Trap1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Trap1
Entrez Gene ID	68015
Full Name	TNF receptor-associated protein 1
Synonyms	2410002K23Rik,HSP75
General protein information	Preferred Names TNF receptor-associated protein 1 Names heat shock protein 75 kDa, mitochondrial HSP 75 TNFR-associated protein 1 TRAP-1 tumor necrosis factor type 1 receptor-associated protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 16 Map Location: 16 A1\|16 2.38 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_026508.2	NP_080784.1	heat shock protein 75 kDa, mitochondrial precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Trap1	NP_080784.1
Gallus gallus (chicken)	TRAP1	NP_001006175.1
Danio rerio (zebrafish)	trap1	NP_001107097.1
Drosophila melanogaster (fruit fly)	Trap1	NP_001260726.1
Caenorhabditis elegans (roundworm)	R151.7	NP_741220.2
Pan troglodytes (chimpanzee)	TRAP1	XP_001167908.1
	TRAP1	XP_001094589.2
Canis lupus familiaris (dog)	TRAP1	XP_005621672.1
Bos taurus (cattle)	TRAP1	NP_001033764.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010691	XP_311405.3
Homo sapiens (human)	TRAP1	NP_057376.2
Rattus norvegicus (Norway rat)	Trap1	NP_001034090.1
Danio rerio (zebrafish)	LOC101884569	XP_005163784.1
Xenopus tropicalis (tropical clawed frog)	trap1	XP_002932506.1

Gene Ontology
Bibliography

Related articles in PubMed

TRAP1 ameliorates renal tubulointerstitial fibrosis in mice with unilateral ureteral obstruction by protecting renal tubular epithelial cell mitochondria.
Chen JF, Wu QS, Xie YX, Si BL, Yang PP, Wang WY, Hua Q, He Q
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(10)4503-4514(2017 Oct)

Cytosolic Hsp90? and its mitochondrial isoform Trap1 are differentially required in a breast cancer model.
Vartholomaiou E, Madon-Simon M, Hagmann S, M?hlebach G, Wurst W, Floss T, Picard D
Oncotarget8(11)17428-17442(2017 Mar)

Transgenic Expression of the Mitochondrial Chaperone TNFR-associated Protein 1 (TRAP1) Accelerates Prostate Cancer Development.
Lisanti S, Garlick DS, Bryant KG, Tavecchio M, Mills GB, Lu Y, Kossenkov AV, Showe LC, Languino LR, Altieri DC
The Journal of biological chemistry291(48)25247-25254(2016 Nov)

Overexpression of mitochondrial Hsp75 protects neural stem cells against microglia-derived soluble factor-induced neurotoxicity by regulating mitochondrial permeability transition pore opening in vitro.
Wang Y, Lin J, Chen QZ, Zhu N, Jiang DQ, Li MX, Wang Y
International journal of molecular medicine36(6)1487-96(2015 Dec)

TRAP1 Provides Protection Against Myocardial Ischemia-Reperfusion Injury by Ameliorating Mitochondrial Dysfunction.
Zhang P, Lu Y, Yu D, Zhang D, Hu W
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology36(5)2072-82(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

show that TRAP1 could protect the mitochondrial structure in renal tubular epithelial cells; maintain the levels of mitochondrial membrane potential, ATP, and mitochondrial DNA copy number
Title: TRAP1 ameliorates renal tubulointerstitial fibrosis in mice with unilateral ureteral obstruction by protecting renal tubular epithelial cell mitochondria.

TRAP1 increases cell proliferation, reduces apoptosis, and promotes cell invasion without changes in mitochondrial bioenergetics. Therefore, TRAP1 is a driver of prostate cancer in vivo and an "actionable" therapeutic target.
Title: Transgenic Expression of the Mitochondrial Chaperone TNFR-associated Protein 1 (TRAP1) Accelerates Prostate Cancer Development.

Data show that the overexpression of heat shock protein 75 (Hsp75) decreased neural stem cells (NSCs) apoptosis and preserved mitochondrial membrane potential.
Title: Overexpression of mitochondrial Hsp75 protects neural stem cells against microglia-derived soluble factor-induced neurotoxicity by regulating mitochondrial permeability transition pore opening in vitro.

TRAP-1-/- mice are viable and show reduced incidence of age-associated pathologies. Loss of TRAP-1 upregulates oxidative phosphorylation and glycolysis transcriptomes.
Title: Deletion of the mitochondrial chaperone TRAP-1 uncovers global reprogramming of metabolic networks.

overexpression of TRAP1 leads to mitochondrial aberrations, including an increase in basal ROS levels and decrease in mitochondrial biogenesis, together with a decrease in peroxisome proliferator-activated receptor gamma coactivator-1alpha mRNA levels
Title: Overexpression of tumor necrosis factor receptor-associated protein 1 (TRAP1), leads to mitochondrial aberrations in mouse fibroblast NIH/3T3 cells.

