Inpp5e cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Inpp5e
Entrez Gene ID	64436
Full Name	inositol polyphosphate-5-phosphatase E
Synonyms	1200002L24Rik,72kDa,mKIAA0123
General protein information	Preferred Names inositol polyphosphate-5-phosphatase E Names 72 kDa inositol polyphosphate 5-phosphatase inositol polyphosphate-5-phosphatase, 72 kDa phosphatidylinositol 4,5-bisphosphate 5-phosphatase phosphatidylinositol polyphosphate 5-phosphatase type IV
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 2 Map Location: 2\|2 A3

mRNA and Protein(s)

mRNA	Protein	Name
NM_001290437.1	NP_001277366.1	phosphatidylinositol polyphosphate 5-phosphatase type IV isoform b
NM_033134.3	NP_149125.1	phosphatidylinositol polyphosphate 5-phosphatase type IV isoform a

Pathways from BioSystems

Homologies

	INPP5E	XP_001095203.1
Mus musculus (house mouse)	Inpp5e	NP_149125.1
Xenopus tropicalis (tropical clawed frog)	inpp5e	XP_002935265.1
Pan troglodytes (chimpanzee)	INPP5E	NP_001070981.1
Rattus norvegicus (Norway rat)	Inpp5e	NP_446084.1
Homo sapiens (human)	INPP5E	NP_063945.2
Canis lupus familiaris (dog)	INPP5E	XP_005625166.1
Bos taurus (cattle)	INPP5E	NP_001179019.1
Gallus gallus (chicken)	INPP5E	XP_415418.2
Danio rerio (zebrafish)	inpp5e	NP_001096089.2

Gene Ontology
Bibliography

Related articles in PubMed

Mechanism and dynamics of INPP5E transport into and inside the ciliary compartment.
K?sling SK, Fansa EK, Maffini S, Wittinghofer A
Biological chemistry(2018 Jan)

A compartmentalized phosphoinositide signaling axis at cilia is regulated by INPP5E to maintain cilia and promote Sonic Hedgehog medulloblastoma.
Conduit SE, Ramaswamy V, Remke M, Watkins DN, Wainwright BJ, Taylor MD, Mitchell CA, Dyson JM
Oncogene36(43)5969-5984(2017 Oct)

Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins.
Badgandi HB, Hwang SH, Shimada IS, Loriot E, Mukhopadhyay S
The Journal of cell biology216(3)743-760(2017 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Therefore our study identifies a compartmentalized PtdIns(3,4,5)P3/AKT/GSK3beta signaling axis at cilia in SHH-dependent medulloblastoma that is regulated by INPP5E to maintain tumor cell cilia, promote SHH signaling and thereby medulloblastoma progression.
Title: A compartmentalized phosphoinositide signaling axis at cilia is regulated by INPP5E to maintain cilia and promote Sonic Hedgehog medulloblastoma.

INPP5E localizes to centrosomes, chromosomes, and kinetochores in early mitosis and shuttles to the midzone spindle at mitotic exit.
Title: INPP5E Preserves Genomic Stability through Regulation of Mitosis.

INPP5E is an essential point of convergence between Hedgehog and phosphoinositide signaling at cilia that maintains transition zone function and Hedgehog-dependent embryonic development.
Title: INPP5E regulates phosphoinositide-dependent cilia transition zone function.

we identify Inpp5e as an essential inhibitor of the PI3K/Akt/mTORC1 signaling axis in renal epithelial cells, and demonstrate a critical role for Inpp5e-dependent mTORC1 regulation in Polycystic kidney disease (PKD) suppression
Title: Inpp5e suppresses polycystic kidney disease via inhibition of PI3K/Akt-dependent mTORC1 signaling.

the affinity to PDE6delta and the release by Arl2/3 in addition to a retention signal are the determinants for cargo sorting and enrichment at its destination.
Title: PDE6?-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity.

