Gpr17 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gpr17
Entrez Gene ID	574402
Full Name	G protein-coupled receptor 17
Synonyms	AI853548
General protein information	Preferred Names G protein-coupled receptor 17 Names uracil nucleotide/cysteinyl leukotriene receptor UDP/CysLT receptor gpr17
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 18 Map Location: 18 B1\|18

mRNA and Protein(s)

mRNA	Protein	Name
NM_001025381.2	NP_001020552.1	uracil nucleotide/cysteinyl leukotriene receptor

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	gpr17	XP_004917917.1
Canis lupus familiaris (dog)	GPR17	XP_005631925.1
Rattus norvegicus (Norway rat)	Gpr17	NP_001065245.1
Homo sapiens (human)	GPR17	NP_001154887.1
Mus musculus (house mouse)	Gpr17	NP_001020552.1
Danio rerio (zebrafish)	si:ch73-194h10.4	XP_005166015.1
Pan troglodytes (chimpanzee)	GPR17	XP_003309280.1
	GPR17	XP_001089260.1
Bos taurus (cattle)	GPR17	NP_001075939.1
Gallus gallus (chicken)	GPR17	XP_001231870.1

Gene Ontology
Bibliography

Related articles in PubMed

The role of oligodendrocyte precursor cells expressing the GPR17 receptor in brain remodeling after stroke.
Bonfanti E, Gelosa P, Fumagalli M, Dimou L, Vigan? F, Tremoli E, Cimino M, Sironi L, Abbracchio MP
Cell death & disease8(6)e2871(2017 Jun)

The Orphan Receptor GPR17 Is Unresponsive to Uracil Nucleotides and Cysteinyl Leukotrienes.
Simon K, Merten N, Schr?der R, Hennen S, Preis P, Schmitt NK, Peters L, Schrage R, Vermeiren C, Gillard M, Mohr K, Gomeza J, Kostenis E
Molecular pharmacology91(5)518-532(2017 May)

Olig2-Targeted G-Protein-Coupled Receptor Gpr17 Regulates Oligodendrocyte Survival in Response to Lysolecithin-Induced Demyelination.
Ou Z, Sun Y, Lin L, You N, Liu X, Li H, Ma Y, Cao L, Han Y, Liu M, Deng Y, Yao L, Lu QR, Chen Y
The Journal of neuroscience : the official journal of the Society for Neuroscience36(41)10560-10573(2016 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

uracil nucleotides and cysteinyl leukotrienes do not activate human, mouse, or rat GPR17 in various cellular backgrounds.
Title: The Orphan Receptor GPR17 Is Unresponsive to Uracil Nucleotides and Cysteinyl Leukotrienes.

The loss of Gpr17 in mice led to precocious myelination and an earlier onset of remyelination after demyelination
Title: Olig2-Targeted G-Protein-Coupled Receptor Gpr17 Regulates Oligodendrocyte Survival in Response to Lysolecithin-Induced Demyelination.

Results show a crucial role of SNX27 in modulating GPR17 levels by means of a post-translational mechanism and highlights the relationship between the trafficking of the receptor through the endomembrane system and oligodendrocyte differentiation; and provide novel evidence of impairment of GPR17 expression and oligodendrocyte maturation in a mouse model of Down syndrome that is characterized by SNX27 down-regulation.
Title: SNX27, a protein involved in down syndrome, regulates GPR17 trafficking and oligodendrocyte differentiation.

GPR17(+) cells--in contrast to GPR17(-) NG2-glia--did not differentiate within 3 months, a peculiarity that was overcome after cerebral damage induced by acute injury or ischemia
Title: GPR17 expressing NG2-Glia: Oligodendrocyte progenitors serving as a reserve pool after injury.

stimulation of GPR17 by the small molecule agonist MDL29,951 (2-carboxy-4,6-dichloro-1H-indole-3-propionic acid) decreases myelin basic protein expression levels mainly by triggering the Galphai/o signaling pathway.
Title: The Orphan G Protein-coupled Receptor GPR17 Negatively Regulates Oligodendrocyte Differentiation via G?i/o and Its Downstream Effector Molecules.

