Gpx7 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gpx7
Entrez Gene ID	67305
Full Name	glutathione peroxidase 7
Synonyms	3110050F08Rik,AI327032,GPX6
General protein information	Preferred Names glutathione peroxidase 7 Names glutathione peroxidase 7 GPx-7 GSHPx-7
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4\|4 C7

mRNA and Protein(s)

mRNA	Protein	Name
NM_024198.3	NP_077160.1	glutathione peroxidase 7 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	GPX7	NP_056511.2
Pan troglodytes (chimpanzee)	GPX7	NP_001139309.1
Canis lupus familiaris (dog)	GPX7	XP_005629467.1
Bos taurus (cattle)	GPX7	NP_001094583.1
Danio rerio (zebrafish)	gpx7	NP_001018337.1
Magnaporthe oryzae (rice blast fungus)	MGG_07460	XP_003711364.1
Kluyveromyces lactis	KLLA0F06732g	XP_455385.1
Saccharomyces cerevisiae (baker's yeast)	HYR1	NP_012303.1
	GPX7	NP_001152840.1
Mus musculus (house mouse)	Gpx7	NP_077160.1
Rattus norvegicus (Norway rat)	Gpx7	NP_001100143.1
Gallus gallus (chicken)	GPX7	NP_001156717.1
Eremothecium gossypii	AGOS_AFL039C	NP_985509.1
Schizosaccharomyces pombe (fission yeast)	gpx1	NP_596146.1
Neurospora crassa	NCU09534	XP_957919.1
Xenopus tropicalis (tropical clawed frog)	gpx7	NP_001072404.1

Gene Ontology
Bibliography

Related articles in PubMed

Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury.
Wu Y, Wei FY, Kawarada L, Suzuki T, Araki K, Komohara Y, Fujimura A, Kaitsuka T, Takeya M, Oike Y, Suzuki T, Tomizawa K
PLoS genetics12(9)e1006355(2016 Sep)

Deficiency of NPGPx, an oxidative stress sensor, leads to obesity in mice and human.
Chang YC, Yu YH, Shew JY, Lee WJ, Hwang JJ, Chen YH, Chen YR, Wei PC, Chuang LM, Lee WH
EMBO molecular medicine5(8)1165-79(2013 Aug)

Protein disulfide isomerase and glutathione are alternative substrates in the one Cys catalytic cycle of glutathione peroxidase 7.
Bosello-Travain V, Conrad M, Cozza G, Negro A, Quartesan S, Rossetto M, Roveri A, Toppo S, Ursini F, Zaccarin M, Maiorino M
Biochimica et biophysica acta1830(6)3846-57(2013 Jun)

Loss of the oxidative stress sensor NPGPx compromises GRP78 chaperone activity and induces systemic disease.
Wei PC, Hsieh YH, Su MI, Jiang X, Hsu PH, Lo WT, Weng JY, Jeng YM, Wang JM, Chen PL, Chang YC, Lee KF, Tsai MD, Shew JY, Lee WH
Molecular cell48(5)747-59(2012 Dec)

A mouse knockout library for secreted and transmembrane proteins.
Tang T, Li L, Tang J, Li Y, Lin WY, Martin F, Grant D, Solloway M, Parker L, Ye W, Forrest W, Ghilardi N, Oravecz T, Platt KA, Rice DS, Hansen GM, Abuin A, Eberhart DE, Godowski P, Holt KH, Peterson A, Zambrowicz BP, de Sauvage FJ
Nature biotechnology28(7)749-55(2010 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

NPGPx protects against fat accumulation in mice and human via modulating ROS
Title: Deficiency of NPGPx, an oxidative stress sensor, leads to obesity in mice and human.

GPx7 is an unusual CysGPx catalyzing the peroxidatic cycle by a one Cys mechanism in which GSH and PDI are alternative substrates.
Title: Protein disulfide isomerase and glutathione are alternative substrates in the one Cys catalytic cycle of glutathione peroxidase 7.

NPGPx is essential for releasing excessive ER stress by enhancing GRP78 chaperone activity to maintain physiological homeostasis.
Title: Loss of the oxidative stress sensor NPGPx compromises GRP78 chaperone activity and induces systemic disease.

The following Gpx7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gpx7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu18024	NM_024198.3 Latest version!	Mus musculus glutathione peroxidase 7 (Gpx7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gpx7 ( NM_024198.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_077160.1 Mus musculus glutathione peroxidase 7 (Gpx7), mRNA.

