Akr1a1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Akr1a1
Entrez Gene ID	58810
Full Name	aldo-keto reductase family 1, member A1 (aldehyde reductase)
Synonyms	2610201A18Rik,Akr1a4
General protein information	Preferred Names aldo-keto reductase family 1, member A1 (aldehyde reductase) Names alcohol dehydrogenase [NADP(+)] alcohol dehydrogenase aldehyde reductase aldo-keto reductase family 1 member A1 aldo-keto reductase family 1, member A4 (aldehyde reductase)
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 4 Map Location: 4\|4 D1

mRNA and Protein(s)

mRNA	Protein	Name
NM_021473.3	NP_067448.1	aldo-keto reductase family 1 member A1

Pathways from BioSystems

Homologies

	AKR1A1	XP_001082982.1
Schizosaccharomyces pombe (fission yeast)	SPBC8E4.04	NP_596843.1
Arabidopsis thaliana (thale cress)	AT2G37760	NP_565871.1
Canis lupus familiaris (dog)	AKR1A1	NP_001239097.1
Bos taurus (cattle)	AKR1A1	NP_001069981.1
Xenopus tropicalis (tropical clawed frog)	akr1a1	NP_001016137.1
Rattus norvegicus (Norway rat)	Akr1a1	NP_112262.1
Neurospora crassa	NCU04510	XP_956921.1
Homo sapiens (human)	AKR1A1	NP_697021.1
Pan troglodytes (chimpanzee)	AKR1A1	XP_001157388.1
Mus musculus (house mouse)	Akr1a1	NP_067448.1
Gallus gallus (chicken)	AKR1A1	NP_001006539.1
Danio rerio (zebrafish)	akr1a1b	NP_001017640.1
Schizosaccharomyces pombe (fission yeast)	SPAC26F1.07	NP_594888.1
Magnaporthe oryzae (rice blast fungus)	MGG_07938	XP_003713188.1

Gene Ontology
Bibliography

Related articles in PubMed

Heightened aggressive behavior in mice deficient in aldo-keto reductase 1a (Akr1a).
Homma T, Akihara R, Okano S, Shichiri M, Yoshida Y, Yamada KI, Miyata S, Nakajima O, Fujii J
Behavioural brain research319219-224(2017 02)

A novel osteoporosis model with ascorbic acid deficiency in Akr1A1 gene knockout mice.
Lai CW, Chen HL, Tu MY, Lin WY, R?hrig T, Yang SH, Lan YW, Chong KY, Chen CM
Oncotarget8(5)7357-7369(2017 Jan)

Ablation of aldehyde reductase aggravates carbon tetrachloride-induced acute hepatic injury involving oxidative stress and endoplasmic reticulum stress.
Akihara R, Homma T, Lee J, Yamada K, Miyata S, Fujii J
Biochemical and biophysical research communications478(2)765-71(2016 09)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results suggest that Akr1a might be involved in the metabolism of steroids and other carbonyl-containing compounds.
Title: Heightened aggressive behavior in mice deficient in aldo-keto reductase 1a (Akr1a).

Aldehyde reductase exerts a protective effect against carbon tetrachloride-induced hepatic steatosis by replenishing ascorbic acid via its antioxidative properties.
Title: Ablation of aldehyde reductase aggravates carbon tetrachloride-induced acute hepatic injury involving oxidative stress and endoplasmic reticulum stress.

The crystal structure of AKR1a4 in its apo form at high resolution.
Title: High-resolution structure of AKR1a4 in the apo form and its interaction with ligands.

A novel mechanism of regulation of oxidative stress by ATM through modulation of SMAR1-AKR1a4 complex, is proposed.
Title: SMAR1 regulates free radical stress through modulation of AKR1a4 enzyme activity.

The following Akr1a1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Akr1a1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu15851	NM_021473.3 Latest version!	Mus musculus aldo-keto reductase family 1, member A1 (aldehyde reductase) (Akr1a1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Akr1a1 ( NM_021473.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_067448.1 Mus musculus aldo-keto reductase family 1, member A1 (aldehyde reductase) (Akr1a1), mRNA.

