Aggf1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Aggf1
Entrez Gene ID	66549
Full Name	angiogenic factor with G patch and FHA domains 1
Synonyms	2010009L17Rik,2310029P06Rik,AW112072,Peg3,VG5Q
General protein information	Preferred Names angiogenic factor with G patch and FHA domains 1 Names angiogenic factor with G patch and FHA domains 1 angiogenic factor VG5Q
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 13 Map Location: 13\|13 D1

mRNA and Protein(s)

mRNA	Protein	Name
NM_025630.3	NP_079906.2	angiogenic factor with G patch and FHA domains 1

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	aggf1	XP_002940925.2
Canis lupus familiaris (dog)	AGGF1	XP_005618241.1
Gallus gallus (chicken)	AGGF1	XP_414679.3
Homo sapiens (human)	AGGF1	NP_060516.2
	AGGF1	XP_001106588.1
Mus musculus (house mouse)	Aggf1	NP_079906.2
Rattus norvegicus (Norway rat)	Aggf1	XP_006231882.1
Pan troglodytes (chimpanzee)	AGGF1	XP_526886.1
Bos taurus (cattle)	AGGF1	NP_001069000.2

Gene Ontology
Bibliography

Related articles in PubMed

A non-canonical pathway regulates ER stress signaling and blocks ER stress-induced apoptosis and heart failure.
Yao Y, Lu Q, Hu Z, Yu Y, Chen Q, Wang QK
Nature communications8(1)133(2017 07)

Targeting AGGF1 (angiogenic factor with G patch and FHA domains 1) for Blocking Neointimal Formation After Vascular Injury.
Yao Y, Hu Z, Ye J, Hu C, Song Q, Da X, Yu Y, Li H, Xu C, Chen Q, Wang QK
Journal of the American Heart Association6(6)(2017 Jun)

Angiogenic factor with G patch and FHA domains 1 (Aggf1) promotes hepatic steatosis in mice.
Shao J, Zeng S, Zhou B, Xu H, Bian Y, Xu Y
Biochemical and biophysical research communications482(1)134-140(2017 Jan)

Haploinsufficiency of Klippel-Trenaunay syndrome gene Aggf1 inhibits developmental and pathological angiogenesis by inactivating PI3K and AKT and disrupts vascular integrity by activating VE-cadherin.
Zhang T, Yao Y, Wang J, Li Y, He P, Pasupuleti V, Hu Z, Jia X, Song Q, Tian XL, Hu C, Chen Q, Wang QK
Human molecular genetics25(23)5094-5110(2016 12)

Angiogenic Factor AGGF1 Activates Autophagy with an Essential Role in Therapeutic Angiogenesis for Heart Disease.
Lu Q, Yao Y, Hu Z, Hu C, Song Q, Ye J, Xu C, Wang AZ, Chen Q, Wang QK
PLoS biology14(8)e1002529(2016 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Mechanistically, Aggf1 activated the expression of gluconeogenesis gene and skewed the insulin signaling pathway to induce insulin resistance. Taken together, our data suggest that Aggf1 plays a role in steatosis in vivo and as such may be a new target in the development of therapeutics solutions against steatosis.
Title: Angiogenic factor with G patch and FHA domains 1 (Aggf1) promotes hepatic steatosis in mice.

Together with recent identification of somatic mutations in p110a (encoded by PIK3CA), our data establish a potential mechanistic link between AGGF1 and PIK3CA, the two genes identified for Klippel-Trenaunay syndrome (KTS)
Title: Haploinsufficiency of Klippel-Trenaunay syndrome gene Aggf1 inhibits developmental and pathological angiogenesis by inactivating PI3K and AKT and disrupts vascular integrity by activating VE-cadherin.

Data indicate that angiogenic factor Aggf1+/- knockout (KO) mice show reduced autophagy, which was associated with inhibition of angiogenesis and larger infarct areas.
Title: Angiogenic Factor AGGF1 Activates Autophagy with an Essential Role in Therapeutic Angiogenesis for Heart Disease.

Sphingolipid modulation of angiogenic factor expression in neuroblastoma
Title: Sphingolipid modulation of angiogenic factor expression in neuroblastoma.

The following Aggf1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Aggf1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu00791	NM_025630.3 Latest version!	Mus musculus angiogenic factor with G patch and FHA domains 1 (Aggf1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$419.30 $599.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Aggf1 ( NM_025630.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_079906.2 Mus musculus angiogenic factor with G patch and FHA domains 1 (Aggf1), mRNA.