The following Inpp5e gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Inpp5e cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu13842	NM_033134.3 Latest version!	Mus musculus inositol polyphosphate-5-phosphatase E (Inpp5e), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00
OMu17410	NM_001290437.1 Latest version!	Mus musculus inositol polyphosphate-5-phosphatase E (Inpp5e), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Inpp5e ( NM_033134.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_149125.1 Mus musculus inositol polyphosphate-5-phosphatase E (Inpp5e), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu13842
Clone ID Related Accession (Same CDS sequence)	NM_033134.3
Accession Version	NM_033134.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1944bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-13
Organism	Mus musculus(house mouse)
Product	phosphatidylinositol polyphosphate 5-phosphatase type IV isoform a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL732541.11 and BC052717.1. On Mar 13, 2014 this sequence version replaced NM_033134.2. Transcript Variant: This variant (1) encodes the longer isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC052717.1, AK154097.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164138 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCATCCA AGTCAGCTTG CCTGCGTCAC ACTGAGGCAC CTGGGCAGCT AGAAGGCAGA 
ATGCTCCAGG GACAGCCTCC GAACACGGAA AAGAAGCTCA TCCCAACACC AGGCTTCTTA 
CCAGCCTCTG ACTCTCAGGG TTCAGAGACA AACCCCATGC CTCCTTTCAG CATTCCAGCA 
AAAACAAGCA ACCAGAACCC ACAAACTAAG GCAAATCTCA TCACCCCACA GCCACCCATT 
AGACCCAAGT TGGAGCGAAC CCTGTCCCTC GATGACAAGG GCTGGAGAAG GAGGCGTTTC 
CGGGGTAGTC AGGAGGATCT GACTGTCCAG AATGGGGCCA GTCCCTGCAG GGGCTCCTTG 
CAAGACTCAG TAGCCCAGTC CCCTGCCTAC AGCCGTCCCC TGCCCTGCCT CAGCACATCC 
TTGCAGGAGA TACCTAAGTC CCGAAGGGCC ACAGGCAGTG AGGGAGGGAG CCCATCCTTG 
TGGAGTGACT GTCTTTCTGG AATGATCAGC ACCTCCTTGG ACCTCCTGCA CAGAGATGCT 
GCCTCAGGTG GGCCCCCCTC CAGGTTGGCA AGTTTGCATG CCTCACACAC ACCACCAGCT 
ATGGACCTCA GCATAGCCTC CAGCTCCCTG AGAACAGCAA ACAAGGTTGA CCCCGAGCAC 
ACGGACTACA AGCTCCGCAT GCAGACCAGA CTGGTCAGGG CCCACAGCAA CCTGGGCCCT 
