Dynll1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Dynll1
Entrez Gene ID	56455
Full Name	dynein light chain LC8-type 1
Synonyms	Dlc8,Dnclc1,Pin
General protein information	Preferred Names dynein light chain LC8-type 1 Names dynein light chain 1, cytoplasmic 8 kDa dynein light chain 8kD LC 8kDa LC dynein, cytoplasmic, light chain 1 dynein, cytoplasmic, light peptide mPIN protein inhibitor of neuronal nitric oxide synthase protein inhibitor of nitric oxide synthase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5\|5 F

mRNA and Protein(s)

mRNA	Protein	Name
NM_019682.4	NP_062656.3	dynein light chain 1, cytoplasmic

Pathways from BioSystems

Homologies

Bos taurus (cattle)	DYNLL1	NP_001003901.1
Rattus norvegicus (Norway rat)	Dynll1	NP_445771.1
Canis lupus familiaris (dog)	DYNLL1	XP_863417.1
	DYNLL1	XP_001089607.1
Mus musculus (house mouse)	Dynll1	NP_062656.3
Homo sapiens (human)	DYNLL1	NP_001032583.1
Pan troglodytes (chimpanzee)	DYNLL1	XP_003952374.1

Gene Ontology
Bibliography

Related articles in PubMed

The Transcription Factor ASCIZ and Its Target DYNLL1 Are Essential for the Development and Expansion of MYC-Driven B Cell Lymphoma.
Wong DM, Li L, Jurado S, King A, Bamford R, Wall M, Walia MK, Kelly GL, Walkley CR, Tarlinton DM, Strasser A, Heierhorst J
Cell reports14(6)1488-1499(2016 Feb)

An AUTS2-Polycomb complex activates gene expression in the CNS.
Gao Z, Lee P, Stafford JM, von Schimmelmann M, Schaefer A, Reinberg D
Nature516(7531)349-54(2014 Dec)

Arl3 and LC8 regulate dissociation of dynactin from dynein.
Jin M, Yamada M, Arai Y, Nagai T, Hirotsune S
Nature communications55295(2014 Oct)

ATMIN is a transcriptional regulator of both lung morphogenesis and ciliogenesis.
Goggolidou P, Stevens JL, Agueci F, Keynton J, Wheway G, Grimes DT, Patel SH, Hilton H, Morthorst SK, DiPaolo A, Williams DJ, Sanderson J, Khoronenkova SV, Powles-Glover N, Ermakov A, Esapa CT, Romero R, Dianov GL, Briscoe J, Johnson CA, Pedersen LB, Norris DP
Development (Cambridge, England)141(20)3966-77(2014 Oct)

BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE
Nucleic acids research31(1)278-81(2003 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

oncogenic MYC expression, which is synthetic lethal with Dynll1 deletion in B-2 cells, did not further reduce B-1a cell numbers in Dynll1-defcient mice. we found that the ASCIZ-DYNLL1 axis was also required for the early-juvenile development of aggressive MYC-driven and p53-deficient B cell lymphomas.
Title: Dynein light chain regulates adaptive and innate B cell development by distinctive genetic mechanisms.

ASCIZ and its target DYNLL1 are essential for the development and expansion of MYC-driven B cell lymphoma.
Title: The Transcription Factor ASCIZ and Its Target DYNLL1 Are Essential for the Development and Expansion of MYC-Driven B Cell Lymphoma.

These findings uncovered the surprising functional relevance of GTP-bound Arl3 and LC8 for the unloading regulation of dynactin-bound cargo from dynein motor.
Title: Arl3 and LC8 regulate dissociation of dynactin from dynein.

a key role for ASCIZ in regulating the survival of developing B cells by activating DYNLL1 expression, which may then modulate Bim-dependent apoptosis
Title: The Zinc-finger protein ASCIZ regulates B cell development via DYNLL1 and Bim.

The ASCIZ-DYNLL1 feedback loop represents a novel mechanism for auto-regulation of gene expression, where the gene product directly inhibits the transcriptional activator while bound at its own promoter.
Title: ATM substrate Chk2-interacting Zn2+ finger (ASCIZ) Is a bi-functional transcriptional activator and feedback sensor in the regulation of dynein light chain (DYNLL1) expression.

