Uqcrb cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Uqcrb
Entrez Gene ID	67530
Full Name	ubiquinol-cytochrome c reductase binding protein
Synonyms	2210415M14Rik,QP-C,QPC,UQBC,UQBP,UQPC
General protein information	Preferred Names ubiquinol-cytochrome c reductase binding protein Names cytochrome b-c1 complex subunit 7 complex III subunit 7 complex III subunit VII ubiquinol-cytochrome c reductase complex 14 kDa protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 13 Map Location: 13\|13 B3

mRNA and Protein(s)

mRNA	Protein	Name
NM_026219.2	NP_080495.1	cytochrome b-c1 complex subunit 7
NM_026219.1	NP_080495.1	cytochrome b-c1 complex subunit 7

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	LOC477944	XP_535132.4
Xenopus tropicalis (tropical clawed frog)	LOC101732809	XP_004915192.1
Pan troglodytes (chimpanzee)	UQCRB	XP_519866.1
Gallus gallus (chicken)	UQCRB	XP_418347.4
Drosophila melanogaster (fruit fly)	CG17856	NP_651614.1
Drosophila melanogaster (fruit fly)	CG3560	NP_573110.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012188	XP_320347.4
Homo sapiens (human)	UQCRB	NP_006285.1
	UQCRB	XP_001094441.2
Bos taurus (cattle)	UQCRB	NP_001029969.1
Mus musculus (house mouse)	Uqcrb	NP_080495.1
Danio rerio (zebrafish)	uqcrb	NP_001019613.1

Gene Ontology
Bibliography

Related articles in PubMed

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H
Nucleic acids research42(Database issue)D802-9(2014 Jan)

Terpestacin inhibits tumor angiogenesis by targeting UQCRB of mitochondrial complex III and suppressing hypoxia-induced reactive oxygen species production and cellular oxygen sensing.
Jung HJ, Shim JS, Lee J, Song YM, Park KC, Choi SH, Kim ND, Yoon JH, Mungai PT, Schumacker PT, Kwon HJ
The Journal of biological chemistry285(15)11584-95(2010 Apr)

Identification and mRNA expression of Ogdh, QP-C, and two predicted genes in the postnatal mouse brain.
Sadakata T, Furuichi T
Neuroscience letters405(3)217-22(2006 Sep)

Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, Cheng T, Kho Y, Xiao H, Xiao L, Grishin NV, White M, Yang XJ, Zhao Y
Molecular cell23(4)607-18(2006 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Terpestacin inhibits tumor angiogenesis by targeting UQCRB of mitochondrial complex III and suppressing hypoxia-induced reactive oxygen species production and cellular oxygen sensing
Title: Terpestacin inhibits tumor angiogenesis by targeting UQCRB of mitochondrial complex III and suppressing hypoxia-induced reactive oxygen species production and cellular oxygen sensing.

In the postnatal mouse brain ,c1502/QP-C mRNA was localized at high levels in the olfactory bulb, cerebral cortex, hippocampus, thalamus, tegmentum (red nucleus), cerebellum (Purkinje and granule cells), and pons.
Title: Identification and mRNA expression of Ogdh, QP-C, and two predicted genes in the postnatal mouse brain.

The following Uqcrb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Uqcrb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu14630	NM_026219.2 Latest version!	Mus musculus ubiquinol-cytochrome c reductase binding protein (Uqcrb), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OMu14630	NM_026219.1	Mus musculus ubiquinol-cytochrome c reductase binding protein (Uqcrb), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Uqcrb ( NM_026219.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_080495.1 Mus musculus ubiquinol-cytochrome c reductase binding protein (Uqcrb), mRNA.

Price & Availability↑

CloneID	OMu14630
Clone ID Related Accession (Same CDS sequence)	NM_026219.2 , NM_026219.1
Accession Version	NM_026219.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 336bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-05
Organism	Mus musculus(house mouse)
Product	cytochrome b-c1 complex subunit 7
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK008945.1 and AC124433.4. On Apr 14, 2018 this sequence version replaced NM_026219.1. ##Evidence-Data-START## Transcript exon combination :: AK008945.1, CA469146.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849385, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGGGCC GATCTGCTGT TTCAGCATCA AGCAAGTGGC TGGATGGTTT TCGAAAGTGG 
TATTATAATG CTGCAGGATT CAATAAACTG GGGTTAATGC GAGATGATAC ACTACATGAA 
ACTGAAGATG TAAAAGAAGC CATAAGAAGG CTTCCTGAGG ACCTTTATAA TGACAGGATG 
TTTCGAATTA AGAGAGCCCT GGACCTGACT ATGAGGCATC AGATCTTGCC TAAGGATCAG 
TGGACAAAAT ATGAGGAGGA CAAATTCTAC CTTGAACCCT ATCTAAAAGA GGTTATTCGG 
GAAAGAAAGG AGAGAGAAGA GTGGGCAAAG AAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_080495.1
CDS	40..375
Translation	MAGRSAVSASSKWLDGFRKWYYNAAGFNKLGLMRDDTLHETEDVKEAIRRLPEDLYNDRMFRIKRALDLTMRHQILPKDQWTKYEEDKFYLEPYLKEVIRERKEREEWAKK

