Prdm14 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Prdm14
Entrez Gene ID	383491
Full Name	PR domain containing 14
General protein information	Preferred Names PR domain containing 14 Names PR domain zinc finger protein 14 PR domain-containing protein 14
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1\|1 A3

mRNA and Protein(s)

mRNA	Protein	Name
NM_001081209.2	NP_001074678.2	PR domain zinc finger protein 14

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	PRDM14	XP_003640063.1
Danio rerio (zebrafish)	prdm14	NP_001157303.1
Homo sapiens (human)	PRDM14	NP_078780.1
	PRDM14	XP_002805420.1
Rattus norvegicus (Norway rat)	LOC100365184	XP_003749932.1
Xenopus tropicalis (tropical clawed frog)	prdm14	XP_002937124.1
Pan troglodytes (chimpanzee)	PRDM14	XP_519800.2
Mus musculus (house mouse)	Prdm14	NP_001074678.2
Bos taurus (cattle)	PRDM14	NP_001178193.1
Gallus gallus (chicken)	LOC100858709	XP_003640888.1

Gene Ontology
Bibliography

Related articles in PubMed

Esrrb Complementation Rescues Development of Nanog-Null Germ Cells.
Zhang M, Leitch HG, Tang WWC, Festuccia N, Hall-Ponsele E, Nichols J, Surani MA, Smith A, Chambers I
Cell reports22(2)332-339(2018 Jan)

Silencing PRDM14 expression by an innovative RNAi therapy inhibits stemness, tumorigenicity, and metastasis of breast cancer.
Taniguchi H, Hoshino D, Moriya C, Zembutsu H, Nishiyama N, Yamamoto H, Kataoka K, Imai K
Oncotarget8(29)46856-46874(2017 Jul)

PRDM14 Drives OCT3/4 Recruitment via Active Demethylation in the Transition from Primed to Naive Pluripotency.
Okashita N, Suwa Y, Nishimura O, Sakashita N, Kadota M, Nagamatsu G, Kawaguchi M, Kashida H, Nakajima A, Tachibana M, Seki Y
Stem cell reports7(6)1072-1086(2016 12)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PRDM14 recruited OCT3/4 to the enhancer regions of naive pluripotency genes via TET-base excision repair-mediated demethylation.
Title: PRDM14 Drives OCT3/4 Recruitment via Active Demethylation in the Transition from Primed to Naive Pluripotency.

JARID2 physically interacts with ESRRB, SALL4A, and PRDM14
Title: Combined Overexpression of JARID2, PRDM14, ESRRB, and SALL4A Dramatically Improves Efficiency and Kinetics of Reprogramming to Induced Pluripotent Stem Cells.

This repressive function is mediated through an ETO-family co-repressor Mtgr1, which tightly binds to the pre-SET/SET domains of Prdm14 and co-occupies its genomic targets in mouse embryonic stem cells.
Title: ETO family protein Mtgr1 mediates Prdm14 functions in stem cell maintenance and primordial germ cell formation.

Both TET1 and TET2 are required for the repression of embryonic stem cells differentiation by PRDM14.
Title: PRDM14 maintains pluripotency of embryonic stem cells through TET-mediated active DNA demethylation.

the H3K27-specific demethylase Utx regulates the expression of the master regulators for XCI and XCR: Prdm14, Tsix, and Xist.
Title: Histone demethylation maintains Prdm14 and Tsix expression and represses xIst in embryonic stem cells.

The following Prdm14 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Prdm14 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu22154	NM_001081209.2 Latest version!	Mus musculus PR domain containing 14 (Prdm14), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Prdm14 ( NM_001081209.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001074678.2 Mus musculus PR domain containing 14 (Prdm14), mRNA.