The following Dynll1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dynll1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu15359	NM_019682.4 Latest version!	Mus musculus dynein light chain LC8-type 1 (Dynll1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Dynll1 ( NM_019682.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_062656.3 Mus musculus dynein light chain LC8-type 1 (Dynll1), mRNA.

Price & Availability↑

CloneID	OMu15359
Clone ID Related Accession (Same CDS sequence)	NM_019682.4
Accession Version	NM_019682.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 270bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Mus musculus(house mouse)
Product	dynein light chain 1, cytoplasmic
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CN832868.1, CA465333.1, AK147977.1, AK002522.1 and BF456225.1. On Nov 21, 2008 this sequence version replaced NM_019682.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK082923.1, AK147977.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGCGACC GGAAGGCGGT GATCAAAAAT GCAGACATGT CGGAAGAGAT GCAACAGGAC 
TCGGTGGAGT GCGCTACCCA GGCGTTGGAG AAGTACAACA TCGAGAAGGA TATTGCGGCC 
CATATCAAGA AGGAGTTTGA CAAGAAGTAC AACCCTACCT GGCACTGCAT TGTGGGCCGA 
AACTTCGGTA GTTATGTGAC ACATGAAACC AAACACTTCA TCTACTTCTA CCTGGGTCAG 
GTGGCCATTC TTCTGTTCAA ATCTGGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062656.3
CDS	166..435
Translation	MCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAILLFKSG

Target ORF information:

RefSeq Version	NM_019682.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus dynein light chain LC8-type 1 (Dynll1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019682.4

ORF Insert Sequence:

ATGTGCGACC GGAAGGCGGT GATCAAAAAT GCAGACATGT CGGAAGAGAT GCAACAGGAC 
TCGGTGGAGT GCGCTACCCA GGCGTTGGAG AAGTACAACA TCGAGAAGGA TATTGCGGCC 
CATATCAAGA AGGAGTTTGA CAAGAAGTAC AACCCTACCT GGCACTGCAT TGTGGGCCGA 
AACTTCGGTA GTTATGTGAC ACATGAAACC AAACACTTCA TCTACTTCTA CCTGGGTCAG 
GTGGCCATTC TTCTGTTCAA ATCTGGTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Transcription Factor ASCIZ and Its Target DYNLL1 Are Essential for the Development and Expansion of MYC-Driven B Cell Lymphoma.
Cell reports14(6)1488-1499(2016 Feb)
Wong DM,Li L,Jurado S,King A,Bamford R,Wall M,Walia MK,Kelly GL,Walkley CR,Tarlinton DM,Strasser A,Heierhorst J

An AUTS2-Polycomb complex activates gene expression in the CNS.
Nature516(7531)349-54(2014 Dec)
Gao Z,Lee P,Stafford JM,von Schimmelmann M,Schaefer A,Reinberg D

Arl3 and LC8 regulate dissociation of dynactin from dynein.
Nature communications55295(2014 Oct)
Jin M,Yamada M,Arai Y,Nagai T,Hirotsune S

ATMIN is a transcriptional regulator of both lung morphogenesis and ciliogenesis.
Development (Cambridge, England)141(20)3966-77(2014 Oct)
Goggolidou P,Stevens JL,Agueci F,Keynton J,Wheway G,Grimes DT,Patel SH,Hilton H,Morthorst SK,DiPaolo A,Williams DJ,Sanderson J,Khoronenkova SV,Powles-Glover N,Ermakov A,Esapa CT,Romero R,Dianov GL,Briscoe J,Johnson CA,Pedersen LB,Norris DP

BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Nucleic acids research31(1)278-81(2003 Jan)
Stryke D,Kawamoto M,Huang CC,Johns SJ,King LA,Harper CA,Meng EC,Lee RE,Yee A,L'Italien L,Chuang PT,Young SG,Skarnes WC,Babbitt PC,Ferrin TE

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Dynll1 cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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