Price & Availability↑

CloneID	OMu00791
Clone ID Related Accession (Same CDS sequence)	NM_025630.3
Accession Version	NM_025630.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2136bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	angiogenic factor with G patch and FHA domains 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK132575.1, BC052410.1 and AA138180.1. On Aug 9, 2013 this sequence version replaced NM_025630.2. ##Evidence-Data-START## Transcript exon combination :: BC052410.1, AY500995.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164138 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCTCCG AGGCGCCCTC GCCGCCTTCG CCTTCTCCGC CGCCGCCCGC CTCTCCGGAG 
CCGGAGCTGG CGCAGCTCAG GCGGAAGGTG GAGAAGTTGG AGCGCGAGCT GCGGAGCTGC 
CGGAGGCAGG TGCGGGAGGT GGAGAAGCTG CTGCAGCACA CGGAGCGACT CTACCGCAAC 
GCCGAGAGCG ACAACCAGGA GCTCCGCACG CAGGTAGAAG AACTTAGTAA AATACTCCAT 
TGTGGGAAAA ATGAAGATAA TCCGAAGTCT GATGTAGAAG TACAGACAGA GAGCCAAGCT 
CCTTGGGCGA TTTCAGATTA TTACTATCAG ACATGTTATA ATGACGACAG TCTTCCCAGT 
AAAGAGACGG AGCTGTGTGT ACAGCAGAGT CAGTGTGCTC AGGCTTCCGC TCTTGATCCT 
CAGGACGAGT CACACATAGA CAGCGGGAGT TATGCTGGTG CTGATGCCAC AGAAGGTGTT 
AGCCATAGAC AGGAGGACGC CGTCACCTCT GACTCACAGG AGAGTGTGTC CGCGCTAGCA 
GAAGGCCCAG CACTCGAAGG GTCCTCGCTT GCTGAGAGCT TGAGAGCTGC AGCGGAGGCT 
GCTGTGTCGC AGACCGGCTT CACCTACGAC GAGAGCACGG GCTTATATTT TGACCACAGC 
ACTGGTTTCT ATTATGATTC TGAAAACCAG CTGTATTATG ACCCTTCCAC GGGGATTTAT 
TACTACTGCG ATGTGGAGAG TGGTCGGTAC CAGTTTCACT CTCGCGTAGA CCTGCAGCCT 
TACCAGACCT CTAGCACAAA ACCAAACAGA GAAAGAAGAC TGAAGAAGAG AAGAAAGGAG 
CCAGGTTTTT ATACAGCAAA TGAAGAAAAG GATTTGAGCT CAGAAGATCA GAAAGTCTGC 
AGTGTAGAAT ATATAAACTG CAGTGAGGAT GAACATTCTG GAAATGTGAA AAAGAAGGCC 
AGAACAGACA CTTCTCACAA AAGCAGTCCC TTACAGCTCA CGGTGGCAGT TAGTGGAGAC 
ACTGTGGAGT CTCCTGGAGA TGATAACTCA GCGTCATCTA AGGATGAGAG AATCGGAGAG 
AGTGAGAGCG AGCCGGAAGA AGGTGAGATC ACAGACTCTC AGAGTGAGAA GAGCTATGAT 