AGCAGACCCC GGAGCCCCTT GGCTGGTGAC GATCACTCCA TTCACTCAGC CAGATCTTTC 
AGCCTTCTGG CCCCCATCCG CACCAAGGAC ATCAGAAGCA GGAGCTATCT GGAGGGAAGT 
CTTCTGGCCA GTGGGGCCCT GCTAGGAGCA GAAGAGCTGG CCAGGTACTT CCCAGACCGA 
AACATGGCTC TCTTCGTGGC TACCTGGAAC ATGCAGGGCC AGAAGGAGCT CCCAGCGAGC 
CTGGATGAGT TTCTGCTCCC CACCGAGGCT GACTACACTC AGGACCTGTA TGTCATTGGA 
ATTCAGGAGG GCTGCTCTGA CAGGCGGGAG TGGGAGACAC GCCTGCAGGA GACACTGGGC 
CCTCAGTATG TACTGCTGTC ATCAGCAGCA CATGGGGTCC TGTACATGTC CCTGTTTATC 
CGTAGGGACC TCATCTGGTT CTGCTCAGAG GTCGAGTACT CCACAGTAAC TACACGCATC 
GTGTCTCAGA TCAAGACCAA GGGGGCCCTG GGCGTCAGCT TCACCTTTTT TGGCACCTCC 
TTCCTCTTCA TCACATCTCA CTTCACCTCT GGAGATGGGA AGGTAGCAGA GCGGCTACTG 
GACTACAGCA GAACCATCCA AGCCCTAGCC CTGCCCCGGA ATGTGCCAGA CACAAATCCC 
TACCGCTCTA GTGCAGGGGA TGTCACTACC CGGTTTGATG AGGTCTTCTG GTTTGGGGAC 
TTCAACTTCC GCCTGAGTGG TGGACGAGTG GCTGTGGAGG CCTTCCTGAA GCAGAAACCT 
GAGGTGGATG TGCTGGCTCT CCTCCAACAC GACCAGCTCA CCCGGGAGAT GAAGAAAGGG 
TCCATCTTCA GGGGCTTTGA GGAGGCAGAG ATTCACTTTC TTCCATCCTA CAAGTTTGAC 
ATTGGGAAGG ACACCTACGA CAGCACCTCC AAGCAAAGGA CACCCTCCTA CACAGACCGA 
GTCCTATACA AAAGCCGTCA CAAGGGTGAC ATCTGTCCCA TGAAGTATTC CTCTTGTCCT 
GGGATCAAGA CTTCAGACCA CCGTCCTGTG TATGGCTTGT TCCAGGTGAA AGTGAGGCCA 
GGACGAGACA ACATCCCATT AGCTGCCGGC AAGTTTGACC GAGAATTGTA CTTGATAGGA 
ATTAAAAGGC GGATTTCAAA GGAGATTCAG AGACAGGAAG CACTGAAGAG CCAGAGCTCC 
AGTGCAGTTT GCACCGTGTC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_149125.1
CDS	633..2576
Translation	MPSKSACLRHTEAPGQLEGRMLQGQPPNTEKKLIPTPGFLPASDSQGSETNPMPPFSIPAKTSNQNPQTKANLITPQPPIRPKLERTLSLDDKGWRRRRFRGSQEDLTVQNGASPCRGSLQDSVAQSPAYSRPLPCLSTSLQEIPKSRRATGSEGGSPSLWSDCLSGMISTSLDLLHRDAASGGPPSRLASLHASHTPPAMDLSIASSSLRTANKVDPEHTDYKLRMQTRLVRAHSNLGPSRPRSPLAGDDHSIHSARSFSLLAPIRTKDIRSRSYLEGSLLASGALLGAEELARYFPDRNMALFVATWNMQGQKELPASLDEFLLPTEADYTQDLYVIGIQEGCSDRREWETRLQETLGPQYVLLSSAAHGVLYMSLFIRRDLIWFCSEVEYSTVTTRIVSQIKTKGALGVSFTFFGTSFLFITSHFTSGDGKVAERLLDYSRTIQALALPRNVPDTNPYRSSAGDVTTRFDEVFWFGDFNFRLSGGRVAVEAFLKQKPEVDVLALLQHDQLTREMKKGSIFRGFEEAEIHFLPSYKFDIGKDTYDSTSKQRTPSYTDRVLYKSRHKGDICPMKYSSCPGIKTSDHRPVYGLFQVKVRPGRDNIPLAAGKFDRELYLIGIKRRISKEIQRQEALKSQSSSAVCTVS

