Ubqln2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ubqln2
Entrez Gene ID	54609
Full Name	ubiquilin 2
Synonyms	Chap1,Dsk2,HRIHFB2157,Plic-2,Plic2
General protein information	Preferred Names ubiquilin 2 Names ubiquilin-2 Ubiquitin-related protein protein linking IAP with cytoskeleton 2 ubiquitin-like product Chap1/Dsk2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: X Map Location: X\|X F3

mRNA and Protein(s)

mRNA	Protein	Name
NM_018798.2	NP_061268.2	ubiquilin-2

Pathways from BioSystems

Homologies

Homo sapiens (human)	UBQLN2	NP_038472.2
Rattus norvegicus (Norway rat)	Ubqln2	NP_001101721.1
Bos taurus (cattle)	UBQLN2	NP_001192611.1
Mus musculus (house mouse)	Ubqln2	NP_061268.2
Caenorhabditis elegans (roundworm)	ubql-1	NP_740883.1
Arabidopsis thaliana (thale cress)	AT2G17190	NP_565407.1
Oryza sativa (rice)	Os10g0542200	NP_001065193.1
	LOC707967	XP_001096401.2
Pan troglodytes (chimpanzee)	UBQLN2	XP_003317539.1
Canis lupus familiaris (dog)	UBQLN2	XP_549029.3
Arabidopsis thaliana (thale cress)	DSK2	NP_179311.1
Oryza sativa (rice)	Os03g0131300	NP_001048862.1

Gene Ontology
Bibliography

Related articles in PubMed

Motor neuron disease, TDP-43 pathology, and memory deficits in mice expressing ALS-FTD-linked UBQLN2 mutations.
Le NT, Chang L, Kovlyagina I, Georgiou P, Safren N, Braunstein KE, Kvarta MD, Van Dyke AM, LeGates TA, Philips T, Morrison BM, Thompson SM, Puche AC, Gould TD, Rothstein JD, Wong PC, Monteiro MJ
Proceedings of the National Academy of Sciences of the United States of America113(47)E7580-E7589(2016 Nov)

UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome.
Hjerpe R, Bett JS, Keuss MJ, Solovyova A, McWilliams TG, Johnson C, Sahu I, Varghese J, Wood N, Wightman M, Osborne G, Bates GP, Glickman MH, Trost M, Knebel A, Marchesi F, Kurz T
Cell166(4)935-949(2016 Aug)

Ubiquilin-2 drives NF-?B activity and cytosolic TDP-43 aggregation in neuronal cells.
Picher-Martel V, Dutta K, Phaneuf D, Sobue G, Julien JP
Molecular brain8(1)71(2015 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

UBQLN2 most evidently bound to HSP70-type chaperones, UBQLN1 and UBQLN4 and to a lesser extent to proteasomal subunits; UBQLN2 may be involved in the regulation of misfolded proteins. Mutations in UBQLN2, which lead to neurodegeneration in humans, are defective in chaperone binding, impair aggregate clearance, and cause cognitive deficits in mice.
Title: UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome.

UBQLN2 dysregulation in neurons can drive NF-kappaB activation and cytosolic TDP-43 aggregation.
Title: Ubiquilin-2 drives NF-?B activity and cytosolic TDP-43 aggregation in neuronal cells.

Results showed that UBQLN2 is selectively recruited to nuclear inclusions in Huntington's disease but not spinocerebellar ataxia type 3
Title: Differential recruitment of UBQLN2 to nuclear inclusions in the polyglutamine diseases HD and SCA3.

Transduction of UBQLN2 mutants (P497H, P497S, and P506T) induce proteinopathy and cause behavioral deficits, supporting a "toxic" gain-of-function amyotrophic lateral sclerosis model, in mice.
Title: Viral expression of ALS-linked ubiquilin-2 mutants causes inclusion pathology and behavioral deficits in mice.

results were confirmed by similar findings for ubiquilin-1 and -2 in human brain tissue sections, where accumulation was observed in huntingtin inclusions
Title: Unbiased screen reveals ubiquilin-1 and -2 highly associated with huntingtin inclusions.

