Wsb2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Wsb2
Entrez Gene ID	59043
Full Name	WD repeat and SOCS box-containing 2
Synonyms	AA673511,Swip2,WSB-2
General protein information	Preferred Names WD repeat and SOCS box-containing 2 Names WD repeat and SOCS box-containing protein 2 SOCS box-containing WD protein SWiP-2 WD-40-repeat-containing protein with a SOCS box 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5\|5 F

mRNA and Protein(s)

mRNA	Protein	Name
XM_030254744.1	XP_030110604.1	WD repeat and SOCS box-containing protein 2 isoform X1
NM_021539.4	NP_067514.2	WD repeat and SOCS box-containing protein 2
NM_021539.5	NP_067514.2	WD repeat and SOCS box-containing protein 2

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Wsb2	NP_067514.2
Canis lupus familiaris (dog)	WSB2	XP_005636336.1
Bos taurus (cattle)	WSB2	NP_001068825.1
Homo sapiens (human)	WSB2	NP_061109.1
Pan troglodytes (chimpanzee)	WSB2	XP_001156920.1
Rattus norvegicus (Norway rat)	Wsb2	NP_001007617.1
Xenopus tropicalis (tropical clawed frog)	wsb2	NP_001120198.1
	WSB2	XP_001107891.2
Gallus gallus (chicken)	WSB2	XP_415313.3

Gene Ontology
Bibliography

Related articles in PubMed

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H
Nucleic acids research42(Database issue)D802-9(2014 Jan)

Expression of Wsb2 in the developing and adult mouse testis.
Sarraj MA, McClive PJ, Szczepny A, Daggag H, Loveland KL, Sinclair AH
Reproduction (Cambridge, England)133(4)753-61(2007 Apr)

Novel role of WD40 and SOCS box protein-2 in steady-state distribution of granulocyte colony-stimulating factor receptor and G-CSF-controlled proliferation and differentiation signaling.
Erkeland SJ, Aarts LH, Irandoust M, Roovers O, Klomp A, Valkhof M, Gits J, Eyckerman S, Tavernier J, Touw IP
Oncogene26(14)1985-94(2007 Mar)

SWiP-1: novel SOCS box containing WD-protein regulated by signalling centres and by Shh during development.
Vasiliauskas D, Hancock S, Stern CD
Mechanisms of development82(1-2)79-94(1999 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Wsb-2 binding to the G-CSF-R reduced its cell surface expression and inhibited proliferation signaling.
Title: Novel role of WD40 and SOCS box protein-2 in steady-state distribution of granulocyte colony-stimulating factor receptor and G-CSF-controlled proliferation and differentiation signaling.

The following Wsb2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Wsb2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu12462	NM_021539.5 Latest version!	Mus musculus WD repeat and SOCS box-containing 2 (Wsb2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
OMu88989	XM_030254744.1 Latest version!	Mus musculus WD repeat and SOCS box-containing 2 (Wsb2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OMu12462	NM_021539.4	Mus musculus WD repeat and SOCS box-containing 2 (Wsb2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Wsb2 ( NM_021539.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_067514.2 Mus musculus WD repeat and SOCS box-containing 2 (Wsb2), mRNA.