Price & Availability↑

CloneID	OMu15851
Clone ID Related Accession (Same CDS sequence)	NM_021473.3
Accession Version	NM_021473.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 978bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Mus musculus(house mouse)
Product	aldo-keto reductase family 1 member A1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL831786.7, BY329410.1, AK164461.1 and BC046762.1. On Dec 16, 2011 this sequence version replaced NM_021473.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY207463.1, AK011908.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGACGGCCT CCAGTGTCCT CCTGCACACT GGACAGAAGA TGCCTCTGAT TGGTCTGGGG 
ACATGGAAGA GTGAGCCTGG TCAGGTGAAA GCAGCCATTA AACATGCCCT TAGCGCAGGC 
TACCGCCACA TTGATTGTGC TTCTGTATAT GGCAATGAAA CTGAGATTGG GGAGGCCCTG 
AAGGAGAGTG TGGGGTCAGG CAAGGCAGTC CCTCGAGAGG AGCTGTTTGT GACATCCAAG 
CTGTGGAATA CTAAGCACCA CCCTGAGGAT GTAGAACCTG CCCTCCGGAA GACACTGGCT 
GATCTGCAAC TGGAGTATTT GGACCTCTAT TTGATGCACT GGCCTTATGC CTTTGAGCGG 
GGAGACAATC CCTTTCCCAA GAATGCCGAT GGAACTGTCA GATATGACTC AACTCACTAT 
AAAGAGACCT GGAAGGCTCT GGAGGTACTG GTGGCAAAGG GGCTGGTGAA AGCCCTGGGC 
TTGTCCAACT TCAACAGTCG GCAGATTGAT GATGTCCTCA GTGTGGCCTC TGTGCGCCCA 
GCTGTCTTGC AGGTGGAATG CCATCCATAC CTGGCTCAGA ATGAGCTCAT TGCCCACTGT 
CACGCACGGG GCTTGGAGGT GACTGCTTAT AGCCCCTTGG GTTCCTCTGA CCGTGCTTGG 
CGCCATCCTG ATGAGCCAGT CCTGCTTGAA GAACCAGTAG TCTTGGCACT AGCTGAAAAA 
CATGGCCGAT CTCCAGCTCA GATCTTGCTT AGATGGCAGG TTCAGCGGAA AGTGATCTGC 
ATCCCCAAAA GCATCAATCC TTCCCGCATC CTTCAGAACA TTCAGGTATT TGATTTCACC 
TTTAGCCCAG AGGAGATGAA ACAATTAGAT GCTCTGAACA AAAATTGGCG GTATATTGTG 
CCCATGATTA CGGTGGATGG GAAGAGGGTT CCCAGAGATG CTGGACACCC TCTGTATCCC 
TTTAATGACC CATACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067448.1
CDS	343..1320
Translation	MTASSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKESVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPAVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKHGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIVPMITVDGKRVPRDAGHPLYPFNDPY

Target ORF information:

RefSeq Version	NM_021473.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus aldo-keto reductase family 1, member A1 (aldehyde reductase) (Akr1a1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021473.3

ORF Insert Sequence:

ATGACGGCCT CCAGTGTCCT CCTGCACACT GGACAGAAGA TGCCTCTGAT TGGTCTGGGG 
ACATGGAAGA GTGAGCCTGG TCAGGTGAAA GCAGCCATTA AACATGCCCT TAGCGCAGGC 
TACCGCCACA TTGATTGTGC TTCTGTATAT GGCAATGAAA CTGAGATTGG GGAGGCCCTG 
AAGGAGAGTG TGGGGTCAGG CAAGGCAGTC CCTCGAGAGG AGCTGTTTGT GACATCCAAG 
CTGTGGAATA CTAAGCACCA CCCTGAGGAT GTAGAACCTG CCCTCCGGAA GACACTGGCT 
GATCTGCAAC TGGAGTATTT GGACCTCTAT TTGATGCACT GGCCTTATGC CTTTGAGCGG 
GGAGACAATC CCTTTCCCAA GAATGCCGAT GGAACTGTCA GATATGACTC AACTCACTAT 
AAAGAGACCT GGAAGGCTCT GGAGGTACTG GTGGCAAAGG GGCTGGTGAA AGCCCTGGGC 
TTGTCCAACT TCAACAGTCG GCAGATTGAT GATGTCCTCA GTGTGGCCTC TGTGCGCCCA 
GCTGTCTTGC AGGTGGAATG CCATCCATAC CTGGCTCAGA ATGAGCTCAT TGCCCACTGT 
CACGCACGGG GCTTGGAGGT GACTGCTTAT AGCCCCTTGG GTTCCTCTGA CCGTGCTTGG 
CGCCATCCTG ATGAGCCAGT CCTGCTTGAA GAACCAGTAG TCTTGGCACT AGCTGAAAAA 
CATGGCCGAT CTCCAGCTCA GATCTTGCTT AGATGGCAGG TTCAGCGGAA AGTGATCTGC 
ATCCCCAAAA GCATCAATCC TTCCCGCATC CTTCAGAACA TTCAGGTATT TGATTTCACC 
TTTAGCCCAG AGGAGATGAA ACAATTAGAT GCTCTGAACA AAAATTGGCG GTATATTGTG 
CCCATGATTA CGGTGGATGG GAAGAGGGTT CCCAGAGATG CTGGACACCC TCTGTATCCC 
TTTAATGACC CATACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Heightened aggressive behavior in mice deficient in aldo-keto reductase 1a (Akr1a).
Behavioural brain research319219-224(2017 02)
Homma T,Akihara R,Okano S,Shichiri M,Yoshida Y,Yamada KI,Miyata S,Nakajima O,Fujii J

A novel osteoporosis model with ascorbic acid deficiency in Akr1A1 gene knockout mice.
Oncotarget8(5)7357-7369(2017 Jan)
Lai CW,Chen HL,Tu MY,Lin WY,R?hrig T,Yang SH,Lan YW,Chong KY,Chen CM

Ablation of aldehyde reductase aggravates carbon tetrachloride-induced acute hepatic injury involving oxidative stress and endoplasmic reticulum stress.
Biochemical and biophysical research communications478(2)765-71(2016 09)
Akihara R,Homma T,Lee J,Yamada K,Miyata S,Fujii J