Serpina12 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Serpina12
Entrez Gene ID	68054
Full Name	serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
Synonyms	4632419J12Rik
General protein information	Preferred Names serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 Names serpin A12 serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 vaspin visceral adipose tissue-derived serine protease inhibitor visceral adipose-specific SERPIN
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 12 Map Location: 12\|12 E

mRNA and Protein(s)

mRNA	Protein	Name
NM_026535.2	NP_080811.1	serpin A12 precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	SERPINA12	XP_855210.1
Bos taurus (cattle)	SERPINA12	NP_001070985.1
Mus musculus (house mouse)	Serpina12	NP_080811.1
Pan troglodytes (chimpanzee)	SERPINA12	XP_001152987.1
	SERPINA12	XP_001099453.1
Rattus norvegicus (Norway rat)	Serpina12	NP_620180.2
Gallus gallus (chicken)	SERPINA3	XP_004941983.1
Homo sapiens (human)	SERPINA12	NP_776249.1

Gene Ontology
Bibliography

Related articles in PubMed

Brown adipose tissue (BAT) specific vaspin expression is increased after obesogenic diets and cold exposure and linked to acute changes in DNA-methylation.
Weiner J, Rohde K, Krause K, Zieger K, Kl?ting N, Kralisch S, Kovacs P, Stumvoll M, Bl?her M, B?ttcher Y, Heiker JT
Molecular metabolism6(6)482-493(2017 Jun)

Vaspin attenuates the progression of atherosclerosis by inhibiting ER stress-induced macrophage apoptosis in apoE?/? mice.
Lin Y, Zhuang J, Li H, Zhu G, Zhou S, Li W, Peng W, Xu Y
Molecular medicine reports13(2)1509-16(2016 Feb)

Update of the human and mouse SERPIN gene superfamily.
Heit C, Jackson BC, McAndrews M, Wright MW, Thompson DC, Silverman GA, Nebert DW, Vasiliou V
Human genomics722(2013 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The results of the current study indicated that vaspin inhibited the progression of atherosclerotic plaques in apoE(/) mice by inhibiting endoplasmic reticulum stress-induced macrophage apoptosis.
Title: Vaspin attenuates the progression of atherosclerosis by inhibiting ER stress-induced macrophage apoptosis in apoE?/? mice.

Vaspin is a novel ligand for the cell-surface GRP78/voltage-dependent anion channel complex in endothelial cells and promotes proliferation, inhibits apoptosis, and protects vascular injuries in diabetes mellitus.
Title: Visceral adipose tissue-derived serine proteinase inhibitor inhibits apoptosis of endothelial cells as a ligand for the cell-surface GRP78/voltage-dependent anion channel complex.

Vaspin inhibited RANKL-induced osteoclastogenesis in RAW264.7 cells and bone marrow cells.
Title: Vaspin attenuates RANKL-induced osteoclast formation in RAW264.7 cells.

Data suggest that vaspin is ligand for cell-surface GRP78 (glucose-regulated protein 78kD)/MTJ-1 (DnaJ-like protein 1) complex; subsequent signal transduction benefits endoplasmic reticulum stress-induced metabolic dysfunctions as seen in obesity.
Title: Vaspin is an adipokine ameliorating ER stress in obesity as a ligand for cell-surface GRP78/MTJ-1 complex.

may be the compensatory molecule in the pathogenesis of metabolic syndrome. (review)
Title: [Vaspin and insulin resistance].

The following Serpina12 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Serpina12 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu02525	NM_026535.2 Latest version!	Mus musculus serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 (Serpina12), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Serpina12 ( NM_026535.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_080811.1 Mus musculus serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 (Serpina12), mRNA.

