Cldn13 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cldn13
Entrez Gene ID	57255
Full Name	claudin 13
Synonyms	2500004B14Rik
General protein information	Preferred Names claudin 13 Names claudin-13
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5\|5 G2
Summary	This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a developmentally expressed renal tight junction protein. This gene is expressed in the cecum, colon, liver and kidney of mice, but is not identified in rat tissues. Humans and chimpanzees lack this gene. [provided by RefSeq, Aug 2010].

mRNA and Protein(s)

mRNA	Protein	Name
NM_020504.4	NP_065250.1	claudin-13

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

Androgen-dependent sertoli cell tight junction remodeling is mediated by multiple tight junction components.
Chakraborty P, William Buaas F, Sharma M, Smith BE, Greenlee AR, Eacker SM, Braun RE
Molecular endocrinology (Baltimore, Md.)28(7)1055-72(2014 Jul)

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H
Nucleic acids research42(Database issue)D802-9(2014 Jan)

Dynamic distribution of claudin proteins in pancreatic epithelia undergoing morphogenesis or neoplastic transformation.
Westmoreland JJ, Drosos Y, Kelly J, Ye J, Means AL, Washington MK, Sosa-Pineda B
Developmental dynamics : an official publication of the American Association of Anatomists241(3)583-94(2012 Mar)

Probiotic bacteria induce maturation of intestinal claudin 3 expression and barrier function.
Patel RM, Myers LS, Kurundkar AR, Maheshwari A, Nusrat A, Lin PW
The American journal of pathology180(2)626-35(2012 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CLDN13 is a constituent of Sertoli cell tight junctions. CLDN13 is expressed throughout the seminiferous cycle and is localized to bicellular tight junctions.
Title: Androgen-dependent sertoli cell tight junction remodeling is mediated by multiple tight junction components.

Cldn13 is regulated as part of a stress induced erythropoiesis pathway and is expressed in tissues associated with haematopoietic function.
Title: Claudin 13, a member of the claudin family regulated in mouse stress induced erythropoiesis.

developmentally expressed claudin isoforms include claudin 6, claudin 9, and claudin 13
Title: Claudins 6, 9, and 13 are developmentally expressed renal tight junction proteins.

The following Cldn13 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cldn13 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu12007	NM_020504.4 Latest version!	Mus musculus claudin 13 (Cldn13), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cldn13 ( NM_020504.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_065250.1 Mus musculus claudin 13 (Cldn13), mRNA.

Price & Availability↑

CloneID	OMu12007
Clone ID Related Accession (Same CDS sequence)	NM_020504.4
Accession Version	NM_020504.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 636bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-21
Organism	Mus musculus(house mouse)
Product	claudin-13
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY079003.1 and AK010869.1. On Aug 11, 2010 this sequence version replaced NM_020504.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF516681.2, BY710282.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135, SAMN01164140 [ECO:0000348] ##Evidence-Data-END##

ATGGTCGTCA GCAAACAAGA GGCCATCAGC TTCTCTGTGA CTTCACTGGG TTGGGTGGGT 
GCCATTGTGA GCTGCGTGCT GCCCGTTTGG AGGGTGACCT TTCCAGATGA TGAGACAGAC 
CCAGATGCCA CCATTTGGGA GGGTCTGTGG CACATATGCC AGGTTCGGGA AAACAGGTGG 
ATACAGTGTA CACTGTATGA CACCCGGATA CTGGTAGCAC AGGACATAAA AGTGTCTCGA 
GTCTTTATGG TCATCTGTAC CATTGGAACC TGGCTGGGAT TGCTGCTCTG TGTGCTTGGG 
GATTGGCGCA TCAATTGTTT CATGAATTTT ACTATTGAAG AGAACCTCTT GAAAGTAGCC 
GGTGGGATGT TTCTTAGTGT TGGCCTTCTG ATGCTGGTAC CCCTGTCCTG GGTAACACAC 
AACATCATCC ATGGCTTCTT TAACCCATTG CTTGGCTTCT CGAAGAAAGT ACAGATGGGC 
TCTTCACTCT CCCTGGCCTG GACCAGCTCC CTGCTGCTGT TGCTGGGAGG CATCCTGCTC 
TGTGTCAACA TCCCAGTATG CAGAGACTTT CCCCGTTGCA TTGAGACCCC TAGTGCTAGA 
CCTTCAGGAG CCAACAACGA TACCTTAGAT GTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065250.1
CDS	202..837
Translation	MVVSKQEAISFSVTSLGWVGAIVSCVLPVWRVTFPDDETDPDATIWEGLWHICQVRENRWIQCTLYDTRILVAQDIKVSRVFMVICTIGTWLGLLLCVLGDWRINCFMNFTIEENLLKVAGGMFLSVGLLMLVPLSWVTHNIIHGFFNPLLGFSKKVQMGSSLSLAWTSSLLLLLGGILLCVNIPVCRDFPRCIETPSARPSGANNDTLDV