The following Gpr17 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gpr17 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu13368	NM_001025381.2 Latest version!	Mus musculus G protein-coupled receptor 17 (Gpr17), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gpr17 ( NM_001025381.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001020552.1 Mus musculus G protein-coupled receptor 17 (Gpr17), mRNA.

Price & Availability↑

CloneID	OMu13368
Clone ID Related Accession (Same CDS sequence)	NM_001025381.2
Accession Version	NM_001025381.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1020bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	uracil nucleotide/cysteinyl leukotriene receptor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC070439.1 and AI853548.1. On Feb 5, 2010 this sequence version replaced NM_001025381.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC070439.1, CX241083.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164132 [ECO:0000348] ##Evidence-Data-END##

ATGAACGGTC TGGAGGCAGC CCTACCGAGT CTGACTGACA ACTCCTCCCT GGCTTACTCT 
GAGCAATGCG GACAAGAGAC CCCCCTGGAG AACATGCTCT TCGCCTGCTT CTACCTTCTG 
GACTTCATCC TCGCTTTTGT GGGCAATGCT CTGGCCCTGT GGCTTTTCAT ATGGGACCAC 
AAGTCAGGCA CTCCGGCCAA TGTCTTCCTC ATGCACCTGG CTGTGGCCGA CCTGTCCTGC 
GTGTTGGTCC TGCCTACCCG GTTGGTTTAT CACTTCTCTG GGAATCACTG GCCATTTGGG 
GAGATCCCAT GCCGACTCAC TGGCTTCCTC TTCTATCTGA ACATGTATGC CAGCATCTAC 
TTTCTCACCT GCATCAGCGC TGACCGGTTC CTGGCCATTG TGCACCCTGT CAAGTCCCTC 
AAGCTTCGAA GACCTCTCTA TGCTCACCTG GCCTGCGCCT TCCTGTGGAT CGTGGTGGCT 
GTGGCTATGG CCCCACTGCT AGTCAGCCCA CAGACAGTGC AGACCAACCA CACAGTTGTC 
TGCCTGCAAC TGTACCGGGA GAAGGCCTCC CATCACGCCC TGGCATCCCT GGCTGTGGCT 
TTTACCTTCC CATTCATCAC CACGGTCACC TGCTACCTGC TGATCATTCG CAGCCTGCGC 
CAGGGTCCCC GGATAGAGAA GCACCTCAAG AATAAAGCCG TCCGCATGAT TGCTATGGTT 
CTGGCCATCT TCCTGATTTG TTTTGTGCCC TACCACATCC ACCGTTCAGT CTATGTGCTT 
CACTACCGTG GTGGTGGGAC TTCGTGCGCT GCTCAGCGTG CCCTGGCCCT GGGGAACCGG 
ATCACCTCCT GCCTCACCAG CCTCAACGGG GCCCTGGATC CTGTCATGTA CTTCTTTGTG 
GCTGAGAAGT TCCGCCACGC CTTGTGCAAC TTGCTCTGCA GCAAACGGCT CACAGGTCCA 
CCTCCCAGCT TCGAAGGGAA AACCAACGAG AGCTCCCTGA GTGCCCGATC CGAGCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001020552.1
CDS	184..1203
Translation	MNGLEAALPSLTDNSSLAYSEQCGQETPLENMLFACFYLLDFILAFVGNALALWLFIWDHKSGTPANVFLMHLAVADLSCVLVLPTRLVYHFSGNHWPFGEIPCRLTGFLFYLNMYASIYFLTCISADRFLAIVHPVKSLKLRRPLYAHLACAFLWIVVAVAMAPLLVSPQTVQTNHTVVCLQLYREKASHHALASLAVAFTFPFITTVTCYLLIIRSLRQGPRIEKHLKNKAVRMIAMVLAIFLICFVPYHIHRSVYVLHYRGGGTSCAAQRALALGNRITSCLTSLNGALDPVMYFFVAEKFRHALCNLLCSKRLTGPPPSFEGKTNESSLSARSEL

