Gabarap cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gabarap
Entrez Gene ID	56486
Full Name	gamma-aminobutyric acid receptor associated protein
General protein information	Preferred Names gamma-aminobutyric acid receptor associated protein Names gamma-aminobutyric acid receptor-associated protein GABA-A receptor-associated protein gamma-aminobutyric acid reseptor associated protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11 B3\|11 42.95 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_019749.4	NP_062723.1	gamma-aminobutyric acid receptor-associated protein

Pathways from BioSystems

Homologies

Homo sapiens (human)	GABARAP	NP_009209.1
Rattus norvegicus (Norway rat)	Gabarap	NP_742033.1
	GABARAP	XP_001107079.1
Mus musculus (house mouse)	Gabarap	NP_062723.1
Danio rerio (zebrafish)	gabarapa	NP_001013278.1
Pan troglodytes (chimpanzee)	GABARAP	XP_003315392.1
Canis lupus familiaris (dog)	GABARAP	XP_536616.2
Bos taurus (cattle)	GABARAP	NP_001029220.1

Gene Ontology
Bibliography

Related articles in PubMed

Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense.
Sasai M, Sakaguchi N, Ma JS, Nakamura S, Kawabata T, Bando H, Lee Y, Saitoh T, Akira S, Iwasaki A, Standley DM, Yoshimori T, Yamamoto M
Nature immunology18(8)899-910(2017 Aug)

The space where aging acts: focus on the GABAergic synapse.
Rozycka A, Liguz-Lecznar M
Aging cell16(4)634-643(2017 Aug)

Development of LC3/GABARAP sensors containing a LIR and a hydrophobic domain to monitor autophagy.
Lee YK, Jun YW, Choi HE, Huh YH, Kaang BK, Jang DJ, Lee JA
The EMBO journal36(8)1100-1116(2017 04)

Widespread and dynamic translational control of red blood cell development.
Alvarez-Dominguez JR, Zhang X, Hu W
Blood129(5)619-629(2017 02)

Tumor suppression in mice lacking GABARAP, an Atg8/LC3 family member implicated in autophagy, is associated with alterations in cytokine secretion and cell death.
Salah FS, Ebbinghaus M, Muley VY, Zhou Z, Al-Saadi KR, Pacyna-Gengelbach M, O'Sullivan GA, Betz H, K?nig R, Wang ZQ, Br?uer R, Petersen I
Cell death & disease7e2205(2016 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Cells that lacked GABARAPs and mice that lacked Gate-16 alone were defective in the IFN-gamma-induced clearance of vacuolar pathogens such as Toxoplasma. GABARAPs are uniquely required for antimicrobial host defense through cytosolic distribution of interferon-inducible GTPases.
Title: Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense.

GABAergic synapse is proposed as a focus of aging. (Review)
Title: The space where aging acts: focus on the GABAergic synapse.

Development of LC3/GABARAP sensors containing a LIR and a hydrophobic domain to monitor autophagy.
Title: Development of LC3/GABARAP sensors containing a LIR and a hydrophobic domain to monitor autophagy.

Ablation of GABARAP inhibits tumor initiation and progression through enhancement of both antitumor immunity and cell death signaling.
Title: Tumor suppression in mice lacking GABARAP, an Atg8/LC3 family member implicated in autophagy, is associated with alterations in cytokine secretion and cell death.

Lipidation of the LC3/GABARAP family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3.
Title: Lipidation of the LC3/GABARAP family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3.

The following Gabarap gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gabarap cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu19514	NM_019749.4 Latest version!	Mus musculus gamma-aminobutyric acid receptor associated protein (Gabarap), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gabarap ( NM_019749.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_062723.1 Mus musculus gamma-aminobutyric acid receptor associated protein (Gabarap), mRNA.