The following Ubqln2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ubqln2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu17497	NM_018798.2 Latest version!	Mus musculus ubiquilin 2 (Ubqln2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ubqln2 ( NM_018798.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_061268.2 Mus musculus ubiquilin 2 (Ubqln2), mRNA.

Price & Availability↑

CloneID	OMu17497
Clone ID Related Accession (Same CDS sequence)	NM_018798.2
Accession Version	NM_018798.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1917bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Mus musculus(house mouse)
Product	ubiquilin-2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC053022.1. On Aug 28, 2003 this sequence version replaced NM_018798.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC053022.1 [ECO:0000345] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGAGA ACGGCGAGAG CAGCGGCCCC CCGCGCCCCT CCCGCGGCCC TGCGGCGGCC 
CCAGGCGCGG CCAGCCCGCC GGCCGAGCCC AAAATCATCA AAGTCACTGT GAAGACCCCC 
AAAGAGAAGG AGGAGTTCGC GGTGCCCGAG AACAGCACCG TGCAGCAGTT CAAGGAAGCG 
ATTTCCAAAC GCTTCAAATC GCAGACCGAT CAGCTCGTGC TGATTTTCGC CGGAAAGATC 
CTGAAAGATC AAGATACCTT GATGCAGCAT GGCATCCATG ATGGACTGAC TGTTCACCTG 
GTTATCAAAA GCCAGAACCG TCCGCAGGGC CAGGCCACCA CGCAGCCCAG CACGACTGCG 
GGAACGAGCA CGACGACCAC GACCACCACC ACGGCGGCGG CGCCGGCGGC GACGACATCA 
TCGGCTCCCA GGAGTAGCTC CACACCTACC ACCACGAATA GCAGCTCCTT TGGGCTGGGA 
AGCCTTTCCA GCCTTAGTAA CCTGGGCTTG AACTCGCCCA ACTTCACCGA GCTTCAGAAC 
CAGATGCAGC AGCAGCTCCT GGCCAGCCCT GAGATGATGA TCCAGATCAT GGAAAATCCC 
TTTGTTCAGA GCATGCTTTC GAATCCTGAT CTGATGAGGC AGCTCATCAT GGCCAATCCA 
CAGATGCAAC AATTGATCCA GAGAAACCCA GAAATCAGCC ACCTACTGAA CAACCCAGAT 
ATAATGAGGC AGACGCTGGA AATCGCCAGG AATCCTGCCA TGATGCAAGA GATGATGCGA 
AATCAAGACC TGGCTCTCAG TAATCTCGAA AGCATCCCAG GTGGCTACAA TGCTCTGCGG 
CGCATGTACA CTGACATTCA AGAACCTATG CTGAATGCCG CACAGGAGCA GTTTGGGGGC 
