Nenf cDNA ORF clone, Mus musculus(house mouse)

Deletion of the Neurotrophic Factor neudesin Prevents Diet-induced Obesity by Increased Sympathetic Activity.
Ohta H, Konishi M, Kobayashi Y, Kashio A, Mochiyama T, Matsumura S, Inoue K, Fushiki T, Nakao K, Kimura I, Itoh N
Scientific reports510049(2015 May)

Identification of hypothalamic neuron-derived neurotrophic factor as a novel factor modulating appetite.
Byerly MS, Swanson RD, Semsarzadeh NN, McCulloh PS, Kwon K, Aja S, Moran TH, Wong GW, Blackshaw S
American journal of physiology. Regulatory, integrative and comparative physiology304(12)R1085-95(2013 Jun)

Neudesin is involved in anxiety behavior: structural and neurochemical correlates.
Novais A, Ferreira AC, Marques F, P?go JM, Cerqueira JJ, David-Pereira A, Campos FL, Dalla C, Kokras N, Sousa N, Palha JA, Sousa JC
Frontiers in behavioral neuroscience7119(2013)

Neudesin, an extracellular heme-binding protein, suppresses adipogenesis in 3T3-L1 cells via the MAPK cascade.
Kimura I, Konishi M, Asaki T, Furukawa N, Ukai K, Mori M, Hirasawa A, Tsujimoto G, Ohta M, Itoh N, Fujimoto M
Biochemical and biophysical research communications381(1)75-80(2009 Mar)

Neurotrophic activity of neudesin, a novel extracellular heme-binding protein, is dependent on the binding of heme to its cytochrome b5-like heme/steroid-binding domain.
Kimura I, Nakayama Y, Yamauchi H, Konishi M, Miyake A, Mori M, Ohta M, Itoh N, Fujimoto M
The Journal of biological chemistry283(7)4323-31(2008 Feb)

neudesin, which may be a negative regulator of sympathetic activity, could represent a novel regulator of the development of obesity and obesity-related metabolic dysfunctions.
Title: Deletion of the Neurotrophic Factor neudesin Prevents Diet-induced Obesity by Increased Sympathetic Activity.

Neuron-derived neurotrophic factor (NENF) is an important central modulator of food intake.
Title: Identification of hypothalamic neuron-derived neurotrophic factor as a novel factor modulating appetite.

These findings suggest that neudesin plays a critical role in the early stage of adipocyte differentiation in which C/EBPbeta induces PPARgamma and C/EBPalpha expressions, by controlling the MAPK pathway.
Title: Neudesin, an extracellular heme-binding protein, suppresses adipogenesis in 3T3-L1 cells via the MAPK cascade.

Neudesin is the first extracellular heme-binding protein that shows signal transducing activity by itself. The present findings may shed new light on the function of extracellular heme-binding proteins
Title: Neurotrophic activity of neudesin, a novel extracellular heme-binding protein, is dependent on the binding of heme to its cytochrome b5-like heme/steroid-binding domain.

The present findings have revealed new potential roles of neudesin in neural cell proliferation and neuronal differentiation.
Title: Neudesin, a secreted factor, promotes neural cell proliferation and neuronal differentiation in mouse neural precursor cells.