Target ORF information:

RefSeq Version	NM_033134.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus inositol polyphosphate-5-phosphatase E (Inpp5e), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033134.3

ORF Insert Sequence:

ATGCCATCCA AGTCAGCTTG CCTGCGTCAC ACTGAGGCAC CTGGGCAGCT AGAAGGCAGA 
ATGCTCCAGG GACAGCCTCC GAACACGGAA AAGAAGCTCA TCCCAACACC AGGCTTCTTA 
CCAGCCTCTG ACTCTCAGGG TTCAGAGACA AACCCCATGC CTCCTTTCAG CATTCCAGCA 
AAAACAAGCA ACCAGAACCC ACAAACTAAG GCAAATCTCA TCACCCCACA GCCACCCATT 
AGACCCAAGT TGGAGCGAAC CCTGTCCCTC GATGACAAGG GCTGGAGAAG GAGGCGTTTC 
CGGGGTAGTC AGGAGGATCT GACTGTCCAG AATGGGGCCA GTCCCTGCAG GGGCTCCTTG 
CAAGACTCAG TAGCCCAGTC CCCTGCCTAC AGCCGTCCCC TGCCCTGCCT CAGCACATCC 
TTGCAGGAGA TACCTAAGTC CCGAAGGGCC ACAGGCAGTG AGGGAGGGAG CCCATCCTTG 
TGGAGTGACT GTCTTTCTGG AATGATCAGC ACCTCCTTGG ACCTCCTGCA CAGAGATGCT 
GCCTCAGGTG GGCCCCCCTC CAGGTTGGCA AGTTTGCATG CCTCACACAC ACCACCAGCT 
ATGGACCTCA GCATAGCCTC CAGCTCCCTG AGAACAGCAA ACAAGGTTGA CCCCGAGCAC 
ACGGACTACA AGCTCCGCAT GCAGACCAGA CTGGTCAGGG CCCACAGCAA CCTGGGCCCT 
AGCAGACCCC GGAGCCCCTT GGCTGGTGAC GATCACTCCA TTCACTCAGC CAGATCTTTC 
AGCCTTCTGG CCCCCATCCG CACCAAGGAC ATCAGAAGCA GGAGCTATCT GGAGGGAAGT 
CTTCTGGCCA GTGGGGCCCT GCTAGGAGCA GAAGAGCTGG CCAGGTACTT CCCAGACCGA 
AACATGGCTC TCTTCGTGGC TACCTGGAAC ATGCAGGGCC AGAAGGAGCT CCCAGCGAGC 
CTGGATGAGT TTCTGCTCCC CACCGAGGCT GACTACACTC AGGACCTGTA TGTCATTGGA 
ATTCAGGAGG GCTGCTCTGA CAGGCGGGAG TGGGAGACAC GCCTGCAGGA GACACTGGGC 
CCTCAGTATG TACTGCTGTC ATCAGCAGCA CATGGGGTCC TGTACATGTC CCTGTTTATC 
CGTAGGGACC TCATCTGGTT CTGCTCAGAG GTCGAGTACT CCACAGTAAC TACACGCATC 
GTGTCTCAGA TCAAGACCAA GGGGGCCCTG GGCGTCAGCT TCACCTTTTT TGGCACCTCC 
TTCCTCTTCA TCACATCTCA CTTCACCTCT GGAGATGGGA AGGTAGCAGA GCGGCTACTG 
GACTACAGCA GAACCATCCA AGCCCTAGCC CTGCCCCGGA ATGTGCCAGA CACAAATCCC 
TACCGCTCTA GTGCAGGGGA TGTCACTACC CGGTTTGATG AGGTCTTCTG GTTTGGGGAC 
TTCAACTTCC GCCTGAGTGG TGGACGAGTG GCTGTGGAGG CCTTCCTGAA GCAGAAACCT 
GAGGTGGATG TGCTGGCTCT CCTCCAACAC GACCAGCTCA CCCGGGAGAT GAAGAAAGGG 
TCCATCTTCA GGGGCTTTGA GGAGGCAGAG ATTCACTTTC TTCCATCCTA CAAGTTTGAC 
