Eif2s2 cDNA ORF clone, Mus musculus(house mouse)

Defective Mitochondrial tRNA Taurine Modification Activates Global Proteostress and Leads to Mitochondrial Disease.
Fakruddin M, Wei FY, Suzuki T, Asano K, Kaieda T, Omori A, Izumi R, Fujimura A, Kaitsuka T, Miyata K, Araki K, Oike Y, Scorrano L, Suzuki T, Tomizawa K
Cell reports22(2)482-496(2018 Jan)

Mutant eIF2B leads to impaired mitochondrial oxidative phosphorylation in vanishing white matter disease.
Raini G, Sharet R, Herrero M, Atzmon A, Shenoy A, Geiger T, Elroy-Stein O
Journal of neurochemistry141(5)694-707(2017 Jun)

Perturbations in actin dynamics reconfigure protein complexes that modulate GCN2 activity and promote an eIF2 response.
Silva RC, Sattlegger E, Castilho BA
Journal of cell science129(24)4521-4533(2016 12)

Involvement of the osteoinductive factors, Tmem119 and BMP-2, and the ER stress response PERK-eIF2?-ATF4 pathway in the commitment of myoblastic into osteoblastic cells.
Tanaka K, Kaji H, Yamaguchi T, Kanazawa I, Canaff L, Hendy GN, Sugimoto T
Calcified tissue international94(4)454-64(2014 Apr)

Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2.
Cambiaghi TD, Pereira CM, Shanmugam R, Bolech M, Wek RC, Sattlegger E, Castilho BA
Biochemical and biophysical research communications443(2)592-7(2014 Jan)

This study provides evidence that even a mild mutation in eIF2B, leading merely to a ~ 20% decrease in its enzymatic activity, is associated with mitochondrial malfunction caused by defective oxphos and with increased mitochondrial biogenesis compensating for energetic needs.
Title: Mutant eIF2B leads to impaired mitochondrial oxidative phosphorylation in vanishing white matter disease.

GCN2 activation increased phosphorylation of its substrate eIF2alpha and the induction of the integrated stress response master regulator, ATF4.
Title: Perturbations in actin dynamics reconfigure protein complexes that modulate GCN2 activity and promote an eIF2 response.

BMP-2 stimulates differentiation of myoblasts into osteoblasts via the PERK-eIF2alpha-ATF4 pathway but in addition stimulates Tmem119, which itself increases ATF4
Title: Involvement of the osteoinductive factors, Tmem119 and BMP-2, and the ER stress response PERK-eIF2?-ATF4 pathway in the commitment of myoblastic into osteoblastic cells.

This study extends our understanding of the roles played by GCN1 in GCN2 activation induced by a variety of stress arrangements and suggests that IMPACT and YIH1 use similar mechanisms for regulating this eIF2alpha kinase.
Title: Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2.

Study found that the incidence of testicular germ cell tumor in affected males was reduced 2-fold in mice that were partially deficient for Eif2s2 and embryonic lethality occurred near the time of implantation in mice that were fully deficient for Eif2s2.
Title: Deletion of eIF2beta suppresses testicular cancer incidence and causes recessive lethality in agouti-yellow mice.