Cpb2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cpb2
Entrez Gene ID	56373
Full Name	carboxypeptidase B2 (plasma)
Synonyms	1110032P04Rik,4930405E17Rik,AI255929,CPR,Cpu,TAFI
General protein information	Preferred Names carboxypeptidase B2 (plasma) Names carboxypeptidase B2 carboxypeptidase R carboxypeptidase U thrombin-activable fibrinolysis inhibitor thrombin-activatable fibrinolysis inhibitor
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 14 Map Location: 14\|14 D3
Summary	This gene encodes carboxypeptidase B, a zinc-dependent metalloprotease that cleaves peptide bonds at the C-terminus of protein substrates. The encoded preproprotein undergoes proteolytic activation to generate a mature, functional enzyme, and secreted into plasma. [provided by RefSeq, Jan 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_019775.3	NP_062749.2	carboxypeptidase B2 preproprotein

Pathways from BioSystems

Homologies

Homo sapiens (human)	CPB2	NP_001863.3
Bos taurus (cattle)	CPB2	NP_001039462.1
Mus musculus (house mouse)	Cpb2	NP_062749.2
Gallus gallus (chicken)	CPB2	XP_417046.4
Pan troglodytes (chimpanzee)	CPB2	XP_509667.2
Caenorhabditis elegans (roundworm)	F02D8.4	NP_506684.3
Danio rerio (zebrafish)	cpb2	NP_001018539.2
	CPB2	XP_001097608.1
Canis lupus familiaris (dog)	CPB2	XP_851154.1
Rattus norvegicus (Norway rat)	Cpb2	NP_446069.1
Xenopus tropicalis (tropical clawed frog)	cpb2	NP_001025617.1

Gene Ontology
Bibliography

Related articles in PubMed

Activated TAFI Promotes the Development of Chronic Thromboembolic Pulmonary Hypertension: A Possible Novel Therapeutic Target.
Satoh T, Satoh K, Yaoita N, Kikuchi N, Omura J, Kurosawa R, Numano K, Al-Mamun E, Siddique MA, Sunamura S, Nogi M, Suzuki K, Miyata S, Morser J, Shimokawa H
Circulation research120(8)1246-1262(2017 Apr)

Thrombin-activatable fibrinolysis inhibitor influences disease severity in humans and mice with pneumococcal meningitis.
Mook-Kanamori BB, Valls Ser?n M, Geldhoff M, Havik SR, van der Ende A, Baas F, van der Poll T, Meijers JC, P Morgan B, Brouwer MC, van de Beek D
Journal of thrombosis and haemostasis : JTH13(11)2076-86(2015 Nov)

Collaborative cross mice in a genetic association study reveal new candidate genes for bone microarchitecture.
Levy R, Mott RF, Iraqi FA, Gabet Y
BMC genomics161013(2015 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results indicate that TAFIa could be a novel biomarker and realistic therapeutic target of chronic thromboembolic pulmonary hypertension.
Title: Activated TAFI Promotes the Development of Chronic Thromboembolic Pulmonary Hypertension: A Possible Novel Therapeutic Target.

Cpb2-deficient mice had decreased pneumococcal meningitis mortality and attenuated cytokine levels and bacterial outgrowth in the systemic compartment but not in the brain compartment, as compared with wild-type mice.
Title: Thrombin-activatable fibrinolysis inhibitor influences disease severity in humans and mice with pneumococcal meningitis.

Carboxypeptidase B2 deficiency reveals that complement C3a limits infection and C5a exacerbates infection in a murine polymicrobial sepsis model.
Title: Carboxypeptidase B2 deficiency reveals opposite effects of complement C3a and C5a in a murine polymicrobial sepsis model.

In an induced osteoarthritis model, CPB2 knockout mice developed dramatically greater cartilage damage than did wild-type mice, had a greater number of osteophytes, and a greater degree of synovitis.
Title: Brief report: carboxypeptidase B serves as a protective mediator in osteoarthritis.

Combination of TAFI-I and a low dose of rtPA was not as effective as the standard dose of rtPA in treating thromboembolic stroke, while TAFI inhibition alone was not effective at all.
Title: Effects of a TAFI-inhibitor combined with a suboptimal dose of rtPA in a murine thromboembolic model of stroke.