The following Trap1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Trap1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu13402	NM_026508.2 Latest version!	Mus musculus TNF receptor-associated protein 1 (Trap1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$419.30 $599.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Trap1 ( NM_026508.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_080784.1 Mus musculus TNF receptor-associated protein 1 (Trap1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu13402
Clone ID Related Accession (Same CDS sequence)	NM_026508.2
Accession Version	NM_026508.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2121bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Mus musculus(house mouse)
Product	heat shock protein 75 kDa, mitochondrial precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC132380.6 and AC087900.19. On Nov 17, 2006 this sequence version replaced NM_026508.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK010341.1, AK143494.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END##

ATGGCGTGCG AGCTGCGAGC TGTGTTGCTG TGGGGCCGCG GGCTGCAGAC TGTACTGCGG 
GCCCCCGCGC TGGCTGGAGT TCGGCGAGGA AAGCCAGTTC TGCACCTTCA GAAGACTACA 
GTCCAGTTTA GGGGCCCCAC ACAAAGTCTG GCTTCAGGGA TCTCTGCAGG ACAGTTATAC 
AGCACACAGG CAGCCGAGGA CAAGGAGGAG GAGAGCCTGC ACTCCATCAT CAGCAACACT 
GAGGCAGTGC GGGGTTCTGT CTCCAAACAT GAGTTCCAGG CAGAGACAAA GAAACTTTTG 
GACATCGTAG CCCGTTCTCT GTACTCAGAA AAAGAGGTGT TCATACGAGA GCTCATCTCC 
AATGCCAGTG ATGCCTTGGA GAAACTGCGG CACAAGCTGG TGTGTGAAGG CCAGGTGCTG 
CCAGAAATGG AGATTCACCT TCAGACGGAT GCCAAGAAGG GCACTATTAC CATTCAGGAC 
ACTGGCATTG GGATGACACA GGAGGAGCTG GTGTCCAACC TTGGCACAAT TGCCAGATCG 
GGGTCAAAGG CCTTCCTGGA AGCACTGCAG AACCAGGCAG AGACCAGCAG CAAGATCATT 
GGTCAGTTTG GAGTGGGTTT CTATTCAGCC TTCATGGTAG CTGACAAGGT TGAAGTCTAT 
TCTCGATCAG CAGCTCCAGA GAGCCCAGGT TACCAGTGGC TTTCAGATGG TTCTGGAGTG 
TTTGAAATTG CCGAAGCTTC AGGAGTTAGA CCTGGGACCA AAATAATCAT CCACCTCAAG 
TCAGACTGTA AAGATTTTGC CAGCGAGTCC CGGGTACAAG ATGTGGTAAC AAAGTACAGT 
AACTTTGTCA GCTTCCCCTT GTACCTTAAT GGAAAGCGGA TTAACACTTT GCAGGCCATC 
TGGATGATGG ACCCAAAGGA CATCAGTGAA TTTCAGCATG AGGAATTCTA CCGTTATATT 
