Elovl2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Elovl2
Entrez Gene ID	54326
Full Name	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2
Synonyms	AI317360,Ssc2
General protein information	Preferred Names elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2 Names elongation of very long chain fatty acids protein 2 3-keto acyl-CoA synthase Elovl2 ELOVL FA elongase 2 ELOVL family member 2 ELOVL fatty acid elongase 2 sequence similarity to Cig30 2 very long chain 3-ketoacyl-CoA synthase 2 very long chain 3-oxoacyl-CoA synthase 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 13 Map Location: 13\|13 A3.3

mRNA and Protein(s)

mRNA	Protein	Name
NM_001311121.1	NP_001298050.1	elongation of very long chain fatty acids protein 2 isoform 2
NM_019423.2	NP_062296.1	elongation of very long chain fatty acids protein 2 isoform 1

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	elovl2	NP_001035452.1
Canis lupus familiaris (dog)	ELOVL2	XP_005640091.1
Mus musculus (house mouse)	Elovl2	NP_062296.1
Gallus gallus (chicken)	ELOVL2	NP_001184237.1
Homo sapiens (human)	ELOVL2	NP_060240.3
	ELOVL2	XP_001091337.1
Bos taurus (cattle)	ELOVL2	NP_001076986.1
Rattus norvegicus (Norway rat)	Elovl2	NP_001102588.1
Xenopus tropicalis (tropical clawed frog)	elovl2	NP_001016159.1
Pan troglodytes (chimpanzee)	ELOVL2	XP_001175069.1

Gene Ontology
Bibliography

Related articles in PubMed

Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for
Cruciani-Guglielmacci C, Bellini L, Denom J, Oshima M, Fernandez N, Normandie-Levi P, Berney XP, Kassis N, Rouch C, Dairou J, Gorman T, Smith DM, Marley A, Liechti R, Kuznetsov D, Wigger L, Burdet F, Lef?vre AL, Wehrle I, Uphues I, Hildebrandt T, Rust W, Bernard C, Ktorza A, Rutter GA, Scharfmann R, Xenarios I, Le Stunff H, Thorens B, Magnan C, Ibberson M
Molecular metabolism6(4)340-351(2017 Apr)

Both maternal and offspring Elovl2 genotypes determine systemic DHA levels in perinatal mice.
Pauter AM, Trattner S, Gonzalez-Bengtsson A, Talamonti E, Asadi A, Dethlefsen O, Jacobsson A
Journal of lipid research58(1)111-123(2017 Jan)

Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil.
Lau CG, Marikawa Y
Molecular reproduction and development81(11)994-1008(2014 Nov)

Elovl2 ablation demonstrates that systemic DHA is endogenously produced and is essential for lipid homeostasis in mice.
Pauter AM, Olsson P, Asadi A, Hersl?f B, Csikasz RI, Zadravec D, Jacobsson A
Journal of lipid research55(4)718-28(2014 Apr)

Impaired epidermal permeability barrier in mice lacking elovl1, the gene responsible for very-long-chain fatty acid production.
Sassa T, Ohno Y, Suzuki S, Nomura T, Nishioka C, Kashiwagi T, Hirayama T, Akiyama M, Taguchi R, Shimizu H, Itohara S, Kihara A
Molecular and cellular biology33(14)2787-96(2013 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The proportion of DHA in the liver and serum of the Elovl2(-/-) offspring was significantly lower than in the Elovl2(+/+) offspring. Remarkably, the DHA level in the Elovl2(+/-) offspring nursed by DHA-free-fed Elovl2(-/-) mothers was almost as high as in +/+ pups delivered by +/+ mothers, suggesting that endogenous synthesis in the offspring can compensate for maternal DHA deficiency.
Title: Both maternal and offspring Elovl2 genotypes determine systemic DHA levels in perinatal mice.

Liver docosahexanoic acid synthesis (via ELOVL2), in addition to controlling de novo lipogenesis, also regulates lipid storage and fat mass expansion in an SREBP-1c-independent fashion.
Title: Elovl2 ablation demonstrates that systemic DHA is endogenously produced and is essential for lipid homeostasis in mice.

heterozygous Elovl2(+/-) male mice exhibited haploinsufficiency, with reduced levels of C28:5 and C30:5n-6 PUFAs, which gave rise to impaired formation and function of haploid spermatides.
Title: ELOVL2 controls the level of n-6 28:5 and 30:5 fatty acids in testis, a prerequisite for male fertility and sperm maturation in mice.