Target ORF information:

RefSeq Version	NM_001025381.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus G protein-coupled receptor 17 (Gpr17), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001025381.2

ORF Insert Sequence:

ATGAACGGTC TGGAGGCAGC CCTACCGAGT CTGACTGACA ACTCCTCCCT GGCTTACTCT 
GAGCAATGCG GACAAGAGAC CCCCCTGGAG AACATGCTCT TCGCCTGCTT CTACCTTCTG 
GACTTCATCC TCGCTTTTGT GGGCAATGCT CTGGCCCTGT GGCTTTTCAT ATGGGACCAC 
AAGTCAGGCA CTCCGGCCAA TGTCTTCCTC ATGCACCTGG CTGTGGCCGA CCTGTCCTGC 
GTGTTGGTCC TGCCTACCCG GTTGGTTTAT CACTTCTCTG GGAATCACTG GCCATTTGGG 
GAGATCCCAT GCCGACTCAC TGGCTTCCTC TTCTATCTGA ACATGTATGC CAGCATCTAC 
TTTCTCACCT GCATCAGCGC TGACCGGTTC CTGGCCATTG TGCACCCTGT CAAGTCCCTC 
AAGCTTCGAA GACCTCTCTA TGCTCACCTG GCCTGCGCCT TCCTGTGGAT CGTGGTGGCT 
GTGGCTATGG CCCCACTGCT AGTCAGCCCA CAGACAGTGC AGACCAACCA CACAGTTGTC 
TGCCTGCAAC TGTACCGGGA GAAGGCCTCC CATCACGCCC TGGCATCCCT GGCTGTGGCT 
TTTACCTTCC CATTCATCAC CACGGTCACC TGCTACCTGC TGATCATTCG CAGCCTGCGC 
CAGGGTCCCC GGATAGAGAA GCACCTCAAG AATAAAGCCG TCCGCATGAT TGCTATGGTT 
CTGGCCATCT TCCTGATTTG TTTTGTGCCC TACCACATCC ACCGTTCAGT CTATGTGCTT 
CACTACCGTG GTGGTGGGAC TTCGTGCGCT GCTCAGCGTG CCCTGGCCCT GGGGAACCGG 
ATCACCTCCT GCCTCACCAG CCTCAACGGG GCCCTGGATC CTGTCATGTA CTTCTTTGTG 
GCTGAGAAGT TCCGCCACGC CTTGTGCAAC TTGCTCTGCA GCAAACGGCT CACAGGTCCA 
CCTCCCAGCT TCGAAGGGAA AACCAACGAG AGCTCCCTGA GTGCCCGATC CGAGCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The role of oligodendrocyte precursor cells expressing the GPR17 receptor in brain remodeling after stroke.
Cell death & disease8(6)e2871(2017 Jun)
Bonfanti E,Gelosa P,Fumagalli M,Dimou L,Vigan? F,Tremoli E,Cimino M,Sironi L,Abbracchio MP

The Orphan Receptor GPR17 Is Unresponsive to Uracil Nucleotides and Cysteinyl Leukotrienes.
Molecular pharmacology91(5)518-532(2017 May)
Simon K,Merten N,Schr?der R,Hennen S,Preis P,Schmitt NK,Peters L,Schrage R,Vermeiren C,Gillard M,Mohr K,Gomeza J,Kostenis E

Olig2-Targeted G-Protein-Coupled Receptor Gpr17 Regulates Oligodendrocyte Survival in Response to Lysolecithin-Induced Demyelination.
The Journal of neuroscience : the official journal of the Society for Neuroscience36(41)10560-10573(2016 Oct)
Ou Z,Sun Y,Lin L,You N,Liu X,Li H,Ma Y,Cao L,Han Y,Liu M,Deng Y,Yao L,Lu QR,Chen Y

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Gpr17 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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