Tnfsf14 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tnfsf14
Entrez Gene ID	50930
Full Name	tumor necrosis factor (ligand) superfamily, member 14
Synonyms	HVEM-L,HVEML,LIGHT,LTg,Ly113,Tnlg1d
General protein information	Preferred Names tumor necrosis factor (ligand) superfamily, member 14 Names tumor necrosis factor ligand superfamily member 14 tumor necrosis factor ligand 1d
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 17 Map Location: 17\|17 D

mRNA and Protein(s)

mRNA	Protein	Name
NM_019418.3	NP_062291.1	tumor necrosis factor ligand superfamily member 14

Pathways from BioSystems

Homologies

	TNFSF14	XP_001089169.2
Canis lupus familiaris (dog)	TNFSF14	XP_854328.1
Mus musculus (house mouse)	Tnfsf14	NP_062291.1
Rattus norvegicus (Norway rat)	Tnfsf14	NP_001178732.1
Homo sapiens (human)	TNFSF14	NP_003798.2
Pan troglodytes (chimpanzee)	TNFSF14	XP_001149848.1
Bos taurus (cattle)	TNFSF14	NP_001095325.1

Gene Ontology
Bibliography

Related articles in PubMed

Shining LIGHT on the metabolic role of the cytokine TNFSF14 and the implications on hepatic IL-6 production.
Saunders BM, Rudnicka C, Filipovska A, Davies S, Ward N, Hricova J, Schlaich MP, Matthews VB
Immunology and cell biology96(1)41-53(2018 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

LIGHT promote myeloid differentiation of Hematopoietic stem/progenitor cells via LIGHT receptor signaling.
Title: Hematopoietic stem/progenitor cell differentiation towards myeloid lineage is modulated by LIGHT/LIGHT receptor signaling.

Increasing LIGHT expression increased T-cell proliferation, activation, and infiltration, resulting in enhanced tumor-specific immune-mediated tumor regressions in primary tumors and colorectal liver metastases.
Title: LIGHT Elevation Enhances Immune Eradication of Colon Cancer Metastases.

Together, these results demonstrate that the LIGHT signaling pathway is not only required for inflammatory cytokine production as part of the host response to chlamydial infection, but also influences the differentiation of CD4(+) CD25(+) FoxP3(+) Treg cells, both of which may be essential for control of C. psittaci respiratory tract infection.
Title: Deficiency of LIGHT signaling pathway exacerbates Chlamydia psittaci respiratory tract infection in mice.

LIGHT signalling pathway combined with IFN-gamma induces beta cells apoptosis via an NF-kappaB/Bcl2-dependent mitochondrial pathway.
Title: LIGHT/IFN-? triggers ? cells apoptosis via NF-?B/Bcl2-dependent mitochondrial pathway.

The LIGHT (Tumour necrosis factor ligand superfamily member 14, TNFSF14)/Lymphotoxin beta-Receptor(LTbeta-R) pathway, which is involved in T-cell and macrophage activation, was diminished in plasma and in apoE-/-Irs2+/-HL-/- atheromas.
Title: Hepatic lipase inactivation decreases atherosclerosis in insulin resistance by reducing LIGHT/Lymphotoxin ?-Receptor pathway.

The following Tnfsf14 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tnfsf14 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu10869	NM_019418.3 Latest version!	Mus musculus tumor necrosis factor (ligand) superfamily, member 14 (Tnfsf14), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tnfsf14 ( NM_019418.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_062291.1 Mus musculus tumor necrosis factor (ligand) superfamily, member 14 (Tnfsf14), mRNA.