ELOVL2 overexpression enhances triacylglycerol synthesis in 3T3-L1 and F442A cells.
Title: ELOVL2 overexpression enhances triacylglycerol synthesis in 3T3-L1 and F442A cells.

The following Elovl2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Elovl2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu17458	NM_019423.2 Latest version!	Mus musculus elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2 (Elovl2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00
OMu69532	NM_001311121.1 Latest version!	Mus musculus elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2 (Elovl2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Elovl2 ( NM_019423.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_062296.1 Mus musculus elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2 (Elovl2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu17458
Clone ID Related Accession (Same CDS sequence)	NM_019423.2
Accession Version	NM_019423.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 879bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Mus musculus(house mouse)
Product	elongation of very long chain fatty acids protein 2 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY126714.1, BC098215.1, BB277808.1 and BB279541.1. On Dec 8, 2007 this sequence version replaced NM_019423.1. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660819.68762.1, AK044770.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164143 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCAGC TGAAGGCCTT TGATAATGAA GTCAATGCTT TCTTGGACAA CATGTTTGGA 
CCACGAGATT CTCGAGTTCG CGGGTGGTTC CTGCTGGACT CTTACCTTCC CACCTTCATC 
CTCACCATCA CGTACCTGCT CTCGATATGG CTGGGTAACA AGTACATGAA GAACAGGCCT 
GCTCTGTCTC TCAGGGGCAT CCTCACCTTG TATAACCTCG CAATCACACT TCTTTCTGCG 
TATATGCTGG TGGAGCTCAT CCTCTCCAGC TGGGAAGGAG GTTACAACTT GCAGTGTCAG 
AATCTCGACA GTGCAGGAGA AGGTGATGTC CGGGTAGCCA AGGTCTTGTG GTGGTACTAC 
TTCTCCAAAC TAGTGGAGTT CCTGGACACG ATTTTCTTTG TTCTACGAAA AAAGACCAAT 
CAGATCACCT TCCTTCATGT CTATCACCAC GCGTCCATGT TCAACATCTG GTGGTGTGTT 
TTGAACTGGA TACCTTGTGG TCAAAGCTTC TTTGGACCCA CCCTGAACAG CTTTATCCAC 
ATTCTCATGT ACTCCTACTA CGGCCTGTCT GTGTTCCCGT CCATGCACAA GTACCTTTGG 
TGGAAGAAGT ACCTCACACA GGCTCAGCTG GTGCAGTTCG TACTCACCAT CACGCACACG 
CTGAGTGCCG TGGTGAAGCC CTGTGGCTTC CCCTTTGGCT GTCTCATCTT CCAGTCTTCC 
TATATGATGA CGCTGGTCAT CCTGTTCTTA AACTTCTATA TTCAGACATA CCGGAAAAAG 
CCAGTGAAGA AAGAGCTGCA AGAGAAAGAA GTGAAGAATG GTTTCCCCAA AGCCCACTTA 
ATTGTGGCTA ATGGCATGAC GGACAAGAAG GCTCAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062296.1
CDS	47..925
Translation	MEQLKAFDNEVNAFLDNMFGPRDSRVRGWFLLDSYLPTFILTITYLLSIWLGNKYMKNRPALSLRGILTLYNLAITLLSAYMLVELILSSWEGGYNLQCQNLDSAGEGDVRVAKVLWWYYFSKLVEFLDTIFFVLRKKTNQITFLHVYHHASMFNIWWCVLNWIPCGQSFFGPTLNSFIHILMYSYYGLSVFPSMHKYLWWKKYLTQAQLVQFVLTITHTLSAVVKPCGFPFGCLIFQSSYMMTLVILFLNFYIQTYRKKPVKKELQEKEVKNGFPKAHLIVANGMTDKKAQ

Target ORF information:

RefSeq Version	NM_019423.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2 (Elovl2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019423.2

ORF Insert Sequence:

ATGGAGCAGC TGAAGGCCTT TGATAATGAA GTCAATGCTT TCTTGGACAA CATGTTTGGA 
CCACGAGATT CTCGAGTTCG CGGGTGGTTC CTGCTGGACT CTTACCTTCC CACCTTCATC 
CTCACCATCA CGTACCTGCT CTCGATATGG CTGGGTAACA AGTACATGAA GAACAGGCCT 
GCTCTGTCTC TCAGGGGCAT CCTCACCTTG TATAACCTCG CAATCACACT TCTTTCTGCG 
TATATGCTGG TGGAGCTCAT CCTCTCCAGC TGGGAAGGAG GTTACAACTT GCAGTGTCAG 
AATCTCGACA GTGCAGGAGA AGGTGATGTC CGGGTAGCCA AGGTCTTGTG GTGGTACTAC 
TTCTCCAAAC TAGTGGAGTT CCTGGACACG ATTTTCTTTG TTCTACGAAA AAAGACCAAT 
CAGATCACCT TCCTTCATGT CTATCACCAC GCGTCCATGT TCAACATCTG GTGGTGTGTT 
TTGAACTGGA TACCTTGTGG TCAAAGCTTC TTTGGACCCA CCCTGAACAG CTTTATCCAC 
ATTCTCATGT ACTCCTACTA CGGCCTGTCT GTGTTCCCGT CCATGCACAA GTACCTTTGG 
TGGAAGAAGT ACCTCACACA GGCTCAGCTG GTGCAGTTCG TACTCACCAT CACGCACACG 
CTGAGTGCCG TGGTGAAGCC CTGTGGCTTC CCCTTTGGCT GTCTCATCTT CCAGTCTTCC 
TATATGATGA CGCTGGTCAT CCTGTTCTTA AACTTCTATA TTCAGACATA CCGGAAAAAG 
CCAGTGAAGA AAGAGCTGCA AGAGAAAGAA GTGAAGAATG GTTTCCCCAA AGCCCACTTA 
ATTGTGGCTA ATGGCATGAC GGACAAGAAG GCTCAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Elovl2 ( NM_001311121.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001298050.1 Mus musculus elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2 (Elovl2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu69532
Clone ID Related Accession (Same CDS sequence)	NM_001311121.1
Accession Version	NM_001311121.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 828bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Mus musculus(house mouse)
Product	elongation of very long chain fatty acids protein 2 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK014803.1 and AC158538.2. On Jul 24, 2015 this sequence version replaced XM_006516936.2. Transcript Variant: This variant (2) lacks an alternate 5' exon and includes an alternate 5' terminal exon compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK014803.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164143 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTTGGAC CACGAGATTC TCGAGTTCGC GGGTGGTTCC TGCTGGACTC TTACCTTCCC 
ACCTTCATCC TCACCATCAC GTACCTGCTC TCGATATGGC TGGGTAACAA GTACATGAAG 
AACAGGCCTG CTCTGTCTCT CAGGGGCATC CTCACCTTGT ATAACCTCGC AATCACACTT 
CTTTCTGCGT ATATGCTGGT GGAGCTCATC CTCTCCAGCT GGGAAGGAGG TTACAACTTG 
CAGTGTCAGA ATCTCGACAG TGCAGGAGAA GGTGATGTCC GGGTAGCCAA GGTCTTGTGG 
TGGTACTACT TCTCCAAACT AGTGGAGTTC CTGGACACGA TTTTCTTTGT TCTACGAAAA 
AAGACCAATC AGATCACCTT CCTTCATGTC TATCACCACG CGTCCATGTT CAACATCTGG 
TGGTGTGTTT TGAACTGGAT ACCTTGTGGT CAAAGCTTCT TTGGACCCAC CCTGAACAGC 
TTTATCCACA TTCTCATGTA CTCCTACTAC GGCCTGTCTG TGTTCCCGTC CATGCACAAG 
TACCTTTGGT GGAAGAAGTA CCTCACACAG GCTCAGCTGG TGCAGTTCGT ACTCACCATC 
ACGCACACGC TGAGTGCCGT GGTGAAGCCC TGTGGCTTCC CCTTTGGCTG TCTCATCTTC 
CAGTCTTCCT ATATGATGAC GCTGGTCATC CTGTTCTTAA ACTTCTATAT TCAGACATAC 
CGGAAAAAGC CAGTGAAGAA AGAGCTGCAA GAGAAAGAAG TGAAGAATGG TTTCCCCAAA 
GCCCACTTAA TTGTGGCTAA TGGCATGACG GACAAGAAGG CTCAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001298050.1
CDS	175..1002
Translation	MFGPRDSRVRGWFLLDSYLPTFILTITYLLSIWLGNKYMKNRPALSLRGILTLYNLAITLLSAYMLVELILSSWEGGYNLQCQNLDSAGEGDVRVAKVLWWYYFSKLVEFLDTIFFVLRKKTNQITFLHVYHHASMFNIWWCVLNWIPCGQSFFGPTLNSFIHILMYSYYGLSVFPSMHKYLWWKKYLTQAQLVQFVLTITHTLSAVVKPCGFPFGCLIFQSSYMMTLVILFLNFYIQTYRKKPVKKELQEKEVKNGFPKAHLIVANGMTDKKAQ

