Tmem107 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tmem107
Entrez Gene ID	66910
Full Name	transmembrane protein 107
Synonyms	1110004B13Rik,2810049P21Rik
General protein information	Preferred Names transmembrane protein 107 Names transmembrane protein 107
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11\|11 B3

mRNA and Protein(s)

mRNA	Protein	Name
NM_025838.2	NP_080114.1	transmembrane protein 107 isoform 1
NM_028336.3	NP_082612.2	transmembrane protein 107 isoform 2

Pathways from BioSystems

Homologies

	TMEM107	XP_001112300.1
Homo sapiens (human)	TMEM107	NP_115730.2
Xenopus tropicalis (tropical clawed frog)	LOC101731170	XP_004919448.1
Bos taurus (cattle)	TMEM107	NP_001077126.1
Canis lupus familiaris (dog)	TMEM107	XP_850104.2
Mus musculus (house mouse)	Tmem107	NP_080114.1
Danio rerio (zebrafish)	tmem107l	XP_687791.1
Pan troglodytes (chimpanzee)	TMEM107	XP_003315649.1
Rattus norvegicus (Norway rat)	Tmem107	NP_001103118.1

Gene Ontology
Bibliography

Related articles in PubMed

Ciliopathy Protein Tmem107 Plays Multiple Roles in Craniofacial Development.
Cela P, Hampl M, Shylo NA, Christopher KJ, Kavkova M, Landova M, Zikmund T, Weatherbee SD, Kaiser J, Buchtova M
Journal of dental research97(1)108-117(2018 Jan)

TMEM107 Is a Critical Regulator of Ciliary Protein Composition and Is Mutated in Orofaciodigital Syndrome.
Shylo NA, Christopher KJ, Iglesias A, Daluiski A, Weatherbee SD
Human mutation37(2)155-9(2016 Feb)

TMEM107 recruits ciliopathy proteins to subdomains of the ciliary transition zone and causes Joubert?syndrome.
Lambacher NJ, Bruel AL, van Dam TJ, Szyma?ska K, Slaats GG, Kuhns S, McManus GJ, Kennedy JE, Gaff K, Wu KM, van der Lee R, Burglen L, Doummar D, Rivi?re JB, Faivre L, Atti?-Bitach T, Saunier S, Curd A, Peckham M, Giles RH, Johnson CA, Huynen MA, Thauvin-Robinet C, Blacque OE
Nature cell biology18(1)122-31(2016 Jan)

Forward genetics uncovers Transmembrane protein 107 as a novel factor required for ciliogenesis and Sonic hedgehog signaling.
Christopher KJ, Wang B, Kong Y, Weatherbee SD
Developmental biology368(2)382-92(2012 Aug)

A mouse knockout library for secreted and transmembrane proteins.
Tang T, Li L, Tang J, Li Y, Lin WY, Martin F, Grant D, Solloway M, Parker L, Ye W, Forrest W, Ghilardi N, Oravecz T, Platt KA, Rice DS, Hansen GM, Abuin A, Eberhart DE, Godowski P, Holt KH, Peterson A, Zambrowicz BP, de Sauvage FJ
Nature biotechnology28(7)749-55(2010 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

multiple roles in craniofacial development
Title: Ciliopathy Protein Tmem107 Plays Multiple Roles in Craniofacial Development.

TMEM107 Is a critical regulator of ciliary protein composition and is mutated in orofaciodigital syndrome mice.
Title: TMEM107 Is a Critical Regulator of Ciliary Protein Composition and Is Mutated in Orofaciodigital Syndrome.

TMEM107 recruits ciliopathy proteins to subdomains of the ciliary transition zone and causes Joubert syndrome
Title: TMEM107 recruits ciliopathy proteins to subdomains of the ciliary transition zone and causes Joubert?syndrome.

Data show that Transmembrane protein 107 (Tmem107) is required for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with Gli2 and Gli3 to pattern ventral and intermediate neuronal cell types.
Title: Forward genetics uncovers Transmembrane protein 107 as a novel factor required for ciliogenesis and Sonic hedgehog signaling.