AACCCGTTTG CCACGGTGGG GAGCAGTTCC ACCTCAGGGG AAGGTACTCA GCCCTCCCGC 
ACGGAGAATC GTGATCCGCT GCCCAATCCT TGGGCACCAC CGCCAACAAC CCAGACGGCT 
GCGACCACCA CCACCACCAC GACCACAAGC AGTGGCAGTG GCTCTGGCAG CAGCTCCAGC 
AGCACCACCG CCGGGAACAC CATGGCTGCA GCTAATTACG TGGCTAGCAT CTTCAGCACC 
CCAGGAATGC AGAGCCTGCT GCAGCAGATA ACTGAGAATC CCCAGCTGAT TCAGAATATG 
CTGTCTGCGC CCTACATGCG GAGCATGATG CAGTCGCTGA GCCAGAATCC AGATATGGCG 
GCCCAGATGA TGCTGAGTAG CCCGCTGTTC ACTTCGAATC CTCAGCTGCA GGAGCAGATG 
CGTCCACAGC TCCCGAATTT CCTGCAGCAG ATGCAGAATC CAGAAACCAT CGCGGCCATG 
TCAAACCCGA GAGCGATGCA AGCGCTAATG CAGATCCAGC AGGGGCTACA GACTCTAGCC 
ACTGAAGCAC CTGGCCTCAT TCCCAGCTTC GCTCCAGGTG TGGGGATGGG AGTGCTGGGA 
ACCGCCATAA CCCCTGTGGG CCCAGTCACT CCCATAGGGC CCATCGGCCC TATAGTTCCT 
TTCACCCCCA TAGGCCCCAT CGGGCCTATA GGACCCACTG GCCCTGCAAG CTCCCCCGGC 
TCCACCGGCA CTGGCATCCC GCCTGCAACC ACTGTGTCCA GCTCTGCACC TACTGAAACC 
ATAAGTCCAA CCTCGGAATC TGGACCCAAC CAGCAGTTCA TTCAACAAAT GGTGCAGGCT 
CTCACTGGAG GAAGCCCTCC ACAGCCGCCG AATCCTGAAG TGAGATTTCA GCAGCAACTG 
GAACAGCTCA ACGCCATGGG GTTCTTAAAC CGCGAAGCAA ACTTGCAGGC CCTAATAGCA 
ACAGGAGGCG ACATCAACGC GGCCATTGAG AGGCTGCTGG GCTCTCAGCC ATCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_061268.2
CDS	223..2139
Translation	MAENGESSGPPRPSRGPAAAPGAASPPAEPKIIKVTVKTPKEKEEFAVPENSTVQQFKEAISKRFKSQTDQLVLIFAGKILKDQDTLMQHGIHDGLTVHLVIKSQNRPQGQATTQPSTTAGTSTTTTTTTTAAAPAATTSSAPRSSSTPTTTNSSSFGLGSLSSLSNLGLNSPNFTELQNQMQQQLLASPEMMIQIMENPFVQSMLSNPDLMRQLIMANPQMQQLIQRNPEISHLLNNPDIMRQTLEIARNPAMMQEMMRNQDLALSNLESIPGGYNALRRMYTDIQEPMLNAAQEQFGGNPFATVGSSSTSGEGTQPSRTENRDPLPNPWAPPPTTQTAATTTTTTTTSSGSGSGSSSSSTTAGNTMAAANYVASIFSTPGMQSLLQQITENPQLIQNMLSAPYMRSMMQSLSQNPDMAAQMMLSSPLFTSNPQLQEQMRPQLPNFLQQMQNPETIAAMSNPRAMQALMQIQQGLQTLATEAPGLIPSFAPGVGMGVLGTAITPVGPVTPIGPIGPIVPFTPIGPIGPIGPTGPASSPGSTGTGIPPATTVSSSAPTETISPTSESGPNQQFIQQMVQALTGGSPPQPPNPEVRFQQQLEQLNAMGFLNREANLQALIATGGDINAAIERLLGSQPS