Price & Availability↑

CloneID	OMu22154
Clone ID Related Accession (Same CDS sequence)	NM_001081209.2
Accession Version	NM_001081209.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1686bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-15
Organism	Mus musculus(house mouse)
Product	PR domain zinc finger protein 14
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK134292.1, AK141218.1 and BB283625.1. On Dec 21, 2007 this sequence version replaced NM_001081209.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN01164134 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCTTAC CGCCCTCTGG TGAGACCCAG TCCCAGGACA AGGCGAACTA CCTGCCCCAG 
AGCAACCCTC ACCACCTGAC TACCTACTAC GCGCATGCCC CAGGCTACAG TCACTTTAGG 
AACCTCGCCA CCACCGAGGA GGAGTTTCAA CCTTGGAAAC TGGCAGCTGC AGTGCTTGAG 
TCCCAGGCGA TGGCCCCTCT TGATGCTTTT CGGATGACTG CTCCCTTGTT GAACCCGGGT 
CTGGCTGTTC AGAGCGAGCC GCTCTACAAT CTGCCCTGGT ACAAATTGTC ACCATGGAAC 
CGAATTCCTC AATTCACTCC CGAAGTACCA CGATTTCTAG ACAGCACTGA GCATAGGAGC 
AGCGGTTCCA GCAACCAAAA TTTGGTCCTC GGCGGCGGCG GTGGCCAAAT CAGTGGTCAG 
AGGTGGGAAG CTGAAAATTT ACTTCTGCCA TCCCCGGTAA TTGCTTCCCT ACTACCTGAT 
GGAATTAAGT CGTCCCAGTC AATATCTGTC CCCCAAACCT TGAATCAAGA GGGGAAGCTG 
CCGTTTTGCG GCTTCAACTT CACAGAGGAG GAACTGAGCT TCGTTCTGTA TGGAGCCATC 
GCTAGTCCGG AGCACCCAAC CGACTTACAG CATGCAATTT CAGGCATCCT GGTTCCCACA 
GAGAGTTCTG GGTCTAATCA TCTTCATAAA ACCCTGGACA AAGACTCCCT CCAGCTTCCG 
GAAGGTCTCT GCCTCATGCA GACCTCATTT GGTGATGTGC CACACTTTGG CGTGTTCTGC 
AGCGACTTCA TTGCCAAAGG AGTGAGATTT GGACCCTTTC GAGGTAGAGT GGTCAATGCC 
AGCGAAGTGA AGGCACACAG GGACAACTCT CGGATGTGGG AAATTTTTGA AGATGGTCAC 
CTGAGCCATT TTATCGACGG CAAAGGTTCT GGGAACTGGA TGTCCTATGT CAACTGTGCT 
CGGTTCCCCA AGGAGCAGAA CCTGCTGGCC GTGCAGCACC AAGGGCAGAT ATTTTATGAG 
AGTTGTAGAG ACATCCAGCG GAACCAGGAA CTGCTTGTGT GGTACGGAAA TGGCTATGAG 
AAGTTCCTGG GCGTTCCCAT GAACCTCCGT GTCACTGAGC AAGGAGGCCA GCAGCTGTCT 
GAGTCCTCTG AAGAGTCTGC AGAAGGTTAC AGATGTGAAC GCTGTGGAAA GGTGTTTACC 
TACAAATACT ACAGAGATAA GCACCTGAAG TACACGCCCT GTGTGGACAA GGGGGACAGG 
AAGTTTCCGT GTTCTCTCTG CCAAAGATCC TTTGAAAAGC GCGACCGCCT CCGGATCCAT 
ATTCTTCACG TCCATGAGAG GCACCGGCCC TACCTGTGTT CAACCTGTGG GAAAAGTTTT 
TCTCAGTCTT CCAGCCTGAA CAAGCACATG AGAGTCCACT CTGGAGACAG GCCATACCAG 
TGCGTGTACT GTACAAAGAA GTTCACTGCC TCCAGCATAC TCCGAACACA CATCAGACAG 
CACTCAGGAG AGAAGCCCTT CAAGTGCAAG CATTGTGGTA AAGCCTTTGC ATCTCATGCT 
GCCCACGACA GCCACGTCCG GCGCTCACAC AAGGACAATG GCCGTAGCTC CTGCGATATT 
TGTGGGAAAG GCTTCCTGGA TCAAGAGGCT TTCTATGCCC ACATGAGGCT TCATAAAACC 
TGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001074678.2
CDS	76..1761
Translation	MALPPSGETQSQDKANYLPQSNPHHLTTYYAHAPGYSHFRNLATTEEEFQPWKLAAAVLESQAMAPLDAFRMTAPLLNPGLAVQSEPLYNLPWYKLSPWNRIPQFTPEVPRFLDSTEHRSSGSSNQNLVLGGGGGQISGQRWEAENLLLPSPVIASLLPDGIKSSQSISVPQTLNQEGKLPFCGFNFTEEELSFVLYGAIASPEHPTDLQHAISGILVPTESSGSNHLHKTLDKDSLQLPEGLCLMQTSFGDVPHFGVFCSDFIAKGVRFGPFRGRVVNASEVKAHRDNSRMWEIFEDGHLSHFIDGKGSGNWMSYVNCARFPKEQNLLAVQHQGQIFYESCRDIQRNQELLVWYGNGYEKFLGVPMNLRVTEQGGQQLSESSEESAEGYRCERCGKVFTYKYYRDKHLKYTPCVDKGDRKFPCSLCQRSFEKRDRLRIHILHVHERHRPYLCSTCGKSFSQSSSLNKHMRVHSGDRPYQCVYCTKKFTASSILRTHIRQHSGEKPFKCKHCGKAFASHAAHDSHVRRSHKDNGRSSCDICGKGFLDQEAFYAHMRLHKTC

Target ORF information:

RefSeq Version	NM_001081209.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus PR domain containing 14 (Prdm14), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001081209.2

ORF Insert Sequence:

ATGGCCTTAC CGCCCTCTGG TGAGACCCAG TCCCAGGACA AGGCGAACTA CCTGCCCCAG 
AGCAACCCTC ACCACCTGAC TACCTACTAC GCGCATGCCC CAGGCTACAG TCACTTTAGG 
AACCTCGCCA CCACCGAGGA GGAGTTTCAA CCTTGGAAAC TGGCAGCTGC AGTGCTTGAG 
TCCCAGGCGA TGGCCCCTCT TGATGCTTTT CGGATGACTG CTCCCTTGTT GAACCCGGGT 
CTGGCTGTTC AGAGCGAGCC GCTCTACAAT CTGCCCTGGT ACAAATTGTC ACCATGGAAC 
CGAATTCCTC AATTCACTCC CGAAGTACCA CGATTTCTAG ACAGCACTGA GCATAGGAGC 
AGCGGTTCCA GCAACCAAAA TTTGGTCCTC GGCGGCGGCG GTGGCCAAAT CAGTGGTCAG 
AGGTGGGAAG CTGAAAATTT ACTTCTGCCA TCCCCGGTAA TTGCTTCCCT ACTACCTGAT 
GGAATTAAGT CGTCCCAGTC AATATCTGTC CCCCAAACCT TGAATCAAGA GGGGAAGCTG 
CCGTTTTGCG GCTTCAACTT CACAGAGGAG GAACTGAGCT TCGTTCTGTA TGGAGCCATC 
GCTAGTCCGG AGCACCCAAC CGACTTACAG CATGCAATTT CAGGCATCCT GGTTCCCACA 
GAGAGTTCTG GGTCTAATCA TCTTCATAAA ACCCTGGACA AAGACTCCCT CCAGCTTCCG 
GAAGGTCTCT GCCTCATGCA GACCTCATTT GGTGATGTGC CACACTTTGG CGTGTTCTGC 
AGCGACTTCA TTGCCAAAGG AGTGAGATTT GGACCCTTTC GAGGTAGAGT GGTCAATGCC 
AGCGAAGTGA AGGCACACAG GGACAACTCT CGGATGTGGG AAATTTTTGA AGATGGTCAC 
CTGAGCCATT TTATCGACGG CAAAGGTTCT GGGAACTGGA TGTCCTATGT CAACTGTGCT 
CGGTTCCCCA AGGAGCAGAA CCTGCTGGCC GTGCAGCACC AAGGGCAGAT ATTTTATGAG 
AGTTGTAGAG ACATCCAGCG GAACCAGGAA CTGCTTGTGT GGTACGGAAA TGGCTATGAG 
AAGTTCCTGG GCGTTCCCAT GAACCTCCGT GTCACTGAGC AAGGAGGCCA GCAGCTGTCT 
GAGTCCTCTG AAGAGTCTGC AGAAGGTTAC AGATGTGAAC GCTGTGGAAA GGTGTTTACC 
TACAAATACT ACAGAGATAA GCACCTGAAG TACACGCCCT GTGTGGACAA GGGGGACAGG 
AAGTTTCCGT GTTCTCTCTG CCAAAGATCC TTTGAAAAGC GCGACCGCCT CCGGATCCAT 
ATTCTTCACG TCCATGAGAG GCACCGGCCC TACCTGTGTT CAACCTGTGG GAAAAGTTTT 
TCTCAGTCTT CCAGCCTGAA CAAGCACATG AGAGTCCACT CTGGAGACAG GCCATACCAG 
TGCGTGTACT GTACAAAGAA GTTCACTGCC TCCAGCATAC TCCGAACACA CATCAGACAG 
CACTCAGGAG AGAAGCCCTT CAAGTGCAAG CATTGTGGTA AAGCCTTTGC ATCTCATGCT 
GCCCACGACA GCCACGTCCG GCGCTCACAC AAGGACAATG GCCGTAGCTC CTGCGATATT 
TGTGGGAAAG GCTTCCTGGA TCAAGAGGCT TTCTATGCCC ACATGAGGCT TCATAAAACC 
TGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Esrrb Complementation Rescues Development of Nanog-Null Germ Cells.
Cell reports22(2)332-339(2018 Jan)
Zhang M,Leitch HG,Tang WWC,Festuccia N,Hall-Ponsele E,Nichols J,Surani MA,Smith A,Chambers I

Silencing PRDM14 expression by an innovative RNAi therapy inhibits stemness, tumorigenicity, and metastasis of breast cancer.
Oncotarget8(29)46856-46874(2017 Jul)
Taniguchi H,Hoshino D,Moriya C,Zembutsu H,Nishiyama N,Yamamoto H,Kataoka K,Imai K

PRDM14 Drives OCT3/4 Recruitment via Active Demethylation in the Transition from Primed to Naive Pluripotency.
Stem cell reports7(6)1072-1086(2016 12)
Okashita N,Suwa Y,Nishimura O,Sakashita N,Kadota M,Nagamatsu G,Kawaguchi M,Kashida H,Nakajima A,Tachibana M,Seki Y

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Prdm14 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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