoglobin, family 3A, member 1 (Scgb3a1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu09038
Clone ID Related Accession (Same CDS sequence)	NM_054037.2
Accession Version	NM_054037.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 315bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	secretoglobin family 3A member 1 isoform a precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AV578532.1 and AF313456.1. On Jan 17, 2013 this sequence version replaced NM_054037.1. Transcript Variant: This variant (1, also known as type A) represents the shorter transcript and encodes the longer isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF313456.1, W20910.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGCTTA CCACCACCTT TCTAGTGCTC TGTGTGGCTC TGCTCAGTGA CTCTGGTGTT 
GCTTTCTTCA TGGACTCATT GGCCAAGCCT GCGGTAGAAC CCGTGGCCGC CCTTGCTCCA 
GCTGCAGAGG CTGTGGCAGG GGCTGTGCCT AGCCTACCAT TAAGCCACTT GGCCATCCTG 
AGGTTCATCC TGGCCAGCAT GGGCATCCCA TTGGATCCTC TCATAGAGGG ATCCAGGAAG 
TGTGTCACCG AGCTGGGCCC TGAGGCTGTA GGAGCTGTGA AGTCACTGCT GGGGGTCCTG 
ACAATGTTCG GTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_473378.1
CDS	67..381
Translation	MKLTTTFLVLCVALLSDSGVAFFMDSLAKPAVEPVAALAPAAEAVAGAVPSLPLSHLAILRFILASMGIPLDPLIEGSRKCVTELGPEAVGAVKSLLGVLTMFG

Target ORF information:

RefSeq Version	NM_054037.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus secretoglobin, family 3A, member 1 (Scgb3a1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_054037.2

ORF Insert Sequence:

ATGAAGCTTA CCACCACCTT TCTAGTGCTC TGTGTGGCTC TGCTCAGTGA CTCTGGTGTT 
GCTTTCTTCA TGGACTCATT GGCCAAGCCT GCGGTAGAAC CCGTGGCCGC CCTTGCTCCA 
GCTGCAGAGG CTGTGGCAGG GGCTGTGCCT AGCCTACCAT TAAGCCACTT GGCCATCCTG 
AGGTTCATCC TGGCCAGCAT GGGCATCCCA TTGGATCCTC TCATAGAGGG ATCCAGGAAG 
TGTGTCACCG AGCTGGGCCC TGAGGCTGTA GGAGCTGTGA AGTCACTGCT GGGGGTCCTG 
ACAATGTTCG GTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

In utero exposure to arsenic alters lung development and genes related to immune and mucociliary function in mice.
Environmental health perspectives121(2)244-50(2013 Feb)
Ramsey KA,Bosco A,McKenna KL,Carter KW,Elliot JG,Berry LJ,Sly PD,Larcombe AN,Zosky GR

RNAi screen reveals potentially novel roles of cytokines in myoblast differentiation.
PloS one8(7)e68068(2013)
Ge Y,Waldemer RJ,Nalluri R,Nuzzi PD,Chen J

Neonatal hyperoxic exposure persistently alters lung secretoglobins and annexin A1.
BioMed research international2013408485(2013)
Raffay TM,Locy ML,Hill CL,Jindal NS,Rogers LK,Welty SE,Tipple TE

Induction of uteroglobin-related protein 2 (Ugrp2) expression by EGF and TGFalpha.
FEBS letters579(10)2221-5(2005 Apr)
Yamada A,Kimura S

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Scgb3a1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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