Price & Availability↑

CloneID	OMu12462
Clone ID Related Accession (Same CDS sequence)	NM_021539.4 , NM_021539.5
Accession Version	NM_021539.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1215bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-25
Organism	Mus musculus(house mouse)
Product	WD repeat and SOCS box-containing protein 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC055100.1. On Apr 6, 2007 this sequence version replaced NM_021539.3. ##Evidence-Data-START## Transcript exon combination :: BC055100.1, SRR1660817.235637.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGAGGCCG GAGAGGAGCC GCTGCTGCTG GCTGAACTCA AGCCTGGGCG CCCCCACCAG 
TTCGACTGGA AGTCAAGCTG TGAGACCTGG AGCGTGGCCT TCTCGCCAGA CGGTTCCTGG 
TTCGCCTGGT CTCAAGGACA CTGCGTGGTC AAGCTGGTCC CCTGGCCCTT AGAGGAACAG 
TTCATCCCTA AAGGATTCGA AGCCAAGAGC CGAAGCAGCA AGAATGACCC AAAAGGACGG 
GGCAGTCTGA AGGAGAAGAC GCTGGACTGT GGCCAGATTG TGTGGGGGCT GGCCTTCAGC 
CCATGGCCCT CTCCACCCAG CAGGAAACTC TGGGCACGTC ACCATCCCCA GGCGCCTGAT 
GTTTCTTGCC TGATCCTGGC CACAGGTCTC AACGATGGGC AGATCAAGAT TTGGGAGGTA 
CAGACAGGCC TCCTGCTTCT GAATCTTTCT GGCCACCAAG ACGTCGTGAG AGATCTGAGC 
TTCACGCCCA GCGGCAGTTT GATTTTGGTC TCTGCATCCC GGGATAAGAC ACTTCGAATT 
TGGGACCTGA ATAAGCACGG TAAGCAGATC CAGGTGTTAT CCGGCCATCT GCAGTGGGTT 
TACTGCTGCT CCATCTCCCC TGACTGTAGC ATGCTGTGCT CTGCAGCTGG GGAGAAGTCG 
GTCTTTCTGT GGAGCATGCG GTCCTACACA CTAATCCGGA AACTAGAAGG CCACCAAAGC 
AGTGTTGTCT CCTGTGATTT CTCTCCTGAT TCAGCCTTGC TTGTCACAGC TTCGTATGAC 
ACCAGTGTGA TTATGTGGGA CCCCTACACC GGCGAGAGGC TGAGGTCACT TCATCACACA 
CAGCTTGAAC CCACCATGGA TGACAGTGAC GTCCACATGA GCTCCCTGAG GTCCGTGTGC 
TTCTCACCTG AAGGCTTGTA TCTCGCTACG GTGGCAGATG ACAGGCTGCT CAGGATCTGG 
GCTCTGGAAC TGAAGGCTCC GGTTGCCTTT GCTCCGATGA CCAATGGTCT TTGCTGCACG 
TTCTTCCCAC ACGGTGGAAT TATTGCCACA GGGACGAGAG ATGGCCATGT CCAGTTCTGG 
ACAGCTCCCC GGGTCCTGTC CTCACTGAAG CACTTATGCA GGAAAGCCCT CCGAAGTTTC 
CTGACAACGT ATCAAGTCCT AGCACTGCCA ATCCCCAAGA AGATGAAAGA GTTCCTCACA 
TACAGGACTT TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067514.2
CDS	157..1371
Translation	MEAGEEPLLLAELKPGRPHQFDWKSSCETWSVAFSPDGSWFAWSQGHCVVKLVPWPLEEQFIPKGFEAKSRSSKNDPKGRGSLKEKTLDCGQIVWGLAFSPWPSPPSRKLWARHHPQAPDVSCLILATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDPYTGERLRSLHHTQLEPTMDDSDVHMSSLRSVCFSPEGLYLATVADDRLLRIWALELKAPVAFAPMTNGLCCTFFPHGGIIATGTRDGHVQFWTAPRVLSSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYRTF

Target ORF information:

RefSeq Version	NM_021539.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus WD repeat and SOCS box-containing 2 (Wsb2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021539.4

ORF Insert Sequence:

ATGGAGGCCG GAGAGGAGCC GCTGCTGCTG GCTGAACTCA AGCCTGGGCG CCCCCACCAG 
TTCGACTGGA AGTCAAGCTG TGAGACCTGG AGCGTGGCCT TCTCGCCAGA CGGTTCCTGG 
TTCGCCTGGT CTCAAGGACA CTGCGTGGTC AAGCTGGTCC CCTGGCCCTT AGAGGAACAG 
TTCATCCCTA AAGGATTCGA AGCCAAGAGC CGAAGCAGCA AGAATGACCC AAAAGGACGG 
GGCAGTCTGA AGGAGAAGAC GCTGGACTGT GGCCAGATTG TGTGGGGGCT GGCCTTCAGC 
CCATGGCCCT CTCCACCCAG CAGGAAACTC TGGGCACGTC ACCATCCCCA GGCGCCTGAT 
GTTTCTTGCC TGATCCTGGC CACAGGTCTC AACGATGGGC AGATCAAGAT TTGGGAGGTA 
CAGACAGGCC TCCTGCTTCT GAATCTTTCT GGCCACCAAG ACGTCGTGAG AGATCTGAGC 
TTCACGCCCA GCGGCAGTTT GATTTTGGTC TCTGCATCCC GGGATAAGAC ACTTCGAATT 
TGGGACCTGA ATAAGCACGG TAAGCAGATC CAGGTGTTAT CCGGCCATCT GCAGTGGGTT 
TACTGCTGCT CCATCTCCCC TGACTGTAGC ATGCTGTGCT CTGCAGCTGG GGAGAAGTCG 
GTCTTTCTGT GGAGCATGCG GTCCTACACA CTAATCCGGA AACTAGAAGG CCACCAAAGC 
AGTGTTGTCT CCTGTGATTT CTCTCCTGAT TCAGCCTTGC TTGTCACAGC TTCGTATGAC 
ACCAGTGTGA TTATGTGGGA CCCCTACACC GGCGAGAGGC TGAGGTCACT TCATCACACA 
CAGCTTGAAC CCACCATGGA TGACAGTGAC GTCCACATGA GCTCCCTGAG GTCCGTGTGC 
TTCTCACCTG AAGGCTTGTA TCTCGCTACG GTGGCAGATG ACAGGCTGCT CAGGATCTGG 
GCTCTGGAAC TGAAGGCTCC GGTTGCCTTT GCTCCGATGA CCAATGGTCT TTGCTGCACG 
TTCTTCCCAC ACGGTGGAAT TATTGCCACA GGGACGAGAG ATGGCCATGT CCAGTTCTGG 
ACAGCTCCCC GGGTCCTGTC CTCACTGAAG CACTTATGCA GGAAAGCCCT CCGAAGTTTC 
CTGACAACGT ATCAAGTCCT AGCACTGCCA ATCCCCAAGA AGATGAAAGA GTTCCTCACA 
TACAGGACTT TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Wsb2 ( NM_021539.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_067514.2 Mus musculus WD repeat and SOCS box-containing 2 (Wsb2), mRNA.