Price & Availability↑

CloneID	OMu19514
Clone ID Related Accession (Same CDS sequence)	NM_019749.4
Accession Version	NM_019749.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 354bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Mus musculus(house mouse)
Product	gamma-aminobutyric acid receptor-associated protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL596185.12 and AV029091.2. On Apr 7, 2009 this sequence version replaced NM_019749.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. An in-frame AUG is located 46 codons upstream of the annotated translation start site but is not being annotated as a start site since it is not conserved and is in a weak Kozak sequence context. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AV029091.2, BC030350.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END##

ATGAAGTTCG TGTACAAAGA GGAGCATCCG TTCGAGAAGC GCCGCTCTGA GGGCGAGAAA 
ATCCGAAAGA AATACCCAGA CCGGGTCCCG GTGATAGTGG AAAAAGCCCC CAAAGCTCGG 
ATAGGAGACC TGGACAAAAA GAAATACCTG GTGCCTTCTG ATCTTACAGT TGGTCAATTC 
TACTTCTTGA TCCGGAAGCG AATTCATCTC CGTGCTGAAG ATGCCTTGTT TTTCTTTGTC 
AACAATGTCA TTCCACCCAC CAGTGCCACG ATGGGTCAGC TGTACCAGGA ACACCATGAA 
GAAGACTTCT TTCTATACAT TGCCTACAGT GATGAAAGCG TCTATGGTCT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062723.1
CDS	344..697
Translation	MKFVYKEEHPFEKRRSEGEKIRKKYPDRVPVIVEKAPKARIGDLDKKKYLVPSDLTVGQFYFLIRKRIHLRAEDALFFFVNNVIPPTSATMGQLYQEHHEEDFFLYIAYSDESVYGL

Target ORF information:

RefSeq Version	NM_019749.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus gamma-aminobutyric acid receptor associated protein (Gabarap), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019749.4

ORF Insert Sequence:

ATGAAGTTCG TGTACAAAGA GGAGCATCCG TTCGAGAAGC GCCGCTCTGA GGGCGAGAAA 
ATCCGAAAGA AATACCCAGA CCGGGTCCCG GTGATAGTGG AAAAAGCCCC CAAAGCTCGG 
ATAGGAGACC TGGACAAAAA GAAATACCTG GTGCCTTCTG ATCTTACAGT TGGTCAATTC 
TACTTCTTGA TCCGGAAGCG AATTCATCTC CGTGCTGAAG ATGCCTTGTT TTTCTTTGTC 
AACAATGTCA TTCCACCCAC CAGTGCCACG ATGGGTCAGC TGTACCAGGA ACACCATGAA 
GAAGACTTCT TTCTATACAT TGCCTACAGT GATGAAAGCG TCTATGGTCT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense.
Nature immunology18(8)899-910(2017 Aug)
Sasai M,Sakaguchi N,Ma JS,Nakamura S,Kawabata T,Bando H,Lee Y,Saitoh T,Akira S,Iwasaki A,Standley DM,Yoshimori T,Yamamoto M

The space where aging acts: focus on the GABAergic synapse.
Aging cell16(4)634-643(2017 Aug)
Rozycka A,Liguz-Lecznar M

Development of LC3/GABARAP sensors containing a LIR and a hydrophobic domain to monitor autophagy.
The EMBO journal36(8)1100-1116(2017 04)
Lee YK,Jun YW,Choi HE,Huh YH,Kaang BK,Jang DJ,Lee JA

Widespread and dynamic translational control of red blood cell development.
Blood129(5)619-629(2017 02)
Alvarez-Dominguez JR,Zhang X,Hu W

Tumor suppression in mice lacking GABARAP, an Atg8/LC3 family member implicated in autophagy, is associated with alterations in cytokine secretion and cell death.
Cell death & disease7e2205(2016 Apr)
Salah FS,Ebbinghaus M,Muley VY,Zhou Z,Al-Saadi KR,Pacyna-Gengelbach M,O'Sullivan GA,Betz H,K?nig R,Wang ZQ,Br?uer R,Petersen I

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Gabarap cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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