The following Cables1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cables1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OMu19263 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001146287.1 | |
| Accession Version | NM_001146287.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1785bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-09-21 | |
| Organism | Mus musculus(house mouse) | |
| Product | CDK5 and ABL1 enzyme substrate 1 isoform 1 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC100751.6, AK158396.1, BQ917292.1, CX202925.1, CB205636.1 and CA751142.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK156273.1, AK158396.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGGCGGCGG CGACCGCCAC CGCGGGCACG GCCGCCTGCA GCAGCAGCAG CAGCAGTCGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001139759.1 |
| CDS | 533..2317 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_001146287.1 |
1 | ATGGCGGCGG CGACCGCCAC CGCGGGCACG GCCGCCTGCA GCAGCAGCAG CAGCAGTCGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OMu19595 | |
| Clone ID Related Accession (Same CDS sequence) | NM_022021.2 | |
| Accession Version | NM_022021.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1707bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-27 | |
| Organism | Mus musculus(house mouse) | |
| Product | CDK5 and ABL1 enzyme substrate 1 isoform 2 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC100751.6, CX213994.1, BQ917292.1, CX202925.1, CB205636.1 and CA751142.1. On Apr 4, 2009 this sequence version replaced NM_022021.1. Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. This difference results in a shorter protein (isoform 2), compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF133208.1, AF328140.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGGCGGCGG CGACCGCCAC CGCGGGCACG GCCGCCTGCA GCAGCAGCAG CAGCAGTCGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_071304.2 |
| CDS | 533..2239 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_022021.2 |
1 | ATGGCGGCGG CGACCGCCAC CGCGGGCACG GCCGCCTGCA GCAGCAGCAG CAGCAGTCGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Truncated Cables1 causes agenesis of the corpus callosum in mice. |
Cables1 is a tumor suppressor gene that regulates intestinal tumor progression in Apc(Min) mice. |
A novel locus on proximal chromosome 18 associated with agenesis of the corpus callosum in mice. |
Cables1 protects p63 from proteasomal degradation to ensure deletion of cells after genotoxic stress. |
Loss of CABLES1, a cyclin-dependent kinase-interacting protein that inhibits cell cycle progression, results in germline expansion at the expense of oocyte quality in adult female mice. |