The following Cpb2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cpb2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu18214	NM_019775.3 Latest version!	Mus musculus carboxypeptidase B2 (plasma) (Cpb2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cpb2 ( NM_019775.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_062749.2 Mus musculus carboxypeptidase B2 (plasma) (Cpb2), mRNA.

Price & Availability↑

CloneID	OMu18214
Clone ID Related Accession (Same CDS sequence)	NM_019775.3
Accession Version	NM_019775.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1269bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	carboxypeptidase B2 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AA048136.1, AK004045.1 and CO807338.1. On Aug 14, 2009 this sequence version replaced NM_019775.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF164524.1, BC089577.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849385, SAMN00849386 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGCTTC ATGGCCTTGG AATCCTGGTA GCCATCATCC TCTATGAGCA GCATGGCTTC 
GCCTTTCAGA GTGGCCAGGT TTTATCTGCT CTTCCAAGAA CCTCCAGGCA AGTTCAACTA 
CTTCAGAATC TTACTACAAC GTATGAGGTC GTTCTCTGGC AGCCAGTGAC AGCTGAATTC 
ATCGAGAAGA AAAAGGAAGT CCACTTTTTT GTGAATGCGT CTGATGTCGA CAGTGTCAAA 
GCGCATTTAA ATGTGAGCAG AATTCCATTT AACGTTCTGA TGAACAACGT GGAGGACCTA 
ATTGAACAGC AGACTTTCAA TGACACGGTC AGCCCCCGCG CCTCCGCTTC ATACTATGAG 
CAGTATCACT CGCTAAATGA AATCTATTCC TGGATAGAAG TCATAACTGA ACAGCATCCT 
GACATGCTCC AGAAAATCTA CATCGGATCA TCATTCGAGA AGTACCCACT TTATGTTTTA 
AAGGTCTCAG GAAAGGAACA AAGAATCAAA AATGCCATCT GGATCGACTG TGGAATCCAT 
GCCAGAGAAT GGATTTCACC TGCTTTCTGT TTGTGGTTCA TAGGCTACGT GACACAATTC 
CATGGGAAAG AAAATCTGTA TACCAGACTT CTGAGGCACG TGGATTTCTA CATCATGCCC 
GTGATGAACG TGGATGGCTA TGACTACACG TGGAAAAAGA ATCGAATGTG GAGGAAGAAC 
CGCTCTGCTC ACAAGAACAA CCGCTGCGTG GGCACAGACC TGAACAGGAA CTTCGCTTCC 
AAACACTGGT GTGAGAAAGG TGCGTCAAGT TCCTCCTGCT CTGAAACCTA CTGTGGACTT 
TATCCTGAGT CTGAGCCAGA GGTGAAGGCA GTGGCTGACT TCTTGAGAAG AAATATCGAC 
CACATTAAAG CTTACATCAG TATGCACTCA TACTCCCAAC AAATACTGTT TCCCTATTCC 
TATAACAGAA GCAAAAGCAA GGACCACGAA GAACTGTCTC TAGTGGCCAG CGAAGCAGTT 
CGTGCAATTG AAAGTATTAA TAAAAACACC AGGTACACAC ACGGCAGTGG CTCAGAAAGT 
TTATATCTAG CTCCTGGAGG TTCTGACGAT TGGATCTATG ATTTGGGCAT CAAATATTCG 
TTTACAATTG AGCTCCGAGA TACAGGCAGA TACGGATTCT TGCTGCCTGA GAGATACATC 
AAACCCACTT GTGCAGAAGC TTTGGCCGCC ATCTCTAAAA TAGTTTGGCA TGTCATCAGG 
AACACTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062749.2
CDS	69..1337
Translation	MKLHGLGILVAIILYEQHGFAFQSGQVLSALPRTSRQVQLLQNLTTTYEVVLWQPVTAEFIEKKKEVHFFVNASDVDSVKAHLNVSRIPFNVLMNNVEDLIEQQTFNDTVSPRASASYYEQYHSLNEIYSWIEVITEQHPDMLQKIYIGSSFEKYPLYVLKVSGKEQRIKNAIWIDCGIHAREWISPAFCLWFIGYVTQFHGKENLYTRLLRHVDFYIMPVMNVDGYDYTWKKNRMWRKNRSAHKNNRCVGTDLNRNFASKHWCEKGASSSSCSETYCGLYPESEPEVKAVADFLRRNIDHIKAYISMHSYSQQILFPYSYNRSKSKDHEELSLVASEAVRAIESINKNTRYTHGSGSESLYLAPGGSDDWIYDLGIKYSFTIELRDTGRYGFLLPERYIKPTCAEALAAISKIVWHVIRNT