GCTCAGGCTT ATGATAAGCC CCGCTTCACT TTGCACTACA AGACGGACGC ACCACTCAAC 
ATCCGCAGCA TCTTCTATGT GCCAGAGATG AAACCATCCA TGTTTGATGT GAGCAGGGAG 
CTGGGCTCCA GCGTGGCACT GTATAGCCGC AAGGTCCTCA TCCAGACCAA GGCTGCAGAC 
ATCCTGCCCA AGTGGCTGCG CTTCATTCGA GGTGTGGTGG ATAGTGAGGA CATTCCCCTG 
AACCTCAGCA GAGAGCTCCT GCAGGAGAGT GCGCTCATCC GGAAACTCCG GGATGTTCTA 
CAACAGAGAT TGATCAAGTT CTTCATTGAC CAGAGTAAAA AAGATGCTGA AAAATACGCA 
AAGTTTTTTG AAGATTATGG CTTGTTCATG AGGGAGGGCA TTGTGACCAC TGCAGAGCAA 
GACATCAAGG AGGATATTGC AAAACTGCTA CGGTATGAGT CCTCAGCCCT GCCTGCTGGG 
CAGCTGACCA GCTTACCAGA CTATGCCAGC CGAATGCAGG CTGGCACCCG CAACATCTAT 
TACCTGTGTG CCCCTAACCG TCACCTGGCT GAACATTCAC CCTATTACGA AGCCATGAAG 
CAGAAACATA CTGAGGTGCT CTTCTGCTAT GAGCAGTTCG ATGAGCTTAC TCTGCTGCAC 
CTGAGGGAGT TTGACAAGAA GAAGCTCATC TCTGTGGAAA CAGACATCGT CGTTGATCAC 
TACAAGGAGG AAAAGTTTGA GGACACATCT CCAGCTGATG AGCGCCTCTC GGAGAAGGAA 
ACAGAAGATC TAATGGCGTG GATGAGAAAT GCACTAGGGT CCCGTGTCAC CAATGTGAAG 
GTGACTTTCC GCCTAGACAC CCACCCTGCC ATGGTGACCG TGCTGGAGAT GGGGGCTGCT 
CGGCATTTCT TGCGTATGCA GCAGCTGGCC AAGACCCAGG AGGAACGTGC CCAACTGCTA 
CAGCCCACAC TGGAGATCAA CCCCAGGCAC ACACTGATAA AGAAGCTCTG CCAGCTGAGG 
GAGAGCGAGC CGGAGCTGGC CCAGCTGCTC GTGGATCAGA TCTATGAGAA TGCCATGATA 
GCAGCAGGAC TCGTTGATGA CCCCCGGGCC ATGGTCGGCC GCCTGAACGA CCTTTTGGTC 
AAGGTCCTGG AGAAACACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_080784.1
CDS	31..2151
Translation	MACELRAVLLWGRGLQTVLRAPALAGVRRGKPVLHLQKTTVQFRGPTQSLASGISAGQLYSTQAAEDKEEESLHSIISNTEAVRGSVSKHEFQAETKKLLDIVARSLYSEKEVFIRELISNASDALEKLRHKLVCEGQVLPEMEIHLQTDAKKGTITIQDTGIGMTQEELVSNLGTIARSGSKAFLEALQNQAETSSKIIGQFGVGFYSAFMVADKVEVYSRSAAPESPGYQWLSDGSGVFEIAEASGVRPGTKIIIHLKSDCKDFASESRVQDVVTKYSNFVSFPLYLNGKRINTLQAIWMMDPKDISEFQHEEFYRYIAQAYDKPRFTLHYKTDAPLNIRSIFYVPEMKPSMFDVSRELGSSVALYSRKVLIQTKAADILPKWLRFIRGVVDSEDIPLNLSRELLQESALIRKLRDVLQQRLIKFFIDQSKKDAEKYAKFFEDYGLFMREGIVTTAEQDIKEDIAKLLRYESSALPAGQLTSLPDYASRMQAGTRNIYYLCAPNRHLAEHSPYYEAMKQKHTEVLFCYEQFDELTLLHLREFDKKKLISVETDIVVDHYKEEKFEDTSPADERLSEKETEDLMAWMRNALGSRVTNVKVTFRLDTHPAMVTVLEMGAARHFLRMQQLAKTQEERAQLLQPTLEINPRHTLIKKLCQLRESEPELAQLLVDQIYENAMIAAGLVDDPRAMVGRLNDLLVKVLEKH

