Ppp1r3c cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ppp1r3c
Entrez Gene ID	53412
Full Name	protein phosphatase 1, regulatory (inhibitor) subunit 3C
Synonyms	PTG,Ppp1r5
General protein information	Preferred Names protein phosphatase 1, regulatory (inhibitor) subunit 3C Names protein phosphatase 1 regulatory subunit 3C PP1 subunit R5 ppp1r3c protein phosphatase 1 binding protein PTG protein phosphatase 1 regulatory subunit 5 protein phosphatase 1, regulatory (inhibitor) subunit 5 protein targeting to glicogen protein targeting to glycogen
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 19 Map Location: 19\|19 C2

mRNA and Protein(s)

mRNA	Protein	Name
NM_016854.2	NP_058550.1	protein phosphatase 1 regulatory subunit 3C

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	PPP1R3C	XP_534961.3
Rattus norvegicus (Norway rat)	Ppp1r3c	NP_001012072.1
Pan troglodytes (chimpanzee)	PPP1R3C	XP_507911.2
Gallus gallus (chicken)	PPP1R3C	XP_423102.2
	PPP1R3C	XP_001088532.1
Bos taurus (cattle)	PPP1R3C	NP_001069632.1
Mus musculus (house mouse)	Ppp1r3c	NP_058550.1
Homo sapiens (human)	PPP1R3C	NP_005389.1
Rattus norvegicus (Norway rat)	LOC100910671	XP_006231374.1
Danio rerio (zebrafish)	ppp1r3cb	NP_957128.1
Xenopus tropicalis (tropical clawed frog)	ppp1r3c.1	NP_001106579.1

Gene Ontology
Bibliography

Related articles in PubMed

Effects of hepatic glycogen on food intake and glucose homeostasis are mediated by the vagus nerve in mice.
L?pez-Soldado I, Fuentes-Romero R, Duran J, Guinovart JJ
Diabetologia60(6)1076-1083(2017 Jun)

Elf5 is a principal cell lineage specific transcription factor in the kidney that contributes to Aqp2 and Avpr2 gene expression.
Grassmeyer J, Mukherjee M, deRiso J, Hettinger C, Bailey M, Sinha S, Visvader JE, Zhao H, Fogarty E, Surendran K
Developmental biology424(1)77-89(2017 04)

Loss of Zeb2 in mesenchyme-derived nephrons causes primary glomerulocystic disease.
Rasouly HM, Kumar S, Chan S, Pisarek-Horowitz A, Sharma R, Xi QJ, Nishizaki Y, Higashi Y, Salant DJ, Maas RL, Lu W
Kidney international90(6)1262-1273(2016 Dec)

Metabolic crosstalk: molecular links between glycogen and lipid metabolism in obesity.
Lu B, Bridges D, Yang Y, Fisher K, Cheng A, Chang L, Meng ZX, Lin JD, Downes M, Yu RT, Liddle C, Evans RM, Saltiel AR
Diabetes63(9)2935-48(2014 Sep)

PTG protein depletion rescues malin-deficient Lafora disease in mouse.
Turnbull J, Epp JR, Goldsmith D, Zhao X, Pencea N, Wang P, Frankland PW, Ackerley CA, Minassian BA
Annals of neurology75(3)442-6(2014 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

metabolic crosstalk is due to decreased mTORC1 and SREBP activity in PTG knockout mice or knockdown cells, suggesting a positive feedback loop in which once accumulated, glycogen stimulates the mTORC1/SREBP1 pathway to shift energy storage to lipogenesis.
Title: Metabolic crosstalk: molecular links between glycogen and lipid metabolism in obesity.

removing PTG, a glycogen synthesis activator protein, nearly completely eliminates Lafora bodies and rescues the neurodegeneration, myoclonus,seizure susceptibility, and behavioral abnormality.
Title: PTG protein depletion rescues malin-deficient Lafora disease in mouse.

Laforin-deficient mice lacking PTG have greatly decreased Lafora bodies and normal glycogen levels.
Title: PTG depletion removes Lafora bodies and rescues the fatal epilepsy of Lafora disease.

mouse protein targeting to glycogen (PTG) promoter is regulated by the FoxA2 forkhead protein and by 3',5'-cyclic adenosine 5'-monophosphate in H4IIE hepatoma cells
Title: Regulation of the mouse protein targeting to glycogen (PTG) promoter by the FoxA2 forkhead protein and by 3',5'-cyclic adenosine 5'-monophosphate in H4IIE hepatoma cells.