Target ORF information:

RefSeq Version	NM_020504.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus claudin 13 (Cldn13), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020504.4

ORF Insert Sequence:

ATGGTCGTCA GCAAACAAGA GGCCATCAGC TTCTCTGTGA CTTCACTGGG TTGGGTGGGT 
GCCATTGTGA GCTGCGTGCT GCCCGTTTGG AGGGTGACCT TTCCAGATGA TGAGACAGAC 
CCAGATGCCA CCATTTGGGA GGGTCTGTGG CACATATGCC AGGTTCGGGA AAACAGGTGG 
ATACAGTGTA CACTGTATGA CACCCGGATA CTGGTAGCAC AGGACATAAA AGTGTCTCGA 
GTCTTTATGG TCATCTGTAC CATTGGAACC TGGCTGGGAT TGCTGCTCTG TGTGCTTGGG 
GATTGGCGCA TCAATTGTTT CATGAATTTT ACTATTGAAG AGAACCTCTT GAAAGTAGCC 
GGTGGGATGT TTCTTAGTGT TGGCCTTCTG ATGCTGGTAC CCCTGTCCTG GGTAACACAC 
AACATCATCC ATGGCTTCTT TAACCCATTG CTTGGCTTCT CGAAGAAAGT ACAGATGGGC 
TCTTCACTCT CCCTGGCCTG GACCAGCTCC CTGCTGCTGT TGCTGGGAGG CATCCTGCTC 
TGTGTCAACA TCCCAGTATG CAGAGACTTT CCCCGTTGCA TTGAGACCCC TAGTGCTAGA 
CCTTCAGGAG CCAACAACGA TACCTTAGAT GTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

Androgen-dependent sertoli cell tight junction remodeling is mediated by multiple tight junction components.
Molecular endocrinology (Baltimore, Md.)28(7)1055-72(2014 Jul)
Chakraborty P,William Buaas F,Sharma M,Smith BE,Greenlee AR,Eacker SM,Braun RE

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Nucleic acids research42(Database issue)D802-9(2014 Jan)
Koscielny G,Yaikhom G,Iyer V,Meehan TF,Morgan H,Atienza-Herrero J,Blake A,Chen CK,Easty R,Di Fenza A,Fiegel T,Grifiths M,Horne A,Karp NA,Kurbatova N,Mason JC,Matthews P,Oakley DJ,Qazi A,Regnart J,Retha A,Santos LA,Sneddon DJ,Warren J,Westerberg H,Wilson RJ,Melvin DG,Smedley D,Brown SD,Flicek P,Skarnes WC,Mallon AM,Parkinson H

Dynamic distribution of claudin proteins in pancreatic epithelia undergoing morphogenesis or neoplastic transformation.
Developmental dynamics : an official publication of the American Association of Anatomists241(3)583-94(2012 Mar)
Westmoreland JJ,Drosos Y,Kelly J,Ye J,Means AL,Washington MK,Sosa-Pineda B

Probiotic bacteria induce maturation of intestinal claudin 3 expression and barrier function.
The American journal of pathology180(2)626-35(2012 Feb)
Patel RM,Myers LS,Kurundkar AR,Maheshwari A,Nusrat A,Lin PW

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Cldn13 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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