ATTGGGAAGG ACACCTACGA CAGCACCTCC AAGCAAAGGA CACCCTCCTA CACAGACCGA 
GTCCTATACA AAAGCCGTCA CAAGGGTGAC ATCTGTCCCA TGAAGTATTC CTCTTGTCCT 
GGGATCAAGA CTTCAGACCA CCGTCCTGTG TATGGCTTGT TCCAGGTGAA AGTGAGGCCA 
GGACGAGACA ACATCCCATT AGCTGCCGGC AAGTTTGACC GAGAATTGTA CTTGATAGGA 
ATTAAAAGGC GGATTTCAAA GGAGATTCAG AGACAGGAAG CACTGAAGAG CCAGAGCTCC 
AGTGCAGTTT GCACCGTGTC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Inpp5e ( NM_001290437.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001277366.1 Mus musculus inositol polyphosphate-5-phosphatase E (Inpp5e), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu17410
Clone ID Related Accession (Same CDS sequence)	NM_001290437.1
Accession Version	NM_001290437.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1818bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	phosphatidylinositol polyphosphate 5-phosphatase type IV isoform b
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK085439.1 and BC052717.1. On Mar 13, 2014 this sequence version replaced XM_006498217.1. Transcript Variant: This variant (2) differs in the 5' UTR, and uses an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct and shorter C-terminus, compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK085439.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164138 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCATCCA AGTCAGCTTG CCTGCGTCAC ACTGAGGCAC CTGGGCAGCT AGAAGGCAGA 
ATGCTCCAGG GACAGCCTCC GAACACGGAA AAGAAGCTCA TCCCAACACC AGGCTTCTTA 
CCAGCCTCTG ACTCTCAGGG TTCAGAGACA AACCCCATGC CTCCTTTCAG CATTCCAGCA 
AAAACAAGCA ACCAGAACCC ACAAACTAAG GCAAATCTCA TCACCCCACA GCCACCCATT 
AGACCCAAGT TGGAGCGAAC CCTGTCCCTC GATGACAAGG GCTGGAGAAG GAGGCGTTTC 
CGGGGTAGTC AGGAGGATCT GACTGTCCAG AATGGGGCCA GTCCCTGCAG GGGCTCCTTG 
CAAGACTCAG TAGCCCAGTC CCCTGCCTAC AGCCGTCCCC TGCCCTGCCT CAGCACATCC 
TTGCAGGAGA TACCTAAGTC CCGAAGGGCC ACAGGCAGTG AGGGAGGGAG CCCATCCTTG 
TGGAGTGACT GTCTTTCTGG AATGATCAGC ACCTCCTTGG ACCTCCTGCA CAGAGATGCT 
GCCTCAGGTG GGCCCCCCTC CAGGTTGGCA AGTTTGCATG CCTCACACAC ACCACCAGCT 