These data indicate that disruption of PTG expression resulted in the uncoupling of PP1 activity from glycogen metabolizing enzymes, the enhancement of glycogenolysis, and a dramatic decrease in cellular glycogen levels.
Title: Central role for protein targeting to glycogen in the maintenance of cellular glycogen stores in 3T3-L1 adipocytes.

The following Ppp1r3c gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ppp1r3c cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu10695	NM_016854.2 Latest version!	Mus musculus protein phosphatase 1, regulatory subunit 3C (Ppp1r3c), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ppp1r3c ( NM_016854.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_058550.1 Mus musculus protein phosphatase 1, regulatory subunit 3C (Ppp1r3c), mRNA.

Price & Availability↑

CloneID	OMu10695
Clone ID Related Accession (Same CDS sequence)	NM_016854.2
Accession Version	NM_016854.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 954bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	protein phosphatase 1 regulatory subunit 3C
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC054739.1. On Jun 3, 2007 this sequence version replaced NM_016854.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC054739.1, BC052769.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164135 [ECO:0000348] ##Evidence-Data-END##

ATGAGCTGCA CCAGAATGAT CCATGTGCTA GATCCACGTC CTTTGACAAG TTCCGTCATG 
CCCGTGGACA TGGCCATGAG GATTTGCTTG GCTCATTCAC CACCTCTGAA GAGTTTCCTG 
GGTCCTTACA ATGGTTTTCA ACGAAGAAAT TTTGTGAATA AATTGAAACC TTTGAAACCA 
TGTCTCAGTG TCAAGCAGGA AGCCAAATCG CAGAGTGAGT GGAAGAGCCC ACACAACCAA 
GCCAAGAAGC GGGTCGTGTT TGCGGACTCC AAGGGGCTGT CACTCACTGC TATCCATGTC 
TTCTCCGACC TTCCAGAAGA ACCAGCGTGG GACCTGCAGT TTGATCTCTT GGACCTTAAC 
GATATCTCCT CCAGCTTAAA ACTTCACGAG GAGAAAAATT TGGTTTTTGA TTTTCCCCAG 
CCCTCAACCG ACTACTTAAG TTTCCGGGAC CGCTTTCAGA AGAACTTTGT CTGCCTCGAG 
AACTGCTCTT TGCAAGATCG GACGGTGACC GGGACAGTGA AAGTGAAGAA TGTGAGCTTT 
GAGAAGAAGG TTCAGGTCCG GATCACCTTT GACACCTGGA AAACCTACAC AGATGTGGAC 
TGTGTCTACA TGAAGAATGT TTACAGCAGC TCAGACAGCG ACACCTTCTC CTTTGCCATC 
GACTTGCCCC GTGTCATTCC AACTGAGGAG AAAATTGAGT TCTGCATTTC TTATCACGCT 
AATGGGAGGA TCTTCTGGGA CAACAATGAG GGTCAGAATT ACAGAATTGT CCATGTGCAA 
TGGAAACCTG ACGGAGTGCA GACTCAGGTG GCACCCAAAG ACTGTGCATT CCAACAGGGG 
CCCCCTAAGA CTGAGATAGA GCCCACAGTC TTTGGCAGTC CAAGGCTTGC TAGCGGCCTC 
TTCCCAGAGT GGCAGAGCTG GGGGAGAGTG GAGAACTTGA CCTCCTATCG ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058550.1
CDS	39..992
Translation	MSCTRMIHVLDPRPLTSSVMPVDMAMRICLAHSPPLKSFLGPYNGFQRRNFVNKLKPLKPCLSVKQEAKSQSEWKSPHNQAKKRVVFADSKGLSLTAIHVFSDLPEEPAWDLQFDLLDLNDISSSLKLHEEKNLVFDFPQPSTDYLSFRDRFQKNFVCLENCSLQDRTVTGTVKVKNVSFEKKVQVRITFDTWKTYTDVDCVYMKNVYSSSDSDTFSFAIDLPRVIPTEEKIEFCISYHANGRIFWDNNEGQNYRIVHVQWKPDGVQTQVAPKDCAFQQGPPKTEIEPTVFGSPRLASGLFPEWQSWGRVENLTSYR