Target ORF information:

RefSeq Version	NM_026508.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus TNF receptor-associated protein 1 (Trap1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_026508.2

ORF Insert Sequence:

ATGGCGTGCG AGCTGCGAGC TGTGTTGCTG TGGGGCCGCG GGCTGCAGAC TGTACTGCGG 
GCCCCCGCGC TGGCTGGAGT TCGGCGAGGA AAGCCAGTTC TGCACCTTCA GAAGACTACA 
GTCCAGTTTA GGGGCCCCAC ACAAAGTCTG GCTTCAGGGA TCTCTGCAGG ACAGTTATAC 
AGCACACAGG CAGCCGAGGA CAAGGAGGAG GAGAGCCTGC ACTCCATCAT CAGCAACACT 
GAGGCAGTGC GGGGTTCTGT CTCCAAACAT GAGTTCCAGG CAGAGACAAA GAAACTTTTG 
GACATCGTAG CCCGTTCTCT GTACTCAGAA AAAGAGGTGT TCATACGAGA GCTCATCTCC 
AATGCCAGTG ATGCCTTGGA GAAACTGCGG CACAAGCTGG TGTGTGAAGG CCAGGTGCTG 
CCAGAAATGG AGATTCACCT TCAGACGGAT GCCAAGAAGG GCACTATTAC CATTCAGGAC 
ACTGGCATTG GGATGACACA GGAGGAGCTG GTGTCCAACC TTGGCACAAT TGCCAGATCG 
GGGTCAAAGG CCTTCCTGGA AGCACTGCAG AACCAGGCAG AGACCAGCAG CAAGATCATT 
GGTCAGTTTG GAGTGGGTTT CTATTCAGCC TTCATGGTAG CTGACAAGGT TGAAGTCTAT 
TCTCGATCAG CAGCTCCAGA GAGCCCAGGT TACCAGTGGC TTTCAGATGG TTCTGGAGTG 
TTTGAAATTG CCGAAGCTTC AGGAGTTAGA CCTGGGACCA AAATAATCAT CCACCTCAAG 
TCAGACTGTA AAGATTTTGC CAGCGAGTCC CGGGTACAAG ATGTGGTAAC AAAGTACAGT 
AACTTTGTCA GCTTCCCCTT GTACCTTAAT GGAAAGCGGA TTAACACTTT GCAGGCCATC 
TGGATGATGG ACCCAAAGGA CATCAGTGAA TTTCAGCATG AGGAATTCTA CCGTTATATT 
GCTCAGGCTT ATGATAAGCC CCGCTTCACT TTGCACTACA AGACGGACGC ACCACTCAAC 
ATCCGCAGCA TCTTCTATGT GCCAGAGATG AAACCATCCA TGTTTGATGT GAGCAGGGAG 
CTGGGCTCCA GCGTGGCACT GTATAGCCGC AAGGTCCTCA TCCAGACCAA GGCTGCAGAC 
ATCCTGCCCA AGTGGCTGCG CTTCATTCGA GGTGTGGTGG ATAGTGAGGA CATTCCCCTG 
AACCTCAGCA GAGAGCTCCT GCAGGAGAGT GCGCTCATCC GGAAACTCCG GGATGTTCTA 
CAACAGAGAT TGATCAAGTT CTTCATTGAC CAGAGTAAAA AAGATGCTGA AAAATACGCA 
AAGTTTTTTG AAGATTATGG CTTGTTCATG AGGGAGGGCA TTGTGACCAC TGCAGAGCAA 
GACATCAAGG AGGATATTGC AAAACTGCTA CGGTATGAGT CCTCAGCCCT GCCTGCTGGG 
CAGCTGACCA GCTTACCAGA CTATGCCAGC CGAATGCAGG CTGGCACCCG CAACATCTAT 
TACCTGTGTG CCCCTAACCG TCACCTGGCT GAACATTCAC CCTATTACGA AGCCATGAAG 
CAGAAACATA CTGAGGTGCT CTTCTGCTAT GAGCAGTTCG ATGAGCTTAC TCTGCTGCAC 
CTGAGGGAGT TTGACAAGAA GAAGCTCATC TCTGTGGAAA CAGACATCGT CGTTGATCAC 
TACAAGGAGG AAAAGTTTGA GGACACATCT CCAGCTGATG AGCGCCTCTC GGAGAAGGAA 
ACAGAAGATC TAATGGCGTG GATGAGAAAT GCACTAGGGT CCCGTGTCAC CAATGTGAAG 
GTGACTTTCC GCCTAGACAC CCACCCTGCC ATGGTGACCG TGCTGGAGAT GGGGGCTGCT 
CGGCATTTCT TGCGTATGCA GCAGCTGGCC AAGACCCAGG AGGAACGTGC CCAACTGCTA 
CAGCCCACAC TGGAGATCAA CCCCAGGCAC ACACTGATAA AGAAGCTCTG CCAGCTGAGG 
GAGAGCGAGC CGGAGCTGGC CCAGCTGCTC GTGGATCAGA TCTATGAGAA TGCCATGATA 
GCAGCAGGAC TCGTTGATGA CCCCCGGGCC ATGGTCGGCC GCCTGAACGA CCTTTTGGTC 
AAGGTCCTGG AGAAACACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

TRAP1 ameliorates renal tubulointerstitial fibrosis in mice with unilateral ureteral obstruction by protecting renal tubular epithelial cell mitochondria.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology31(10)4503-4514(2017 Oct)
Chen JF,Wu QS,Xie YX,Si BL,Yang PP,Wang WY,Hua Q,He Q

Cytosolic Hsp90? and its mitochondrial isoform Trap1 are differentially required in a breast cancer model.
Oncotarget8(11)17428-17442(2017 Mar)
Vartholomaiou E,Madon-Simon M,Hagmann S,M?hlebach G,Wurst W,Floss T,Picard D

Transgenic Expression of the Mitochondrial Chaperone TNFR-associated Protein 1 (TRAP1) Accelerates Prostate Cancer Development.
The Journal of biological chemistry291(48)25247-25254(2016 Nov)
Lisanti S,Garlick DS,Bryant KG,Tavecchio M,Mills GB,Lu Y,Kossenkov AV,Showe LC,Languino LR,Altieri DC

Overexpression of mitochondrial Hsp75 protects neural stem cells against microglia-derived soluble factor-induced neurotoxicity by regulating mitochondrial permeability transition pore opening in vitro.
International journal of molecular medicine36(6)1487-96(2015 Dec)
Wang Y,Lin J,Chen QZ,Zhu N,Jiang DQ,Li MX,Wang Y

TRAP1 Provides Protection Against Myocardial Ischemia-Reperfusion Injury by Ameliorating Mitochondrial Dysfunction.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology36(5)2072-82(2015)
Zhang P,Lu Y,Yu D,Zhang D,Hu W

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Trap1 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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