ATGGACCTCA GCATAGCCTC CAGCTCCCTG AGAACAGCAA ACAAGGTTGA CCCCGAGCAC 
ACGGACTACA AGCTCCGCAT GCAGACCAGA CTGGTCAGGG CCCACAGCAA CCTGGGCCCT 
AGCAGACCCC GGAGCCCCTT GGCTGGTGAC GATCACTCCA TTCACTCAGC CAGATCTTTC 
AGCCTTCTGG CCCCCATCCG CACCAAGGAC ATCAGAAGCA GGAGCTATCT GGAGGGAAGT 
CTTCTGGCCA GTGGGGCCCT GCTAGGAGCA GAAGAGCTGG CCAGGTACTT CCCAGACCGA 
AACATGGCTC TCTTCGTGGC TACCTGGAAC ATGCAGGGCC AGAAGGAGCT CCCAGCGAGC 
CTGGATGAGT TTCTGCTCCC CACCGAGGCT GACTACACTC AGGACCTGTA TGTCATTGGA 
ATTCAGGAGG GCTGCTCTGA CAGGCGGGAG TGGGAGACAC GCCTGCAGGA GACACTGGGC 
CCTCAGTATG TACTGCTGTC ATCAGCAGCA CATGGGGTCC TGTACATGTC CCTGTTTATC 
CGTAGGGACC TCATCTGGTT CTGCTCAGAG GTCGAGTACT CCACAGTAAC TACACGCATC 
GTGTCTCAGA TCAAGACCAA GGGGGCCCTG GGCGTCAGCT TCACCTTTTT TGGCACCTCC 
TTCCTCTTCA TCACATCTCA CTTCACCTCT GGAGATGGGA AGGTAGCAGA GCGGCTACTG 
GACTACAGCA GAACCATCCA AGCCCTAGCC CTGCCCCGGA ATGTGCCAGA CACAAATCCC 
TACCGCTCTA GTGCAGGGGA TGTCACTACC CGGTTTGATG AGGTCTTCTG GTTTGGGGAC 
TTCAACTTCC GCCTGAGTGG TGGACGAGTG GCTGTGGAGG CCTTCCTGAA GCAGAAACCT 
GAGGTGGATG TGCTGGCTCT CCTCCAACAC GACCAGCTCA CCCGGGAGAT GAAGAAAGGG 
TCCATCTTCA GGGGCTTTGA GGAGGCAGAG ATTCACTTTC TTCCATCCTA CAAGTTTGAC 
ATTGGGAAGG ACACCTACGA CAGCACCTCC AAGCAAAGGA CACCCTCCTA CACAGACCGA 
GTCCTATACA AAAGCCGTCA CAAGGGTGAC ATCTGTCCCA TGAAGTATTC CTCTTGTCCT 
GGGATCAAGA CTTCAGACCA CCGTCCTGTG TATGGCTTGT TCCAGGTGAA AGTGAGGCCA 
GGACGAGACA AGAATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001277366.1
CDS	349..2166
Translation	MPSKSACLRHTEAPGQLEGRMLQGQPPNTEKKLIPTPGFLPASDSQGSETNPMPPFSIPAKTSNQNPQTKANLITPQPPIRPKLERTLSLDDKGWRRRRFRGSQEDLTVQNGASPCRGSLQDSVAQSPAYSRPLPCLSTSLQEIPKSRRATGSEGGSPSLWSDCLSGMISTSLDLLHRDAASGGPPSRLASLHASHTPPAMDLSIASSSLRTANKVDPEHTDYKLRMQTRLVRAHSNLGPSRPRSPLAGDDHSIHSARSFSLLAPIRTKDIRSRSYLEGSLLASGALLGAEELARYFPDRNMALFVATWNMQGQKELPASLDEFLLPTEADYTQDLYVIGIQEGCSDRREWETRLQETLGPQYVLLSSAAHGVLYMSLFIRRDLIWFCSEVEYSTVTTRIVSQIKTKGALGVSFTFFGTSFLFITSHFTSGDGKVAERLLDYSRTIQALALPRNVPDTNPYRSSAGDVTTRFDEVFWFGDFNFRLSGGRVAVEAFLKQKPEVDVLALLQHDQLTREMKKGSIFRGFEEAEIHFLPSYKFDIGKDTYDSTSKQRTPSYTDRVLYKSRHKGDICPMKYSSCPGIKTSDHRPVYGLFQVKVRPGRDKN