Target ORF information:

RefSeq Version	NM_016854.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus protein phosphatase 1, regulatory subunit 3C (Ppp1r3c), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016854.2

ORF Insert Sequence:

ATGAGCTGCA CCAGAATGAT CCATGTGCTA GATCCACGTC CTTTGACAAG TTCCGTCATG 
CCCGTGGACA TGGCCATGAG GATTTGCTTG GCTCATTCAC CACCTCTGAA GAGTTTCCTG 
GGTCCTTACA ATGGTTTTCA ACGAAGAAAT TTTGTGAATA AATTGAAACC TTTGAAACCA 
TGTCTCAGTG TCAAGCAGGA AGCCAAATCG CAGAGTGAGT GGAAGAGCCC ACACAACCAA 
GCCAAGAAGC GGGTCGTGTT TGCGGACTCC AAGGGGCTGT CACTCACTGC TATCCATGTC 
TTCTCCGACC TTCCAGAAGA ACCAGCGTGG GACCTGCAGT TTGATCTCTT GGACCTTAAC 
GATATCTCCT CCAGCTTAAA ACTTCACGAG GAGAAAAATT TGGTTTTTGA TTTTCCCCAG 
CCCTCAACCG ACTACTTAAG TTTCCGGGAC CGCTTTCAGA AGAACTTTGT CTGCCTCGAG 
AACTGCTCTT TGCAAGATCG GACGGTGACC GGGACAGTGA AAGTGAAGAA TGTGAGCTTT 
GAGAAGAAGG TTCAGGTCCG GATCACCTTT GACACCTGGA AAACCTACAC AGATGTGGAC 
TGTGTCTACA TGAAGAATGT TTACAGCAGC TCAGACAGCG ACACCTTCTC CTTTGCCATC 
GACTTGCCCC GTGTCATTCC AACTGAGGAG AAAATTGAGT TCTGCATTTC TTATCACGCT 
AATGGGAGGA TCTTCTGGGA CAACAATGAG GGTCAGAATT ACAGAATTGT CCATGTGCAA 
TGGAAACCTG ACGGAGTGCA GACTCAGGTG GCACCCAAAG ACTGTGCATT CCAACAGGGG 
CCCCCTAAGA CTGAGATAGA GCCCACAGTC TTTGGCAGTC CAAGGCTTGC TAGCGGCCTC 
TTCCCAGAGT GGCAGAGCTG GGGGAGAGTG GAGAACTTGA CCTCCTATCG ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Effects of hepatic glycogen on food intake and glucose homeostasis are mediated by the vagus nerve in mice.
Diabetologia60(6)1076-1083(2017 Jun)
L?pez-Soldado I,Fuentes-Romero R,Duran J,Guinovart JJ

Elf5 is a principal cell lineage specific transcription factor in the kidney that contributes to Aqp2 and Avpr2 gene expression.
Developmental biology424(1)77-89(2017 04)
Grassmeyer J,Mukherjee M,deRiso J,Hettinger C,Bailey M,Sinha S,Visvader JE,Zhao H,Fogarty E,Surendran K

Loss of Zeb2 in mesenchyme-derived nephrons causes primary glomerulocystic disease.
Kidney international90(6)1262-1273(2016 Dec)
Rasouly HM,Kumar S,Chan S,Pisarek-Horowitz A,Sharma R,Xi QJ,Nishizaki Y,Higashi Y,Salant DJ,Maas RL,Lu W

Metabolic crosstalk: molecular links between glycogen and lipid metabolism in obesity.
Diabetes63(9)2935-48(2014 Sep)
Lu B,Bridges D,Yang Y,Fisher K,Cheng A,Chang L,Meng ZX,Lin JD,Downes M,Yu RT,Liddle C,Evans RM,Saltiel AR

PTG protein depletion rescues malin-deficient Lafora disease in mouse.
Annals of neurology75(3)442-6(2014 Mar)
Turnbull J,Epp JR,Goldsmith D,Zhao X,Pencea N,Wang P,Frankland PW,Ackerley CA,Minassian BA

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Ppp1r3c cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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