GGAGACAGTA GCAGTGGGGA CAGGGAGACC TCAGAAGAAT CCGACGATGA AGATGAGGAA 
AGAATTTGGC CGCCCTGTAT TCGCGTGATT GTCATTAGGT CTCCAGTGTT GCAGATGGGC 
TCGCTGTTCA TCATCACCGC TGTGAGCCCA GCCACCATTG GGAGAGAGAA GGACATGGAG 
CATACTGTGA GAATCCCTGA AGTCGCTGTT AGTAAGTTCC ACGCAGAAGT TTACTTCGAC 
CATGACTTGC AAAGCTACGT TCTTGTGGAT CAGGGCAGCC AGAATGGTAC CATTGTCAAC 
GGGAAACAGA TTCTTCAGCC AAAAACTAAA TGTGATCCTT ACGTCCTCGA ACACGGCGAC 
GAAGTGAAAA TTGGGGAGAC TGTGCTGTCT TTTCACATTC ACCCTGGCAG TGAGACGTGC 
GATGGCTGTG AGCCGGGGCA GGTCAGAGCT CACCTCCGCC TCGATAGAAA GGACGAGCCT 
CTGGTCGGTC CAGCACTAAG TAAGGAGGAA AAAGAGTTGG AAAGAAGAAA AGCACTCAAG 
AAAATACGAG TAAAGTATGG CTTGCAGAAT ACAGATTATG AAGCTGAAAA AGCGTTGAAG 
AATCCTAAGT ATAAAGACAG AGCTGGAAAA CGCAGGGAGC AGGTGGGAAG CGAAGGGACT 
TTCCAAAGAG ATGACGCCCC TGCGTCTGTT CACTCTGAAA TTACAGATAG CAACAAAGGC 
CGAAAGATGT TGGAGAAGAT GGGGTGGAAA CGGGGAGAAG GCCTGGGAAA GGACGGTGGA 
GGGATGAAAA CGCCGATCCA GCTTCAGCTT CGACGGACAC ATGCTGGCTT GGGGACAGGG 
AAGCTGTCCT CGATTGATGA CGTTCACCTC ATCCAGAATA AGAGCAAAAA ACACTGGGAC 
AAAGCCCGGG AGCGGTTTGC GGAAACTTTC ACAGAAAACA AACCTCGGAA AGAGACCCCA 
GGGGCAGTGC CGTGGGTGAC AGGGACTGCA GAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_079906.2
CDS	300..2435
Translation	MASEAPSPPSPSPPPPASPEPELAQLRRKVEKLERELRSCRRQVREVEKLLQHTERLYRNAESDNQELRTQVEELSKILHCGKNEDNPKSDVEVQTESQAPWAISDYYYQTCYNDDSLPSKETELCVQQSQCAQASALDPQDESHIDSGSYAGADATEGVSHRQEDAVTSDSQESVSALAEGPALEGSSLAESLRAAAEAAVSQTGFTYDESTGLYFDHSTGFYYDSENQLYYDPSTGIYYYCDVESGRYQFHSRVDLQPYQTSSTKPNRERRLKKRRKEPGFYTANEEKDLSSEDQKVCSVEYINCSEDEHSGNVKKKARTDTSHKSSPLQLTVAVSGDTVESPGDDNSASSKDERIGESESEPEEGEITDSQSEKSYDGDSSSGDRETSEESDDEDEERIWPPCIRVIVIRSPVLQMGSLFIITAVSPATIGREKDMEHTVRIPEVAVSKFHAEVYFDHDLQSYVLVDQGSQNGTIVNGKQILQPKTKCDPYVLEHGDEVKIGETVLSFHIHPGSETCDGCEPGQVRAHLRLDRKDEPLVGPALSKEEKELERRKALKKIRVKYGLQNTDYEAEKALKNPKYKDRAGKRREQVGSEGTFQRDDAPASVHSEITDSNKGRKMLEKMGWKRGEGLGKDGGGMKTPIQLQLRRTHAGLGTGKLSSIDDVHLIQNKSKKHWDKARERFAETFTENKPRKETPGAVPWVTGTAE