Price & Availability↑

CloneID	OMu12462
Clone ID Related Accession (Same CDS sequence)	NM_021539.4 , NM_021539.5
Accession Version	NM_021539.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1215bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-22
Organism	Mus musculus(house mouse)
Product	WD repeat and SOCS box-containing protein 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC110234.11 and AC113299.14. On Aug 22, 2018 this sequence version replaced NM_021539.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: BC055100.1, SRR7345562.4488801.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGAGGCCG GAGAGGAGCC GCTGCTGCTG GCTGAACTCA AGCCTGGGCG CCCCCACCAG 
TTCGACTGGA AGTCAAGCTG TGAGACCTGG AGCGTGGCCT TCTCGCCAGA CGGTTCCTGG 
TTCGCCTGGT CTCAAGGACA CTGCGTGGTC AAGCTGGTCC CCTGGCCCTT AGAGGAACAG 
TTCATCCCTA AAGGATTCGA AGCCAAGAGC CGAAGCAGCA AGAATGACCC AAAAGGACGG 
GGCAGTCTGA AGGAGAAGAC GCTGGACTGT GGCCAGATTG TGTGGGGGCT GGCCTTCAGC 
CCATGGCCCT CTCCACCCAG CAGGAAACTC TGGGCACGTC ACCATCCCCA GGCGCCTGAT 
GTTTCTTGCC TGATCCTGGC CACAGGTCTC AACGATGGGC AGATCAAGAT TTGGGAGGTA 
CAGACAGGCC TCCTGCTTCT GAATCTTTCT GGCCACCAAG ACGTCGTGAG AGATCTGAGC 
TTCACGCCCA GCGGCAGTTT GATTTTGGTC TCTGCATCCC GGGATAAGAC ACTTCGAATT 
TGGGACCTGA ATAAGCACGG TAAGCAGATC CAGGTGTTAT CCGGCCATCT GCAGTGGGTT 
TACTGCTGCT CCATCTCCCC TGACTGTAGC ATGCTGTGCT CTGCAGCTGG GGAGAAGTCG 
GTCTTTCTGT GGAGCATGCG GTCCTACACA CTAATCCGGA AACTAGAAGG CCACCAAAGC 
AGTGTTGTCT CCTGTGATTT CTCTCCTGAT TCAGCCTTGC TTGTCACAGC TTCGTATGAC 
ACCAGTGTGA TTATGTGGGA CCCCTACACC GGCGAGAGGC TGAGGTCACT TCATCACACA 
CAGCTTGAAC CCACCATGGA TGACAGTGAC GTCCACATGA GCTCCCTGAG GTCCGTGTGC 
TTCTCACCTG AAGGCTTGTA TCTCGCTACG GTGGCAGATG ACAGGCTGCT CAGGATCTGG 
GCTCTGGAAC TGAAGGCTCC GGTTGCCTTT GCTCCGATGA CCAATGGTCT TTGCTGCACG 
TTCTTCCCAC ACGGTGGAAT TATTGCCACA GGGACGAGAG ATGGCCATGT CCAGTTCTGG 
ACAGCTCCCC GGGTCCTGTC CTCACTGAAG CACTTATGCA GGAAAGCCCT CCGAAGTTTC 
CTGACAACGT ATCAAGTCCT AGCACTGCCA ATCCCCAAGA AGATGAAAGA GTTCCTCACA 
TACAGGACTT TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067514.2
CDS	157..1371
Translation	MEAGEEPLLLAELKPGRPHQFDWKSSCETWSVAFSPDGSWFAWSQGHCVVKLVPWPLEEQFIPKGFEAKSRSSKNDPKGRGSLKEKTLDCGQIVWGLAFSPWPSPPSRKLWARHHPQAPDVSCLILATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDPYTGERLRSLHHTQLEPTMDDSDVHMSSLRSVCFSPEGLYLATVADDRLLRIWALELKAPVAFAPMTNGLCCTFFPHGGIIATGTRDGHVQFWTAPRVLSSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYRTF

Target ORF information:

RefSeq Version	NM_021539.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus WD repeat and SOCS box-containing 2 (Wsb2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021539.5

ORF Insert Sequence:

ATGGAGGCCG GAGAGGAGCC GCTGCTGCTG GCTGAACTCA AGCCTGGGCG CCCCCACCAG 
TTCGACTGGA AGTCAAGCTG TGAGACCTGG AGCGTGGCCT TCTCGCCAGA CGGTTCCTGG 
TTCGCCTGGT CTCAAGGACA CTGCGTGGTC AAGCTGGTCC CCTGGCCCTT AGAGGAACAG 
TTCATCCCTA AAGGATTCGA AGCCAAGAGC CGAAGCAGCA AGAATGACCC AAAAGGACGG 
GGCAGTCTGA AGGAGAAGAC GCTGGACTGT GGCCAGATTG TGTGGGGGCT GGCCTTCAGC 
CCATGGCCCT CTCCACCCAG CAGGAAACTC TGGGCACGTC ACCATCCCCA GGCGCCTGAT 
GTTTCTTGCC TGATCCTGGC CACAGGTCTC AACGATGGGC AGATCAAGAT TTGGGAGGTA 
CAGACAGGCC TCCTGCTTCT GAATCTTTCT GGCCACCAAG ACGTCGTGAG AGATCTGAGC 
TTCACGCCCA GCGGCAGTTT GATTTTGGTC TCTGCATCCC GGGATAAGAC ACTTCGAATT 
TGGGACCTGA ATAAGCACGG TAAGCAGATC CAGGTGTTAT CCGGCCATCT GCAGTGGGTT 
TACTGCTGCT CCATCTCCCC TGACTGTAGC ATGCTGTGCT CTGCAGCTGG GGAGAAGTCG 
GTCTTTCTGT GGAGCATGCG GTCCTACACA CTAATCCGGA AACTAGAAGG CCACCAAAGC 
AGTGTTGTCT CCTGTGATTT CTCTCCTGAT TCAGCCTTGC TTGTCACAGC TTCGTATGAC 
ACCAGTGTGA TTATGTGGGA CCCCTACACC GGCGAGAGGC TGAGGTCACT TCATCACACA 
CAGCTTGAAC CCACCATGGA TGACAGTGAC GTCCACATGA GCTCCCTGAG GTCCGTGTGC 
TTCTCACCTG AAGGCTTGTA TCTCGCTACG GTGGCAGATG ACAGGCTGCT CAGGATCTGG 
GCTCTGGAAC TGAAGGCTCC GGTTGCCTTT GCTCCGATGA CCAATGGTCT TTGCTGCACG 
TTCTTCCCAC ACGGTGGAAT TATTGCCACA GGGACGAGAG ATGGCCATGT CCAGTTCTGG 
ACAGCTCCCC GGGTCCTGTC CTCACTGAAG CACTTATGCA GGAAAGCCCT CCGAAGTTTC 
CTGACAACGT ATCAAGTCCT AGCACTGCCA ATCCCCAAGA AGATGAAAGA GTTCCTCACA 
TACAGGACTT TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Wsb2 ( XM_030254744.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_030110604.1 Mus musculus WD repeat and SOCS box-containing 2 (Wsb2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu88989
Clone ID Related Accession (Same CDS sequence)	XM_030254744.1
Accession Version	XM_030254744.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 585bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	WD repeat and SOCS box-containing protein 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000071.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGTGCT CTGCAGCTGG GGAGAAGTCG GTCTTTCTGT GGAGCATGCG GTCCTACACA 
CTAATCCGGA AACTAGAAGG CCACCAAAGC AGTGTTGTCT CCTGTGATTT CTCTCCTGAT 
TCAGCCTTGC TTGTCACAGC TTCGTATGAC ACCAGTGTGA TTATGTGGGA CCCCTACACC 
GGCGAGAGGC TGAGGTCACT TCATCACACA CAGCTTGAAC CCACCATGGA TGACAGTGAC 
GTCCACATGA GCTCCCTGAG GTCCGTGTGC TTCTCACCTG AAGGCTTGTA TCTCGCTACG 
GTGGCAGATG ACAGGCTGCT CAGGATCTGG GCTCTGGAAC TGAAGGCTCC GGTTGCCTTT 
GCTCCGATGA CCAATGGTCT TTGCTGCACG TTCTTCCCAC ACGGTGGAAT TATTGCCACA 
GGGACGAGAG ATGGCCATGT CCAGTTCTGG ACAGCTCCCC GGGTCCTGTC CTCACTGAAG 
CACTTATGCA GGAAAGCCCT CCGAAGTTTC CTGACAACGT ATCAAGTCCT AGCACTGCCA 
ATCCCCAAGA AGATGAAAGA GTTCCTCACA TACAGGACTT TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_030110604.1
CDS	803..1387
Translation	MLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDPYTGERLRSLHHTQLEPTMDDSDVHMSSLRSVCFSPEGLYLATVADDRLLRIWALELKAPVAFAPMTNGLCCTFFPHGGIIATGTRDGHVQFWTAPRVLSSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYRTF

Target ORF information:

RefSeq Version	XM_030254744.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus WD repeat and SOCS box-containing 2 (Wsb2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_030254744.1

ORF Insert Sequence:

ATGCTGTGCT CTGCAGCTGG GGAGAAGTCG GTCTTTCTGT GGAGCATGCG GTCCTACACA 
CTAATCCGGA AACTAGAAGG CCACCAAAGC AGTGTTGTCT CCTGTGATTT CTCTCCTGAT 
TCAGCCTTGC TTGTCACAGC TTCGTATGAC ACCAGTGTGA TTATGTGGGA CCCCTACACC 
GGCGAGAGGC TGAGGTCACT TCATCACACA CAGCTTGAAC CCACCATGGA TGACAGTGAC 
GTCCACATGA GCTCCCTGAG GTCCGTGTGC TTCTCACCTG AAGGCTTGTA TCTCGCTACG 
GTGGCAGATG ACAGGCTGCT CAGGATCTGG GCTCTGGAAC TGAAGGCTCC GGTTGCCTTT 
GCTCCGATGA CCAATGGTCT TTGCTGCACG TTCTTCCCAC ACGGTGGAAT TATTGCCACA 
GGGACGAGAG ATGGCCATGT CCAGTTCTGG ACAGCTCCCC GGGTCCTGTC CTCACTGAAG 
CACTTATGCA GGAAAGCCCT CCGAAGTTTC CTGACAACGT ATCAAGTCCT AGCACTGCCA 
ATCCCCAAGA AGATGAAAGA GTTCCTCACA TACAGGACTT TCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Nucleic acids research42(Database issue)D802-9(2014 Jan)
Koscielny G,Yaikhom G,Iyer V,Meehan TF,Morgan H,Atienza-Herrero J,Blake A,Chen CK,Easty R,Di Fenza A,Fiegel T,Grifiths M,Horne A,Karp NA,Kurbatova N,Mason JC,Matthews P,Oakley DJ,Qazi A,Regnart J,Retha A,Santos LA,Sneddon DJ,Warren J,Westerberg H,Wilson RJ,Melvin DG,Smedley D,Brown SD,Flicek P,Skarnes WC,Mallon AM,Parkinson H

Expression of Wsb2 in the developing and adult mouse testis.
Reproduction (Cambridge, England)133(4)753-61(2007 Apr)
Sarraj MA,McClive PJ,Szczepny A,Daggag H,Loveland KL,Sinclair AH

Novel role of WD40 and SOCS box protein-2 in steady-state distribution of granulocyte colony-stimulating factor receptor and G-CSF-controlled proliferation and differentiation signaling.
Oncogene26(14)1985-94(2007 Mar)
Erkeland SJ,Aarts LH,doust M,Roovers O,Klomp A,Valkhof M,Gits J,Eyckerman S,Tavernier J,Touw IP

SWiP-1: novel SOCS box containing WD-protein regulated by signalling centres and by Shh during development.
Mechanisms of development82(1-2)79-94(1999 Apr)
Vasiliauskas D,Hancock S,Stern CD

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Wsb2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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