Target ORF information:

RefSeq Version	NM_001290437.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus inositol polyphosphate-5-phosphatase E (Inpp5e), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001290437.1

ORF Insert Sequence:

ATGCCATCCA AGTCAGCTTG CCTGCGTCAC ACTGAGGCAC CTGGGCAGCT AGAAGGCAGA 
ATGCTCCAGG GACAGCCTCC GAACACGGAA AAGAAGCTCA TCCCAACACC AGGCTTCTTA 
CCAGCCTCTG ACTCTCAGGG TTCAGAGACA AACCCCATGC CTCCTTTCAG CATTCCAGCA 
AAAACAAGCA ACCAGAACCC ACAAACTAAG GCAAATCTCA TCACCCCACA GCCACCCATT 
AGACCCAAGT TGGAGCGAAC CCTGTCCCTC GATGACAAGG GCTGGAGAAG GAGGCGTTTC 
CGGGGTAGTC AGGAGGATCT GACTGTCCAG AATGGGGCCA GTCCCTGCAG GGGCTCCTTG 
CAAGACTCAG TAGCCCAGTC CCCTGCCTAC AGCCGTCCCC TGCCCTGCCT CAGCACATCC 
TTGCAGGAGA TACCTAAGTC CCGAAGGGCC ACAGGCAGTG AGGGAGGGAG CCCATCCTTG 
TGGAGTGACT GTCTTTCTGG AATGATCAGC ACCTCCTTGG ACCTCCTGCA CAGAGATGCT 
GCCTCAGGTG GGCCCCCCTC CAGGTTGGCA AGTTTGCATG CCTCACACAC ACCACCAGCT 
ATGGACCTCA GCATAGCCTC CAGCTCCCTG AGAACAGCAA ACAAGGTTGA CCCCGAGCAC 
ACGGACTACA AGCTCCGCAT GCAGACCAGA CTGGTCAGGG CCCACAGCAA CCTGGGCCCT 
AGCAGACCCC GGAGCCCCTT GGCTGGTGAC GATCACTCCA TTCACTCAGC CAGATCTTTC 
AGCCTTCTGG CCCCCATCCG CACCAAGGAC ATCAGAAGCA GGAGCTATCT GGAGGGAAGT 
CTTCTGGCCA GTGGGGCCCT GCTAGGAGCA GAAGAGCTGG CCAGGTACTT CCCAGACCGA 
AACATGGCTC TCTTCGTGGC TACCTGGAAC ATGCAGGGCC AGAAGGAGCT CCCAGCGAGC 
CTGGATGAGT TTCTGCTCCC CACCGAGGCT GACTACACTC AGGACCTGTA TGTCATTGGA 
ATTCAGGAGG GCTGCTCTGA CAGGCGGGAG TGGGAGACAC GCCTGCAGGA GACACTGGGC 
CCTCAGTATG TACTGCTGTC ATCAGCAGCA CATGGGGTCC TGTACATGTC CCTGTTTATC 
CGTAGGGACC TCATCTGGTT CTGCTCAGAG GTCGAGTACT CCACAGTAAC TACACGCATC 
GTGTCTCAGA TCAAGACCAA GGGGGCCCTG GGCGTCAGCT TCACCTTTTT TGGCACCTCC 
TTCCTCTTCA TCACATCTCA CTTCACCTCT GGAGATGGGA AGGTAGCAGA GCGGCTACTG 
GACTACAGCA GAACCATCCA AGCCCTAGCC CTGCCCCGGA ATGTGCCAGA CACAAATCCC 
TACCGCTCTA GTGCAGGGGA TGTCACTACC CGGTTTGATG AGGTCTTCTG GTTTGGGGAC 
TTCAACTTCC GCCTGAGTGG TGGACGAGTG GCTGTGGAGG CCTTCCTGAA GCAGAAACCT 
GAGGTGGATG TGCTGGCTCT CCTCCAACAC GACCAGCTCA CCCGGGAGAT GAAGAAAGGG 
TCCATCTTCA GGGGCTTTGA GGAGGCAGAG ATTCACTTTC TTCCATCCTA CAAGTTTGAC 
ATTGGGAAGG ACACCTACGA CAGCACCTCC AAGCAAAGGA CACCCTCCTA CACAGACCGA 
GTCCTATACA AAAGCCGTCA CAAGGGTGAC ATCTGTCCCA TGAAGTATTC CTCTTGTCCT 
GGGATCAAGA CTTCAGACCA CCGTCCTGTG TATGGCTTGT TCCAGGTGAA AGTGAGGCCA 
GGACGAGACA AGAATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mechanism and dynamics of INPP5E transport into and inside the ciliary compartment.
Biological chemistry(2018 Jan)
K?sling SK,Fansa EK,Maffini S,Wittinghofer A

A compartmentalized phosphoinositide signaling axis at cilia is regulated by INPP5E to maintain cilia and promote Sonic Hedgehog medulloblastoma.
Oncogene36(43)5969-5984(2017 Oct)
Conduit SE,Ramaswamy V,Remke M,Watkins DN,Wainwright BJ,Taylor MD,Mitchell CA,Dyson JM

Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins.
The Journal of cell biology216(3)743-760(2017 Mar)
Badgandi HB,Hwang SH,Shimada IS,Loriot E,Mukhopadhyay S

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

Inpp5e cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報