The following Tmem107 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tmem107 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu15258	NM_028336.3 Latest version!	Mus musculus transmembrane protein 107 (Tmem107), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OMu15279	NM_025838.2 Latest version!	Mus musculus transmembrane protein 107 (Tmem107), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tmem107 ( NM_028336.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_082612.2 Mus musculus transmembrane protein 107 (Tmem107), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu15258
Clone ID Related Accession (Same CDS sequence)	NM_028336.3
Accession Version	NM_028336.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 432bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Mus musculus(house mouse)
Product	transmembrane protein 107 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AA217716.1, AK003403.1, AK012938.1 and AI835650.1. On May 28, 2009 this sequence version replaced NM_028336.2. Transcript Variant: This variant (2) is the longer transcript and encodes the longer isoform (2). ##Evidence-Data-START## Transcript exon combination :: AK012938.1, BY712023.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGGTCGGA TCTCCGGGCT CGTGCCCTCT CGGTTCCTGA CGCTCTTGGC TCATCTGGTG 
GTTGTCATCA CGTTGTTCTG GTCCCGGGAA AGCAACATCC AGGCTTGCCT GCCTCTCAAA 
TTCACCCCGG AGGAATACGA AAAGCAGGAC AACCAGCTGG TAGCCGCGCT CTGTCTCACC 
CTGGGCCTCT TTGCAGTGGA GCTGGCTGGC TTCCTCTCAG GAGTCTCCAT GTTCAATAGC 
ACCCAGAGCC TCCTCTCCAT TGCAGCCCAC TGTAGCGCGT CTGTGGCCCT GTCTTTCTTC 
GTATTCGAGC GATGGGAATG TACCACGTAC TGGTACATTT TTACCTTCTG CAGGTGCCCT 
AGCACCCAAT ATTTTGGAAT GGGGGGGGGT GGTGGAAAAT CGATCCCAAA TCTGAAGGTT 
TCCCCCACCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_082612.2
CDS	139..570
Translation	MGRISGLVPSRFLTLLAHLVVVITLFWSRESNIQACLPLKFTPEEYEKQDNQLVAALCLTLGLFAVELAGFLSGVSMFNSTQSLLSIAAHCSASVALSFFVFERWECTTYWYIFTFCRCPSTQYFGMGGGGGKSIPNLKVSPT

Target ORF information:

RefSeq Version	NM_028336.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus transmembrane protein 107 (Tmem107), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_028336.3

ORF Insert Sequence:

ATGGGTCGGA TCTCCGGGCT CGTGCCCTCT CGGTTCCTGA CGCTCTTGGC TCATCTGGTG 
GTTGTCATCA CGTTGTTCTG GTCCCGGGAA AGCAACATCC AGGCTTGCCT GCCTCTCAAA 
TTCACCCCGG AGGAATACGA AAAGCAGGAC AACCAGCTGG TAGCCGCGCT CTGTCTCACC 
CTGGGCCTCT TTGCAGTGGA GCTGGCTGGC TTCCTCTCAG GAGTCTCCAT GTTCAATAGC 
ACCCAGAGCC TCCTCTCCAT TGCAGCCCAC TGTAGCGCGT CTGTGGCCCT GTCTTTCTTC 
GTATTCGAGC GATGGGAATG TACCACGTAC TGGTACATTT TTACCTTCTG CAGGTGCCCT 
AGCACCCAAT ATTTTGGAAT GGGGGGGGGT GGTGGAAAAT CGATCCCAAA TCTGAAGGTT 
TCCCCCACCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Tmem107 ( NM_025838.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_080114.1 Mus musculus transmembrane protein 107 (Tmem107), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu15279
Clone ID Related Accession (Same CDS sequence)	NM_025838.2
Accession Version	NM_025838.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 423bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Mus musculus(house mouse)
Product	transmembrane protein 107 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AA217716.1, AK003403.1 and CO044635.1. On May 28, 2009 this sequence version replaced NM_025838.1. Transcript Variant: This variant (1) lacks an internal segment in the 3' region, as compared to variant 2. The resulting isoform (1) is shorter and has a different C-terminus, as compared to isoform 2. ##Evidence-Data-START## Transcript exon combination :: AK154279.1, AK003403.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGGTCGGA TCTCCGGGCT CGTGCCCTCT CGGTTCCTGA CGCTCTTGGC TCATCTGGTG 
GTTGTCATCA CGTTGTTCTG GTCCCGGGAA AGCAACATCC AGGCTTGCCT GCCTCTCAAA 
TTCACCCCGG AGGAATACGA AAAGCAGGAC AACCAGCTGG TAGCCGCGCT CTGTCTCACC 
CTGGGCCTCT TTGCAGTGGA GCTGGCTGGC TTCCTCTCAG GAGTCTCCAT GTTCAATAGC 
ACCCAGAGCC TCCTCTCCAT TGCAGCCCAC TGTAGCGCGT CTGTGGCCCT GTCTTTCTTC 
GTATTCGAGC GATGGGAATG TACCACGTAC TGGTACATTT TTACCTTCTG CAGCGCCTTC 
CCAGCTGTCA CTGAAACTGC ATTATTCATC GCTGTCTTTG GGCTGAAAAA GAAACCCTTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_080114.1
CDS	139..561
Translation	MGRISGLVPSRFLTLLAHLVVVITLFWSRESNIQACLPLKFTPEEYEKQDNQLVAALCLTLGLFAVELAGFLSGVSMFNSTQSLLSIAAHCSASVALSFFVFERWECTTYWYIFTFCSAFPAVTETALFIAVFGLKKKPF