Target ORF information:

RefSeq Version	NM_001311121.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2 (Elovl2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001311121.1

ORF Insert Sequence:

ATGTTTGGAC CACGAGATTC TCGAGTTCGC GGGTGGTTCC TGCTGGACTC TTACCTTCCC 
ACCTTCATCC TCACCATCAC GTACCTGCTC TCGATATGGC TGGGTAACAA GTACATGAAG 
AACAGGCCTG CTCTGTCTCT CAGGGGCATC CTCACCTTGT ATAACCTCGC AATCACACTT 
CTTTCTGCGT ATATGCTGGT GGAGCTCATC CTCTCCAGCT GGGAAGGAGG TTACAACTTG 
CAGTGTCAGA ATCTCGACAG TGCAGGAGAA GGTGATGTCC GGGTAGCCAA GGTCTTGTGG 
TGGTACTACT TCTCCAAACT AGTGGAGTTC CTGGACACGA TTTTCTTTGT TCTACGAAAA 
AAGACCAATC AGATCACCTT CCTTCATGTC TATCACCACG CGTCCATGTT CAACATCTGG 
TGGTGTGTTT TGAACTGGAT ACCTTGTGGT CAAAGCTTCT TTGGACCCAC CCTGAACAGC 
TTTATCCACA TTCTCATGTA CTCCTACTAC GGCCTGTCTG TGTTCCCGTC CATGCACAAG 
TACCTTTGGT GGAAGAAGTA CCTCACACAG GCTCAGCTGG TGCAGTTCGT ACTCACCATC 
ACGCACACGC TGAGTGCCGT GGTGAAGCCC TGTGGCTTCC CCTTTGGCTG TCTCATCTTC 
CAGTCTTCCT ATATGATGAC GCTGGTCATC CTGTTCTTAA ACTTCTATAT TCAGACATAC 
CGGAAAAAGC CAGTGAAGAA AGAGCTGCAA GAGAAAGAAG TGAAGAATGG TTTCCCCAAA 
GCCCACTTAA TTGTGGCTAA TGGCATGACG GACAAGAAGG CTCAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for
Molecular metabolism6(4)340-351(2017 Apr)
Cruciani-Guglielmacci C,Bellini L,Denom J,Oshima M,Fernandez N,Normandie-Levi P,Berney XP,Kassis N,Rouch C,Dairou J,Gorman T,Smith DM,Marley A,Liechti R,Kuznetsov D,Wigger L,Burdet F,Lef?vre AL,Wehrle I,Uphues I,Hildebrandt T,Rust W,Bernard C,Ktorza A,Rutter GA,Scharfmann R,Xenarios I,Le Stunff H,Thorens B,Magnan C,Ibberson M

Both maternal and offspring Elovl2 genotypes determine systemic DHA levels in perinatal mice.
Journal of lipid research58(1)111-123(2017 Jan)
Pauter AM,Trattner S,Gonzalez-Bengtsson A,Talamonti E,Asadi A,Dethlefsen O,Jacobsson A

Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil.
Molecular reproduction and development81(11)994-1008(2014 Nov)
Lau CG,Marikawa Y

Elovl2 ablation demonstrates that systemic DHA is endogenously produced and is essential for lipid homeostasis in mice.
Journal of lipid research55(4)718-28(2014 Apr)
Pauter AM,Olsson P,Asadi A,Hersl?f B,Csikasz RI,Zadravec D,Jacobsson A

Impaired epidermal permeability barrier in mice lacking elovl1, the gene responsible for very-long-chain fatty acid production.
Molecular and cellular biology33(14)2787-96(2013 Jul)
Sassa T,Ohno Y,Suzuki S,Nomura T,Nishioka C,Kashiwagi T,Hirayama T,Akiyama M,Taguchi R,Shimizu H,Itohara S,Kihara A

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Elovl2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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