Target ORF information:

RefSeq Version	NM_025630.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus angiogenic factor with G patch and FHA domains 1 (Aggf1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_025630.3

ORF Insert Sequence:

ATGGCCTCCG AGGCGCCCTC GCCGCCTTCG CCTTCTCCGC CGCCGCCCGC CTCTCCGGAG 
CCGGAGCTGG CGCAGCTCAG GCGGAAGGTG GAGAAGTTGG AGCGCGAGCT GCGGAGCTGC 
CGGAGGCAGG TGCGGGAGGT GGAGAAGCTG CTGCAGCACA CGGAGCGACT CTACCGCAAC 
GCCGAGAGCG ACAACCAGGA GCTCCGCACG CAGGTAGAAG AACTTAGTAA AATACTCCAT 
TGTGGGAAAA ATGAAGATAA TCCGAAGTCT GATGTAGAAG TACAGACAGA GAGCCAAGCT 
CCTTGGGCGA TTTCAGATTA TTACTATCAG ACATGTTATA ATGACGACAG TCTTCCCAGT 
AAAGAGACGG AGCTGTGTGT ACAGCAGAGT CAGTGTGCTC AGGCTTCCGC TCTTGATCCT 
CAGGACGAGT CACACATAGA CAGCGGGAGT TATGCTGGTG CTGATGCCAC AGAAGGTGTT 
AGCCATAGAC AGGAGGACGC CGTCACCTCT GACTCACAGG AGAGTGTGTC CGCGCTAGCA 
GAAGGCCCAG CACTCGAAGG GTCCTCGCTT GCTGAGAGCT TGAGAGCTGC AGCGGAGGCT 
GCTGTGTCGC AGACCGGCTT CACCTACGAC GAGAGCACGG GCTTATATTT TGACCACAGC 
ACTGGTTTCT ATTATGATTC TGAAAACCAG CTGTATTATG ACCCTTCCAC GGGGATTTAT 
TACTACTGCG ATGTGGAGAG TGGTCGGTAC CAGTTTCACT CTCGCGTAGA CCTGCAGCCT 
TACCAGACCT CTAGCACAAA ACCAAACAGA GAAAGAAGAC TGAAGAAGAG AAGAAAGGAG 
CCAGGTTTTT ATACAGCAAA TGAAGAAAAG GATTTGAGCT CAGAAGATCA GAAAGTCTGC 
AGTGTAGAAT ATATAAACTG CAGTGAGGAT GAACATTCTG GAAATGTGAA AAAGAAGGCC 
AGAACAGACA CTTCTCACAA AAGCAGTCCC TTACAGCTCA CGGTGGCAGT TAGTGGAGAC 
ACTGTGGAGT CTCCTGGAGA TGATAACTCA GCGTCATCTA AGGATGAGAG AATCGGAGAG 
AGTGAGAGCG AGCCGGAAGA AGGTGAGATC ACAGACTCTC AGAGTGAGAA GAGCTATGAT 
GGAGACAGTA GCAGTGGGGA CAGGGAGACC TCAGAAGAAT CCGACGATGA AGATGAGGAA 
AGAATTTGGC CGCCCTGTAT TCGCGTGATT GTCATTAGGT CTCCAGTGTT GCAGATGGGC 
TCGCTGTTCA TCATCACCGC TGTGAGCCCA GCCACCATTG GGAGAGAGAA GGACATGGAG 
CATACTGTGA GAATCCCTGA AGTCGCTGTT AGTAAGTTCC ACGCAGAAGT TTACTTCGAC 
CATGACTTGC AAAGCTACGT TCTTGTGGAT CAGGGCAGCC AGAATGGTAC CATTGTCAAC 
GGGAAACAGA TTCTTCAGCC AAAAACTAAA TGTGATCCTT ACGTCCTCGA ACACGGCGAC 
GAAGTGAAAA TTGGGGAGAC TGTGCTGTCT TTTCACATTC ACCCTGGCAG TGAGACGTGC 
GATGGCTGTG AGCCGGGGCA GGTCAGAGCT CACCTCCGCC TCGATAGAAA GGACGAGCCT 
CTGGTCGGTC CAGCACTAAG TAAGGAGGAA AAAGAGTTGG AAAGAAGAAA AGCACTCAAG 
AAAATACGAG TAAAGTATGG CTTGCAGAAT ACAGATTATG AAGCTGAAAA AGCGTTGAAG 
AATCCTAAGT ATAAAGACAG AGCTGGAAAA CGCAGGGAGC AGGTGGGAAG CGAAGGGACT 
TTCCAAAGAG ATGACGCCCC TGCGTCTGTT CACTCTGAAA TTACAGATAG CAACAAAGGC 
CGAAAGATGT TGGAGAAGAT GGGGTGGAAA CGGGGAGAAG GCCTGGGAAA GGACGGTGGA 
GGGATGAAAA CGCCGATCCA GCTTCAGCTT CGACGGACAC ATGCTGGCTT GGGGACAGGG 
AAGCTGTCCT CGATTGATGA CGTTCACCTC ATCCAGAATA AGAGCAAAAA ACACTGGGAC 
AAAGCCCGGG AGCGGTTTGC GGAAACTTTC ACAGAAAACA AACCTCGGAA AGAGACCCCA 
GGGGCAGTGC CGTGGGTGAC AGGGACTGCA GAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A non-canonical pathway regulates ER stress signaling and blocks ER stress-induced apoptosis and heart failure.
Nature communications8(1)133(2017 07)
Yao Y,Lu Q,Hu Z,Yu Y,Chen Q,Wang QK

Targeting AGGF1 (angiogenic factor with G patch and FHA domains 1) for Blocking Neointimal Formation After Vascular Injury.
Journal of the American Heart Association6(6)(2017 Jun)
Yao Y,Hu Z,Ye J,Hu C,Song Q,Da X,Yu Y,Li H,Xu C,Chen Q,Wang QK

Angiogenic factor with G patch and FHA domains 1 (Aggf1) promotes hepatic steatosis in mice.
Biochemical and biophysical research communications482(1)134-140(2017 Jan)
Shao J,Zeng S,Zhou B,Xu H,Bian Y,Xu Y

Haploinsufficiency of Klippel-Trenaunay syndrome gene Aggf1 inhibits developmental and pathological angiogenesis by inactivating PI3K and AKT and disrupts vascular integrity by activating VE-cadherin.
Human molecular genetics25(23)5094-5110(2016 12)
Zhang T,Yao Y,Wang J,Li Y,He P,Pasupuleti V,Hu Z,Jia X,Song Q,Tian XL,Hu C,Chen Q,Wang QK

Angiogenic Factor AGGF1 Activates Autophagy with an Essential Role in Therapeutic Angiogenesis for Heart Disease.
PLoS biology14(8)e1002529(2016 Aug)
Lu Q,Yao Y,Hu Z,Hu C,Song Q,Ye J,Xu C,Wang AZ,Chen Q,Wang QK

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Aggf1 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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