Target ORF information:

RefSeq Version	NM_025838.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus transmembrane protein 107 (Tmem107), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_025838.2

ORF Insert Sequence:

ATGGGTCGGA TCTCCGGGCT CGTGCCCTCT CGGTTCCTGA CGCTCTTGGC TCATCTGGTG 
GTTGTCATCA CGTTGTTCTG GTCCCGGGAA AGCAACATCC AGGCTTGCCT GCCTCTCAAA 
TTCACCCCGG AGGAATACGA AAAGCAGGAC AACCAGCTGG TAGCCGCGCT CTGTCTCACC 
CTGGGCCTCT TTGCAGTGGA GCTGGCTGGC TTCCTCTCAG GAGTCTCCAT GTTCAATAGC 
ACCCAGAGCC TCCTCTCCAT TGCAGCCCAC TGTAGCGCGT CTGTGGCCCT GTCTTTCTTC 
GTATTCGAGC GATGGGAATG TACCACGTAC TGGTACATTT TTACCTTCTG CAGCGCCTTC 
CCAGCTGTCA CTGAAACTGC ATTATTCATC GCTGTCTTTG GGCTGAAAAA GAAACCCTTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ciliopathy Protein Tmem107 Plays Multiple Roles in Craniofacial Development.
Journal of dental research97(1)108-117(2018 Jan)
Cela P,Hampl M,Shylo NA,Christopher KJ,Kavkova M,Landova M,Zikmund T,Weatherbee SD,Kaiser J,Buchtova M

TMEM107 Is a Critical Regulator of Ciliary Protein Composition and Is Mutated in Orofaciodigital Syndrome.
Human mutation37(2)155-9(2016 Feb)
Shylo NA,Christopher KJ,Iglesias A,Daluiski A,Weatherbee SD

TMEM107 recruits ciliopathy proteins to subdomains of the ciliary transition zone and causes Joubert?syndrome.
Nature cell biology18(1)122-31(2016 Jan)
Lambacher NJ,Bruel AL,van Dam TJ,Szyma?ska K,Slaats GG,Kuhns S,McManus GJ,Kennedy JE,Gaff K,Wu KM,van der Lee R,Burglen L,Doummar D,Rivi?re JB,Faivre L,Atti?-Bitach T,Saunier S,Curd A,Peckham M,Giles RH,Johnson CA,Huynen MA,Thauvin-Robinet C,Blacque OE

Forward genetics uncovers Transmembrane protein 107 as a novel factor required for ciliogenesis and Sonic hedgehog signaling.
Developmental biology368(2)382-92(2012 Aug)
Christopher KJ,Wang B,Kong Y,Weatherbee SD

A mouse knockout library for secreted and transmembrane proteins.
Nature biotechnology28(7)749-55(2010 Jul)
Tang T,Li L,Tang J,Li Y,Lin WY,Martin F,Grant D,Solloway M,Parker L,Ye W,Forrest W,Ghilardi N,Oravecz T,Platt KA,Rice DS,Hansen GM,Abuin A,Eberhart DE,Godowski P,Holt KH,Peterson A,Zambrowicz BP,de Sauvage FJ

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Tmem107 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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