Price & Availability↑

CloneID	OMu02525
Clone ID Related Accession (Same CDS sequence)	NM_026535.2
Accession Version	NM_026535.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1242bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-10
Organism	Mus musculus(house mouse)
Product	serpin A12 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC134902.7. On Nov 17, 2006 this sequence version replaced NM_026535.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK014589.1, AY326419.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

ATGACTCGCA TGCTGGACCT GGGCCTGTTT CTGGCAGGCC TCCTCACTGT GAAAGGTCTC 
CTGCAGGACA GAGATGCTCC AGATATGTAT GATTCTCCAG TCAGGGTCCA AGAGTGGAGG 
GGCAAGAAGG ATGCCCGGCA GCTTGCTCGA CACAACATGG AATTTGGCTT CAAGCTACTG 
CAGAGGCTGG CCAGCAATAG CCCTCAGGGA AACATCTTCC TATCCCCACT GAGCATCTCC 
ACTGCCTTCT CCATGCTGTC TCTCGGGGCC CAGAACTCCA CACTGGAGGA AATCCGGGAG 
GGCTTCAACT TCAAAGAGAT GTCAAACTGG GACGTCCATG CGGCTTTCCA CTACCTTCTC 
CACAAGCTCA ACCAGGAGAC GGAGGACACA AAGATGAACT TAGGCAATGC TTTATTTATG 
GATCAGAAGC TGAGGCCCCA ACAGAGGTTC CTGAACCTGG CTAAGAATGT GTATGATGCG 
GACATGGTGC TCACTAACTT CCAGGACTTA GAAAACACTC AGAAGGATAT CAACAGATAC 
ATCAGTCAGA AAACCCACAG CAGAATCAAA AACATGGTAA AAAGCATAGA CCCAGGCACC 
GTGATGATTC TCACAAATTA TATTTACTTT CGAGGCAGGT GGCAGTATGA ATTCGACCCA 
AAACAGACCA AGGAGGAGGA GTTCTTCATA GAGAAAGGCA AGACCGTGAA GGTACCCATG 
ATGTTCCAAA GGGGCTTGTA CGACATGGCC TATGACAGCC AGCTCTCCTG CACCATCTTG 
GAAATCCCCT ACCGGGGAAA CATCACAGCC ACATTTGTCC TTCCTGACAA TGGCAAGCTG 
AAGCTGCTGG AGCAGGGGTT GCAGGCAGAC ATCTTTGCCA AGTGGAAAAG CCTTCTCTCA 
AAAAGAGTGG TGGATGTGTG GGTGCCCAAG CTCCGCATCT CGTCTACTTA CAACATGAAG 
AAGGTTCTGT CCCGCCTGGG CATCAGCAAA ATCTTTGAGG AGAATGGTGA CCTCACCCGG 
ATCTCATCTC ATCGAAGCCT GAAGGTGGGA GAGGCTGTGC ACAAGGCTGA ACTGAAGATG 
GATGAGAAAG GCATGGAAGG GGCTGCAGGC TCTGGAGCCC AGACATTGCC CATGGAGACC 
CCACGACATA TGAAGCTAGA CAGACCCTTC CTCATGATGA TCTATGAGAA TTTCATGCCT 
TCCATGGTCT TCTTGGCAAG GATTTATGAC CCTAGTGGGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_080811.1
CDS	199..1440
Translation	MTRMLDLGLFLAGLLTVKGLLQDRDAPDMYDSPVRVQEWRGKKDARQLARHNMEFGFKLLQRLASNSPQGNIFLSPLSISTAFSMLSLGAQNSTLEEIREGFNFKEMSNWDVHAAFHYLLHKLNQETEDTKMNLGNALFMDQKLRPQQRFLNLAKNVYDADMVLTNFQDLENTQKDINRYISQKTHSRIKNMVKSIDPGTVMILTNYIYFRGRWQYEFDPKQTKEEEFFIEKGKTVKVPMMFQRGLYDMAYDSQLSCTILEIPYRGNITATFVLPDNGKLKLLEQGLQADIFAKWKSLLSKRVVDVWVPKLRISSTYNMKKVLSRLGISKIFEENGDLTRISSHRSLKVGEAVHKAELKMDEKGMEGAAGSGAQTLPMETPRHMKLDRPFLMMIYENFMPSMVFLARIYDPSG

Target ORF information:

RefSeq Version	NM_026535.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 (Serpina12), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_026535.2

ORF Insert Sequence:

ATGACTCGCA TGCTGGACCT GGGCCTGTTT CTGGCAGGCC TCCTCACTGT GAAAGGTCTC 
CTGCAGGACA GAGATGCTCC AGATATGTAT GATTCTCCAG TCAGGGTCCA AGAGTGGAGG 
GGCAAGAAGG ATGCCCGGCA GCTTGCTCGA CACAACATGG AATTTGGCTT CAAGCTACTG 
CAGAGGCTGG CCAGCAATAG CCCTCAGGGA AACATCTTCC TATCCCCACT GAGCATCTCC 
ACTGCCTTCT CCATGCTGTC TCTCGGGGCC CAGAACTCCA CACTGGAGGA AATCCGGGAG 
GGCTTCAACT TCAAAGAGAT GTCAAACTGG GACGTCCATG CGGCTTTCCA CTACCTTCTC 
CACAAGCTCA ACCAGGAGAC GGAGGACACA AAGATGAACT TAGGCAATGC TTTATTTATG 
GATCAGAAGC TGAGGCCCCA ACAGAGGTTC CTGAACCTGG CTAAGAATGT GTATGATGCG 
GACATGGTGC TCACTAACTT CCAGGACTTA GAAAACACTC AGAAGGATAT CAACAGATAC 
ATCAGTCAGA AAACCCACAG CAGAATCAAA AACATGGTAA AAAGCATAGA CCCAGGCACC 
GTGATGATTC TCACAAATTA TATTTACTTT CGAGGCAGGT GGCAGTATGA ATTCGACCCA 
AAACAGACCA AGGAGGAGGA GTTCTTCATA GAGAAAGGCA AGACCGTGAA GGTACCCATG 
ATGTTCCAAA GGGGCTTGTA CGACATGGCC TATGACAGCC AGCTCTCCTG CACCATCTTG 
GAAATCCCCT ACCGGGGAAA CATCACAGCC ACATTTGTCC TTCCTGACAA TGGCAAGCTG 
AAGCTGCTGG AGCAGGGGTT GCAGGCAGAC ATCTTTGCCA AGTGGAAAAG CCTTCTCTCA 
AAAAGAGTGG TGGATGTGTG GGTGCCCAAG CTCCGCATCT CGTCTACTTA CAACATGAAG 
AAGGTTCTGT CCCGCCTGGG CATCAGCAAA ATCTTTGAGG AGAATGGTGA CCTCACCCGG 
ATCTCATCTC ATCGAAGCCT GAAGGTGGGA GAGGCTGTGC ACAAGGCTGA ACTGAAGATG 
GATGAGAAAG GCATGGAAGG GGCTGCAGGC TCTGGAGCCC AGACATTGCC CATGGAGACC 
CCACGACATA TGAAGCTAGA CAGACCCTTC CTCATGATGA TCTATGAGAA TTTCATGCCT 
TCCATGGTCT TCTTGGCAAG GATTTATGAC CCTAGTGGGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Brown adipose tissue (BAT) specific vaspin expression is increased after obesogenic diets and cold exposure and linked to acute changes in DNA-methylation.
Molecular metabolism6(6)482-493(2017 Jun)
Weiner J,Rohde K,Krause K,Zieger K,Kl?ting N,Kralisch S,Kovacs P,Stumvoll M,Bl?her M,B?ttcher Y,Heiker JT

Vaspin attenuates the progression of atherosclerosis by inhibiting ER stress-induced macrophage apoptosis in apoE?/? mice.
Molecular medicine reports13(2)1509-16(2016 Feb)
Lin Y,Zhuang J,Li H,Zhu G,Zhou S,Li W,Peng W,Xu Y

Update of the human and mouse SERPIN gene superfamily.
Human genomics722(2013 Oct)
Heit C,Jackson BC,McAndrews M,Wright MW,Thompson DC,Silverman GA,Nebert DW,Vasiliou V

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Serpina12 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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