Target ORF information:

RefSeq Version	NM_018798.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus ubiquilin 2 (Ubqln2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018798.2

ORF Insert Sequence:

ATGGCTGAGA ACGGCGAGAG CAGCGGCCCC CCGCGCCCCT CCCGCGGCCC TGCGGCGGCC 
CCAGGCGCGG CCAGCCCGCC GGCCGAGCCC AAAATCATCA AAGTCACTGT GAAGACCCCC 
AAAGAGAAGG AGGAGTTCGC GGTGCCCGAG AACAGCACCG TGCAGCAGTT CAAGGAAGCG 
ATTTCCAAAC GCTTCAAATC GCAGACCGAT CAGCTCGTGC TGATTTTCGC CGGAAAGATC 
CTGAAAGATC AAGATACCTT GATGCAGCAT GGCATCCATG ATGGACTGAC TGTTCACCTG 
GTTATCAAAA GCCAGAACCG TCCGCAGGGC CAGGCCACCA CGCAGCCCAG CACGACTGCG 
GGAACGAGCA CGACGACCAC GACCACCACC ACGGCGGCGG CGCCGGCGGC GACGACATCA 
TCGGCTCCCA GGAGTAGCTC CACACCTACC ACCACGAATA GCAGCTCCTT TGGGCTGGGA 
AGCCTTTCCA GCCTTAGTAA CCTGGGCTTG AACTCGCCCA ACTTCACCGA GCTTCAGAAC 
CAGATGCAGC AGCAGCTCCT GGCCAGCCCT GAGATGATGA TCCAGATCAT GGAAAATCCC 
TTTGTTCAGA GCATGCTTTC GAATCCTGAT CTGATGAGGC AGCTCATCAT GGCCAATCCA 
CAGATGCAAC AATTGATCCA GAGAAACCCA GAAATCAGCC ACCTACTGAA CAACCCAGAT 
ATAATGAGGC AGACGCTGGA AATCGCCAGG AATCCTGCCA TGATGCAAGA GATGATGCGA 
AATCAAGACC TGGCTCTCAG TAATCTCGAA AGCATCCCAG GTGGCTACAA TGCTCTGCGG 
CGCATGTACA CTGACATTCA AGAACCTATG CTGAATGCCG CACAGGAGCA GTTTGGGGGC 
AACCCGTTTG CCACGGTGGG GAGCAGTTCC ACCTCAGGGG AAGGTACTCA GCCCTCCCGC 
ACGGAGAATC GTGATCCGCT GCCCAATCCT TGGGCACCAC CGCCAACAAC CCAGACGGCT 
GCGACCACCA CCACCACCAC GACCACAAGC AGTGGCAGTG GCTCTGGCAG CAGCTCCAGC 
AGCACCACCG CCGGGAACAC CATGGCTGCA GCTAATTACG TGGCTAGCAT CTTCAGCACC 
CCAGGAATGC AGAGCCTGCT GCAGCAGATA ACTGAGAATC CCCAGCTGAT TCAGAATATG 
CTGTCTGCGC CCTACATGCG GAGCATGATG CAGTCGCTGA GCCAGAATCC AGATATGGCG 
GCCCAGATGA TGCTGAGTAG CCCGCTGTTC ACTTCGAATC CTCAGCTGCA GGAGCAGATG 
CGTCCACAGC TCCCGAATTT CCTGCAGCAG ATGCAGAATC CAGAAACCAT CGCGGCCATG 
TCAAACCCGA GAGCGATGCA AGCGCTAATG CAGATCCAGC AGGGGCTACA GACTCTAGCC 
ACTGAAGCAC CTGGCCTCAT TCCCAGCTTC GCTCCAGGTG TGGGGATGGG AGTGCTGGGA 
ACCGCCATAA CCCCTGTGGG CCCAGTCACT CCCATAGGGC CCATCGGCCC TATAGTTCCT 
TTCACCCCCA TAGGCCCCAT CGGGCCTATA GGACCCACTG GCCCTGCAAG CTCCCCCGGC 
TCCACCGGCA CTGGCATCCC GCCTGCAACC ACTGTGTCCA GCTCTGCACC TACTGAAACC 
ATAAGTCCAA CCTCGGAATC TGGACCCAAC CAGCAGTTCA TTCAACAAAT GGTGCAGGCT 
CTCACTGGAG GAAGCCCTCC ACAGCCGCCG AATCCTGAAG TGAGATTTCA GCAGCAACTG 
GAACAGCTCA ACGCCATGGG GTTCTTAAAC CGCGAAGCAA ACTTGCAGGC CCTAATAGCA 
ACAGGAGGCG ACATCAACGC GGCCATTGAG AGGCTGCTGG GCTCTCAGCC ATCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Motor neuron disease, TDP-43 pathology, and memory deficits in mice expressing ALS-FTD-linked UBQLN2 mutations.
Proceedings of the National Academy of Sciences of the United States of America113(47)E7580-E7589(2016 Nov)
Le NT,Chang L,Kovlyagina I,Georgiou P,Safren N,Braunstein KE,Kvarta MD,Van Dyke AM,LeGates TA,Philips T,Morrison BM,Thompson SM,Puche AC,Gould TD,Rothstein JD,Wong PC,Monteiro MJ

UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome.
Cell166(4)935-949(2016 Aug)
Hjerpe R,Bett JS,Keuss MJ,Solovyova A,McWilliams TG,Johnson C,Sahu I,Varghese J,Wood N,Wightman M,Osborne G,Bates GP,Glickman MH,Trost M,Knebel A,Marchesi F,Kurz T

Ubiquilin-2 drives NF-?B activity and cytosolic TDP-43 aggregation in neuronal cells.
Molecular brain8(1)71(2015 Oct)
Picher-Martel V,Dutta K,Phaneuf D,Sobue G,Julien JP