Price & Availability↑

CloneID	OMu10869
Clone ID Related Accession (Same CDS sequence)	NM_019418.3
Accession Version	NM_019418.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 720bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-13
Organism	Mus musculus(house mouse)
Product	tumor necrosis factor ligand superfamily member 14
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY208945.1, BC125477.1, CT025692.15 and BY554892.1. On Dec 18, 2013 this sequence version replaced NM_019418.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB029155.1, BC125477.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGAGAGTG TGGTACAGCC TTCAGTGTTT GTGGTGGATG GACAGACGGA CATCCCATTC 
AGGCGGCTGG AACAGAACCA CCGGAGACGG CGCTGTGGCA CTGTCCAGGT CAGCCTGGCC 
CTGGTGCTGC TGCTAGGTGC TGGGCTGGCC ACTCAGGGCT GGTTTCTCCT GAGACTGCAT 
CAACGTCTTG GAGACATAGT AGCTCATCTG CCAGATGGAG GCAAAGGCTC CTGGGAGAAG 
CTGATACAAG ATCAACGATC TCACCAGGCC AACCCAGCAG CACATCTTAC AGGAGCCAAC 
GCCAGCTTGA TAGGTATTGG TGGACCTCTG TTATGGGAGA CACGACTTGG CCTGGCCTTC 
TTGAGGGGCT TGACGTATCA TGATGGGGCC CTGGTGACCA TGGAGCCCGG TTACTACTAT 
GTGTACTCCA AAGTGCAGCT GAGCGGCGTG GGCTGCCCCC AGGGGCTGGC CAATGGCCTC 
CCCATCACCC ATGGACTATA CAAGCGCACA TCCCGCTACC CGAAGGAGTT AGAACTGCTG 
GTCAGTCGGC GGTCACCCTG TGGCCGGGCC AACAGCTCCC GAGTCTGGTG GGACAGCAGC 
TTCCTGGGCG GCGTGGTACA TCTGGAGGCT GGGGAAGAGG TGGTGGTCCG CGTGCCTGGA 
AACCGCCTGG TCAGACCACG TGACGGCACC AGGTCCTATT TCGGAGCTTT CATGGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062291.1
CDS	113..832
Translation	MESVVQPSVFVVDGQTDIPFRRLEQNHRRRRCGTVQVSLALVLLLGAGLATQGWFLLRLHQRLGDIVAHLPDGGKGSWEKLIQDQRSHQANPAAHLTGANASLIGIGGPLLWETRLGLAFLRGLTYHDGALVTMEPGYYYVYSKVQLSGVGCPQGLANGLPITHGLYKRTSRYPKELELLVSRRSPCGRANSSRVWWDSSFLGGVVHLEAGEEVVVRVPGNRLVRPRDGTRSYFGAFMV

Target ORF information:

RefSeq Version	NM_019418.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus tumor necrosis factor (ligand) superfamily, member 14 (Tnfsf14), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019418.3

ORF Insert Sequence:

ATGGAGAGTG TGGTACAGCC TTCAGTGTTT GTGGTGGATG GACAGACGGA CATCCCATTC 
AGGCGGCTGG AACAGAACCA CCGGAGACGG CGCTGTGGCA CTGTCCAGGT CAGCCTGGCC 
CTGGTGCTGC TGCTAGGTGC TGGGCTGGCC ACTCAGGGCT GGTTTCTCCT GAGACTGCAT 
CAACGTCTTG GAGACATAGT AGCTCATCTG CCAGATGGAG GCAAAGGCTC CTGGGAGAAG 
CTGATACAAG ATCAACGATC TCACCAGGCC AACCCAGCAG CACATCTTAC AGGAGCCAAC 
GCCAGCTTGA TAGGTATTGG TGGACCTCTG TTATGGGAGA CACGACTTGG CCTGGCCTTC 
TTGAGGGGCT TGACGTATCA TGATGGGGCC CTGGTGACCA TGGAGCCCGG TTACTACTAT 
GTGTACTCCA AAGTGCAGCT GAGCGGCGTG GGCTGCCCCC AGGGGCTGGC CAATGGCCTC 
CCCATCACCC ATGGACTATA CAAGCGCACA TCCCGCTACC CGAAGGAGTT AGAACTGCTG 
GTCAGTCGGC GGTCACCCTG TGGCCGGGCC AACAGCTCCC GAGTCTGGTG GGACAGCAGC 
TTCCTGGGCG GCGTGGTACA TCTGGAGGCT GGGGAAGAGG TGGTGGTCCG CGTGCCTGGA 
AACCGCCTGG TCAGACCACG TGACGGCACC AGGTCCTATT TCGGAGCTTT CATGGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Shining LIGHT on the metabolic role of the cytokine TNFSF14 and the implications on hepatic IL-6 production.
Immunology and cell biology96(1)41-53(2018 Jan)
Saunders BM,Rudnicka C,Filipovska A,Davies S,Ward N,Hricova J,Schlaich MP,Matthews VB

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Tnfsf14 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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