Target ORF information:

RefSeq Version	NM_026219.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus ubiquinol-cytochrome c reductase binding protein (Uqcrb), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_026219.2

ORF Insert Sequence:

ATGGCGGGCC GATCTGCTGT TTCAGCATCA AGCAAGTGGC TGGATGGTTT TCGAAAGTGG 
TATTATAATG CTGCAGGATT CAATAAACTG GGGTTAATGC GAGATGATAC ACTACATGAA 
ACTGAAGATG TAAAAGAAGC CATAAGAAGG CTTCCTGAGG ACCTTTATAA TGACAGGATG 
TTTCGAATTA AGAGAGCCCT GGACCTGACT ATGAGGCATC AGATCTTGCC TAAGGATCAG 
TGGACAAAAT ATGAGGAGGA CAAATTCTAC CTTGAACCCT ATCTAAAAGA GGTTATTCGG 
GAAAGAAAGG AGAGAGAAGA GTGGGCAAAG AAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Uqcrb ( NM_026219.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_080495.1 Mus musculus ubiquinol-cytochrome c reductase binding protein (Uqcrb), mRNA.

Price & Availability↑

CloneID	OMu14630
Clone ID Related Accession (Same CDS sequence)	NM_026219.2 , NM_026219.1
Accession Version	NM_026219.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 336bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Mus musculus(house mouse)
Product	cytochrome b-c1 complex subunit 7
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AK008945.1. ##Evidence-Data-START## Transcript exon combination :: AK008945.1, BY708830.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849385, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END##

ATGGCGGGCC GATCTGCTGT TTCAGCATCA AGCAAGTGGC TGGATGGTTT TCGAAAGTGG 
TATTATAATG CTGCAGGATT CAATAAACTG GGGTTAATGC GAGATGATAC ACTACATGAA 
ACTGAAGATG TAAAAGAAGC CATAAGAAGG CTTCCTGAGG ACCTTTATAA TGACAGGATG 
TTTCGAATTA AGAGAGCCCT GGACCTGACT ATGAGGCATC AGATCTTGCC TAAGGATCAG 
TGGACAAAAT ATGAGGAGGA CAAATTCTAC CTTGAACCCT ATCTAAAAGA GGTTATTCGG 
GAAAGAAAGG AGAGAGAAGA GTGGGCAAAG AAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_080495.1
CDS	40..375
Translation	MAGRSAVSASSKWLDGFRKWYYNAAGFNKLGLMRDDTLHETEDVKEAIRRLPEDLYNDRMFRIKRALDLTMRHQILPKDQWTKYEEDKFYLEPYLKEVIRERKEREEWAKK

Target ORF information:

RefSeq Version	NM_026219.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus ubiquinol-cytochrome c reductase binding protein (Uqcrb), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_026219.1

ORF Insert Sequence:

ATGGCGGGCC GATCTGCTGT TTCAGCATCA AGCAAGTGGC TGGATGGTTT TCGAAAGTGG 
TATTATAATG CTGCAGGATT CAATAAACTG GGGTTAATGC GAGATGATAC ACTACATGAA 
ACTGAAGATG TAAAAGAAGC CATAAGAAGG CTTCCTGAGG ACCTTTATAA TGACAGGATG 
TTTCGAATTA AGAGAGCCCT GGACCTGACT ATGAGGCATC AGATCTTGCC TAAGGATCAG 
TGGACAAAAT ATGAGGAGGA CAAATTCTAC CTTGAACCCT ATCTAAAAGA GGTTATTCGG 
GAAAGAAAGG AGAGAGAAGA GTGGGCAAAG AAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Nucleic acids research42(Database issue)D802-9(2014 Jan)
Koscielny G,Yaikhom G,Iyer V,Meehan TF,Morgan H,Atienza-Herrero J,Blake A,Chen CK,Easty R,Di Fenza A,Fiegel T,Grifiths M,Horne A,Karp NA,Kurbatova N,Mason JC,Matthews P,Oakley DJ,Qazi A,Regnart J,Retha A,Santos LA,Sneddon DJ,Warren J,Westerberg H,Wilson RJ,Melvin DG,Smedley D,Brown SD,Flicek P,Skarnes WC,Mallon AM,Parkinson H

Terpestacin inhibits tumor angiogenesis by targeting UQCRB of mitochondrial complex III and suppressing hypoxia-induced reactive oxygen species production and cellular oxygen sensing.
The Journal of biological chemistry285(15)11584-95(2010 Apr)
Jung HJ,Shim JS,Lee J,Song YM,Park KC,Choi SH,Kim ND,Yoon JH,Mungai PT,Schumacker PT,Kwon HJ

Identification and mRNA expression of Ogdh, QP-C, and two predicted genes in the postnatal mouse brain.
Neuroscience letters405(3)217-22(2006 Sep)
Sadakata T,Furuichi T

Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
Molecular cell23(4)607-18(2006 Aug)
Kim SC,Sprung R,Chen Y,Xu Y,Ball H,Pei J,Cheng T,Kho Y,Xiao H,Xiao L,Grishin NV,White M,Yang XJ,Zhao Y

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Uqcrb cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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