Target ORF information:

RefSeq Version	NM_019775.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus carboxypeptidase B2 (plasma) (Cpb2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019775.3

ORF Insert Sequence:

ATGAAGCTTC ATGGCCTTGG AATCCTGGTA GCCATCATCC TCTATGAGCA GCATGGCTTC 
GCCTTTCAGA GTGGCCAGGT TTTATCTGCT CTTCCAAGAA CCTCCAGGCA AGTTCAACTA 
CTTCAGAATC TTACTACAAC GTATGAGGTC GTTCTCTGGC AGCCAGTGAC AGCTGAATTC 
ATCGAGAAGA AAAAGGAAGT CCACTTTTTT GTGAATGCGT CTGATGTCGA CAGTGTCAAA 
GCGCATTTAA ATGTGAGCAG AATTCCATTT AACGTTCTGA TGAACAACGT GGAGGACCTA 
ATTGAACAGC AGACTTTCAA TGACACGGTC AGCCCCCGCG CCTCCGCTTC ATACTATGAG 
CAGTATCACT CGCTAAATGA AATCTATTCC TGGATAGAAG TCATAACTGA ACAGCATCCT 
GACATGCTCC AGAAAATCTA CATCGGATCA TCATTCGAGA AGTACCCACT TTATGTTTTA 
AAGGTCTCAG GAAAGGAACA AAGAATCAAA AATGCCATCT GGATCGACTG TGGAATCCAT 
GCCAGAGAAT GGATTTCACC TGCTTTCTGT TTGTGGTTCA TAGGCTACGT GACACAATTC 
CATGGGAAAG AAAATCTGTA TACCAGACTT CTGAGGCACG TGGATTTCTA CATCATGCCC 
GTGATGAACG TGGATGGCTA TGACTACACG TGGAAAAAGA ATCGAATGTG GAGGAAGAAC 
CGCTCTGCTC ACAAGAACAA CCGCTGCGTG GGCACAGACC TGAACAGGAA CTTCGCTTCC 
AAACACTGGT GTGAGAAAGG TGCGTCAAGT TCCTCCTGCT CTGAAACCTA CTGTGGACTT 
TATCCTGAGT CTGAGCCAGA GGTGAAGGCA GTGGCTGACT TCTTGAGAAG AAATATCGAC 
CACATTAAAG CTTACATCAG TATGCACTCA TACTCCCAAC AAATACTGTT TCCCTATTCC 
TATAACAGAA GCAAAAGCAA GGACCACGAA GAACTGTCTC TAGTGGCCAG CGAAGCAGTT 
CGTGCAATTG AAAGTATTAA TAAAAACACC AGGTACACAC ACGGCAGTGG CTCAGAAAGT 
TTATATCTAG CTCCTGGAGG TTCTGACGAT TGGATCTATG ATTTGGGCAT CAAATATTCG 
TTTACAATTG AGCTCCGAGA TACAGGCAGA TACGGATTCT TGCTGCCTGA GAGATACATC 
AAACCCACTT GTGCAGAAGC TTTGGCCGCC ATCTCTAAAA TAGTTTGGCA TGTCATCAGG 
AACACTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Activated TAFI Promotes the Development of Chronic Thromboembolic Pulmonary Hypertension: A Possible Novel Therapeutic Target.
Circulation research120(8)1246-1262(2017 Apr)
Satoh T,Satoh K,Yaoita N,Kikuchi N,Omura J,Kurosawa R,Numano K,Al-Mamun E,Siddique MA,Sunamura S,Nogi M,Suzuki K,Miyata S,Morser J,Shimokawa H

Thrombin-activatable fibrinolysis inhibitor influences disease severity in humans and mice with pneumococcal meningitis.
Journal of thrombosis and haemostasis : JTH13(11)2076-86(2015 Nov)
Mook-Kanamori BB,Valls Ser?n M,Geldhoff M,Havik SR,van der Ende A,Baas F,van der Poll T,Meijers JC,P Morgan B,Brouwer MC,van de Beek D

Collaborative cross mice in a genetic association study reveal new candidate genes for bone microarchitecture.
BMC genomics161013(2015 Nov)
Levy R,Mott RF,Iraqi FA,Gabet Y

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Cpb2 cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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