Price & Availability↑

CloneID	OMu18024
Clone ID Related Accession (Same CDS sequence)	NM_024198.3
Accession Version	NM_024198.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 561bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-01-19
Organism	Mus musculus(house mouse)
Product	glutathione peroxidase 7 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AK165221.1. On Apr 6, 2007 this sequence version replaced NM_024198.2. ##Evidence-Data-START## Transcript exon combination :: AK165221.1, AK014199.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849382, SAMN01164133 [ECO:0000348] ##Evidence-Data-END##

ATGGTTGCAG CTGTGGCGAC GGCGTGGCTG CTCCTGTGGG CCGCGGCCTG CGCGCAATCC 
GAGCAGGACT TCTACGACTT CAAGGCGGTC AACATCCGGG GCAAGCTGGT GTCGCTGGAG 
AAGTACCGTG GCTCGGTTTC CCTGGTGGTG AACGTAGCTA GCGAATGTGG CTTCACAGAC 
CAGAACTACC GAGCCTTGCA GCAGCTGCAG CGGGACCTGG GCCCCCATCA TTTTAATGTG 
CTTGCCTTCC CTTGCAACCA GTTTGGCCAA CAGGAACCAG ACACCAACAG GGAGATTGAG 
AACTTTGCCC GCCGCACCTA CAGTGTCTCT TTTCCCATGT TTAGCAAGAT CGCAGTCACT 
GGCACTGGTG CCCACCCTGC CTTCAAGTAC CTAACCCAGA CTTCTGGGAA GGAGCCCACC 
TGGAACTTCT GGAAGTACCT AGTGGACCCA GACGGAAAGG TGGTGGGAGC ATGGGACCCC 
ACTGTGCCAG TGGCGGAGAT CAAGCCCCGT ATTACAGAGC AGGTGATGAA ACTCATCCTT 
CGGAAACGAG AAGACTTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_077160.1
CDS	37..597
Translation	MVAAVATAWLLLWAAACAQSEQDFYDFKAVNIRGKLVSLEKYRGSVSLVVNVASECGFTDQNYRALQQLQRDLGPHHFNVLAFPCNQFGQQEPDTNREIENFARRTYSVSFPMFSKIAVTGTGAHPAFKYLTQTSGKEPTWNFWKYLVDPDGKVVGAWDPTVPVAEIKPRITEQVMKLILRKREDL

Target ORF information:

RefSeq Version	NM_024198.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus glutathione peroxidase 7 (Gpx7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024198.3

ORF Insert Sequence:

ATGGTTGCAG CTGTGGCGAC GGCGTGGCTG CTCCTGTGGG CCGCGGCCTG CGCGCAATCC 
GAGCAGGACT TCTACGACTT CAAGGCGGTC AACATCCGGG GCAAGCTGGT GTCGCTGGAG 
AAGTACCGTG GCTCGGTTTC CCTGGTGGTG AACGTAGCTA GCGAATGTGG CTTCACAGAC 
CAGAACTACC GAGCCTTGCA GCAGCTGCAG CGGGACCTGG GCCCCCATCA TTTTAATGTG 
CTTGCCTTCC CTTGCAACCA GTTTGGCCAA CAGGAACCAG ACACCAACAG GGAGATTGAG 
AACTTTGCCC GCCGCACCTA CAGTGTCTCT TTTCCCATGT TTAGCAAGAT CGCAGTCACT 
GGCACTGGTG CCCACCCTGC CTTCAAGTAC CTAACCCAGA CTTCTGGGAA GGAGCCCACC 
TGGAACTTCT GGAAGTACCT AGTGGACCCA GACGGAAAGG TGGTGGGAGC ATGGGACCCC 
ACTGTGCCAG TGGCGGAGAT CAAGCCCCGT ATTACAGAGC AGGTGATGAA ACTCATCCTT 
CGGAAACGAG AAGACTTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury.
PLoS genetics12(9)e1006355(2016 Sep)
Wu Y,Wei FY,Kawarada L,Suzuki T,Araki K,Komohara Y,Fujimura A,Kaitsuka T,Takeya M,Oike Y,Suzuki T,Tomizawa K

Deficiency of NPGPx, an oxidative stress sensor, leads to obesity in mice and human.
EMBO molecular medicine5(8)1165-79(2013 Aug)
Chang YC,Yu YH,Shew JY,Lee WJ,Hwang JJ,Chen YH,Chen YR,Wei PC,Chuang LM,Lee WH

Protein disulfide isomerase and glutathione are alternative substrates in the one Cys catalytic cycle of glutathione peroxidase 7.
Biochimica et biophysica acta1830(6)3846-57(2013 Jun)
Bosello-Travain V,Conrad M,Cozza G,Negro A,Quartesan S,Rossetto M,Roveri A,Toppo S,Ursini F,Zaccarin M,Maiorino M

Loss of the oxidative stress sensor NPGPx compromises GRP78 chaperone activity and induces systemic disease.
Molecular cell48(5)747-59(2012 Dec)
Wei PC,Hsieh YH,Su MI,Jiang X,Hsu PH,Lo WT,Weng JY,Jeng YM,Wang JM,Chen PL,Chang YC,Lee KF,Tsai MD,Shew JY,Lee WH

A mouse knockout library for secreted and transmembrane proteins.
Nature biotechnology28(7)749-55(2010 Jul)
Tang T,Li L,Tang J,Li Y,Lin WY,Martin F,Grant D,Solloway M,Parker L,Ye W,Forrest W,Ghilardi N,Oravecz T,Platt KA,Rice DS,Hansen GM,Abuin A,Eberhart DE,Godowski P,Holt KH,Peterson A,Zambrowicz BP,de Sauvage FJ

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Gpx7 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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